Article
Neurosciences
Ruilong Hu, Janam Shankar, Grant Z. Z. Dong, Pablo S. S. Villar, Ricardo C. C. Araneda
Summary: In the olfactory bulb (OB), noradrenaline (NA) modulates the hyperpolarization-activated currents (I-h) in adult-born granule cells (abGCs) through alpha(2)-adrenergic receptors (ARs), enhancing lateral inhibition onto mitral and tufted cells (MCs). This modulation also affects the subthreshold resonance in GCs, potentially impacting the temporal integration of abGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell & Tissue Engineering
Cagla Defterali, Mireia Moreno-Estelles, Carlos Crespo, Eva Diaz-Guerra, Maria Diaz-Moreno, Eva Vergano-Vera, Vanesa Nieto-Estevez, Anahi Hurtado-Chong, Antonella Consiglio, Helena Mira, Carlos Vicario
Summary: In this study, injected EGFP-labeled retroviral particles in the adult olfactory bulb core of mice revealed that NSCs could generate multipotent neurons and glial cells. These newly generated neurons were able to establish synaptic contacts and be integrated into the olfactory bulb circuits.
Article
Behavioral Sciences
Hanaa Malloul, Sara Bonzano, Mohammed Bennis, Silvia De Marchis, Saadia Ba-M'hamed
Summary: Exposure to volatile solvents can affect olfactory functioning and behavior in mice, but alterations in adult olfactory neurogenesis do not seem to be associated with impaired olfactory performances in chronically exposed animals.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Francisco J. Fernandez Acosta, Inma Luque-Molina, Rebeca Vecino, Eva Diaz-Guerra, Cagla Defterali, Jaime Pignatelli, Carlos Vicario
Summary: This study found that neural stem cells in the olfactory bulb of adult mice can generate CalR(+) neurons, and these adult cells exhibit different morphologies when migrating to different layers of the olfactory bulb. The study also revealed that altering the expression of the transcription factor Tbr1 can affect the migration and morphology of these newly generated neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Developmental Biology
Angela del Aguila, Mike Adam, Kristy Ullom, Nicholas Shaw, Shenyue Qin, Jacqueline Ehrman, Diana Nardini, Joseph Salomone, Brian Gebelein, Q. Richard Lu, Steven S. Potter, Ronald Waclaw, Kenneth Campbell, Masato Nakafuku
Summary: The basic helix-loop-helix transcription factor Olig2 defines a unique subset of adult neural stem cells in the ventral aspect of the subventricular zone, playing an important role in cell cycle, metabolic properties, and specification of olfactory bulb interneuron subtypes.
Article
Toxicology
Bunichiro Ogawa, Yutaka Nakanishi, Masaki Wakamatsu, Yasunori Takahashi, Makoto Shibutani
Summary: Acrylamide (AA) is a neurotoxicant that inhibits synaptic function and neural cell differentiation in the hippocampus and olfactory bulb-subventricular zone (OB-SVZ) region. AA exposure decreased neuroblasts in the OB by suppressing neuronal migration and downregulating genes related to neuronal differentiation and migration. These findings indicate that AA has a similar detrimental effect on neurogenesis in the OB-SVZ as it does in the hippocampus.
TOXICOLOGY LETTERS
(2023)
Review
Developmental Biology
Candida Tufo, Subathra Poopalasundaram, Ana Dorrego-Rivas, Marc C. Ford, Anthony Graham, Matthew S. Grubb
Summary: This review summarizes the development of the mammalian olfactory bulb, including prenatal, postnatal, and adult stages, focusing on the maturation, morphology, functions, and interactions of its diverse glutamatergic and GABAergic cell types. The review highlights the significant advances made in understanding olfactory bulb development in recent years, as well as the remaining gaps in knowledge that require urgent attention.
