Article
Pharmacology & Pharmacy
Wen-Chi Su, Zan-Yu Chen, Young-Sheng Chang, King-Song Jeng, Uyen Nguyen Phuong Le, Yu-Chi Chou, Li-Lan Kuo, Ivonne Melano, Jesse Wei-Jan Jesse, Wei-Jan Wang, Ying-Chyi Song, Sin-Rong Li, Mien-Chie Hung, Michael M. C. Lai, Cheng-Wen Lin
Summary: This study demonstrated the use of a trans-complementation system to generate SARS-CoV-2 SRIPs with variant-specific S proteins. The SBA.1-based SRIPs showed lower virus yield and infectivity compared to SWH1-based SRIPs. Furthermore, the SBA.1-based SRIPs exhibited intermediate resistance to neutralizing antibodies but were effective at infecting cells with low ACE2 expression.
ANTIVIRAL RESEARCH
(2023)
Review
Genetics & Heredity
Konstantin Kochergin-Nikitsky, Lyubava Belova, Alexander Lavrov, Svetlana Smirnikhina
Summary: Gene therapy for genetically determined diseases requires efficient transgene delivery methods, with rAAV vectors being widely used due to their simplicity and ability to transduce eukaryotic cells. Various approaches, such as capsid modifications and tissue-specific promoters, have been explored to retarget rAAV to respiratory cells. Challenges remain in transduction of stem and progenitor lung cells using AAV.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Virology
Winston McCormick, Leonard A. Mermel
Summary: The COVID-19 pandemic has highlighted the importance of the basic reproductive number (R0) and the particle-to-plaque ratio (P:PFU) as epidemiologic measurements. Comparing these two parameters may provide insights into viral transmission dynamics.
Article
Pharmacology & Pharmacy
Palang Chotsiri, Almahamoudou Mahamar, Richard M. Hoglund, Fanta Koita, Koualy Sanogo, Halimatou Diawara, Alassane Dicko, Julie A. Simpson, Teun Bousema, Nicholas J. White, Joelle M. Brown, Roly Gosling, Ingrid Chen, Joel Tarning
Summary: Clinical studies have shown that adding a single dose of primaquine to antimalarial regimens can rapidly eliminate Plasmodium falciparum gametocytes. However, the mechanism and impact on malaria transmission remain unclear. This study used data from Malian adults with gametocytemia to investigate the pharmacokinetic-pharmacodynamic relationships of primaquine's transmission blocking activity. It was found that a low dose of primaquine can effectively prevent the transmission of P. falciparum.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Shumei Wang, Li Zhao, Xiaowei Zhang, Jingjing Zhang, Hong Shang, Guoxin Liang
Summary: This study reveals that neuropilin-1 (NRP-1) is highly expressed in macrophages and dendritic cells (DCs) but not CD4(+) T cells. NRP-1 functions as an antiviral protein, inhibiting the infectivity of HIV-1 by reducing the ability of the virions to attach to target cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Alejandro Fernandez-Montero, Jon Zuaznabar, Manuel Pina-Sanchez, Sheila Maestro, Loreto Martin-Navarro, Natalia Munoz-Rodriguez, Cristina Olague, Marta Pastrana, Maria Martinez-Fernandez, Gracian Camps, Jose Antonio Rodriguez, Francesco P. Marchese, Jon Zazpe, Marta Pozuelo, Jose Luis Del Pozo, Jorge Quiroga, Antonio Pineda-Lucena, Gabriel Reina, Jack Kolenda, Laura Moreno-Galarraga, Gloria Gonzalez-Aseguinolaza, Marta Rua, Cristian Smerdou, Francisco Carmona-Torre, Josepmaria Argemi
Summary: The study aimed to evaluate the efficacy of intranasal photodynamic therapy (PDT) in reducing the infectivity period in mildly symptomatic SARS-CoV-2 carriers. The study also analyzed the immune-stimulating effects and safety of PDT. The results showed that intranasal PDT reduced infectivity on day 3 post-treatment and increased the probability of PCR negativity on day 7. It also decelerated the decline of SARS-CoV-2 specific immune responses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Ayna Alfadhli, CeAnn Romanaggi, Robin Lid Barklis, Ilaria Merutka, Timothy A. Bates, G. Tafesse, Eric Barklis
Summary: Specific nanobodies can be used for detecting HIV-1 CA with sensitivity and specificity. NTD-specific nanobodies can efficiently assemble into virions, while CTD-specific nanobodies reduce virus release and infectivity. These findings suggest the potential of Gag-targeted nanobodies for inhibiting HIV-1.
