期刊
GENE THERAPY
卷 18, 期 7, 页码 646-655出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2011.4
关键词
experimental autoimmune encephalomyelitis (EAE); Herpes simplex virus (HSV); interleukin; interferon; Toll-like receptor
类别
资金
- Academy of Finland [118366, 128915]
- Swedish Cultural Foundation in Finland
- Finnish Cultural Foundation
- Research and Science foundation of Farmos
- Paulo Foundation
- Turku Graduate School of Biomedical Sciences
- Academy of Finland (AKA) [118366, 118366, 128915, 128915] Funding Source: Academy of Finland (AKA)
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune inflammation of the central nervous system and is used as the experimental model of multiple sclerosis (MS). The exact mechanism behind the disease is still unknown, but interleukin (IL)-17 expressing T cells are thought to mediate the disease. Toll-like receptors (TLRs) are known to have a role in the innate immune response against pathogens, and several TLRs have also a role in the disease course of EAE. Here, we show that treatment with a herpes simplex virus type 1 vector expressing the Th2 cytokine IL-5 ameliorates EAE and decreases the numbers of infiltrating lymphocytes in the brain. The effect involves downregulation of TLR 2, 3 and 9 mRNA expression and upregulation of type I interferons (IFNs) in brains during onset of disease. The elevated expression of type I IFNs was also observed during recovery. Gene Therapy (2011) 18, 646-655; doi:10.1038/gt.2011.4; published online 17 February 2011
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