Article
Reproductive Biology
Hirofumi Ohga, Michiya Matsuyama
Summary: The chub mackerel LPXRFamide gene produces three mature peptides and does not have the ability to suppress gonadotropin secretion but may promote gonadotropin secretion.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biology
Vitaly Ryu, Anisa Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Kannangara, Liam Cullen, Pokman Chan, TanChun Kuo, Ashley Padilla, Farhath Sultana, Soleil A. Wizman, Natan Kramskiy, Samir Zaidi, Se-Min Kim, Maria New, Clifford J. Rosen, Ki A. Goosens, Tal Frolinger, Vahram Haroutunian, Keqiang Ye, Daria Lizneva, Terry F. Davies, Tony Yuen, Mone Zaidi
Summary: There is increasing evidence that anterior pituitary hormones have multiple functions in regulating somatic tissues and brain receptors. A comprehensive neuroanatomical atlas on the expression of TSHR, LHCGR, and FSHR has been created using single-transcript detection technology. This atlas provides a vital resource for studying the impact of glycoprotein hormone receptors on somatic function and may uncover new pathways for human disease.
Review
Medicine, Research & Experimental
Wenxiu Tian, Huimin Qi, Zhimei Wang, Sen Qiao, Ping Wang, Junhong Dong, Hongmei Wang
Summary: This article summarizes the functions of female-associated hormones in tumors and investigates the mechanisms underlying female hormone-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Eun B. Lee, V. Praveen Chakravarthi, Michael W. Wolfe, M. A. Karim Rumi
Summary: Gonadotropins play vital roles in ovarian development and oocyte maturation, signaling through protein kinases and regulated by estrogen receptors. Er beta is crucial in regulating follicle development and ovulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Victor E. Gomez-Leon, Adam D. Beard, O. J. Ginther, Milo C. Wiltbank
Summary: This study aimed to investigate the impact of low-dose hCG on multiple ovulations in lactating dairy cows. The results showed that increased hCG led to larger follicle sizes and higher FSH concentrations, resulting in an increased frequency of double ovulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mahdi Golshan, Azadeh Hatef, Negar Kazori, Magdalena Socha, Miroslawa Sokolowska-Mikolajczyk, Hamid R. Habibi, Otomar Linhart, Sayyed Mohammad Hadi Alavi
Summary: This study reveals that exposure to bisphenol A (BPA) reduces sperm quality in goldfish and increases the levels of circulating LH and mRNA transcripts of upstream neuroendocrine regulators of reproduction.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Luyang Cheng, Songhe Yang, Lina Si, Meng Wei, Sen Guo, Zhihong Chen, Shusong Wang, Yuebing Qiao
Summary: RFamide-related peptide-3 (RFRP-3) may regulate the hypothalamic-pituitary reproductive axis by inhibiting the expression of hypothalamic kisspeptin and direct binding.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Olayiwola O. Oduwole, Ariel Poliandri, Anthony Okolo, Phil Rawson, Milena Doroszko, Marcin Chrusciel, Nafis A. Rahman, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wolfgang Koechling, Ilpo T. Huhtaniemi
Summary: The study suggests that FSH, rather than LH, may directly stimulate the growth of androgen-independent prostate cancer. Continuous suppression of FSH during GnRH antagonist treatment may offer a therapeutic advantage over agonist in inhibiting tumor growth.
Article
Biochemistry & Molecular Biology
Yuichi Shima, Kanako Miyabayashi, Takami Mori, Koji Ono, Mizuki Kajimoto, Hae Lim Cho, Hitomi Tsuchida, Yoshihisa Uenoyama, Hiroko Tsukamura, Kentaro Suzuki, Man Ho Choi, Kazunori Toida
Summary: This study discovered that deletion of the pituitary enhancer located in the 6th intron of the Nr5a1 gene in mice leads to the disappearance of NR5A1 in the pituitary gland and severely affects the development of reproductive organs. Transcriptomic analysis further identified genes that are specifically dependent on NR5A1 expression in pituitary gonadotropes, which play important roles in reproductive organ development through regulation of pituitary gonadotrope functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rafael Dai Pra, Sarah M. Mohr, Dana K. Merriman, Sviatoslav N. Bagriantsev, Elena O. Gracheva
Summary: Adequate nutrition is crucial for normal reproductive function. Despite being in a state of undernutrition and significant weight loss, ground squirrels initiate reproductive maturation during their intermittent awakenings in hibernation.
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Reproductive Biology
Ge Xu, Xuedan Zhao, Zhihao Li, Junwei Hu, Xu Li, Juanjuan Li, Yuelai Chen
Summary: This study found that electroacupuncture (EA) can improve the reproductive characteristics of PCOS rats by regulating the kisspeptin-GnRH/LH circuit. EA treatment can reduce androgen activity and increase estrogen levels, leading to increased ovulation frequency.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Neurosciences
Cathryn A. Cutia, Leanna K. Leverton, Karen E. Weis, Lori T. Raetzman, Catherine A. Christian-Hinman
Summary: Gonadotropin hormone release is important in regulating reproductive endocrine function. People with epilepsy have altered levels of gonadotropin hormones, but pituitary function is not well-studied in preclinical epilepsy research.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Kim Carol Jonas, Adolfo Rivero Muller, Olayiwola Oduwole, Hellevi Peltoketo, Ilpo Huhtaniemi
Summary: Mouse models with altered gonadotropin functions have provided insight into the essential role of functional LHR and FSHR in mediating ovarian functions. The repurposing of genetically modified mouse models offers potential for answering outstanding questions in reproductive physiology.
