Article
Veterinary Sciences
Fengyang Wu, Lijie Gao, Fei Li, Jia Cui, Xinyu Yang, Yanhua Liu, Saijuan Chen, Baojiang Chen
Summary: This experiment aimed to investigate the effects of zearalenone on ovarian development in prepubertal gilts. The results showed that zearalenone promoted the development of ovaries and follicles through the growth hormone axis, and exerted reproductive toxicity by increasing the expression levels of growth hormone receptor and related proteins.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Estefania Landi, Liliana Karabatas, Tomas Rodriguez Gomez, Lucia Salatino, Paula Scaglia, Laura Ramirez, Ana Keselman, Debora Braslavsky, Nora Sanguineti, Patricia Pennisi, Rodolfo A. Rey, Ignacio Bergada, Hector G. Jasper, Horacio M. Domene, Paola Plazas, Sabina Domene
Summary: Growth hormone activates JAK2-STAT5b pathway, leading to the transcription of IGF1, IGFBP3, and IGFALS. Heterozygous dominant-negative STAT5B variants were found to cause milder growth deficit and immune dysfunction. In zebrafish, overexpression of these variants resulted in developmental malformations, indicating their pathogenicity.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Somayyeh Heidary, Nagendra Awasthi, Nicole Page, Theo Allnutt, Rowena S. Lewis, Clifford Liongue, Alister C. Ward
Summary: This study aimed to generate a zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1) by targeting the stat5.1 gene using CRISPR/Cas9. The zebrafish Stat5.1 mutants exhibited smaller size and increased adiposity, with dysregulation of growth and lipid metabolism genes. The mutants also showed impaired lymphopoiesis with reduced T cells throughout the lifespan, along with broader disruption of the lymphoid compartment in adulthood, including evidence of T cell activation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Evgenia Gurevich, Yael Segev, Daniel Landau
Summary: GH and IGF-1 have important roles in kidney development and function regulation, with GH excess potentially leading to kidney damage. Chronic kidney disease and its complications in children are associated with alterations in the GH/IGF1 axis, with GH treatment being used to promote growth.
Article
Biotechnology & Applied Microbiology
Jun Fang, Dong Zhang, Jun Wei Cao, Li Zhang, Chun Xia Liu, Yan Ping Xing, Feng Wang, Hong Yang Xu, Shi Chao Wang, Yu Ling, Wei Wang, Yan Ru Zhang, Huan Min Zhou
Summary: The study analyzed pituitary and epiphyseal tissues of Debao ponies and Mongolian horses to investigate genetic regulation of body growth in mammals. Differences in expression of growth hormone receptor and pathway components were found, as well as potential involvement of the WNT/Ca2+ pathway in regulating body growth. Debao ponies showed higher levels of IGF-1 and GH compared to Mongolian horses at different developmental stages, indicating differences in hormone regulation between the two breeds.
Article
Developmental Biology
Andrew J. Aman, Margaret Kim, Lauren M. Saunders, David M. Parichy
Summary: This study demonstrates that thyroid hormone regulates the rate of post-embryonic dermal development in zebrafish by interacting with nuclear hormone receptors, resulting in a well-ordered array of correctly proportioned scales. It extends our understanding of thyroid hormone actions on skin by providing in-vivo evidence that thyroid hormone regulates multiple aspects of dermal development.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Cheng Zhao, Yue Zhai, Ruijing Geng, Kun Wu, Weiyi Song, Nana Ai, Wei Ge
Summary: Activin and inhibin play important roles in fish reproduction, particularly in folliculogenesis and ovarian homeostasis. This study investigated the functional roles and importance of beta subunits (beta As: inhbaa and inhbab; beta B: inhbb) in zebrafish development and reproduction using gene editing technology. The loss of all three subunits resulted in early death, indicating their functional importance in development. Beta As, especially inhbaa, were found to be essential in controlling female follicle development, with the loss of inhbaa leading to delayed follicle activation and ovarian fibrosis. The study provides comprehensive evidence for the relative importance of each beta subunit in zebrafish reproduction.
