Review
Nutrition & Dietetics
Alberto Caballero-Garcia, David C. Noriega-Gonzalez, Enrique Roche, Franchek Drobnic, Alfredo Cordova
Summary: Exercise-induced muscle damage leads to decreased physical performance and an inflammatory response in muscle tissue. L-carnitine supplementation has the potential to improve postexercise recovery by reducing oxidative damage and inflammation. However, further research is needed to fully understand the mechanisms underlying these effects and evaluate its efficacy on fatigue perception and muscle soreness.
Article
Medicine, Research & Experimental
Naglaa F. Khedr, Rehab H. Werida
Summary: The study demonstrated that L-carnitine can protect rat testes from trazadone-induced toxicity mainly by suppressing oxidative stress, inflammation, and enhancing autophagy.
Review
Biochemistry & Molecular Biology
Larissa Espindola da Silva, Mariana Pacheco de Oliveira, Mariella Reinol da Silva, Jessica da Silva Abel, Gisele Tartari, Maiara de Aguiar da Costa, Cinara Ludvig Goncalves, Gislaine Tezza Rezin
Summary: Excessive nutrient consumption and obesity cause inflammation, which spreads to the central nervous system and leads to oxidative stress and mitochondrial dysfunction, resulting in brain damage. Current treatments for obesity, such as lifestyle changes and pharmacotherapy, may have adverse effects on health, so it is necessary to search for new therapeutic alternatives. L-carnitine (LC) and acetyl-L-carnitine (LAC) have been found to have neuroprotective effects against oxidative stress and mitochondrial dysfunction in obesity. Therefore, this study conducted a literature review on the effect of LC and LAC on brain damage caused by obesity, highlighting their potential as promising treatments for restoring metabolic homeostasis in the CNS.
NEUROCHEMICAL RESEARCH
(2023)
Review
Neurosciences
Vanessa Castelli, Antonella Paladini, Michele d'Angelo, Marcello Allegretti, Flavio Mantelli, Laura Brandolini, Pasquale Cocchiaro, Annamaria Cimini, Giustino Varrassi
Summary: This review discusses the impact of oxidative stress in retinal neurodegenerative diseases and potential strategies for avoiding or counteracting oxidative damage in retinal tissues, with a specific focus on taurine. Increasing data suggest that taurine may effectively slow down the progression of degenerative retinal diseases, making it a promising candidate for prevention or adjuvant treatment of these diseases. The mechanism of taurine supplementation primarily involves reducing oxidative stress and improving antioxidant enzyme activities in the retina, with further research needed to fully understand its protective effects against retinal damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Plant Sciences
Arosha Maqbool, Muhammad Rizwan, Tahira Yasmeen, Muhammad Saleem Arif, Afzal Hussain, Asim Mansha, Shafaqat Ali, Huda Alshaya, Mohammad K. Okla
Summary: Cadmium toxicity strongly affects plant growth and seed germination. It has been found that the addition of phosphorus fertilizer in an optimal manner can significantly increase the biomass of Solanum nigrum L., enhance antioxidant enzyme activity, and inhibit oxidative stress.
Article
Biophysics
Masoud Eskandani, Morteza Eskandani, Somayeh Vandghanooni, Bahman Navidshad, Farzad Mirzaei Aghjehgheshlagh, Ali Nobakht
Summary: This study successfully enhanced the bioavailability of L-carnitine (LC) using solid lipid nanoparticles (SLNs) as carriers and demonstrated the protective effects of LC-SLNs against intracellular oxidative stress damages.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Environmental Sciences
Walaa A. Rashad, Sara F. Saadawy, Nehal E. Refaay
Summary: This study investigated the toxic impact of atrazine (ATR) on the liver and the potential protective effects of L-carnitine (LC). The results showed that ATR induced oxidative stress, inflammation, and apoptosis in the liver of rats, while LC alleviated these toxic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jurga Andreja Kazlauskaite, Liudas Ivanauskas, Mindaugas Marksa, Jurga Bernatoniene
Summary: This study investigated and compared the effects of different extraction methods on the total phenolic content, flavonoid content, and antioxidant activity of red clover. The results showed that cyclodextrins significantly increased the total phenolic content, with beta-cyclodextrin being the most effective in aqueous samples and gamma-cyclodextrin being the most effective in ethanolic samples. The study also found a strong relationship between total phenolic content and DPPH assay. These findings suggest that cyclodextrins are a valuable tool for obtaining red clover extracts high in antioxidant activity.
