期刊
GENES & DEVELOPMENT
卷 23, 期 13, 页码 1487-1493出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1824009
关键词
Oligodendrocyte; CNS development; Wnt; multiple sclerosis; remyelination; Olig2
资金
- National Multiple Sclerosis Society Career Transition [TA 3008A2/T]
- NIH/NINDS [NS062796-01]
- NIH CBM Predoctoral Training
Balancing extrinsic and intrinsic cues plays an integral part in shaping the complex architecture of the nervous system. During development, oligodendrocyte precursor cells integrate environmental signals and coordinate the activation of the transcriptional machinery necessary for differentiation and myelination. In this issue of Genes & Development, Fancy and colleagues (pp. 1571-1585) demonstrate that canonical Wnt signaling contributes to the decision of an oligodendrocyte precursor cell to differentiate-both during development and after demyelination. These findings provide new insight into the precise spatiotemporal coordination required for oligodendrocyte development.
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