Article
Environmental Sciences
Hyunggyu Kim, Kyunghee Ji
Summary: This study investigated the effects of TMBPF on the endocrine system using zebrafish embryos and larvae. The results showed that TMBPF exposure led to reduced body weight, increased triiodothyronine levels, decreased growth hormone levels, and altered gene transcription associated with thyroid hormones and growth hormones.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Marine & Freshwater Biology
Darren Van Essen, Alper James G. Alcaraz, Justin G. P. Miller, Paul D. Jones, Jon A. Doering, Steve Wiseman
Summary: This study investigated the effects of the brominated flame retardant TBCO on oocyte maturation in zebrafish, suggesting impaired oocyte maturation as a potential mechanism for reduced reproductive performance in TBCO-exposed fish. The findings also indicated that the effects of TBCO on oocyte maturation may be due to molecular perturbations on insulin-like growth factor signaling and expression of microRNAs.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Yoshifumi Horie
Summary: The study aimed to investigate the effects of environmentally relevant concentrations of triclosan on zebrafish development. It was found that triclosan at environmentally detected residual concentrations can cause lethal effects and disrupt thyroid hormone activity in zebrafish.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Chen Lin, Meng Jiang, Ling Liu, Xiaoyuan Chen, Yuancun Zhao, Lu Chen, Yujuan Hong, Xin Wang, Chengye Hong, Xihu Yao, Rongqin Ke
Summary: The asmFISH assay introduces a more efficient and specific method for highly specific imaging of individual transcripts in fixed cells and tissues, compared to the padlock probe assay. It can be applied not only to cultured cells, but also to fresh frozen and formalin-fixed, paraffin-embedded tissue sections.
Article
Biochemistry & Molecular Biology
Yoichiro Takahashi, Kristen R. Maynard, Madhavi Tippani, Andrew E. Jaffe, Keri Martinowich, Joel E. Kleinman, Daniel R. Weinberger, Thomas M. Hyde
Summary: The study identified distinct localization patterns of schizophrenia risk transcripts in the healthy human brain, with SNX19 transcripts potentially disrupting the normal function of glutamatergic neurons and AS3MT leading to disturbances in the GABAergic system.
MOLECULAR PSYCHIATRY
(2021)
Article
Environmental Sciences
Liguo Qiu, Shuhui Wei, Yunsheng Wang, Rui Zhang, Shaoguo Ru, Xiaona Zhang
Summary: This study found that BPS affects the visual function of zebrafish larvae and stimulates the metabolism of all-trans-retinoic acid. By modulating the expression of CYP26A1 and TRO, it was found that CYP26A1 plays a crucial role in the oxidative metabolism of atRA and regeneration of retinoids in the visual cycle, and TRO mediates cyp26a1 expression in zebrafish eyes.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Cell Biology
Zhe Liu, Wei Wang, Xinru Li, Xiujuan Zhao, Hongyu Zhao, Wuritu Yang, Yongchun Zuo, Lu Cai, Yongqiang Xing
Summary: Alternative splicing plays an important role in zebrafish embryo development, especially during the maternal-to-zygotic transition process where it is highly abundant and dynamic. Splicing factors are expressed with developmental stage specificity, with a higher expression during the maternal-to-zygotic transition. The inclusion level of alternative splicing events performs well in cluster analysis and can be used as a novel parameter.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Veterinary Sciences
Vera Stiensmeier, Marion Schmicke
Summary: This study aimed to test the effect of T3 on GHR mRNA expression in a bovine hepatocyte model. The results confirmed the stimulatory effect of T3 on GHR1A mRNA expression.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Editorial Material
