Article
Cell & Tissue Engineering
Yongzhao Zhao, Qian Xiang, Yunzhong Cheng, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study investigated the association between oxidative stress and autophagy in intervertebral disc degeneration (IDD) and explored the potential of stem cell therapy for IDD. The findings suggest that stem cell therapy may reduce oxidative stress and restore autophagy to repair degenerative IVD. This research provides new insights into the mechanism of stem cell therapy for IDD and potential therapeutic targets.
STEM CELLS INTERNATIONAL
(2022)
Review
Cell & Tissue Engineering
Zimo Zhou, Mohammad Showkat Hossain, Da Liu
Summary: The long noncoding RNA H19 plays a vital role in osteogenic differentiation and is recognized as a novel target for promoting bone regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Zimo Zhou, Jiahui Chen, Ying Huang, Da Liu, Senxiang Chen, Sen Qin
Summary: Long noncoding RNAs (lncRNAs) are an important type of RNA encoded in the human transcriptome, and they have been shown to play a crucial role in regulating various genomic processes in human cells. One specific lncRNA, GAS5, has been found to be involved in regulating cell growth, differentiation, and development, as well as participating in the occurrence and prognosis of bone diseases. This review discusses the roles of GAS5 in bone diseases and explores novel targets for the treatment of these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Hematology
Esther Cynn, Daniel Y. Li, Marcella E. O'Reilly, Ying Wang, Alexander C. Bashore, Anjali Jha, Andrea S. Foulkes, Hanrui Zhang, Hanna Winter, Lars Maegdefessel, Hanying Yan, Mingyao Li, Leila Ross, Chenyi Xue, Muredach P. Reilly
Summary: In this study, researchers identified a non-conserved, human-specific long noncoding RNA called SIMALR that suppresses macrophage apoptosis in atherosclerosis. SIMALR interacts with HIF1α to regulate the transcription of a known macrophage survival factor, NTN1. This research highlights the importance of investigating the functions of human lncRNAs and exploring their translational and therapeutic potential in atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Cell Biology
Anuradha Kirtonia, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Amirhossein Zabolian, Atefe K. Bejandi, Reshma Rani, Amit K. Pandey, Prakash Baligar, Vinit Kumar, Bhudev C. Das, Manoj Garg
Summary: Acute myeloid leukemia (AML) is a hematological disorder characterized by blocked myeloid differentiation and increased immature myeloid progenitors. Long noncoding RNAs (lncRNAs) are considered potential diagnostic, therapeutic, and prognostic factors in AML, with altered expression playing a significant role in leukemic transformation and involvement in various molecular pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Yingying Zhang, Lifang Shi, Ke Yang, Xuehui Liu, Xiang Lv
Summary: This study revealed the important role of transglutaminase 2 (TGM2) in fetal liver erythroid differentiation, which is regulated by its cross-linking enzyme activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Tao Li, Yingxing Xu, Yingzhen Wang, Yaping Jiang
Summary: The study found that the effect of Dex depended on exposure time and concentration, with continuous exposure to 10(-6)mol/L Dex for 7 days being a suitable protocol for inducing apoptosis of hBMSCs. Differentially expressed lncRNAs and mRNAs associated with apoptosis, cell cycle, and proliferation were identified, providing a new research direction for further studies.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Andrea Carvelli, Adriano Setti, Fabio Desideri, Silvia Giulia Galfre, Silvia Biscarini, Tiziana Santini, Alessio Colantoni, Giovanna Peruzzi, Matteo Jacopo Marzi, Davide Capauto, Silvia Di Angelantonio, Monica Ballarino, Francesco Nicassio, Pietro Laneve, Irene Bozzoni
Summary: The transition from dividing progenitors to postmitotic motor neurons (MNs) is regulated by a MN-specific transcriptional unit (MN2), which contains a long non-coding RNA (lncMN2-203) and two microRNAs (miR-325-3p and miR-384-5p). The lncMN2-203 affects MN differentiation by upregulating miR-466i-5p targets, while miR-325-3p and miR-384-5p repress proliferation-related factors. This study demonstrates the importance of post-transcriptional regulation in MN differentiation.
