期刊
GENES & DEVELOPMENT
卷 23, 期 20, 页码 2359-2365出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1860609
关键词
SMARCAL1; HARP; DNA damage response; RPA; annealing helicase; DNA replication
资金
- National Institutes of Health [ES016486, ES016867]
- Jane Coffin Childs Memorial Fund for Medical Research
In this issue of Genes & Development, four papers report that the annealing helicase HepA-related protein (HARP, also known as SMARCAL1 [SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1]) binds directly to the ssDNA-binding protein Replication protein A (RPA) and is recruited to sites of replicative stress. Knockdown of HARP results in hypersensitivity to multiple DNA-damaging agents and defects in fork stability or restart. These exciting insights reveal a key new player in the S-phase DNA damage response.
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