Article
Chemistry, Multidisciplinary
Inseon Kim, Seunghun S. Lee, Adhideb Ghosh, Stephen J. Ferguson, Ori Bar-Nur
Summary: This study presents an engineered biomimetic muscle construct that can self-regenerate and produce aligned myotubes using induced myogenic progenitor cells. The construct faithfully recapitulates a step-wise myogenic differentiation program and can rapidly differentiate into aligned myotubes within the constructs when subjected to a damaging myonecrotic agent. This work showcases the potential for translational applicability in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Aiping Lu, Ping Guo, Haiying Pan, Chieh Tseng, Krishna M. Sinha, Fan Yang, Alex Scibetta, Yan Cui, Matthieu Huard, Ling Zhong, Sudheer Ravuri, Johnny Huard
Summary: Research shows that pregnant mice demonstrate accelerated muscle healing, superior muscle regeneration, and reduced inflammation and necrosis following muscle injury. Additionally, MPCs from pregnant mice display improved myogenic differentiation capacity in vitro and muscle regeneration in vivo.
Article
Endocrinology & Metabolism
Yuantong Liu, Qinghe Wang, Zengfu Zhang, Runhan Fu, Tianjian Zhou, Canling Long, Tongzhong He, Dazhi Yang, Zhizhong Li, Songlin Peng
Summary: The study found that promoting myogenic differentiation and myotube hypertrophy in aged muscle can be achieved through an appropriate environment of magnesium (Mg2+), which activates the mTOR signaling pathway. This provides a promising therapeutic strategy for treating MuSC dysfunction and sarcopenia in the elderly through Mg2+ supplementation.
Article
Agriculture, Multidisciplinary
Dingding Zhang, Jingli Tao, Xuan Zhang, Xiangfei Ma, Chengyu Li, Hongmin Li, Weijian Li, Jie Chen, Honglin Liu
Summary: This study reveals the role of neoruscogenin in muscle growth by inhibiting MSTN maturation and promoting protein synthesis metabolism. It also shows its potential in repairing muscle injuries. These findings have important implications for the treatment of muscle disorders and the livestock industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Xin Guan, Qiyang Yan, Dandan Wang, Guocheng Du, Jingwen Zhou
Summary: This study investigates the effects of IGF-1 signaling on mitochondrial remodeling during myogenic differentiation, and identifies key mediators of IGF-1-induced mitochondrial biogenesis and mitophagy. IGF-1 signaling stimulates mitochondrial biogenesis by increasing mitochondrial DNA copy number and the expression of related genes. Additionally, IGF-1 treatment significantly enhances mitophagy levels in differentiating myoblasts, contributing to mitochondrial turnover.
Article
Biochemistry & Molecular Biology
Naoki Ito, Yuko Miyagoe-Suzuki, Shin'ichi Takeda, Akira Kudo
Summary: In this study, the protective role of periostin, a matricellular protein, in skeletal muscle regeneration was identified. Periostin-null mice showed decreased muscle weight due to the loss of muscle fibers during repeated muscle regeneration. The decrease in CD31-positive blood vessels during muscle regeneration in periostin-null mice suggests that the decreased nutritional supply may be the cause of muscle fiber loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Franka Messner, Marco Thurner, Jule Mueller, Michael Blumer, Julia Hofmann, Rainer Marksteiner, Sebastien Couillard-Despres, Jakob Troppmair, Dietmar Oefner, Stefan Schneeberger, Theresa Hautz
Summary: The study established a model of local application of myogenic progenitor cells (MPC) in murine hindlimb ischemia/reperfusion to study cell engraftment and differentiation for muscle regeneration. The results showed that injected MPC had the ability to engraft and differentiate into muscle fibers in IRI-affected muscle, indicating a potential therapeutic strategy for antagonizing muscle damage caused by IRI. Further research is needed to evaluate the regenerative capacity and therapeutic benefit of MPC in ischemic limb injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Hiroshi Todaka, Mikihiko Arikawa, Tatsuya Noguchi, Atsushi Ichikawa, Takayuki Sato
Summary: The study demonstrated that donepezil enhances muscle regeneration by promoting muscle differentiation independently of its acetylcholinesterase-inhibitory action. This finding suggests that donepezil could be a useful therapeutic agent for injured skeletal muscle treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Bartosz Mierzejewski, Iwona Grabowska, Zuzanna Michalska, Kamila Zdunczyk, Franciszek Zareba, Aliksandra Irhashava, Marta Chrzaszcz, Magdalena Patrycy, Wladyslawa Streminska, Katarzyna Janczyk-Ilach, Marta Koblowska, Roksana Iwanicka-Nowicka, Agnieszka Gromadka, Kamil Kowalski, Maria Anna Ciemerych, Edyta Brzoska
Summary: The study found that SDF-1 down-regulates the expression of miR10a, miR425, and miR5100, which affects the regulation of the NOTCH signaling pathway and the differentiation of myogenic cells during skeletal muscle regeneration. However, these changes do not significantly affect the migration and fusion ability of myogenic cells.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Developmental Biology
Emilie Lamarche, Hamood AlSudais, Rashida Rajgara, Dechen Fu, Saadeddine Omaiche, Nadine Wiper-Bergeron
Summary: SMAD2 acts as an important positive regulator of myogenic differentiation, promoting terminal myogenic differentiation independently of TGF beta receptor complex activation. Loss of Smad2 in muscle cells leads to decreased muscle fiber caliber and impaired regeneration.