Review
Virology
Sasidharanpillai Sabeena
Summary: This review discusses the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancer. The existing studies on microRNA signatures in body fluids and cervical cancer tissues lack consistency and lack validated assays. The precise evaluation of immune-associated long noncoding RNA signatures in clinical samples is necessary. Research on the safe delivery methods, toxicities, and side effects of lncRNAs to tumor tissues is needed. Prospective studies on the diagnostic and prognostic roles of circulating lncRNAs and Piwil RNAs in cervical cancer cases are crucial. Comprehensive research is required for the clinical application of lncRNA-based biomarkers, as the impact of noncoding transcripts on molecular pathways is complex. Standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are essential.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Cell Biology
Chang Liu, Yanli Zhang, Zhanchuan Ma, Huanfa Yi
Summary: CD4(+) T-cell differentiation is regulated by a complex mechanism involving lncRNAs, which modulate the plasticity and functional heterogeneity of CD4(+) T cells. Investigating how lncRNAs regulate CD4(+) T-cell differentiation in different immune diseases is of great significance for understanding the pathological mechanisms of immune-mediated diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lingzhi Lai, Zhaodan Wang, Yihong Ge, Wei Qiu, Buling Wu, Fuchun Fang, Huiyong Xu, Zhao Chen
Summary: By constructing a lncRNA-associated ceRNA network, we revealed the induced lncRNAs and mRNAs that are associated with the osteogenesis of PDLSCs, as well as the miRNAs that regulate these lncRNAs and mRNAs. Further functional analysis identified several GO terms and pathways related to osteogenesis, particularly MAPK and TGF-beta pathways. These findings contribute to a better understanding of the molecular regulatory mechanisms of periodontal regeneration.
Article
Multidisciplinary Sciences
Alina Isakova, Norma Neff, Stephen R. Quake
Summary: Smart-seq-total is a method capable of assaying a broad spectrum of coding and noncoding RNA from a single cell, outperforming current RNA-seq protocols by capturing a wide range of transcripts. By analyzing the total RNAome of single cells, it can reveal new roles of noncoding RNA in essential processes such as cell cycle and embryonic development, as well as determine cell-type identity using different classes of short-noncoding RNA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Patrice Cagle, Qi Qi, Suryakant Niture, Deepak Kumar
Summary: KCNQ1OT1 is an lncRNA involved in the development and progression of various cancers, regulating cancer cell functions and associated with poor prognosis in cancer patients.
Article
Oncology
Chengyu Lv, Jiandong Sun, Yuhong Ye, Zihang Lin, Hua Li, Yue Liu, Kaien Mo, Weiwei Xu, Weitao Hu, Eman Draz, Shie Wang
Summary: This study reveals that the lncRNA EIF1AX-AS1 plays an important role in the occurrence and development of endometrial carcinoma (EC). EIF1AX-AS1 is downregulated in clinical EC tissues and is closely correlated with tumor type. It inhibits EC cell proliferation and promotes apoptosis by interacting with EIF1AX mRNA and PCBP1. Moreover, EIF1AX promotes c-Myc translation through its interaction with YBX-1, forming a feed-forward loop to regulate EC cell proliferation.
Review
Biochemistry & Molecular Biology
Xiyin Wang, Luca Parodi, Shannon M. M. Hawkins
Summary: Endometriosis is a chronic gynecologic disease without a cure, requiring improved therapies and noninvasive diagnostic tests. Research suggests that long noncoding RNAs and circular long noncoding RNAs play significant roles in the expression and function of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sarah K. Tasian, Jessica A. Casas, David Posocco, Shilpa Gandre-Babbe, Alyssa L. Gagne, Ge Liang, Mignon L. Loh, Mitchell J. Weiss, Deborah L. French, Stella T. Chou
Letter
Hematology
