Article
Multidisciplinary Sciences
Onelia Gagliano, Camilla Luni, Yan Li, Silvia Angiolillo, Wei Qin, Francesco Panariello, Davide Cacchiarelli, Joseph S. Takahashi, Nicola Elvassore
Summary: This study investigates the effect of oscillatory metabolic signals on the cell-autonomous clock in peripheral tissues, and highlights the role of synchronicity between life-style associated metabolic signals and peripheral clocks on circadian entrainment. The authors controlled cyclic metabolic signals in a microfluidic device to study the impact of glucose and insulin timing, period, and frequency on the transcriptome of cultured fibroblasts.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiaolong Gao, Mingxin Lyu, Mo Zhang, Shihui Lin, Caihuan Ke
Summary: This study identified and described the structural characteristics and circadian expression patterns of orexin receptor type 2 (OX2R) in the nocturnal marine mollusk, Pacific abalone. It found that the expression levels of OX2R were highest in the intestinal tract and that the feeding behavior of abalone correlated with the expression level of OX2R. These findings provide insights into the molecular mechanisms underlying the feeding rhythm of marine nocturnal organisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Computer Science, Information Systems
Wei Zhao, Bo Zhang, Cong Yang, Xianfu Chen, Hui Chen
Summary: With the popularization of surveillance cameras, the demand for video-based person re-identification (Re-ID) applications has increased. A novel framework called MSTN is proposed to utilize spatial-temporal features for accurate person re-identification. Extensive experiments on the MARS dataset demonstrate that MSTN achieves high identification accuracy, outperforming state-of-the-art methods.
INTERNET OF THINGS
(2022)
Review
Cell Biology
Lara Bideyan, Rohith Nagari, Peter Tontonoz
Summary: This passage discusses the complex changes in hepatic gene expression in mammals during fasting and feeding transitions, highlighting the factors influencing these changes and the regulatory effects of dietary modifications on hepatic gene expression programs.
GENES & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Mauricio Castro-Sepulveda, Beatrice Morio, Mauro Tunon-Suarez, Sebastian Jannas-Vela, Francisco Diaz-Castro, Jennifer Rieusset, Hermann Zbinden-Foncea
Summary: This study aimed to investigate the mitochondrial dynamics response in human peripheral blood mononuclear cells during the metabolic transition from fasting to feeding. The results demonstrated that this transition reduces mitochondria-ER interactions, induces mitochondrial fission, and reduces mitochondrial cristae density in human PBMCs.
Article
Cell Biology
Fang Wei, Lijun Gong, Siyu Lu, Yiming Zhou, Li Liu, Zhigui Duan, Rong Xiang, Frank J. Gonzalez, Guolin Li
Summary: The study found that fasting for 16 hours can initiate a circadian resonance of multiple pathways in the liver, which punctually switches following refeeding. This indicates that the hepatic proteasome may serve as a fasting timer and a coordinator of pathway transcriptional resonance.
Article
Reproductive Biology
Gyeong-Min Gim, Kyeong-Hyun Uhm, Dong-Hyeok Kwon, Min-Ji Kim, Dae-Jin Jung, Dae-Hyun Kim, Jun-Koo Yi, Jae-Jung Ha, Soo-Young Yum, Woo-Jae Son, Ji-Hyun Lee, Ji-Hyun Park, Kil-Young Song, Won-Wu Lee, Goo Jang
Summary: This study assessed the germline transmission of MSTN mutations in F0 cattle and demonstrated successful transmission of the mutations to the next generation. Additionally, the study showed the possibility of further gene editing using electroporation in embryos fertilized with the mutant sperms.