Article
Food Science & Technology
Hyeong-Seok Kang, Ji Hye Park, Joong-Hyuck Auh
Summary: This study investigated the effects and active compounds of silkworm pupae on C2C12 muscle differentiation. The protein of silkworm pupae was extracted using sonication after defatting with hexane. The silkworm pupae protein hydrolysate effectively promoted C2C12 myogenic differentiation without cytotoxicity.
Article
Biology
Sheng Wang, Yinlong Liao, Haoyuan Zhang, Yunqi Jiang, Zhelun Peng, Ruimin Ren, Xinyun Li, Heng Wang
Summary: This study elucidates the crucial role of Tcf12 in muscle development and regeneration, showing that its deletion in MuSCs leads to muscle weight loss and delayed regeneration. Tcf12 is essential for chromatin remodelling in MuSCs and works with MYOD to regulate the expression of myogenic genes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Nasa Xu, Jianbo Wu, Jose L. Ortiz-Vitali, Yong Li, Radbod Darabi
Summary: Recent advancements in reprogramming somatic cells into induced pluripotent stem cells (iPSCs) have allowed for the efficient derivation of skeletal myogenic progenitors from human pluripotent stem cells (ESCs/iPSCs) using a directed differentiation method without the need for gene integration or modification. This method induces mesoderm and subsequently myotomal progenitors, enabling the generation of skeletal myogenic progenitors in a short time frame with high efficiency.
Article
Multidisciplinary Sciences
P. Nayak, A. Colas, M. Mercola, S. Varghese, S. Subramaniam
Summary: This research compares the transcriptomic profiles of hiPSC lines of different myogenic specification levels, revealing temporal differences and the role of β-catenin transcriptional cofactors in mediating cellular interactions and external cues during differentiation.
Article
Geriatrics & Gerontology
Patricia Sosa, Elena Alcalde-Estevez, Ana Asenjo-Bueno, Patricia Plaza, Natalia Carrillo-Lopez, Gemma Olmos, Susana Lopez-Ongil, Maria Piedad Ruiz-Torres
Summary: Hyperphosphatemia impairs myogenic differentiation and leads to muscle fibrosis, with studies in older mice demonstrating a close relationship between age-related hyperphosphatemia and the decrease in myogenic factors and increase in fibrotic factors.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Genetics & Heredity
Marcello Scala, Saskia B. Wortmann, Namik Kaya, Menno D. Stellingwerff, Angela Pistorio, Emma Glamuzina, Clara D. van Karnebeek, Cristina Skrypnyk, Katarzyna Iwanicka-Pronicka, Dorota Piekutowska-Abramczuk, Elzbieta Ciara, Frederic Tort, Beth Sheidley, Annapurna Poduri, Parul Jayakar, Anuj Jayakar, Jariya Upadia, Nicolette Walano, Tobias B. Haack, Holger Prokisch, Hesham Aldhalaan, Ehsan G. Karimiani, Yilmaz Yildiz, Ahmet C. Ceylan, Teresa Santiago-Sim, Amy Dameron, Hui Yang, Mehran B. Toosi, Farah Ashrafzadeh, Javad Akhondian, Shima Imannezhad, Hanieh S. Mirzadeh, Shazia Maqbool, Aisha Farid, Mohamed A. Al-Muhaizea, Meznah O. Alshwameen, Lama Aldowsari, Maysoon Alsagob, Ashwaq Alyousef, Rawan AlMass, Aljouhra AlHargan, Ali H. Alwadei, Maha M. AlRasheed, Dilek Colak, Hanan Alqudairy, Sameena Khan, Matthew A. Lines, M. Angeles Garcia Cazorla, Antonia Ribes, Eva Morava, Farah Bibi, Shahzad Haider, Matteo P. Ferla, Jenny C. Taylor, Hessa S. Alsaif, Abdulwahab Firdous, Mais Hashem, Chingiz Shashkin, Kairgali Koneev, Rauan Kaiyrzhanov, Stephanie Efthymiou, Queen Square Genomics, Thomas Schmitt-Mechelke, Andreas Ziegler, Mahmoud Y. Issa, Hasnaa M. Elbendary, Pasquale Striano, Fowzan S. Alkuraya, Maha S. Zaki, Joseph G. Gleeson, Tahsin Stefan Barakat, Jorgen Bierau, Marjo S. van der Knaap, Reza Maroofian, Henry Houlden
Summary: This study elucidates the genotypic and phenotypic spectrum of developmental and epileptic encephalopathy 35 (DEE 35) and analyzes predictors for adverse clinical outcomes. It identifies biallelic variants in the ITPA gene as the cause of severe neurological condition and highlights developmental delay, microcephaly, and refractory epilepsy as common symptoms. Additionally, congenital microcephaly and cardiac involvement are identified as potential predictors of adverse outcomes.
