期刊
GENE EXPRESSION PATTERNS
卷 11, 期 8, 页码 484-490出版社
ELSEVIER
DOI: 10.1016/j.gep.2011.08.004
关键词
Zasp; Drosophila; PDZ-LIM domain protein; Alp/Enigma family; Alternative splicing; Muscle attachment; Z disk assembly; Myofibril assembly; Heart muscle; Visceral muscle; Somatic muscle
资金
- Canadian Foundation for Innovation [9607]
- Canadian Institute of Health Research [MOP-93727]
Zasp52 is a member of the PDZ-LIM domain protein family in Drosophila, which comprises Enigma, ENH, ZASP, Alp, CLP36, RIL, and Mystique in vertebrates. Drosophila Zasp52 colocalizes with integrins at myotendinous junctions and with alpha-actinin at Z-disks, and is required for muscle attachment as well as Z-disk assembly and maintenance. Here we document 13 Zasp52 splice variants giving rise to six different LIM domains. We demonstrate stage- and tissue-specific expression in different muscle types for Zasp52 isoforms encoding different LIM domains. In particular, LIM1b is expressed only in heart muscle and certain somatic muscles, implying muscle-specific functions in Z-disk assembly or maintenance. (C) 2011 Elsevier B.V. All rights reserved.
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