Article
Food Science & Technology
Na He, Xia Lang, Cailian Wang, Cailing Lv, Mingming Li, Ruizhe Sun, Junxia Zhang
Summary: This study aimed to investigate the mutton quality, mRNA expression of main transduction genes in the MSTN/Smad signaling pathway, and their effects on the mutton quality of Tibetan sheep. The mutton quality and gene expression were evaluated in slaughtered Tibetan sheep. Results showed no significant differences in mutton quality between ewes and rams, except for Warner-Bratzler shear force. Various fatty acids were detected in Tibetan sheep muscles. The main transduction genes in the MSTN/Smad signaling pathway were widely expressed in muscle tissues. Correlation analysis revealed significant associations between the main genes and mutton quality. The expression level of MSTN in muscles was positively correlated with Smad2, Smad3, and Smad4 genes and negatively correlated with TGF beta RII genes. These findings provide a theoretical basis for understanding the regulation mechanism of the MSTN/Smad pathway on mutton quality.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Kevin P. Kelly, Kate L. J. Ellacott, Heidi Chen, Owen P. McGuinness, Carl Hirschie Johnson
Summary: Time-restricted feeding is crucial for weight management as it affects metabolism, but previous studies have often confused feeding time with fasting time; Researchers have introduced a new time-optimized feeding plan to better analyze the effects of meal timing on the body, and to more accurately simulate human eating patterns in the laboratory; According to the data, controlling the timing of carbohydrate and fat oxidation can effectively limit fat accumulation.
Article
Multidisciplinary Sciences
Marta Barradas, Adrian Plaza, Gonzalo Colmenarejo, Iolanda Lazaro, Luis Filipe Costa-Machado, Roberto Martin-Hernandez, Victor Mico, Jose Luis Lopez-Aceituno, Jesus Herranz, Cristina Pantoja, Hector Tejero, Alberto Diaz-Ruiz, Fatima Al-Shahrour, Lidia Daimiel, Viviana Loria-Kohen, Ana Ramirez de Molina, Alejo Efeyan, Manuel Serrano, Oscar J. Pozo, Aleix Sala-Vila, Pablo J. Fernandez-Marcos
Summary: The study shows that fasting can provide protection from chemotherapy-associated toxicity. They found that the profile of fatty acids in erythrocyte membranes and gene expression in peripheral blood mononuclear cells are associated with the benefits of fasting during cancer treatment in mice and patients.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Hui-Hao Lin, Meihua Christina Kuang, Imran Hossain, Yinan Xuan, Laura Beebe, Andrew K. Shepherd, Marco Rolandi, Jing W. Wang
Summary: This study explores the molecular and neuronal mechanisms underlying the transition from feeding to courtship in Drosophila melanogaster. The results show that feeding is prioritized over courtship in starved males, but the consumption of protein-rich food rapidly reverses this order. A gut-derived neuropeptide hormone called Diuretic hormone 31 (Dh31) plays a role in switching from feeding to courtship. The findings also reveal that Dh31 stimulates specific brain neurons through the circulation, leading to the prioritization of courtship over feeding through parallel pathways.
Article
Cell Biology
Anne Loft, Soren Fisker Schmidt, Giorgio Caratti, Ulrich Stifel, Jesper Havelund, Revathi Sekar, Yun Kwon, Alba Sulaj, Kan Kau Chow, Ana Jimena Alfaro, Thomas Schwarzmayr, Nikolaj Rittig, Mads Svart, Foivos-Filippos Tsokanos, Adriano Maida, Andreas Blutke, Annette Feuchtinger, Niels Moller, Matthias Blueher, Peter Nawroth, Julia Szendroedi, Nils J. Faergeman, Anja Zeigerer, Jan Tuckermann, Stephan Herzig
Summary: This study investigates the contribution of immune cells to metabolic homeostasis during fasting in healthy subjects. It identifies the glucocorticoid receptor (GR) as a key driver of fasting-induced reprogramming of the macrophage secretome, and shows that lack of macrophage GR impairs induction of ketogenesis during fasting and endotoxemia. This research also highlights the direct influence of liver macrophages on ketogenesis in hepatocytes, providing insights into the immune system's role in regulating metabolic activity during inflammatory diseases and infection.
Article
Genetics & Heredity
Jakaria Jakaria, Wenny Ladhunka Nur Aliyya, Riyadi Ismail, Sri Yuni Siswanti, Mokhamad Fakhrul Ulum, Rudy Priyanto
Summary: This study investigated single-nucleotide polymorphisms (SNPs) and 11-bp deletions in the coding region of the MSTN gene in Belgian Blue, Peranakan Ongole, and their crossbred cattle. Although four SNPs and an 11-bp deletion were found, they were not able to differentiate between normal and double-muscled phenotypes accurately.
