Article
Chemistry, Multidisciplinary
Yuan Lu, Julie Tzu-Wen Wang, Na Li, Xiaoqin Zhu, Yongjun Li, Sukhi Bansal, Yonglin Wang, Khuloud T. Al-Jamal
Summary: This study developed EDV-loaded polymeric nanoparticles for nose-to-brain drug delivery, improving drug stability and bioavailability. The results showed that the nanoparticle formulation achieved higher and more sustained brain uptake of EDV compared to intravenous administration, offering hope for ALS treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Raquel Talens-Visconti, Jesus Vicente de Julian-Ortiz, Ofelia Vila-Buso, Octavio Diez-Sales, Amparo Nacher
Summary: Alzheimer-type dementia (ATD) treatments are limited in their ability to cross the blood-brain barrier and can have adverse effects on the body. Intranasal administration provides a direct route to the brain through the nasal cavity. However, drug absorption and bioavailability can be hindered by nasal physiology, so technological strategies are needed to optimize the physicochemical properties of formulations. Among the strategies explored, lipid-based nanosystems, specifically nanostructured lipid carriers, show promise in preclinical studies with minimal toxicity and therapeutic efficacy. This review focuses on the use of nanostructured lipid carriers for intranasal administration in the treatment of ATD. Currently, no drugs for intranasal administration in ATD have received marketing approval, but three candidates (insulin, rivastigmine, and APH-1105) are being clinically investigated. Further studies with other candidates will help confirm the potential of intranasal administration in the treatment of ATD.
Article
Nanoscience & Nanotechnology
Marta Pardo, Evan R. Roberts, Krystine Pimentel, Yagmur Akin Yildirim, Brayan Navarrete, Ping Wang, Elric Zhang, Ping Liang, Sakhrat Khizroev
Summary: The brain is a complex network of neurons connected through chemical and electrical oscillations. Magnetoelectric nanoparticles (MENs) have been introduced to wirelessly control nanoelectrodes in the brain, but achieving effective delivery remains a challenge. Intranasal administration of MENs has shown at least a 4-fold improvement in targeted delivery efficacy compared to intravenous administration.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Barbara Sanchez-Dengra, Maria Alfonso, Isabel Gonzalez-Alvarez, Marival Bermejo, Marta Gonzalez-Alvarez, Ramon Martinez-Manez
Summary: The two types of nanoparticles loaded with ponatinib have been proven to be non-toxic to blood-brain barrier cells and have shown improved drug delivery to the brain compared to the free drug when administered intranasally. This research is significant for the treatment of brain cancer.
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Article
Pharmacology & Pharmacy
Angela Bonaccorso, Cinzia Cimino, Daniela Erminia Manno, Barbara Tomasello, Antonio Serra, Teresa Musumeci, Giovanni Puglisi, Rosario Pignatello, Claudia Carbone
Summary: This study focuses on the development of nanostructured lipid carriers (NLC) for intranasal delivery of essential oils, showing that NLC formulated with Lavandula or Rosmarinus exhibit more ordered structures and higher cytocompatibility with murine and human fibroblasts. These results suggest that positively charged NLC containing Lavandula or Rosmarinus could be a potential add-on strategy for the treatment of neurodegenerative diseases through intranasal administration.
Article
Biochemistry & Molecular Biology
Ilzira A. Minigalieva, Yuliya V. Ryabova, Ivan G. Shelomencev, Lev A. Amromin, Regina F. Minigalieva, Yuliya M. Sutunkova, Larisa I. Privalova, Marina P. Sutunkova
Summary: We investigated the effects of Fe2O3 nanoparticles on the brain structure and function in rats. Electron microscopy revealed the presence of Fe2O3 nanoparticles in the olfactory bulb tissues but not in the brain's basal ganglia. We observed an increase in axons with damaged myelin sheaths and pathologically altered mitochondria in the exposed animals' brains. Our findings suggest that Fe2O3 nanoparticles can have a toxic effect on the central nervous system even at low doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Zhiyu Jin, Yu Han, Danshen Zhang, Zhongqiu Li, Yongshuai Jing, Beibei Hu, Shiguo Sun
Summary: Depression is a growing mental disease in modern society, with low cure rates and high recurrence rates. The current treatment methods, primarily drug therapy combined with psychological and physical therapy, have limitations. Intranasal administration may provide a better option for the delivery of antidepressant medication.
Article
Medicine, Research & Experimental
Jaidev Chakka, Mohammed Maniruzzaman
Summary: In this study, a novel extrusion-based Sprayed Multi Adsorbed-droplet Reposing Technology (SMART) was used to prepare 150 nm plasmid DNA nanoparticles, which were successfully applied in vitro transfection experiments with cancer cells.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Soraia Silva, Joana Bicker, Carla Fonseca, Nuno R. Ferreira, Carla Vitorino, Gilberto Alves, Amilcar Falcao, Ana Fortuna
Summary: The study found that nanostructured lipid carriers have the potential to enhance nose-to-brain delivery of antidepressants, reducing systemic and lung exposure and minimizing adverse effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Asya Petkova, Ilona Kubajewska, Alexandra Vaideanu, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: Gene delivery to the cerebral cortex can be achieved via intranasal administration of hyaluronidase-coated polyplexes (GCPH).
Article
Chemistry, Multidisciplinary
Shunping Han, Julie Tzu-Wen Wang, Emine Yavuz, Alaa Zam, Nadia Rouatbi, Rifka Nurul Utami, Revadee Liam-Or, Alexander Griffiths, Wayne Dickson, Jane Sosabowski, Khuloud T. Al-Jamal
Summary: This study investigated the brain region-specific distribution of gold nanorods (AuNRs) and their potential as a drug delivery platform for CNS therapy after intranasal administration in mice. It was found that AuNRs entered the brain via the olfactory bulb and diffused to other brain regions within 1 hour. The presence of AuNRs in glioblastoma tumors was also confirmed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Madeleine S. A. Tan, Preeti Pandey, Rink-Jan Lohman, James R. Falconer, Dan J. Siskind, Harendra S. Parekh
Summary: This study aimed to develop and characterize a clozapine-loaded nanoemulsion sol-gel for intranasal delivery. The formulation showed desirable physicochemical properties and sustained drug release, with no severe ciliotoxicity on nasal mucosa.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Tahereh Jamshidnejad-Tosaramandani, Soheila Kashanian, Isaac Karimi, Helgi B. Schioth
Summary: Intranasal administration is a non-invasive drug delivery approach that provides a pharmacological response in the central nervous system with minimal peripheral side effects. Mucoadhesive polymers, such as chitosan, can be used to improve the residence time of intranasal drug delivery systems. Insulin-loaded chitosan nanoparticles were synthesized and evaluated for their physiochemical properties to meet the requirements of intranasal administration.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Lamia Said Kandil, Ragwa M. Farid, Safaa S. ElGamal, Amira Sayed Hanafy
Summary: This study aimed to investigate whether the long-term administration of CX-NP2 leads to biochemical toxicity in rat brains compared to GH nasal solution. The results showed that after 30 days of treatment, CX-NP2 did not induce a statistically significant oxidative stress or neuroinflammation in rat brains, but rather elicited neuroprotective potentials.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)