Rima S. Zahr, Evadnie Rampersaud, Guolian Kang, Mitchell J. Weiss, Gang Wu, Robert L. Davis, Jane S. Hankins, Jeremie H. Estepp, Jeffrey Lebensburger
Article
Medicine, General & Internal
Ewelina Mamcarz, Sheng Zhou, Timothy Lockey, Hossam Abdelsamed, Shane J. Cross, Guolian Kang, Zhijun Ma, Jose Condori, Jola Dowdy, Brandon Triplett, Chen Li, Gabriela Maron, Juan C. Aldave Becerra, Joseph A. Church, Elif Dokmeci, James T. Love, Ana C. da Matta Ain, Hedi van der Watt, Xing Tang, William Janssen, Byoung Y. Ryu, Suk See De Ravin, Mitchell J. Weiss, Benjamin Youngblood, Janel R. Long-Boyle, Stephen Gottschalk, Michael M. Meagher, Harry L. Malech, Jennifer M. Puck, Morton J. Cowan, Brian P. Sorrentino
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Oncology
Maurice Labuhn, Kelly Perkins, Soeren Matzk, Leila Varghese, Catherine Garnett, Elli Papaemmanuil, Marlen Metzner, Alison Kennedy, Vyacheslav Amstislayskiy, Thomas Risch, Raj Bhayadia, David Samulowski, David Cruz Hernandez, Bilyana Stoilova, Valentina Lotchkova, Udo Oppermann, Carina Scheer, Kenichi Yoshida, Adrian Schwarzer, Jeffrey Taub, John D. Crispino, Mitchell J. Weiss, Asuhide Hayashi, Takashi Taga, Etsuro Ito, Seishi Ogawa, Dirk Reinhardt, Marie-Laure Yaspo, Peter J. Campbell, Irene Roberts, Stefan Constantinescu, Paresh Vyas, Dirk Heckl, Jan-Henning Klusmann
Article
Cell Biology
Christophe Lechauve, Julia Keith, Eugene Khandros, Stephanie Fowler, Kalin Mayberry, Abdullah Freiwan, Christopher S. Thom, Paola Delbini, Emilio Boada Romero, Jingjing Zhang, Irene Motta, Heather Tillman, M. Domenica Cappellini, Mondira Kundu, Mitchell J. Weiss
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Guanjue Xiang, Cheryl A. Keller, Elisabeth Heuston, Belinda M. Giardine, Lin An, Alexander Q. Wixom, Amber Miller, April Cockburn, Michael E. G. Sauria, Kathryn Weaver, Jens Lichtenberg, Berthold Gottgens, Qunhua Li, David Bodine, Shaun Mahony, James Taylor, Gerd A. Blobel, Mitchell J. Weiss, Yong Cheng, Feng Yue, Jim Hughes, Douglas R. Higgs, Yu Zhang, Ross C. Hardison
Letter
Hematology
Naoya Uchida, Alexis Leonard, David Stroncek, Sandhya R. Panch, Kamille West, Eoghan Molloy, Thomas E. Hughes, Sara Hauffe, Tiffani Taylor, Courtney Fitzhugh, Jane S. Hankins, Megan Wilson, Akshay Sharma, Shengdar Q. Tsai, Mitchell J. Weiss, Matthew Hsieh, John F. Tisdale
Article
Hematology
Ti-Cheng Chang, Kelly M. Haupfear, Jing Yu, Evadnie Rampersaud, Vivien A. Sheehan, Jonathan M. Flanagan, Jane S. Hankins, Mitchell J. Weiss, Gang Wu, Sunitha Vege, Connie M. Westhoff, Stella T. Chou, Yan Zheng
Article
Hematology
Peng Xu, Daniel C. Scott, Beisi Xu, Yu Yao, Ruopeng Feng, Li Cheng, Kalin Mayberry, Yong-Dong Wang, Wenjian Bi, Lance E. Palmer, Moeko T. King, Hong Wang, Yuxin Li, Yiping Fan, Arno F. Alpi, Chunliang Li, Junmin Peng, James Papizan, Shondra M. Pruett-Miller, Ria Spallek, Florian Bassermann, Yong Cheng, Brenda A. Schulman, Mitchell J. Weiss
Summary: The E3 ubiquitin ligase FBXO11 relieves PRC2-mediated transcriptional repression during erythroid maturation by targeting its substrate BAHD1. Lack of FBXO11 in erythroblasts leads to developmental delay and reduced expression of maturation-associated genes. BAHD1 acts as a novel effector of PRC2-mediated repression and interacts physically with PRC2, highlighting a mechanism for eliminating PRC2 repression at developmentally poised genes during erythropoiesis.
Article
Biochemistry & Molecular Biology
Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C. Ly, Yemin Lan, Zhe Zhang, Nicholas Aboreden, Kunhua Qin, John R. Horton, Jeremy D. Grevet, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Merlin Crossley, Mitchell J. Weiss, Xiaodong Cheng, Junwei Shi, Gerd A. Blobel
Summary: ZNF410 is a pentadactyl DNA-binding protein that activates only one gene, CHD4, in human erythroid cells. Loss of ZNF410 leads to decreased CHD4 levels and derepression of fetal hemoglobin genes, revealing their sensitivity to reduced CHD4 levels. The specific binding sites near the CHD4 gene provide the specificity of ZNF410's transcriptional activation in erythroid cells.