Article
Plant Sciences
Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang, Yuan-Yuan Sun
Summary: The study revealed that Rb1 may ameliorate obesity through the MSTN/FNDC5 signaling pathway. Rb1 was shown to reduce body weight, adipocyte size, improve glucose tolerance, and increase basic metabolic activity.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Christian Peters, Songwei He, Federica Fermani, Hansol Lim, Wenyu Ding, Christian Mayer, Ruediger Klein
Summary: Using single-nucleus RNA sequencing, this study identifies nine clusters of cells in the central amygdala (CeA) and finds that certain cells are associated with appetitive and aversive behaviors. The study focuses on serotonin receptor 2a (Htr2a)-expressing neurons (CeAHtr2a) in the CeA that promote feeding and finds that these neurons are activated by fasting, ghrelin, and the presence of food. They also project to the parabrachial nucleus, inhibiting target neurons and influencing feeding behavior.
Review
Fisheries
Aiguo Zhou, Yue Zhang, Shaolin Xie, Yuliang Chen, Xiang Li, Jun Wang, Jixing Zou
Summary: The massive production of plastics has led to widespread microplastic pollution, with lasting impacts on the global environment, especially in aquaculture systems. Aquaculture is rapidly developing globally, with aquaculture products becoming important sources of high-quality protein, but there are also issues with microplastic contamination.
REVIEWS IN AQUACULTURE
(2021)
Article
Environmental Sciences
Di Sun, Jun Wang, Shaolin Xie, Huijuan Tang, Chaonan Zhang, Guohuan Xu, Jixing Zou, Aiguo Zhou
Summary: The study found that two economically important freshwater fish species in the north and west rivers of Guangdong province were widely ingesting microplastics, with significant differences in microplastic abundance between different cities. The results also suggested that microplastic abundance and distribution are positively related to economic development, tourism, industry, agriculture, and fishery.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Fisheries
Aiguo Zhou, Shaolin Xie, Muhammad Junaid, Di Sun, Huijuan Tang, Jiacheng Chuan, Xiang Li, Guohuan Xu, Jixing Zou
Summary: This study utilized high-throughput sequencing to investigate the microbiota in different growth stages of pond-cultured tilapias, revealing that the larvae group had a higher diversity of microbial taxa and community richness index. Furthermore, environmental factors were found to significantly impact the distribution and abundance of potential pathogens in the tilapia environments.
Article
Engineering, Environmental
Chaonan Zhang, Jun Wang, Aiguo Zhou, Qiao Ye, Yongyong Feng, Zhenlu Wang, Shaodan Wang, Guohuan Xu, Jixing Zou
Summary: The study revealed that the abundance of microplastics in fish larvae is related to feeding types, with carnivores ingesting less and omnivores displaying less ability to remove microplastics.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Aiguo Zhou, Shaolin Xie, Huijuan Tang, Li Zhang, Yue Zhang, Zhiheng Zuo, Xiang Li, Wenyu Zhao, Guohuan Xu, Jixing Zou
Summary: The study revealed different bacterial community characteristics at different culture stages of great grass carp ponds, with a higher abundance of potential pathogens and mobile elements in the larvae culture stage. Environmental factors such as temperature, stocking density, pH, and transparency significantly impact both microbial communities and potential pathogenic bacteria. Additionally, a wide distribution and high enrichment of antibiotic resistance bacteria and genes were identified in aquaculture production.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Zoology
Aiguo Zhou, Shaolin Xie, Zhuolin Sun, Yongyong Feng, Shulin Liu, Di Sun, Yanfeng Chen, Jixing Zou
Summary: This study conducted a morphological analysis of five Channa species. The results of principal component analysis and cluster analysis revealed their relationship. Discriminant analysis and X-ray photography further confirmed the similarity between O. argus var Kimnra and C. argus.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
Article
Fisheries
Shaodan Wang, Shaolin Xie, Chaonan Zhang, Zhengkun Pan, Di Sun, Aiguo Zhou, Guohuan Xu, Jixing Zou
Summary: This experiment investigated the interactions and effects of nano-microplastics with heavy metals cadmium in hybrid snakehead. Results showed that nano-microplastics and cadmium influenced the morphology of gills, caused oxidative damage to fish liver, and affected the activities of antioxidant enzymes as well as the expression of genes related to inflammation and metal accumulation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Aiguo Zhou, Huijuan Tang, Li Zhang, Muhammad Junaid, Shaolin Xie, Yue Zhang, Xiang Li, Guohuan Xu, Jixing Zou
Summary: Aquaculture plays a vital role in the connection between aquatic products and public health, but the potential hazards in aquaculture have been underestimated. This study identified various pathogenic and antibiotic resistant bacteria in aquaculture ponds and investigated the abundance of antibiotic resistance genes and environmental factors. The results revealed the widespread distribution of pathogenic and antibiotic resistant bacteria in aquaculture ponds, as well as the horizontal migration of antibiotic resistance genes. The findings provide important insights for regulating pathogenic bacteria and preventing ecological and health risks associated with antibiotic resistant bacteria in aquaculture.