Article
Virology
Romano Strobelt, Karin Broennimann, Julia Adler, Yosef Shaul
Summary: The COVID-19 pandemic was caused by the global spread of the SARS-CoV-2 virus. New variants of concern (VOCs) have emerged frequently, altering the course of infection. The Omicron variant of SARS-CoV-2 infects cells less efficiently through membrane fusion and exhibits decreased syncytia formation compared to the Delta variant. Characterizing the unique mutations and phenotypic manifestations of Omicron is crucial.
Article
Virology
Marissa D. Acciani, Maria F. Lay Mendoza, Katherine E. Havranek, Avery M. Duncan, Hersha Iyer, Olivia L. Linn, Melinda A. Brindley
Summary: The Ebola virus utilizes cell surface receptors including C-type lectins and phosphatidylserine receptors to enter target cells. The cellular scramblase protein XKR8 is crucial for regulating viral envelope surface phosphatidylserine (PS) levels, infectivity, and particle budding, highlighting its importance in virus entry and replication.
JOURNAL OF VIROLOGY
(2021)
Article
Energy & Fuels
Yonghong Yan, Wenkun Zhu, Rui Sun, Liutao Sun, Dengke Chen, Hongliang Qi, Jiangquan Wu
Summary: This study experimentally investigated the characteristics of semicoke and high-volatile bituminous coal of different particle sizes during co-firing. The results showed that particle size affected ignition distance and mode, and the relative contributions of semicoke and bituminous coal. A method was proposed to determine the intensive combustion zone and strong reducing zone, which played a crucial role in reducing NO emissions.
Article
Biology
Yuta Tezuka, Kenta M. Hagihara, Kenichi Ohki, Tomoo Hirano, Yoshiaki Tagawa
Summary: Spontaneous network activity in the developing neocortex plays a crucial role in the formation of long-range axonal projections. Manipulating neuronal activity during a critical developmental window is necessary for the establishment of projections in the mouse visual cortex.
Article
Virology
Hideki Saito, Sayaka Sukegawa, Sandra Kao, Klaus Strebel
Summary: hMRC1 acts as an antiviral factor by inhibiting virus release and viral infectivity, restricting the spread of HIV-1. The interaction between hMRC1 and a specific region of Env is found to be critical for its inhibitory effect on viral infectivity.
Article
Biochemistry & Molecular Biology
Tim Aguirre, Ellen Teichmann, Florian Q. Roempp, Ruthey Vivier, Cole Bryant, Matthew A. Hulverson, Wesley C. Van Voorhis, Kayode K. Ojo, J. Stone Doggett, Dorothea Fiedler, Stefan Hecht
Summary: This study developed photoswitchable azopyrazoles as inhibitors to selectively target CDPK1 from Toxoplasma gondii. The inhibitory activity of CDPK1 is dependent on the size of the gatekeeper residue. The photoswitchable inhibitors also showed activity against T. gondii and Cryptosporidium parvum infections in a cell culture model.
