Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Review
Biochemistry & Molecular Biology
Aldona Kasprzak
Summary: Colorectal cancer is a common aggressive carcinoma with poor prognosis, often associated with metabolic syndrome and high blood sugar levels. The role of IGF-1 in glucose metabolism in colorectal carcinogenesis and its potential link to the Warburg effect require further investigation. Current therapeutic strategies targeting impaired glucose metabolism in CRC are being explored to improve treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Armel H. H. Nwabo Kamdje, Paul F. Seke Etet, Maulilio J. Kipanyula, Lorella Vecchio, Richard Tagne Simo, Alfred K. Njamnshi, Kiven E. Lukong, Patrice N. Mimche
Summary: The tumor microenvironment plays a role in tumorigenesis and drug resistance through the overexpression of insulin-like growth factor 1 (IGF-1). Anti-IGF therapies have shown potential in inhibiting cancer and overcoming chemotherapy drug resistance in preclinical studies, but toxicity and resistance are challenges in clinical trials.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Fa Zhang, Emrah Altindis, C. Ronald Kahn, Richard D. DiMarchi, Vasily Gelfanov
Summary: The study identified viral insulin-like peptides with unique biological functions, including one that acts as a potent and full antagonist of the IGF-1R. The results revealed the importance of the internal structure of VILPs in regulating their biological activities and discovered a set of potentially medicinally important antagonists.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Zhou Yu, Baoqiang Song
Summary: The article describes the expression changes and fibrosis-promoting effects of insulin-like growth factor 2 (IGF-2) in different tissues during fibrosis process.
Article
Biochemical Research Methods
Mark S. Pratt, Martijn van Faassen, Noah Remmelts, Rainer Bischoff, Ido P. Kema
Summary: This study presents a simple and fast antibody-free LC-MS/MS method for the quantification of intact IGF-1 and IGF-2 in human plasma, allowing for reliable and simultaneous quantification without the need for enzymatic digestion. The method offers advantages of speed, accuracy, and potential wide application in clinical mass spectrometry laboratories.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Wentao Zhong, Xueqing Wang, Yufei Wang, Guoqian Sun, Jia Zhang, Zhuo Li
Summary: Obesity is a global epidemic and a risk factor for endocrine-related cancers. It affects insulin, IGF-1, sex hormones, IGFBPs, and adipokines, with IGF-1 playing a crucial role in obesity-related endocrine cancers. This review discusses the impact of obesity on prostate, breast, and pancreatic cancers, focusing on the mechanism of IGF-1 and its interaction with estrogen and adipokines. Additionally, the current status of IGF-1R inhibitors in clinical practice and their potential combination with other anticancer drugs are briefly introduced.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolo Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva de Castro, Melvin N. Doster, Ramona Moles, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, David C. Montefiori, Kombo F. N'guessan, Dominic Paquin-Proulx, Pamela A. Kozlowski, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Joshua Kramer, Genoveffa Franchini
Summary: The efficacy of the DNA/ALVAC/gp120/alum vaccine in the absence of neutralizing antibodies is attributed to a delicate balance of pro-and anti-inflammatory immune responses, which effectively reduces the risk of SIVmac251 acquisition in macaques. This efficacy is associated with antibodies recognizing the V2 helical conformation, DC-10 tolerogenic dendritic cells promoting the clearance of apoptotic cells through efferocytosis, and downregulation of CCR5 on vaccine-induced gut homing CD4(+) cells. IGF-1, a potent RAS activator, was found to alter epitope recognition and affect ADCC and efferocytosis, but it also compensates for these negative effects by reducing CCR5 expression on CD4(+) gut-homing T-cells, resulting in equivalent vaccine efficacy (71% with IGF-1 and 69% without).