Article
Environmental Sciences
Chong Wang, Manfei Tang, Yuliang Chen, Dingrui Liu, Shaolin Xie, Jixing Zou, Huijuan Tang, Qibiao Li, Aiguo Zhou
Summary: Water pollution is a serious problem. This study investigated the toxic effects of Cu and Zn ions on G. affinis by analyzing the changes in gene expression. The results showed that Cu and Zn have strong toxic effects on G. affinis. Furthermore, the study identified different gene expression patterns in different tissues of G. affinis exposed to Cu and Zn ions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Genetics & Heredity
Qingshi Chen, Tianli Wei, Bing Yang, Siying Li, Liangjun Ge, Aiguo Zhou, Shaolin Xie
Summary: This study compared the intestinal microbiota composition between mitfa knockout zebrafish and wild-type zebrafish, and found that the deletion of mitfa gene can cause changes in the composition of intestinal microbiota and affect the expression levels of immune and metabolism-related genes.
Article
Engineering, Environmental
Shaodan Wang, Zhiheng Zuo, Qiujie Wang, Aiguo Zhou, Guiqin Wang, Guohuan Xu, Jixing Zou
Summary: Increasing the use of carbohydrates and improving protein synthesis and utilization are essential for reducing ammonia nitrogen emissions. A 60-day cultural experiment found that replacing starch with resistant starch had positive effects on water quality, nitrogen and phosphorus utilization, and microbial composition in hybrid snakehead. The use of resistant starch improved the nutritional content of the fish and increased nitrogen and phosphorus utilization, while reducing pollution and promoting denitrifying bacterial colonization.
WATER ENVIRONMENT RESEARCH
(2023)
Article
Environmental Sciences
Chong Wang, Di Sun, Muhammad Junaid, Shaolin Xie, Guohuan Xu, Xiang Li, Huijuan Tang, Jixing Zou, Aiguo Zhou
Summary: The microbial diversity and differences in the water environment of the Pearl River Estuary in Nansha District were investigated using 16S rRNA gene amplicon sequencing. The study also explored the quantity, type, abundance, and distribution of antibiotic resistance genes (ARGs) and microplastics (MPs) in the water samples from different functional areas. The results showed dominant phyla and genera in the different regions, as well as the presence of various types of ARGs and characteristics of microplastics. This study provides important information for understanding estuarine microbial distribution and preventing environmental health risks from ARGs and microplastics.
Article
Genetics & Heredity
Shaolin Xie, Yongyong Feng, Aiguo Zhou, Zhiyuan Lu, JixingZou
Summary: Two zebrafish models, including a cyp1a low-expression line and a cyp1a knockout line, were constructed in this study to investigate the toxicity mechanism of PAHs and the role of cyp1a in detoxification.
Article
Fisheries
Shaolin Xie, Dongjie Wang, Yun Hu, Qiujie Wang, Zhiheng Zuo, Bin Ye, Liang Lu, Aiguo Zhou, Jixing Zou
Summary: By conducting a genome-wide comparative analysis, genes related to low-temperature resistance were identified. A chromosome-level draft genome of C. bouderius was constructed, and 24,165 protein-coding genes were predicted. Low-temperature stress tests showed that C. bouderius better controlled calcium ion homeostasis in cells compared to P. hypophthalmus, thereby maintaining dynamic changes in mitochondrial fusion and fission and protecting against cell damage caused by low-temperature stress.
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2023)
Article
Engineering, Environmental
Aiguo Zhou, Di Sun, Chong Wang, Yuliang Chen, Shaolin Xie, Peiqin Liu, Guohuan Xu, Huijuan Tang, Jixing Zou
Summary: Microplastics accumulation in aquaculture ponds is influenced by water depth, feeding habits, and diets. Bottom-dwelling omnivorous fish have the highest ingestion, while herbivorous fish and filter-feeders have lower ingestion.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
