Optogenetic therapy for retinitis pigmentosa

Zinc-finger-based transcriptional repression of rhodopsin in a model of dominant retinitis pigmentosa

(2011) Claudio Mussolino et al.   EMBO Molecular Medicine

LiGluR Restores Visual Responses in Rodent Models of Inherited Blindness

(2011) Natalia Caporale et al.   MOLECULAR THERAPY

Virally delivered Channelrhodopsin-2 Safely and Effectively Restores Visual Function in Multiple Mouse Models of Blindness

(2011) M Mehdi Doroudchi et al.   MOLECULAR THERAPY

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

Differential Targeting of Optical Neuromodulators to Ganglion Cell Soma and Dendrites Allows Dynamic Control of Center-Surround Antagonism

(2011) Kenneth P. Greenberg et al.   NEURON

Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve

(2010) Annegret Dahlmann-Noor et al.   CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE

Microbial rhodopsins in the spotlight

(2010) Christian Bamann et al.   CURRENT OPINION IN NEUROBIOLOGY

Gene Therapy in Ophthalmology: Validation on Cultured Retinal Cells and Explants from Postmortem Human Eyes

(2010) Mathias Fradot et al.   HUMAN GENE THERAPY

Visual Function in Mice with Photoreceptor Degeneration and Transgenic Expression of Channelrhodopsin 2 in Ganglion Cells

(2010) S. Thyagarajan et al.   JOURNAL OF NEUROSCIENCE

Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait

(2010) Alan F. Wright et al.   NATURE REVIEWS GENETICS

Eye Smarter than Scientists Believed: Neural Computations in Circuits of the Retina

(2010) Tim Gollisch et al.   NEURON

Treatment Possibilities for Retinitis Pigmentosa

(2010) Samuel G. Jacobson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Nilvadipine on Central Visual Field in Retinitis Pigmentosa: A 30-Month Clinical Trial

(2010) Mitsuru Nakazawa et al.   OPHTHALMOLOGICA

Subretinal electronic chips allow blind patients to read letters and combine them to words

(2010) E. Zrenner et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

PROGRESS TOWARD THE MAINTENANCE AND REPAIR OF DEGENERATING RETINAL CIRCUITRY

(2010) Anthony A Vugler   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

(2010) V. Busskamp et al.   SCIENCE

Rod-Derived Cone Viability Factor for Treating Blinding Diseases: From Clinic to Redox Signaling

(2010) T. Leveillard et al.   Science Translational Medicine

Safety and Efficacy of Subretinal Readministration of a Viral Vector in Large Animals to Treat Congenital Blindness

(2010) D. Amado et al.   Science Translational Medicine

Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats

(2009) Hiroshi Tomita et al.   EXPERIMENTAL EYE RESEARCH

Optobionic vision—a new genetically enhanced light on retinal prosthesis

(2009) Patrick Degenaar et al.   Journal of Neural Engineering

Ectopic Expression of Multiple Microbial Rhodopsins Restores ON and OFF Light Responses in Retinas with Photoreceptor Degeneration

(2009) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

(2009) Francesca Simonelli et al.   MOLECULAR THERAPY

Gene therapy for red–green colour blindness in adult primates

(2009) Katherine Mancuso et al.   NATURE

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Why do Cone Photoreceptors Die in Rod-Specific Forms of Retinal Degenerations?

(2009) Robert K. Koenekoop   OPHTHALMIC GENETICS

Visual Properties of Transgenic Rats Harboring the Channelrhodopsin-2 Gene Regulated by the Thy-1.2 Promoter

(2009) Hiroshi Tomita et al.   PLoS One

A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells

(2009) Ryan R. Klimczak et al.   PLoS One

The Optogenetic Catechism

(2009) G. Miesenbock   SCIENCE

Prospects for retinal gene replacement therapy

(2009) Alexander J. Smith et al.   TRENDS IN GENETICS

Remodeling of cone photoreceptor cells after rod degeneration in rd mice

(2008) Bin Lin et al.   EXPERIMENTAL EYE RESEARCH

Treatment of Leber Congenital Amaurosis Due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

(2008) William W. Hauswirth et al.   HUMAN GENE THERAPY

Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration

(2008) Javier Sancho-Pelluz et al.   MOLECULAR NEUROBIOLOGY

Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration

(2008) Pamela S Lagali et al.   NATURE NEUROSCIENCE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin

(2008) B. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA