期刊
GENE
卷 545, 期 2, 页码 185-193出版社
ELSEVIER
DOI: 10.1016/j.gene.2014.05.031
关键词
Alzheimer's disease (AD); Genetic markers; Diagnosis; Pathogenesis
资金
- Next-Generation BioGreen 21 Program [PJ0081062011]
- Rural Development Administration, Republic of Korea
Alzheimer's disease (AD) is the most common form of dementia in the elderly and represents an important and increasing clinical challenge in terms of diagnosis and treatment. Mutations in the genes encoding amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) are responsible for early-onset autosomal dominant AD. The epsilon 4 allele of the apolipoprotein E (APOE) gene has been recognized as a major genetic risk factor for the more common, complex, late-onset AD. Fibrillar deposits by phosphorylated tau are also a key pathological feature of AD. The retromer complex also has been reported to late-onset AD. More recently, genome-wide association studies (GWASs) identified putative novel candidate genes associated with late-onset AD. Lastly, several studies showed that circulating microRNAs (miRNAs) in the cerebrospinal fluid (CSF) and blood serum of AD patients can be used as biomarkers in AD diagnosis. This review addresses the advances and challenges in determining genetic and diagnostic markers for complex AD pathogenesis. (C) 2014 Elsevier B.V. All rights reserved.
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