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ecology
Zsofia Toth, Katharina Mahr, Gyula Oelveczki, Levente Ori, Adam Zoltan Lendvai
Summary: The study found that bearded reedlings showed variation in their IGF-1 reaction norms during food shortages, with heavier individuals more likely to decrease IGF-1 levels. This individual by environment interaction may have important implications for the evolution of IGF-1 related hormonal phenotypes in this species.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Integrative & Complementary Medicine
Zhihong Xie, Feng Yang
Summary: The meta-analysis found that lycopene intake did not significantly reduce serum IGF-1 levels, but showed a significant decrease under certain dose, intervention period, and age conditions, with potential health benefits in managing patients with cardiac disorders.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Archana Arjunan, Dhiraj Kumar Sah, Minna Woo, Juhyun Song
Summary: Neurodegenerative disorders are characterized by neuronal degeneration and glial dysfunction, leading to impairments in cognition, psychomotor function, and behavior. Metabolic syndrome has been linked to these disorders, and insulin growth factor-1 (IGF-1) deficiency has been associated with MetS-related pathologies. IGF-1 plays a crucial role in neurogenesis, plasticity, angiogenesis, and metabolic function in the brain, making it a potential therapeutic target for MetS-related neurodegenerative diseases. This review highlights the evidence for the potential therapeutic effects of IGF-1 and its involvement in molecular signaling defects in MetS-related neurodegeneration.
CELL AND BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
William B. Zhang, Kenny Ye, Nir Barzilai, Sofiya Milman
Summary: The study found two generalized patterns in the relationship between serum IGF-1 levels and clinical disease: IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy, and the association between IGF-1 and risk is generally U-shaped. These effects were remarkably consistent across a wide range of conditions, except for a more uniformly positive relationship between IGF-1 and cancer.
Article
Biochemistry & Molecular Biology
Meng-Jin Lin, Mei-Chun Lu, Hwan-You Chang
Summary: The study developed a high purity patented silk fibroin film for slow-release of insulin-like growth factor-1 (IGF-1), showing potential for diabetic wound therapy. The results indicate that the IGF-1-loaded SF films accelerated wound healing significantly by continuously activating the IGF1R pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nursing
Harry Adynski, Todd A. Schwartz, Hudson P. Santos
Summary: Food insecurity is associated with an increased risk of depressive symptoms, while food benefit participation does not reduce this risk.
JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
(2023)
Article
Psychology, Social
Kelly Tan, Barbara Fredrickson, Hudson Santos, William Wood, Todd Schwartz, Deborah Mayer
Summary: This study describes the psychological processing of caregivers during the 12 weeks after transplant and the role of positive emotions in caregiving experiences. The majority of caregivers viewed caregiving as a challenge and reported experiencing positive emotions such as gratitude, interest, and hope. Two new themes were identified: mirroring and emotion regulation. The findings suggest that interventions focused on emotion regulation and positive emotion experiences may be helpful in reducing the negative effects of caregiving stress.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2023)
Editorial Material
Surgery
Lisa A. Newman, Todd A. Schwartz, Marja Boermeester
Editorial Material
Surgery
Eric L. Lazar, Todd A. Schwartz, Brian S. Zuckerbraun
Editorial Material
Surgery
Timothy M. Pawlik, Todd A. Schwartz, Kamal M. F. Itani
Article
Oncology
Kelly R. Tan, Ya-Ning Chan, Katie Iadonisi, Elissa Poor, Stephanie Betancur, Ahrang Jung, Kathryn Sagester, Susan Coppola, Mackenzi Pergolotti, Erin E. Kent, Todd Schwartz, Daniel Richardson, Ashley Leak Bryant
Summary: This study investigated the experiences of informal caregivers of older adults with AML. They found that these caregivers face various challenges, including navigating health systems, taking on caregiving responsibilities, and meeting resource needs. To improve caregivers' abilities, attention should be given to their burden and unmet needs.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Rheumatology
Caroline Lisee, Elizabeth Bjornsen, David Berkoff, Karen Blake, Todd Schwartz, W. Zachary Horton, Brian Pietrosimone
Summary: This study aimed to investigate the changes in gait biomechanics, quadricep strength, physical function, and daily steps after an extended-release corticosteroid knee injection in individuals with knee osteoarthritis. The results showed that all participants demonstrated improved knee flexion angle, vertical ground reaction force, quadricep strength, and physical function after the injection. However, non-responders had more deleterious gait biomechanics before the injection, suggesting that they may have a more advanced stage of osteoarthritis.