ACS CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Analytical
Cameron J. Stouffer, R. Kenneth Marcus
Summary: Cloth swipes are commonly used for sampling in various fields such as environmental analysis, forensics, and bioassays. They provide easy sample collection and transportation, and can be used to sample low-volume analytes. The choice of analytical sampling method depends on the means of analysis.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Chemistry, Analytical
Cameron J. Stouffer, R. Kenneth Marcus
Summary: Cloth swipes are a common sampling method with applications in various fields. They offer easy sample collection and transportation, the ability to sample low-volume analytes, and diverse methods for analyzing immobilized materials. ICP-MS is a versatile method for elemental analysis of swipe materials, and direct microextraction shows promise for diverse applications.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2023)
Article
Biotechnology & Applied Microbiology
Mathieu Nonnenmacher, Harm van Bakel, Roger J. Hajjar, Thomas Weber
Article
Medicine, Research & Experimental
Kleopatra Rapti, Francesca Stillitano, Ioannis Karakikes, Mathieu Nonnenmacher, Thomas Weber, Jean-Sebastian Hulot, Roger J. Hajjar
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2015)
Review
Biotechnology & Applied Microbiology
Kyle Chamberlain, Jalish Mahmud Riyad, Thomas Weber
HUMAN GENE THERAPY METHODS
(2016)
Editorial Material
Biochemistry & Molecular Biology
T. Weber
Article
Cardiac & Cardiovascular Systems
Shin Watanabe, Kiyotake Ishikawa, Kenneth Fish, Jae Gyun Oh, Lukas J. Motloch, Erik Kohlbrenner, Philyoung Lee, Chaoqin Xie, Ahyoung Lee, Lifan Liang, Changwon Kho, Lauren Leonardson, Maritza McIntyre, Scott Wilson, R. Jude Samulski, Evangelia G. Kranias, Thomas Weber, Fadi G. Akar, Roger J. Hajjar
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2017)
Review
Biotechnology & Applied Microbiology
Michael G. Katz, Anthony S. Fargnoli, Thomas Weber, Roger J. Hajjar, Charles R. Bridges
HUMAN GENE THERAPY CLINICAL DEVELOPMENT
(2017)
Article
Biotechnology & Applied Microbiology
Kyle Chamberlain, Jalish M. Riyad, Tyrone Garnett, Erik Kohlbrenner, Ananda Mookerjee, Firas Elmastour, Ludovic Benard, Jiqiu Chen, Thierry VandenDriessche, Marinee K. Chuah, Ali J. Marian, Roger J. Hajjar, Priyatansh Gurha, Thomas Weber
HUMAN GENE THERAPY
(2018)
Article
Urology & Nephrology
Fang Zhong, Haibing Chen, Yifan Xie, Evren U. Azeloglu, Chengguo Wei, Weijia Zhang, Zhengzhe Li, Peter Y. Chuang, Belinda Jim, Hong Li, Firas Elmastour, Jalish M. Riyad, Thomas Weber, Hongyu Chen, Yongjun Wang, Aihua Zhang, Weiping Jia, Kyung Lee, John C. He
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Review
Cardiac & Cardiovascular Systems
Kiyotake Ishikawa, Thomas Weber, Roger J. Hajjar
CIRCULATION RESEARCH
(2018)
Article
Medicine, Research & Experimental
Alejandro Orlowski, Michael G. Katz, Sarah M. Gubara, Anthony S. Fargnoli, Kenneth M. Fish, Thomas Weber
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Cardiac & Cardiovascular Systems
Jordi Coste Pradas, Gaelle Auguste, Scot J. Matkovich, Raffaella Lombardi, Suet Nee Chen, Tyrone Garnett, Kyle Chamberlain, Jalish Mahmud Riyad, Thomas Weber, Sanjay K. Singh, Matthew J. Robertson, Cristian Coarfa, Ali J. Marian, Priyatansh Gurha
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Review
Biochemistry & Molecular Biology
Jalish M. Riyad, Thomas Weber
Summary: Recombinant adeno-associated virus has become the most popular gene therapy vector in the last two decades, with higher doses increasing the risk of adverse events. FDA has recently approved AAV gene therapy for two rare genetic disorders, highlighting the need for better vectors to achieve therapeutic levels with lower doses. The review discusses cellular roadblocks that AAV must overcome and recent advancements in AAV biology that can improve vector performance for safer gene therapy.
Correction
Biochemistry & Molecular Biology
Jalish M. Riyad, Thomas Weber
Review
Cardiac & Cardiovascular Systems
Michael G. Katz, Anthony S. Fargnoli, Sarah M. Gubara, Kenneth Fish, Thomas Weber, Charles R. Bridges, Roger J. Hajjar, Kiyotake Ishikawa
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2019)
Review
Cardiac & Cardiovascular Systems
Kyle Chamberlain, Jalish M. Riyad, Thomas Weber
CURRENT OPINION IN CARDIOLOGY
(2017)