Letter
Gastroenterology & Hepatology
Yilmaz Yildiz, Aysegul Tokatli
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Cell Biology
Sara Capiau, Joel Smet, Boel De Paepe, Yilmaz Yildiz, Mutluay Arslan, Olivier Stevens, Maxime Verschoore, Hedwig Stepman, Sara Seneca, Arnaud Vanlander
Summary: Human mitochondrial disease exhibits significant clinical phenotype variation, even in patients with the same gene defect. This study compares clinical and biochemical data of two patients with the rare pathogenic variant MT-ATP6:m.9035T > C, demonstrating the heterogeneity in disease presentation. Biochemical analysis remains valuable in confirming the genetic diagnosis of mitochondrial disease, particularly in patients with new gene variants or atypical clinical symptoms.
Article
Endocrinology & Metabolism
Izzet Erdal, Yilmaz Yildiz, Gizem Onal, Oktay Halit Aktepe, Selin Ardali Duzgun, Arzu Saglam, Serap Dokmeci Emre, Hatice Serap Sivri
Summary: This study revealed the relationship between a rare mutation in the GBA gene and clinical signs and symptoms of Gaucher disease, and showed the significant improvement in the quality of life with enzyme replacement therapy, even in patients with mild symptoms.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Letter
Clinical Neurology
Berin Inan, Filiz Azman, Dilek Aktas, Yilmaz Yildiz, Serap Saygi
ACTA NEUROLOGICA BELGICA
(2023)
Article
Endocrinology & Metabolism
Ayca Burcu Kahraman, Yilmaz Yildiz, Kismet Ciki, Izzet Erdal, Halil Tuna Akar, Ali Dursun, Aysegul Tokatli, Serap Sivri
Summary: In this study, it was found that 13.5% of patients with inherited metabolic disorders tested positive for COVID-19, and 2.7% of them had severe cases, resulting in death. The severity of COVID-19 in children with IMD was associated with complex molecule degradation disorders, while comorbidities and old age were associated with severe cases in adults.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Clinical Neurology
Ayca Burcu Kahraman, Yilmaz Yildiz, Hulya Gokmen-Ozel, Sibel Kadayifcilar, Serap Sivri
Summary: Early-onset long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency is a fatty acid beta oxidation disorder with a poor prognosis. Triheptanoin, an anaplerotic oil with odd-chain fatty acids, can significantly reduce the frequency and severity of rhabdomyolysis in patients with LCHAD deficiency. In this case report, a female patient with LCHAD deficiency experienced a decrease in rhabdomyolysis episodes and hospitalization days after starting triheptanoin treatment, although retinopathy progression was not altered.
NEUROMUSCULAR DISORDERS
(2023)
Article
Urology & Nephrology
Halil Tuna Akar, Yilmaz Yildiz, Ruya Mutluay, Emel Tekin, Aysegul Tokatli
Summary: Metabolic myopathies, such as CPT2 deficiency, can lead to rhabdomyolysis and myoglobinuria, but can be treated. This case report highlights the importance of considering inborn errors of metabolism in cases of rhabdomyolysis. In patients suspected of CPT II deficiency, normal acylcarnitine profile during acute attacks indicates the need for molecular genetic diagnostics.
