Article
Obstetrics & Gynecology
Megan C. Hansel, Hannah R. Murphy, Jessica Brunner, Christina Wang, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett, Zorimar Rivera-Nunez
Summary: The study found that neighborhood stressors were associated with higher levels of maternal testosterone, which may have implications for maternal and child health.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes, Emily S. Barrett
Summary: This study found that cadmium exposure during pregnancy may lead to lower testosterone levels in pregnant women, while estrogen levels remain unchanged. This effect may be stronger in pregnancies carrying female fetuses. Further research is needed to understand how alterations in gestational testosterone activity may impact pregnancy and child health.
Article
Endocrinology & Metabolism
Zixin Cai, Jiaxin Zhong, Yingling Jiang, Jingjing Zhang
Summary: This study summarizes the correlation between sex hormone levels and COVID-19. The findings suggest that COVID-19 patients have lower levels of T/LH, FSH/LH, and SHBG, and higher levels of LH and E-2/T. These findings may be helpful in evaluating the severity of COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Sandra India-Aldana, Andrew G. Rundle, Tess V. Clendenen, James W. Quinn, Alan A. Arslan, Yelena Afanasyeva, Karen L. Koenig, Mengling Liu, Kathryn M. Neckerman, Lorna E. Thorpe, Anne Zeleniuch-Jacquotte, Yu Chen
Summary: The study found that neighborhood walkability is associated with lower levels of androgens and estrone, and increased SHBG in postmenopausal women, as well as lower levels of DHEAS in premenopausal women. It is important to note that the associations were more pronounced in postmenopausal women.
ENVIRONMENTAL RESEARCH
(2022)
Review
Cell Biology
Wenjiao Liu, Ting Gong, Fangxiong Shi, Houqiang Xu, Xiang Chen
Summary: This article explores the signaling mechanisms through which taste receptor factors influence testosterone synthesis in male reproduction and discusses their potential role in regulating male fertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Lei Zhang, JinFeng Wu, QiuMei Wu, XiangJuan Zhang, ShuaiCai Lin, WanLi Ran, Li Zhu, ChengYan Tang, Xing Wang
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms behind male propensity in HCC incidence, prognosis, and treatment responses are complex and inconclusive. This review integrates current knowledge on how hormones regulate HCC development in a sexually dimorphic manner. Understanding the role of sex hormones in HCC may lead to personalized therapeutic strategies in high-risk populations.
Article
Neurosciences
Kevin B. Smith, Emma Murray, James Gardner Gregory, Jacky Liang, Nafissa Ismail
Summary: Puberty is a critical period for cortical and neuronal development, with stress potentially leading to long-term anxiety and depression. Probiotic treatment shows promise in mitigating these mental health issues and influencing the programming of the HPA axis. Sex-specific differences in the gut microbiome's impact on HPA axis programming during puberty warrant further investigation.
BRAIN RESEARCH BULLETIN
(2021)
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: This study established a comprehensive atlas of sex hormone concentrations in tissues and serum of male mice, revealing the distribution characteristics of sex hormones. Brain sex hormone levels are well correlated with serum levels, and white adipose tissue serves as a major reservoir of sex hormones in mice. Progesterone is the most abundant sex hormone in castrated mice.
Review
Endocrinology & Metabolism
Jose Cipolla-Neto, Fernanda Gaspar Amaral, Jose Maria Soares-Jr, Camila Congentino Gallo, Andre Furtado, Jose Eduardo Cavaco, Isabel Goncalves, Cecilia Reis Alves Santos, Telma Quintela
Summary: This study reviews the various effects of melatonin on biological functions, discusses the interactions between melatonin and sex hormones, and highlights the impact of melatonin on female gonadal steroidogenesis and hormonal control. It suggests that there is ambiguity in the influence of sex differences on the circadian rhythms of melatonin, and the debate surrounding the reciprocal relationship between melatonin and reproductive hormones remains inconclusive.
NEUROENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Sara P. Dias, Matthijs C. Brouwer, Anita Boelen, Diederik van de Beek
Summary: This study investigated the association between cerebrospinal fluid (CSF) sex steroid hormone levels and inflammatory parameters, disease severity, and outcome in pneumococcal meningitis. The results showed that higher levels of estradiol and lower levels of sex hormone-binding globulin (SHBG) were associated with unfavorable outcome in patients with pneumococcal meningitis. Estradiol was also positively correlated with inflammatory markers.
Review
Medicine, General & Internal
Le-Tian Huang, Jia-He Wang
Summary: Sarcopenia is characterized by excessive loss of skeletal muscle mass, strength, and function, associated with overall poor muscle performance status in the elderly and chronic disease patients. Its causes are multifactorial, involving molecular mechanisms such as mitochondrial function, inflammatory pathways, and circulating hormones. Age-related changes in sex steroid hormone concentrations play a significant role in the pathogenesis of sarcopenia, suggesting therapeutic interventions targeting these hormones may be beneficial in combination with specific exercise and nutrition regimens.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Helen E. Collins
Summary: For many years, females were excluded from research due to the misconception that they were smaller men with complex hormonal cycles. However, in the past decade, it has become clear that male and female cardiovascular biology and cardiac stress responses differ significantly. Premenopausal women are protected from cardiovascular diseases and have different biological processes that contribute to ventricular remodeling compared to males. Understanding the sex-dependent differences in myocardium response is important for post-infarction remodeling and functional decline.
Article
Immunology
Yanping Jiang, Allison K. Farrell, Erin T. Tobin, Henriette E. Mair-Meijers, Derek E. Wildman, Francesca Luca, Richard B. Slatcher, Samuele Zilioli
Summary: In a study of youth with asthma, it was found that maternal involvement and warmth can mitigate the impact of socioeconomic status on inflammation levels by reducing financial stress.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Endocrinology & Metabolism
Jonathan Wolf Mueller, Nora Vogg, Thomas Alec Lightning, Isabel Weigand, Cristina L. Ronchi, Paul A. Foster, Matthias Kroiss
Summary: The adrenal cortex produces specific steroid hormones including steroid sulfates, which may play a role in the pathophysiology of adrenal tumors and serve as potential biomarkers. Recent analytical developments may target sulfated steroids specifically.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Stephanie M. Correa, David W. Newstrom, James P. Warne, Pierre Flandin, Clement C. Cheung, Alexander T. Lin-Moore, Andrew A. Pierce, Allison W. Xu, John L. Rubenstein, Holly A. Ingraham
Article
Behavioral Sciences
Stephanie M. Correa, Claire M. Horan, Patricia A. Johnson, Elizabeth Adkins-Regan
HORMONES AND BEHAVIOR
(2011)
Article
Genetics & Heredity
Stephanie M. Correa, Linda L. Washburn, Ravi S. Kahlon, Michelle C. Musson, Gerrit J. Bouma, Eva M. Eicher, Kenneth H. Albrecht
Article
Multidisciplinary Sciences
Candice B. Herber, William C. Krause, Liping Wang, James R. Bayrer, Alfred Li, Matthew Schmitz, Aaron Fields, Breanna Ford, Zhi Zhang, Michelle S. Reid, Daniel K. Nomura, Robert A. Nissenson, Stephanie M. Correa, Holly A. Ingraham
NATURE COMMUNICATIONS
(2019)
Review
Endocrinology & Metabolism
Laura G. Kammel, Stephanie M. Correa
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Jeremy W. Prokop, Surya B. Chhetri, J. Edward van Veen, Xuqi Chen, Adam C. Underwood, Katie Uhl, Melinda R. Dwinell, Aron M. Geurts, Stephanie M. Correa, Arthur P. Arnold
BIOLOGY OF SEX DIFFERENCES
(2020)
Review
Biochemistry & Molecular Biology
Megan G. Massa, Stephanie M. Correa
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Multidisciplinary Sciences
Zhi Zhang, Fernando M. C. V. Reis, Yanlin He, Jae W. Park, Johnathon R. DiVittorio, Nilla Sivakumar, J. Edward van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa
NATURE COMMUNICATIONS
(2020)
Article
Biology
Zhi Zhang, Jae Whan Park, In Sook Ahn, Graciel Diamante, Nilla Sivakumar, Douglas Arneson, Xia Yang, J. Edward van Veen, Stephanie M. Correa
Summary: The study found that tamoxifen treatment leads to changes in temperature, bone, and movement in mice. Single-cell RNA sequencing revealed that tamoxifen induces widespread gene expression changes in the hypothalamus and preoptic area, dependent on estrogen receptor alpha (ERa). This indicates that ERa mediates several physiological effects of tamoxifen treatment in mice.
