Leptin gene therapy attenuates neuronal damages evoked by amyloid-β and rescues memory deficits in APP/PS1 mice

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

(2012) Manuel Torres et al.   Molecular Neurodegeneration

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β

(2012) Gayle H. Doherty et al.   NEUROBIOLOGY OF AGING

The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer’s disease

(2010) Carlos Spuch et al.   BIOMATERIALS

Tyk2/STAT3 Signaling Mediates  -Amyloid-Induced Neuronal Cell Death: Implications in Alzheimer's Disease

(2010) J. Wan et al.   JOURNAL OF NEUROSCIENCE

Megalin interacts with APP and the intracellular adapter protein FE65 in neurons

(2010) Ximena Alvira-Botero et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Leptin, Leptin Receptors, and the Control of Body Weight

(2010) Jeffrey M. Friedman   NUTRITION REVIEWS

Neurobehavioral deficits in db/db diabetic mice

(2010) Ajaykumar N. Sharma et al.   PHYSIOLOGY & BEHAVIOR

Cytoplasmic gelsolin increases mitochondrial activity and reduces Aβ burden in a mouse model of Alzheimer's disease

(2009) Desiree Antequera et al.   NEUROBIOLOGY OF DISEASE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

(2008) Cecilia Lundberg et al.   CURRENT GENE THERAPY

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Megalin mediates the transport of leptin across the blood-CSF barrier

(2007) Marcelo O. Dietrich et al.   NEUROBIOLOGY OF AGING

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

(2007) S. Lesné et al.   NEUROSCIENCE