期刊
GENE THERAPY
卷 16, 期 5, 页码 581-588出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/gt.2009.16
关键词
gene targeting; recombinant adeno-associated virus; animal models; zinc-finger nucleases; homologous recombination; somatic cell nuclear transfer
类别
资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R37DK047967, P30DK054759] Funding Source: NIH RePORTER
- NIDDK NIH HHS [P30 DK054759, R37 DK047967-21, R37 DK047967] Funding Source: Medline
In the past 2 years, new gene-targeting approaches using adeno-associated virus and designer zinc-finger nucleases have been successfully applied to the production of genetically modified ferrets, pigs, mice and zebrafish. Gene targeting using these tools has been combined with somatic cell nuclear transfer and germ cell transplantation to generate gene-targeted animal models. These new technical advances, which do not require the generation of embryonic stem cell-derived chimeras, will greatly accelerate the production of non-mouse animal models for biomedical research. Gene Therapy (2009) 16, 581-588; doi: 10.1038/gt.2009.16; published online 19 February 2009
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