Review
Endocrinology & Metabolism
Zhi Zhang, Johnathon R. DiVittorio, Alexia M. Joseph, Stephanie M. Correa
Summary: Declining and variable levels of estrogens during perimenopause are associated with metabolic, vascular, and neuroendocrine changes. The typical adverse effects are vasomotor symptoms like hot flashes and night sweats. Understanding the mechanisms of estrogens on temperature regulation can help to identify new therapeutic targets to reduce negative side effects without the risks of hormone therapies.
Article
Multidisciplinary Sciences
William C. Krause, Ruben Rodriguez, Bruno Gegenhuber, Navneet Matharu, Andreas N. Rodriguez, Adriana M. Padilla-Roger, Kenichi Toma, Candice B. Herber, Stephanie M. Correa, Xin Duan, Nadav Ahituv, Jessica Tollkuhn, Holly A. Ingraham
Summary: Depletion of estrogen leads to inactivity, fat accumulation, and diabetes in rodents and humans. Research has found that estrogen-sensitive neurons in the brain play a role in rebalancing energy allocation in female mice, with implications for metabolism and physical activity. Melanocortin-4 receptor signaling extends beyond regulation of food intake, impacting physical activity levels and offering potential targets for intervention in obesity.
Review
Biochemistry & Molecular Biology
Rizaldy C. C. Zapata, Dinghong Zhang, Avraham Libster, Alessandra Porcu, Patricia Montilla-Perez, Aisha Nur, Baijie Xu, Zhi Zhang, Stephanie M. M. Correa, Chen Liu, Francesca Telese, Olivia Osborn
Summary: Antipsychotic drugs can cause excessive weight gain and metabolic disease as side effects, and increased food intake is one of the underlying causes. This study identifies Nr5a2 as a key driver of antipsychotic-induced hyperphagia, and demonstrates that inhibiting Nr5a2 can reduce excessive food intake and weight gain. These findings provide potential targets for the development of antipsychotics that do not activate hyperphagia and weight gain.
MOLECULAR PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Stephen D. Lee, Christina Priest, Mikael Bjursell, Jie Gao, Douglas Arneson, In Sook Ahn, Gracie Diamante, J. Edward van Veen, Megan G. Massa, Anna C. Calkin, Jason Kim, Harriet Andersen, Prashant Rajbhandari, Michelle Porritt, Alba Carreras, Andrea Ahnmark, Frank Seeligers, Ingela Maxvall, Pernilla Eliasson, Magnus Althage, Peter Akerblad, Daniel Linden, Tracy A. Cole, Richard Lee, Helen Boyd, Mohammad Bohlooly-Y, Stephanie M. Correa, Xia Yang, Peter Tontonoz, Cynthia Hong
Article
Endocrinology & Metabolism
J. Edward van Veen, Laura G. Kammel, Patricia C. Bunda, Michael Shum, Michelle S. Reid, Megan G. Massa, Douglas V. Arneson, Jae W. Park, Zhi Zhang, Alexia M. Joseph, Haley Hrncir, Marc Liesa, Arthur P. Arnold, Xia Yang, Stephanie M. Correa
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)