Article
Environmental Sciences
Handule Lee, Juyoung Park, Kwangsik Park
Summary: Unlike environmental pollutants, chemicals in consumer products may pose higher risks to human health depending on their usage and interaction. A recent study detected endocrine disrupting chemicals in various consumer products, suggesting a wide range of exposures. The study also found that predictions of mixture activity by appropriate models can support the risk assessment and regulation of these chemicals.
Review
Chemistry, Multidisciplinary
Zhihua Ren, Xiaoxi Yang, Zhendong Sun, Jing Ren, Nan Sang, Qunfang Zhou, Guibin Jiang
Summary: More and more chemicals with endocrine disrupting effects are emerging in the environment, posing a threat to wildlife and humans. These chemicals can potentially disturb the endocrine system and cause various toxicological effects and health issues. The estrogen receptors (ERs) mediated pathway is an important aspect in the study of these chemicals' effects.
PROGRESS IN CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Jun Nagata, Yuji Mushirobira, Osamu Nishimiya, You Yamaguchi, Toshiaki Fujita, Naoshi Hiramatsu, Akihiko Hara, Takashi Todo
Summary: Estradiol-17 beta (E2) regulates transcription of estrogen-responsive genes via estrogen receptors (Esr). Different Esr subtypes were distinctly different in their ability to transactivate estrogen-responsive target genes, resulting in differential expression of chg, vtg and esr1a genes in the estrogen-exposed hepatocytes.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Chemistry, Applied
Ying Wang, Minglu Wang, Li Zhou, Xiangye Geng, Zhixiang Xu, Hongyan Zhang
Summary: In competitive broad-spectrum enzyme-linked immunosorbent assays (ELISA), weak competitiveness of the competitive molecule leads to improved detectability. Using dual-estrogen receptor (ER) and three estrogen-enzyme conjugates, ELISA based on bisphenol (BPA)-horseradish peroxidase (HRP) shows the highest detectability and can screen all six estrogen disrupting chemicals (EDCs). Biomarkers with weak competitiveness can be applied to other competitive procedures to enhance detectability.
Article
Biochemistry & Molecular Biology
Huiwon Seo, Hyeyeong Seo, Ha-yeon Lee, Seok-Hee Lee, Yooheon Park
Summary: This study evaluated the comprehensive activity of representative estrogen receptor (ER) ligands using BRET-based assays and provided information about receptor specificity and cellular estrogen signaling pathways. The results showed that various chemicals mediated ER alpha and ER8 dimerization, with some acting as estrogen agonists and others as antagonists. The study also supported the potential use of BRET assays as high-throughput screening methods for assessing the endocrine-disrupting activity of environmental agents.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Environmental Sciences
Petya Stoykova, Hideo Ohkawa, Hideyuki Inui
Summary: Transgenic Arabidopsis plants expressing mER and GFP genes showed high sensitivity in detecting EDCs, making them a promising tool for monitoring organic pollutants in contaminated waters. XmEV19-2 plants were able to detect OP at concentrations as low as 5 ng/mL.
Article
Biochemistry & Molecular Biology
Yoshinao Katsu, Islam M. D. Shariful, Xiaozhi Lin, Wataru Takagi, Hiroshi Urushitani, Satomi Kohno, Susumu Hyodo, Michael E. Baker
Summary: Orthologs of human glucocorticoid receptor (GR) and human mineralocorticoid receptor (MR) first appear in cartilaginous fishes. Subsequently, the MR and GR diverged to respond to different steroids. The study revealed partial functional divergence of elephant shark GR from the MR, with N-terminal domain (NTD) playing a crucial role in the response to corticosteroids. Swapping of NTDs between elephant shark GR and MR generated a chimeric receptor with altered activation properties. This suggests that NTD activation of human GR may have evolved early in the divergence from the MR.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Ashlie Santaliz Casiano, Annah Lee, Dede Teteh, Zeynep Madak Erdogan, Lindsey Trevino
Summary: Endocrine-disrupting chemicals (EDCs) contribute to breast cancer development and there are disparities in EDC exposure across racial/ethnic groups. Addressing the inequality in EDC exposure and improving breast cancer disparities in socially disadvantaged populations is crucial.
Article
Cell Biology
Sumeet Bhanot, Gabriele Hemminger, Cole L. Martin, Stephen G. Aller, John N. Forrest
Summary: The study identified a novel adenosine receptor, A(0), in sharks that likely regulates CFTR and represents an ancestral precursor of mammalian adenosine receptors. Experimental results demonstrated that A(0) activates the chloride channel of CFTR.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Environmental Sciences
Richard C. Kolanczyk, Jeffrey S. Denny, Barbara R. Sheedy, Victoria V. Olson, Jose A. Serrano, Mark A. Tapper
Summary: This study investigates the metabolic activation and estrogenicity of chemicals in fish through the study of estrogen receptor binding and gene expression. The results show that phenolphthalin (PLIN) metabolizes to phenolphthalein (PLEIN), which binds to estrogen receptors and induces gene expression. Another chemical, 4,4'-methylenedianiline (MDA), also undergoes metabolic activation and induces gene expression. These findings provide insights into the potential effects of these chemicals on the environment and organisms.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Chun-Ju Lin, Lih-Ann Li
Summary: Using GC-MS and mass spectral matching techniques, catechol was identified as a potential estrogenic compound in cigarette sidestream smoke particulate matter (CSSP). However, the activity of these compounds in CSSP was too low to explain the estrogenic effects. Nevertheless, the mixture of these compounds in CSSP produced almost one third of the estrogenic activity, raising concerns about public health.