Article
Endocrinology & Metabolism
George A. Stamatiades, Chirine Toufaily, Han Kyeol Kim, Xiang Zhou, Iain R. Thompson, Rona S. Carroll, Min Chen, Lee S. Weinstein, Stefan Offermanns, Ulrich Boehm, Daniel J. Bernard, Ursula B. Kaiser
Summary: GnRH regulates gonadal function by stimulating gonadotropin production. The pulse frequency of GnRH differentially regulates FSH and LH synthesis and secretion. The GnRHR activates G alpha (q/11) signaling, but can also couple with G alpha (s).
Review
Genetics & Heredity
Ya-Jing Liang, Wan-Xi Yang
Article
Cell Biology
Ya-Lan Wei, Wan-Xi Yang
CELL DEATH & DISEASE
(2019)
Article
Genetics & Heredity
Ya-Lan Wei, Tong Yang, Tamas Kovacs, Wan-Xi Yang
Review
Genetics & Heredity
Fei-Da Ni, Shuang-Li Hao, Wan-Xi Yang
Review
Genetics & Heredity
Tong Yang, Wan-Xi Yang
Review
Biotechnology & Applied Microbiology
Lu Jia, Shuang-Li Hao, Wan-Xi Yang
Article
Genetics & Heredity
Tong Yang, Bang-Hong Wei, Shuang-Li Hao, Ya-Lan Wei, Wan-Xi Yang
Review
Genetics & Heredity
Yi Xie, Bang-Hong Wei, Fei-Da Ni, Wan-Xi Yang
Summary: This review categorizes the conversion from spermatogonia to spermatocyte into four development processes, focusing on extracellular cues and downstream transcription network. Potential coordination among Dmrt1, Sohlh1/2 and BMP families mediates Ngn3 upregulation, marking progenitor spermatogonia, and retinoic acid acts as a master regulator promoting A1 spermatogonia formation.
Article
Biochemistry & Molecular Biology
Zeeshan Qureshi, Mashaal Ahmad, Wan-Xi Yang, Fu-Qing Tan
Summary: The study reveals the functional significance of KIF15 in the growth and development of prostate cancer, indicating its potential role as a novel therapeutic target for the treatment of PCa by promoting cell proliferation and inhibiting signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jia-Hao Ni, Wan-Xi Yang
Summary: This review collects the latest knowledge about how fibrous proteins inside and outside cells regulate apoptosis. The extracellular matrix (ECM) fibrous proteins and intracellular intermediate filaments participate in the regulation of death receptor and mitochondrial pathways through various signaling cascades. Microtubules also play a supporting role in the execution phase of apoptosis, and the regulatory roles of polypeptide fragments formed by caspase degradation are discussed.
DNA AND CELL BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Lan-Min Wang, Yu-Ting Wang, Wan-Xi Yang
Summary: This review summarizes the influences of four typical metal/metal oxide nanomaterials on the paracellular permeability of biological barriers, including disruptions on tight junctions, adhesion junctions, gap junctions, and desmosomes. Complex signaling pathways, as well as reactive oxygen species and cytokines, play crucial roles in ENP-triggered alterations in paracellular permeability.
Article
Cell Biology
Zhen-Fang Li, Shuang-Li Hao, Lan-Min Wang, Hong-Yu Qi, Jia-Ming Wang, Fu-Qing Tan, Wan-Xi Yang
Summary: This study identified two core components of the mTOR signaling pathway, es-Raptor and es-Rictor, in spermatogenesis of the Chinese mitten crab. These proteins are crucial for maintaining the actin filament network and cell junctions, which are essential for successful sperm production.
CELL AND TISSUE RESEARCH
(2022)
Article
Cell Biology
Zhen-Fang Li, Hong-Yu Qi, Jia-Ming Wang, Zhan Zhao, Fu-Qing Tan, Wan-Xi Yang
Summary: This study cloned mTORC1/rpS6 and mTORC2/PKC proteins from the testis of Eriocheir sinensis for the first time and found that they regulate spermatogenesis in crustaceans through Arp3-mediated actin microfilament organization. These findings reveal the importance of the mTOR signaling pathway in spermatogenesis in arthropods.
CELL AND TISSUE RESEARCH
(2023)
Article
Environmental Sciences
Lan -Min Wang, Ke Jia, Zhen-Fang Li, Hong -Yu Qi, Ding -Xi Liu, Ya-Jing Liang, Shuang-Li Hao, Fu-Qing Tan, Wan-Xi Yang
Summary: Recent studies found that TiO2 nanoparticles (TiO2-NPs) have reproductive toxicity in males, but there are few reports on the toxicity of TiO2-NPs in crustaceans. In this study, freshwater crustacean Eriocheir sinensis was used to investigate the male toxicity of TiO2-NP exposure and its underlying mechanisms. TiO2-NPs of 3 nm and 25 nm at a dose of 30 mg/kg bw induced apoptosis and damage to the haemolymph-testis-barrier (HTB) and seminiferous tubule structure. The mTORC1-mTORC2 imbalance induced by TiO2-NPs was involved in the mechanism of AJ and HTB disruption, resulting in spermatogenesis in E. sinensis.
ENVIRONMENTAL POLLUTION
(2023)
Article
Genetics & Heredity
Anzana Parvin, Shuang-Li Hao, Fu-Qing Tan, Wan-Xi Yang
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
