期刊
GENES & DEVELOPMENT
卷 25, 期 3, 页码 214-219出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1993611
关键词
RNAi; heterochromatin; H3K14 acetylation; Mst2; transcription; meiotic recombination
资金
- National Institutes of Health (NIH) [R01-GM085145, R01-GM032194, T32-GM008798]
- Cancer Research UK
In Schizosaccharomyces pombe, the RNAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregation, and repression of pericentric meiotic recombination. Here we demonstrate that, when the activity of the histone H3 Lys 14 (H3K14) acetyltransferase Mst2 is eliminated, the RNAi machinery is no longer required for pericentric heterochromatin functions. We further reveal that reducing RNA polymerase II recruitment to pericentric regions is essential for maintaining heterochromatin in the absence of RNAi.
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