CLINICAL RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Terika McCall, Meagan Foster, Todd A. Schwartz
Summary: This study aimed to understand the attitudes and perceptions of Black women toward using mental health services and determine the acceptability and concerns of using mobile technology to support the management of depression. The results showed that Black women have favorable views toward seeking mental health services and are more comfortable with using voice calls or video calls to communicate with professionals for support. Privacy and confidentiality, communication issues, and the impersonal feeling of using mobile phones were the primary concerns.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Orthopedics
A. P. Goode, R. J. Cleveland, V. B. Kraus, K. A. Taylor, S. Z. George, T. A. Schwartz, J. Renner, J. L. Huebner, J. M. Jordan, Y. M. Golightly
Summary: This study investigates the association between baseline biomarkers and longitudinal changes in disc space narrowing, vertebral osteophytes, and low back pain. The findings suggest that markers of inflammation and perceived pressure pain sensitivity are associated with the longitudinal worsening of low back pain.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Ecology
Badreddine Bererhi, Pierre Duchesne, Tonia S. Schwartz, Beata Ujvari, Erik Wapstra, Mats Olsson
Summary: The harmful effects of close inbreeding have been recognized for centuries and are caused by homozygosis. This study investigates the effects of genetic relatedness on pair formation in sand lizards. The results suggest that MHC plays a role in pre-copulatory, but not post-copulatory partner association, indicating that MHC is not the driver of fertilization bias and gamete recognition in sand lizards.
ECOLOGY AND EVOLUTION
(2023)
Article
Health Care Sciences & Services
Terika McCall, Meagan Foster, Holly R. Tomlin, Todd A. Schwartz
Summary: This study aimed to understand Black American women's attitudes toward seeking mental health services and using mobile technology to receive support for managing anxiety. The findings showed that younger Black women were more likely to have greater severity of anxiety compared to their older counterparts. As for communication preferences, respondents were more comfortable with voice or video calls rather than text messaging or mobile apps when seeking anxiety support. Factors such as younger age, higher income, psychological openness, and inclination for seeking help were associated with a greater likelihood of agreeing to use mobile technology. Additionally, Black women from the Southern region of the United States were more likely to agree to the use of mobile apps compared to women from the Midwest and Northeast regions. In conclusion, Black American women generally held favorable views toward using mobile technology for anxiety management. Cultural considerations are important in determining the most suitable digital mental health interventions for each individual.
Article
Biology
B. Dantzer, K. E. Mabry, J. R. Bernhardt, R. M. Cox, C. D. Francis, C. K. Ghalambor, K. L. Hoke, S. Jha, E. Ketterson, N. A. Levis, K. M. Mccain, G. L. Patricelli, S. H. Paull, N. Pinter-Wollman, R. J. Safran, T. S. Schwartz, H. L. Throop, L. Zaman, L. B. Martin
Summary: Human activities are causing rapid changes in ecosystems globally, with implications for biodiversity, agriculture, zoonotic diseases, and sociopolitical conflict. To better understand and predict these biological phenomena, scientists are using observatory networks, which consist of sensors, field researchers, and databases to collect abiotic and biotic measurements across various scales. NEON, a well-known observatory network, provides an unprecedented opportunity for organismal biologists to study organismal variation and its effects on range expansions, disease epidemics, invasive species colonization, macrophysiology, and other biological processes.
INTEGRATIVE ORGANISMAL BIOLOGY
(2023)
Meeting Abstract
Rheumatology
Luis Palomino, Carolina Alvarez, Todd Schwartz, Yvonne Golightly, Amanda Nelson
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Sport Sciences
Elizabeth Bjornsen, Caroline Lisee, Todd Schwartz, Troy Blackburn, Brian Pietrosimone
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