Article
Cell Biology
Chrysoula Dioli, Patricia Patricio, Lucilia-Goreti Pinto, Clemence Marie, Monica Morais, Sheela Vyas, Joao M. Bessa, Luisa Pinto, Ioannis Sotiropoulos
Summary: The study demonstrates the significant role of Tau in neurogenesis under chronic stress conditions, with Tau-KO mice showing higher levels of neuronal migration. These findings highlight the importance of Tau protein in neurogenesis suppression under stress, emphasizing its role in stress-related plasticity deficits.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Anna Athanassi, Marine Breton, Laura Chalencon, Jerome Brunelin, Anne Didier, Kevin Bath, Nathalie Mandairon
Summary: Experiencing chronic stress increases the risk for depression and affects the quality of life. Odorants play a crucial role in social interactions and behavior, and a decrease in olfactory function is associated with depression symptoms. The hedonic value of odorants is encoded by granule cells in the olfactory bulb, which can be affected by chronic mild stress. This study explores the link between olfactory hedonics, neurogenesis, and stress-associated depression.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biology
Kent D. Dunlap, Magda C. Teles, Rui F. Oliveira
Summary: Research indicates that cells born in the adult zebrafish brain are sensitive to social stimuli and may play a role in regulating social behavior. This suggests that adult neurogenesis in fish may contribute to behavioral plasticity, with cells being able to respond to external cues and potentially drive changes in behavior.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Fabio Casciano, Nicoletta Bianchi, Mirta Borin, Vittorio Vellani, Paola Secchiero, Carlo M. Bergamini, Simona Capsoni, Angela Pignatelli
Summary: We demonstrated for the first time that fluorescence intensity correlates very well with the expression of genes typical of different stages of maturation in dopaminergic neurons. We propose that the FACS method used to isolate these neurons may be used to engineer new neurons for therapeutic purposes in widespread pathologies, such as Parkinson's disease.
Article
Biology
Elia Benito-Gutierrez, Giacomo Gattoni, Manuel Stemmer, Silvia D. Rohr, Laura N. Schuhmacher, Jocelyn Tang, Aleksandra Marconi, Gaspar Jekely, Detlev Arendt
Summary: The study reveals overlapping expression of conserved transcription factors that specify the telencephalon in vertebrates in the chordate amphioxus. Specific co-expression is observed in the dorsal part of the anterior brain vesicle, referred to as Pars anterodorsalis (PAD). This suggests homology between the adult amphioxus brain vesicle PAD and the vertebrate telencephalon.
Article
Neurosciences
Yali Chen, Peng Ren, Xiongjie He, Fang Yan, Rou Gu, Jie Bai, Xianwen Zhang
Summary: Olfaction is a crucial sense that relies on the olfactory bulb (OB) as the relay station. The contribution of subventricular zone (SVZ) adult neurogenesis to OB neurogenesis is still not fully understood. Recent studies have focused on understanding the molecular and signaling pathways associated with OB neurogenesis dependent on SVZ function. This understanding is important for improving olfactory dysfunction and developing new therapies based on adult neural stem cells (aNSCs).
Article
Neurosciences
Stephane Bugeon, Clara Haubold, Alexandre Ryzynski, Harold Cremer, Jean-Claude Platel
Summary: The study investigates the impact of neuronal activity on the migration of different interneuron subtypes, revealing a significant increase in intrinsic calcium activity in granule cell precursors during the switch from tangential to radial migration. Neuronal activity is found to be necessary for the positioning and survival of granule cell precursors in the olfactory bulb layers.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Beata Tepper, Paulina Koguc-Sobolewska, Katarzyna Jaslan, Krzysztof Turlejski, Katarzyna Bartkowska, Ruzanna Djavadian
Summary: The study showed that aged female opossums took longer to find food using olfactory cues, and had lower levels of immature neurons marked by doublecortin in the olfactory bulb. Additionally, the protein HuD, associated with learning and memory, was higher in aged opossums compared to young opossums.
SCIENTIFIC REPORTS
(2021)
Article
Developmental Biology
Sanjana Srinivasan, Xinjian He, Sarah Mirza, Jesse Mager
Summary: Exosome Complex Components 1 and 2 (EXOSC1 and 2) are essential proteins in the RNA Exosome complex that play important roles in early mammalian development. Their absence results in developmental delay and morphological abnormalities in embryos.
GENE EXPRESSION PATTERNS
(2024)