Article
Physiology
Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Summary: The study demonstrates that targeted activation of Gs signaling exclusively in renal principal cells (PC) is sufficient to increase ENaC activity and decrease urinary sodium excretion in live animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Toni K. Choueiri, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. McDermott, M. Dror Michaelson, Leonard J. Appleman, Sanjay Thamake, Rodolfo F. Perini, Naseem J. Zojwalla, Eric Jonasch
Summary: The HIF-2 alpha inhibitor belzutifan shows promising clinical activity and a favorable safety profile in heavily pre-treated patients with renal cell carcinoma, suggesting it may offer an effective treatment option. The drug was well tolerated with a confirmed objective response rate of 25% and a median progression-free survival of 14.5 months in patients with ccRCC.
Article
Pharmacology & Pharmacy
Osaze Edosuyi, Ayobami Adesuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan
Summary: Malate regulates blood pressure via nitric oxide production and has effects on renal function in salt-sensitive rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Assaf Buch, Rebecca Goldsmith, Lesley Nitsan, Miri Margaliot, Gabi Shefer, Yonit Marcus, Naftali Stern
Summary: The study indicates that higher potassium excretion is associated with a lower risk of metabolic syndrome, and individuals with higher MS scores tend to have lower potassium excretion. Potassium excretion correlates with all components of MS and can predict the syndrome independently from other variables.
Article
Urology & Nephrology
Mats Nagard, Bhupinder Singh, David W. Boulton
Summary: The study suggests that sodium zirconium cyclosilicate can effectively reduce serum potassium concentration and urinary potassium excretion, with no significant impact on urinary sodium excretion, and is well tolerated.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Akane Miki, Yuka Kawate, Takuro Okamura, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This study investigated the relationship between obesity and high estimated salt intake with and without habitual miso consumption, showing that miso consumption promotes salt excretion and may lead to an apparently higher estimated salt intake than actual. High estimated salt intake was not significantly associated with obesity, indicating the need for clinicians to be aware of the effects of miso consumption on estimated salt intake.
Review
Biochemistry & Molecular Biology
Robert M. Carey, Helmy M. Siragy, John J. Gildea, Susanna R. Keller
Summary: Angiotensin II (Ang II) type-2 receptors (AT(2)R) in the kidney play a crucial role in opposing renal sodium retention induced by Ang II stimulation of Ang II type-1 receptors (AT(1)R). AT(2)Rs induce natriuresis through the activation of bradykinin, nitric oxide, and cyclic GMP signaling cascade. Defects in AT(2)R activation and protein phosphatase 2A (PP2A) in spontaneously hypertensive rats are associated with primary hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Stephanie Franzen, Egidijus Semenas, Micael Taavo, Johan Martensson, Anders Larsson, Robert Frithiof
Summary: Sevoflurane anesthesia reduced urine output and sodium excretion and increased plasma renin compared with propofol anesthesia. The impact of this on acute kidney injury and fluid resuscitation during surgery warrants further investigation.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Peripheral Vascular Disease
Yuta Matsukuma, Masaru Nakayama, Susumu Tsuda, Akiko Fukui, Ryota Yoshitomi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: This study found that a higher UNa/K ratio was independently associated with poor renal outcomes in patients with chronic kidney disease.
HYPERTENSION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jhohann Richard de Lima Benzi, Patricia Pereira dos Santos Melli, Geraldo Duarte, Jashvant D. Unadkat, Vera Lucia Lanchote
Summary: Inflammation reduces the activity of renal OAT1/3 and UGT1A9/1A1, potentially by increasing plasma cytokine concentrations. Dosing regimens for narrow therapeutic window OAT drug substrates may need to be adjusted under inflammatory conditions.
Article
Medicine, General & Internal
Eric Jonasch, Frede Donskov, Othon Iliopoulos, W. Kimryn Rathmell, Vivek K. Narayan, Benjamin L. Maughan, Stephane Oudard, Tobias Else, Jodi K. Maranchie, Sarah J. Welsh, Sanjay Thamake, Eric K. Park, Rodolfo F. Perini, W. Marston Linehan, Ramaprasad Srinivasan
Summary: The HIF-2α inhibitor belzutifan showed efficacy in patients with renal cell carcinoma associated with von Hippel-Lindau disease, with nearly half of the patients having an objective response to treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Veterinary Sciences
Marine Roche-Catholy, Iris Van Cappellen, Laurent Locquet, Bart J. G. Broeckx, Dominique Paepe, Pascale Smets
Summary: The study found that hypochloremia is the most commonly encountered electrolyte anomaly in small animals with acute congestive heart failure. In dogs, there was a significant negative correlation between serum chloride concentrations and furosemide doses, suggesting that hypochloremia could serve as a marker of disease severity and therapeutic response in dogs with acute CHF. No significant associations were found between electrolyte concentrations and duration of hospitalization or survival time.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Physiology
Agnieszka Walkowska, Ludek Cervenka, John D. Imig, John R. Falck, Janusz Sadowski, Elzbieta Kompanowska-Jezierska
Summary: The study demonstrated that in spontaneously hypertensive rats, both EET-A and AAA induced renal vasodilation but did not show additive effects. Both agents have a definite therapeutic potential for hypertension and deserve further experimental and clinical testing for novel antihypertensive therapy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Summary: Clinical hypertension is associated with renal inflammation and elevated levels of proinflammatory cytokines. Inhibition of interleukin-1 may contribute to modulation of the Angiotensin II-induced hypertension response. The study found that IL-1 receptor antagonist plays a crucial role in protecting against renal damage in hypertensive patients.
Article
Nutrition & Dietetics
Puhong Zhang, Fang Fan, Yinghua Li, Yuan Li, Rong Luo, Li Li, Gang Zhang, Lanlan Wang, Xiaofei Jiao, Feng J. He
Summary: The use of low-sodium salt substitute (LSSS) has the potential to reduce sodium and increase potassium intake. However, its real-world use and impact on sodium/potassium intake is unclear.
Article
Medicine, Research & Experimental
D. V. Golosova, T. A. Karavashkina, A. V. Kutina, A. S. Marina, Yu. V. Natochin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
A. V. Kutina, A. S. Marina, Yu. V. Natochin
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Yu. V. Natochin
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2016)
Correction
Biochemistry & Molecular Biology
A. V. Kutina, A. S. Marina, Yu. V. Natochin
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2016)
Article
Endocrinology & Metabolism
A. V. Kutina, D. V. Golosova, A. S. Marina, E. I. Shakhmatova, Y. V. Natochin
JOURNAL OF NEUROENDOCRINOLOGY
(2016)
Article
Medicine, Research & Experimental
E. I. Shakhmatova, D. V. Golosova, Yu. V. Natochin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Pediatrics
Yury Natochin, Alla A. Kuznetsova, Anastasia Prokopenko, Gregorio P. Milani, Sebastiano A. G. Lava, Anna S. Marina
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Article
Medicine, Research & Experimental
Yu Natochin, E. Shakhmatova, A. E. Bogolepova
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Medicine, Research & Experimental
A. S. Marina, A. V. Kutina, E. I. Shakhmatoba, Yu. V. Natochin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)
Article
Endocrinology & Metabolism
E. Balbotkina, M. F. Ballyuzek, V. A. Volovnikova, Y. Natochin, E. Shakhmatova
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)