Article
Medicine, Research & Experimental
Zi-Run Jin, Dong Fang, Bo-Heng Liu, Jie Cai, Wen-Hao Tang, Hui Jiang, Guo-Gang Xing
Summary: The study revealed a functional down-regulation of CatSper channels in both iAZS patients and AZS model rats, leading to impaired sperm function. Electroacupuncture treatment can enhance the functional expression of CatSper channels, improving sperm motility. Inhibition of CatSper1 gene affects the efficacy of electroacupuncture therapy.
Article
Biochemistry & Molecular Biology
Filomena Mottola, Marianna Santonastaso, Valentina Ronga, Renata Finelli, Lucia Rocco
Summary: This study investigated the association between polymorphic rearrangements of chromosome 9 and male infertility. The results suggested that these rearrangements might be associated with abnormalities in sperm quality, indicating their potential impact on spermatogenesis regulation.
Article
Obstetrics & Gynecology
Rita Rahban, Anders Rehfeld, Christian Schiffer, Christoph Brenker, Dorte Louise Egeberg Palme, Tao Wang, Johannes Lorenz, Kristian Almstrup, Niels E. Skakkebaek, Timo Struenker, Serge Nef
Summary: The study found that the SSRI antidepressant Sertraline affects human sperm function by inhibiting the sperm-specific Ca2+ channel CatSper, potentially impairing the fertilization process. This was an in vitro study, and further research is needed to assess the physiological relevance in vivo.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Elis Torrezan-Nitao, Sean G. Brown, Es Eranza Mata-Martinez, Claudia L. Trevino, Christopher Barratt, Stephen Publicover
Summary: Progesterone-induced intracellular calcium oscillations in human sperm are generated in the flagellum through CatSper channels, regulating flagellar beating and acrosome reaction.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Caroline Wiesehoefer, Marc Wiesehoefer, Jaroslaw Thomas Dankert, Jean-Ju Chung, Nicola Edith von Ostau, Bernhard Bonaventura Singer, Gunther Wennemuth
Summary: The CatSper channel and its Ca2+ sensor EFCAB9 play a critical role in controlling the swim path chirality of sperm. Any changes to these channels result in a loss of chirality in the swim path of sperm.
Article
Cell Biology
Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi
Summary: Our study shows that CatSper channels in mouse and human sperm are activated through alkaline conditions and the presence of HCO3-, leading to an influx of Ca2+. Furthermore, HCO3- activates the soluble adenylyl cyclase/protein kinase A pathway, which sensitizes CatSper channels to respond to membrane depolarization, allowing for Ca2+ influx.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Fang Yang, Maria Gracia Gervasi, Gerardo Orta, Darya A. Tourzani, Jose Luis De La Vega-Beltran, Gordon Ruthel, Alberto Darszon, Pablo E. Visconti, P. Jeremy Wang
Summary: The CatSper cation channel is essential for sperm capacitation and male fertility. The study identifies C2CD6 as a subunit of the CatSper complex and demonstrates its role in the formation of calcium signaling nanodomains on flagellar membranes. Deficiency of C2CD6 leads to male sterility due to depleted CatSper nanodomains and impaired sperm function. C2CD6 may facilitate the incorporation of CatSper complex into the flagellar plasma membrane and function as a calcium sensor.
Article
Biochemistry & Molecular Biology
Claudia Sanchez-Cardenas, Ana Romarowski, Gerardo Orta, Jose Luis De la Vega-Beltran, David Martin-Hidalgo, Arturo Hernandez-Cruz, Pablo E. Visconti, Alberto Darszon
Summary: The study found that starvation increases intracellular Ca2+ levels and enhances the sperm's ability to undergo a progesterone-induced acrosome reaction. The CatSper channel remains active in starvation conditions, but an increase in Ca2+ levels was also observed in sperm from CatSper null mice. Addition of energy nutrients can reverse the effects of starvation.
Review
Developmental Biology
Zoe C. Johnston, Franz S. Gruber, Sean G. Brown, Neil R. Norcross, Jason Swedlow, Ian H. Gilbert, Christopher L. R. Barratt
Summary: Despite recent advances, there is still incomplete understanding of male infertility and male non-hormonal contraceptives. Direct observation of compounds' effects on sperm function can increase knowledge and advance the field.
Article
Reproductive Biology
Hayden Holmlund, Yasuhiro Yamauchi, Gerald Durango, Wataru Fujii, Monika A. Ward
Summary: We generated Prssly and Teyorf1 knockout mice using CRISPR/Cas9 technology, and found that these genes are dispensable for male fertility as the knockout mice displayed normal spermatogenic features.
BIOLOGY OF REPRODUCTION
(2022)
Review
Physiology
Jae Yeon Hwang, Jean-Ju Chung
Summary: CatSper, the flagellar-specific Ca2+ channel, is crucial for regulating the acquisition of fertilizing capability in mammalian sperm. This review summarizes key findings from 20 years of CatSper research and provides insights into recent progress and future prospects.
