期刊
GENE EXPRESSION PATTERNS
卷 13, 期 7, 页码 271-279出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gep.2013.05.002
关键词
Microtubules; Intracellular transport; Trigeminal ganglia; Posterior lateral line ganglia; Retina; Neurons; Hindbrain; Spinal cord; Digestive tract
资金
- NIH [R01GM1089979]
- Albert Einstein College of Medicine MSTP training grant [T32-GM007288]
Homo- and heterodimers of Kif5 proteins form the motor domain of Kinesin-1, a major plus-end directed microtubule motor. Kif5s have been implicated in the intracellular transport of organelles, vesicles, proteins, and RNAs in many cell types. There are three mammalian KIF5s. KIF5A and KIF5C proteins are strictly neural in mouse whereas, KIF5B is ubiquitously expressed. Mouse knockouts indicate crucial roles for KIF5 in development and human mutations in KIF5A lead to the neurodegenerative disease Hereditary Spastic Paraplegia. However, the developmental functions and the extent to which individual kif5 functions overlap have not been elucidated. Zebrafish possess five kif5 genes: kif5Aa, kif5Ab, kif5Ba, kif5Bb, and kif5C. Here we report their tissue specific expression patterns in embryonic and larval stages. Specifically, we find that kif5As are strictly zygotic and exhibit neural-specific expression. In contrast, kif5Bs exhibit strong maternal contribution and are ubiquitously expressed. Lastly, kif5C exhibits weak maternal expression followed by enrichment in neural populations. In addition, kif5s show distinct expression domains in the larval retina. (c) 2013 Elsevier B.V. All rights reserved.
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