Article
Biochemistry & Molecular Biology
Oezge Karayel, Peng Xu, Isabell Bludau, Senthil Velan Bhoopalan, Yu Yao, Freitas Colaco Ana Rita, Alberto Santos, Brenda A. Schulman, Arno F. Alpi, Mitchell J. Weiss, Matthias Mann
MOLECULAR SYSTEMS BIOLOGY
(2020)
Article
Oncology
Clay McLeod, Alexander M. Gout, Xin Zhou, Andrew Thrasher, Delaram Rahbarinia, Samuel W. Brady, Michael Macias, Kirby Birch, David Finkelstein, Jobin Sunny, Rahul Mudunuri, Brent A. Orr, Madison Treadway, Bob Davidson, Tracy K. Ard, Arthur Chiao, Andrew Swistak, Stephanie Wiggins, Scott Foy, Jian Wang, Edgar Sioson, Shuoguo Wang, J. Robert Michael, Yu Liu, Xiaotu Ma, Aman Patel, Michael N. Edmonson, Mark R. Wilkinson, Andrew M. Frantz, Ti-Cheng Chang, Liqing Tian, Shaohua Lei, S. M. Ashiqul Islam, Christopher Meyer, Naina Thangaraj, Pamella Tater, Vijay Kandali, Singer Ma, Tuan Nguyen, Omar Serang, Irina McGuire, Nedra Robison, Darrell Gentry, Xing Tang, Lance E. Palmer, Gang Wu, Ed Suh, Leigh Tanner, James McMurry, Matthew Lear, Alberto S. Pappo, Zhaoming Wang, Carmen L. Wilson, Yong Cheng, Soheil Meshinchi, Ludmil B. Alexandrov, Mitchell J. Weiss, Gregory T. Armstrong, Leslie L. Robison, Yutaka Yasui, Kim E. Nichols, David W. Ellison, Chaitanya Bangur, Charles G. Mullighan, Suzanne J. Baker, Michael A. Dyer, Geralyn Miller, Scott Newman, Michael Rusch, Richard Daly, Keith Perry, James R. Downing, Jinghui Zhang
Summary: Effective data sharing is crucial in accelerating research and improving diagnostic precision, treatment efficacy, and long-term survival rates for pediatric cancer. St. Jude Cloud provides a cloud-based ecosystem with over 1.2 petabytes of genomic data from over 10,000 pediatric patients, enabling advanced data analysis and knowledge enhancement in pediatric cancer research.
Article
Medicine, Research & Experimental
Selami Demirci, Jing Zeng, Yuxuan Wu, Naoya Uchida, Anne H. Shen, Danilo Pellin, Jackson Gamer, Morgan Yapundich, Claire Drysdale, Jasmine Bonanno, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Theresa Engels, Robert E. Donahue, Juan J. Haro-Mora, Alexis Leonard, Tina Nassehi, Kevin Luk, Shaina N. Porter, Cicera R. Lazzarotto, Shengdar Q. Tsai, Mitchell J. Weiss, Shondra M. Pruett-Miller, Scot A. Wolfe, Daniel E. Bauer, John F. Tisdale
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Hematology
Jean-Yves Metais, Phillip A. Doerfler, Thiyagaraj Mayuranathan, Daniel E. Bauer, Stephanie C. Fowler, Matthew M. Hsieh, Varun Katta, Sagar Keriwala, Cicera R. Lazzarotto, Kevin Luk, Michael D. Neel, S. Scott Perry, Samuel T. Peters, Shaina N. Porter, Byoung Y. Ryu, Akshay Sharma, Devlin Shea, John F. Tisdale, Naoya Uchida, Scot A. Wolfe, Kaitly J. Woodard, Yuxuan Wu, Yu Yao, Jing Zeng, Shondra Pruett-Miller, Shengdar Q. Tsai, Mitchell J. Weiss
Article
Medicine, Research & Experimental
David Claassen, Michelle Boals, Kevin M. Bowling, Gregory M. Cooper, Jennifer Cox, Michael Hershfield, Sara Lewis, Marcin Wlodarski, Mitchell J. Weiss, Jeremie H. Estepp
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2018)
