期刊
GENERAL AND COMPARATIVE ENDOCRINOLOGY
卷 203, 期 -, 页码 181-185出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2014.03.010
关键词
Radial glial cell; Neuronal migration; Neurogenesis; Neurosteroid synthesis; Steroidogenic enzyme; Aromatase
资金
- Ontario Trillium Scholarship
- Department of Biotechnology, Govt. of India
- NSERC
- University of Ottawa Research Chair in Neuroendocrinology
The radial glial cell (RGC) is a glial cell type in the central nervous system of all vertebrates. Adult teleost fish have abundant RGCs in the brain in contrast to mammals. Adult fish RGCs have many important functions, including forming a structural scaffold to guide neuronal migration and serving as the progenitor cells in the brain to generate neurons. The role of the RGC in adult neurogenesis explains the high regenerative capacity of adult fish brain. There is increasing evidence from several species that some glial cells produce or metabolize steroids. It is now well-known that teleost RGCs express aromatase and produce estrogens from androgen precursors, which may be important for local neuroendocrine functions and regulation of neurogenesis. The question of whether RGCs are capable of de novo steroid synthesis from cholesterol remains unanswered. However, the expression of steroidogenic acute regulatory protein, and the key enzyme cytochrome P450 17alpha-hydroxylase in primary cultures of goldfish RGCs indicate the potential to produce 17 alpha-hydroxy-pregnenolone and thus other steroid intermediates. The possibility of synthesizing additional non-estrogenic steroids may indicate new functions for the RGC. (C) 2014 Elsevier Inc. All rights reserved.
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