Article
Endocrinology & Metabolism
Yilmaz Yildiz, Oya Kuseyri Huebschmann, Ayca Akgoz Karaosmanoglu, Filippo Manti, Meryem Karaca, Ida Vanessa D. Schwartz, Roser Pons, Eduardo Lopez-Laso, Natalia Alexandra Julia Palacios, Francesco Porta, Ivana Kavecan, Mehmet Cihan Balci, Marisela E. E. Dy-Hollins, Suet-Na Wong, Mari Oppeboen, Leonardo Simao Medeiros, Leila Cristina Pedroso de Paula, Angeles Garcia-Cazorla, Georg F. F. Hoffmann, Kathrin Jeltsch, Vincenzo Leuzzi, Gulden Gokcay, Daniel Huebschmann, Inga Harting, Z. Alev Ozon, Serap Sivri, Thomas Opladen
Summary: This study provides standardized results on levodopa-refractory hyperprolactinemia and pituitary magnetic resonance imaging abnormalities in patients with inherited disorders of biogenic amine metabolism. The most common diagnosis was tetrahydrobiopterin deficiency (n = 22). Symptoms related to hyperprolactinemia, such as menstruation-related abnormalities, pubertal delay or arrest, galactorrhea, and decreased sexual functions, were observed in some individuals. Treatment with the dopamine agonist cabergoline was effective in relieving hyperprolactinemia-related symptoms.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Endocrinology & Metabolism
Kismet Ciki, Yilmaz Yildiz, Ayca Burcu Kahraman, R. Koksal Ozgul, Turgay Coskun, Ali Dursun, Aysegul Tokatli, Serap Sivri
Summary: This study found that the Phe:Tyr ratio at diagnosis >5.25 in PKU patients treated initially with sapropterin monotherapy was associated with future dietary treatment. Additionally, the genotypic phenotype value was also linked to the need for dietary treatment.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Cansu Ozdemir, Duygu Akcay, Digdem Yoyen-Ermis, Ekim Zihni Taskiran, Rana Soylu-Kucharz, Guenes Esendagli, Yusuf Cetin Kocaefe
Summary: Chronic skeletal muscle degeneration is characterized by fiber atrophy accompanied by deposition of extracellular matrix (ECM) components and fatty infiltration. Excessive accumulation of ECM leads to fibrosis via the contribution of fibro-adipogenic precursors (FAPs). Fibrosis also accompanies disuse atrophy and sarcopenia without significant inflammation.
Article
Genetics & Heredity
Cansu Kethuda Ensert Cihan, Halil Tuna Akar, Yilmaz Yildiz, Merve Sogukpinar, Gulen Eda Utine, Hasan Tolga Celik
Summary: This article reports on the complications caused by the coexistence of propionic acidemia (PA) and Apert syndrome in a neonatal patient. The presence of both disorders makes clinical management more challenging.
MOLECULAR SYNDROMOLOGY
(2023)
Article
Education, Special
Erdim Sertoglu, Ahmet Rifat Balik, Umut Goktan Duman, Murat Emrah Mavis, Mutluay Arslan, Yilmaz Yildiz, Janserey Batu, Asburce Olgac, Ozlem Hekim
Summary: This study compared the metabolic signatures of autistic patients and healthy individuals through urine analysis and found significant differences in the main metabolic pathways, including branched-chain amino acid metabolism, aromatic amino acid metabolism, tricarboxylic acid cycle, and glycolysis metabolism.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2023)
Article
Medicine, Research & Experimental
C. Ozdemir, B. Muratoglu, B. N. Ozel, E. Alpdundar-Bulut, G. Tonyali, S. Unal, D. Uckan-Cetinkaya
Summary: Secondary acute myeloid leukemia (sAML) can develop after previous therapy or from an antecedent hematological disorder like Fanconi Anemia (FA). The involvement of bone marrow (BM) niche alterations in sAML development was studied in this research. Gene expression analysis revealed significant downregulation of CYPA1, p53, CCNB1, Dicer1, CXCL12, FLT3L, and TGF-Beta genes in FA-MSCs compared to healthy controls. Etoposide (Eto) exposure induced differences in gene expression and intracellular localization profiles between healthy BM-MSCs and FA cells. These findings suggest that Eto has pleiotropic effects on BM-MSCs and that FA cells exhibit altered expression profiles compared to healthy controls.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ozlem Ozkale Yavuz, Ercan Ayaz, Yilmaz Yildiz, Ayca Akgoz Karaosmanoglu, Elif Bulut, H. Serap Kalkanoglu Sivri, Kader K. Oguz
Summary: This study retrospectively examined the ophthalmologic imaging findings of patients with MPS VI, and found that these patients had smaller eyeballs and thicker ocular walls compared to healthy children. Therefore, ophthalmologic imaging findings might serve as an auxiliary tool in the diagnosis of MPS patients.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.