期刊
GENES & DEVELOPMENT
卷 24, 期 9, 页码 857-861出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1921610
关键词
Polycomb; chromatin; Histone methylation; Jarid2
资金
- Jane Coffin Childs Memorial Fund
- NIH [R01CA89455, R01CA150265, R01GM069905]
Polycomb group proteins (PcG) are required for proper developmental regulation and cell fate commitment in metazoans. Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in implementing histone H3 Lys 27 methylation and transcriptional repression during development. Here, we discuss the implications of these studies for an improved understanding of PcG function in development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据