Article
Biochemistry & Molecular Biology
Jorge F. Beltran, Fernanda Parraguez Contreras, Juan-Alejandro Norambuena, Lisandra Herrera Belen, Jennie Risopatron, Ivan Valdebenito, Elias Figueroa, Jorge G. Farias
Summary: Calcium ion concentrations play a crucial role in regulating sperm motility in fish. The CatSper channel, which is scarcely studied in fish, is key in the activation of sperm motility, specifically in anadromous and freshwater fish species.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ferran Barrachina, Kiera Ottino, Maia Lina Elizagaray, Maria Gracia Gervasi, Leona J. Tu, Styliani Markoulaki, Raul G. Spallanzani, Diane Capen, Dennis Brown, Maria Agustina Battistone
Summary: Regulatory T cells play a crucial role in maintaining the tolerogenic state of the testis and epididymis. Depletion of Tregs leads to autoimmune orchitis and epididymitis, affecting sperm production and leading to fertility defects. Understanding these immunoregulatory mechanisms could aid in the development of new treatments for male infertility and immunocontraception.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Genetics & Heredity
Ummet Abur, Sezgin Gunes, Neslihan Hekim, Omer Salih Akar, Engin Altundag, Ramazan Asci
Summary: This study aimed to characterize the clinical, cytogenetic, and molecular findings of 12 infertile men with isodicentric Y-chromosome abnormalities and found that different breakpoints of Y-chromosome were associated with male infertility. Sperm retrieval outcomes using microTESE showed the possibility of finding sperm in patients with idic(Yp) or idic(Yq).
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Cell Biology
Janice K. Jeschke, Cristina Biagioni, Tobias Schierling, Isabel Viola Wagner, Frederik Boergel, Dirk Schepmann, Andreas Schuering, Alexandra E. Kulle, Paul Martin Holterhus, Michael von Wolff, Bernhard Wuensch, Verena Nordhoff, Timo Struenker, Christoph Brenker
Summary: The study reveals that reproductive steroids and prostaglandins can rapidly increase intracellular calcium concentration in sperm through CatSper channels, competing for the same binding site to activate the channel, while zinc ions can suppress their action. These findings reinforce the role of CatSper as a chemosensor, enabling sperm to probe the hormonal microenvironment at different stages during their journey.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Vertika Singh, Deepika Jaiswal, Kanhaiya Singh, Sameer Trivedi, Neeraj K. Agrawal, Gopal Gupta, Singh Rajender, Kiran Singh
Article
Immunology
Snehil Budhwar, Priyanka Verma, Rachna Verma, Shreshtha Gupta, Sangeeta Rai, Singh Rajender, Kiran Singh
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Genetics & Heredity
Andrabi Syed Waseem, Vertika Singh, Girish Chandra Makker, Sameer Trivedi, Geetanjali Mishra, Kiran Singh, Singh Rajender
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Andrology
Kumar Mohanty Sujit, Vertika Singh, Sameer Trivedi, Kiran Singh, Gopal Gupta, Singh Rajender
Review
Obstetrics & Gynecology
Renu Bala, Vertika Singh, Singh Rajender, Kiran Singh
Summary: Lifestyle and environmental factors have a significant impact on women's fertility, particularly with modern lifestyle choices and delayed childbearing age providing more opportunities for these factors to affect fertility. These factors mainly act through neuroendocrine pathways, leading to metabolic disturbances.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Vijay Patidar, Sabby Dias, Shivanand Prakash, Lalit Kumar, Udai Shankar Dwivedi, Sameer Trivedi
Summary: Female urethral defects, especially those involving the bladder neck, are rare and challenging to manage. Bladder wall-based flaps have shown good outcomes in successfully repairing these complex urethral defects, with most patients achieving continence postoperatively. The selection of reconstruction procedure is influenced by factors such as tissue availability and previous surgical interventions.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Review
Cell Biology
Singh Vertika, Keshav K. Singh, Singh Rajender
Article
Reproductive Biology
Arijit Chakraborty, Vertika Singh, Kiran Singh, Singh Rajender
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Urology & Nephrology
Sabby Dias, Vijay Patidar, Rohit Namdev, Sandeep Kumar, Shivanand Prakash, Hari Shankar, Sameer Trivedi
Summary: This study aims to evaluate patient satisfaction and quality of life after urethroplasty using clinician driven and patient reported outcome measures. The results showed significant improvements in maximum flow rate, post-void residual urine volume, and International Prostate Symptom Score after surgery. Patient-reported outcome measurements should be considered along with objective measurements to assess patient satisfaction and quality of life after urethroplasty.
JOURNAL OF UROLOGICAL SURGERY
(2022)
Review
Urology & Nephrology
Manish Pandey, Vaibhav Shrivastava, Sabby Dias, Vijay Patidar, Sameer Trivedi, Uday Shankar Dwivedi
JOURNAL OF CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Manish Pandey, Vaibhav Shrivastava, Vijay Patidar, Sabby Dias, Sameer Trivedi
JOURNAL OF CLINICAL UROLOGY
(2020)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