Developmental Biology
Elias H. Barriga, Paul A. Trainor, Marianne Bronner, Roberto Mayor
Article
Developmental Biology
M. Angeles Rabadan, Antonio Herrera, Lucia Fanlo, Susana Usieto, Carlos Carmona-Fontaine, Elias H. Barriga, Roberto Mayor, Sebastian Pons, Elisa Marti
Review
Developmental Biology
Mansour Alkobtawi, Heather Ray, Elias H. Barriga, Mauricio Moreno, Ryan Kerney, Anne-Helene Monsoro-Burq, Jean-Pierre Saint-Jeannet, Roberto Mayor
DEVELOPMENTAL BIOLOGY
(2018)
Review
Cell Biology
Elias H. Barriga, Roberto Mayor
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Elias H. Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor
Article
Multidisciplinary Sciences
Maria Kotini, Elias H. Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambon, Roberto Mayor
NATURE COMMUNICATIONS
(2018)
Correction
Multidisciplinary Sciences
Maria Kotini, Elias H. Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambony, Roberto Mayor
NATURE COMMUNICATIONS
(2018)
Article
Cell Biology
Luyan Cao, Amina Yonis, Malti Vaghela, Elias H. Barriga, Priyamvada Chugh, Matthew B. Smith, Julien Maufront, Genevieve Lavoie, Antoine Meant, Emma Ferber, Miia Bovellan, Art Alberts, Aurelie Bertin, Roberto Mayor, Ewa K. Paluch, Philippe P. Roux, Antoine Jegou, Guillaume Romet-Lemonne, Guillaume Charras
NATURE CELL BIOLOGY
(2020)
Review
Physiology
Elias H. Barriga, Eric Theveneau
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Jaime A. Espina, Cristian L. Marchant, Elias H. Barriga
Summary: Directed cell migration is crucial in physiological and pathological processes, influenced by both mechanical and chemical signals. Recent focus has been on the mechanical guidance of cell migration via durotaxis, with studies showing how cells sense and respond to environmental mechanics, leading to biased migration. Advances in understanding durotaxis in vivo and its integration with chemotaxis for haptotaxis in native environments have also been discussed.
Editorial Material
Physics, Multidisciplinary
Ivana D. Pajic-Lijakovic, Karine Guevorkian, Elias H. Barriga, Jose J. Munoz
FRONTIERS IN PHYSICS
(2021)
Article
Chemistry, Physical
Cristian L. Marchant, Abdul N. Malmi-Kakkada, Jaime A. Espina, Elias H. Barriga
Summary: Collective cell migration in embryonic tissues is triggered by a mechanosensitive pathway involving Piezo1-mediated microtubule deacetylation, causing cell softening.
Article
Developmental Biology
Elias H. Barriga, Delan N. Alasaadi, Chiara Mencarelli, Roberto Mayor, Franck Pichaud
Summary: This study reveals the essential role of RanBP1 in neural crest cell collective migration, which is involved in establishing front-to-rear polarity and promoting directed chemotaxis. This finding has important implications for our understanding of cell migration and various pathological conditions.
DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Jaime A. Espina, Marilia H. Cordeiro, Milan Milivojevic, Ivana Pajic-Lijakovic, Elias H. Barriga
Summary: Shear stress plays a vital role in normal physiology and malignancy, affecting tissue behavior and important biomedical processes such as wound healing, cancer, and fibrosis. Understanding how cells react and adapt to shear stress is crucial.
JOURNAL OF CELL SCIENCE
(2023)
Article
Developmental Biology
Isabel Bahm, Elias H. Barriga, Antonina Frolov, Eric Theveneau, Paul Frankel, Roberto Mayor
Article
Developmental Biology
Sanjana Srinivasan, Xinjian He, Sarah Mirza, Jesse Mager
Summary: Exosome Complex Components 1 and 2 (EXOSC1 and 2) are essential proteins in the RNA Exosome complex that play important roles in early mammalian development. Their absence results in developmental delay and morphological abnormalities in embryos.
GENE EXPRESSION PATTERNS
(2024)