Review
Endocrinology & Metabolism
Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue
Summary: Estrogens play an important role in the female reproductive system and also regulate physiological processes associated with learning and memory in the brain. They have neuroprotective effects in the pathogenesis of Alzheimer's disease (AD), which has a higher incidence in older and postmenopausal women. Estrogens bind to estrogen receptors (ERs) and activate transcriptional machineries, and also stimulate signal transduction through membrane ERs (mERs). Estrogen-related receptors (ERRs), which lack estrogen-binding capabilities, are expressed in the human brain and implicated in AD pathogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jan Taubenheim, Constantin Kortmann, Sebastian Fraune
Summary: Nuclear receptors play key roles in coordinating postembryonal developmental transitions in animals, controlling metamorphosis and sexual maturation. These processes are regulated by environmental factors and different receptors in vertebrates and insects. While mechanisms of metamorphosis and sexual maturation are well studied in model organisms, the evolution of these systems requires further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Akira Sugimoto, Kaori Oka, Rui Sato, Shinji Adachi, Michael E. Baker, Yoshinao Katsu
BIOCHEMICAL JOURNAL
(2016)
Article
Endocrinology & Metabolism
Yoshinao Katsu, Paul A. Cziko, Charlie Chandsawangbhuwana, Joseph W. Thornton, Rui Sato, Koari Oka, Yoshio Takei, Michael E. Baker, Taisen Iguchi
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Ryohei Yatsu, Yoshinao Katsu, Satomi Kohno, Takeshi Mizutani, Yukiko Ogino, Yasuhiko Ohta, Jan Myburgh, Johannes H. van Wyk, Louis J. Guillette, Shinichi Miyagawa, Taisen Iguchi
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2016)
Article
Endocrinology & Metabolism
Kaori Oka, Satomi Kohno, Yasuhiko Ohta, Louis J. Guillette, Taisen Iguchi, Yoshinao Katsu
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2016)
Article
Toxicology
Kenji Toyota, Nicole A. McNabb, Demetri D. Spyropoulos, Taisen Iguchi, Satomi Kohno
JOURNAL OF APPLIED TOXICOLOGY
(2017)
Article
Endocrinology & Metabolism
Cameron E. Williams, Nicole A. McNabb, Arnold Brunell, Russell H. Lowers, Yoshinao Katsu, Demetri D. Spyropoulos, Satomi Kohno
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Toxicology
Satomi Kohno, Yoshinao Katsu, Nicholas Cipoletti, Lina C. Wang, Zachary G. Jorgenson, Shinichi Miyagawa, Heiko L. Schoenfuss
JOURNAL OF APPLIED TOXICOLOGY
(2018)
Article
Endocrinology & Metabolism
Michael E. Baker, Yoshinao Katsu
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Osamu Nishimiya, Yoshinao Katsu, Hiroyuki Inagawa, Naoshi Hiramatsu, Takashi Todo, Akihiko Hara
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2017)
Article
Marine & Freshwater Biology
Hiroshi Urushitani, Yoshinao Katsu, Hiroyuki Kagechika, Ana C. A. Sousa, Carlos M. Barroso, Yasuhiko Ohta, Hiroaki Shiraishi, Taisen Iguchi, Toshihiro Horiguchi
AQUATIC TOXICOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Yukiko Ogino, Saki Tohyama, Satomi Kohno, Kenji Toyota, Gen Yamada, Ryohei Yatsu, Tohru Kobayashi, Norihisa Tatarazako, Tomomi Sato, Hajime Matsubara, Anke Lange, Charles R. Tyler, Yoshinao Katsu, Taisen Iguchi, Shinichi Miyagawa
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Letter
Multidisciplinary Sciences
Yoshinao Katsu, Michael E. Baker
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Yoshinao Katsu, Kaori Oka, Michael E. Baker
Article
Biochemistry & Molecular Biology
Yoshinao Katsu, Kaori Oka, Michael E. Baker
Article
Biochemistry & Molecular Biology
Yoshinao Katsu, Satomi Kohno, Kaori Oka, Xiaozhi Lin, Sumika Otake, Nisha E. Pillai, Wataru Takagi, Susumu Hyodo, Byrappa Venkatesh, Michael E. Baker
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)