Article
Medicine, Research & Experimental
Tushar Emran, Nowreen Islam Chowdhury, Manoneeta Sarker, Asim Kumar Bepari, Murad Hossain, G. M. Sayedur Rahman, Hasan Mahmud Reza
Summary: The study demonstrated that L-carnitine plays a protective role against cardiac and renal damage in ISO-treated MI rat model by suppressing oxidative stress, increasing antioxidant enzyme functions, and inhibiting TNF-alpha and IL-1 beta.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Amit Kumar, Mohammad Israil Ansari, Pradyumna Kumar Singh, Abu Baker, Kiran Gupta, Sudhakar Srivastava
Summary: Arsenic is a toxic element, but its stress can be mitigated by selenium and silica supplementation. This study found that the combined application of arsenic, selenium, and silica can reduce arsenic accumulation in rice plants and enhance their tolerance to arsenic stress.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Chemistry, Medicinal
Concetta Maria Messina, Rosaria Arena, Simona Manuguerra, Yann Pericot, Eleonora Curcuraci, Fanny Kerninon, Giuseppe Renda, Claire Hellio, Andrea Santulli
Summary: The marine environment is a vital source of bioactive compounds for human health, with plants like Posidonia oceanica producing polyphenols as a form of adaptation to environmental stress. Ethanol extracts from marine plants have significant antioxidant activity, providing protection against photo damage and oxidative stress.
Review
Biochemistry & Molecular Biology
Konrad Kaminiow, Izabella Rygula, Justyna Paprocka
Summary: There are over 150 inherited metabolic disorders that can present as ataxia in children. Neuroimaging studies and genetic studies are essential for diagnosis. Prompt treatment can positively influence neurodevelopment.
Article
Plant Sciences
Jing Ma, Muhammad Hamzah Saleem, Baber Ali, Rizwan Rasheed, Muhammad Arslan Ashraf, Humera Aziz, Sezai Ercisli, Sana Riaz, Mohsen Mohamed Elsharkawy, Iqbal Hussain, Sadeq K. K. Alhag, Ahmed Ezzat Ahmed, Dan C. C. Vodnar, Sahar Mumtaz, Romina Alina Marc
Summary: Soil contamination with toxic heavy metals, such as lead, has a negative impact on plant growth and productivity. In this study, the effects of different concentrations of lead on tomato plants were investigated. The results showed that lead accumulation decreased plant growth, photosynthetic pigments, and antioxidant capacity. However, the application of synergic acid alleviated the toxicity of lead and improved plant growth.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Nutrition & Dietetics
Heba Nageh Gad El-Hak, Hany Salah Mahmoud, Eman A. Ahmed, Heba M. Elnegris, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Mohamed T. A. Soliman, Menna Allah I. El-Menyawy
Summary: This study found that methanolic date flesh extract (MDFE) has the potential to alleviate cisplatin-induced hepatic injury. In a rat model, pretreatment with MDFE reduced liver damage caused by cisplatin, improved liver function, and reduced inflammation.
Review
Cell Biology
Mateus Grings, Moacir Wajner, Guilhian Leipnitz
Summary: Ethylmalonic encephalopathy is a severe intoxication disorder caused by mutations in the ETHE1 gene. Disruption of mitochondrial and redox homeostasis, as well as oxidative stress, are important pathomechanisms in tissue damage. Current treatment does not effectively prevent encephalopathy.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Nicolas Manzke Glanzel, Mateus Grings, Nevton Teixeira da Rosa-Junior, Leila Maria Cereta de Carvalho, Al-Walid Mohsen, Peter Wipf, Moacir Wajner, Jerry Vockley, Guilhian Leipnitz
Summary: Sulfite oxidase (SO) deficiency causes tissue sulfite accumulation and patients present with seizures and neurological damage. Treatment is mainly supportive. Study shows that treatment with JP4-039 can prevent or attenuate oxidative stress and apoptosis induced by sulfite injection.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Endocrinology & Metabolism
Angela Sitta, Gilian Guerreiro, Daniella de Moura Coelho, Vitoria Volfart da Rocha, Bianca Gomes dos Reis, Carmen Sousa, Laura Vilarinho, Moacir Wajner, Carmen Regla Vargas
Summary: Glutaric aciduria type 1 (GA-1) is a rare but treatable inherited disease caused by deficiency of glutaryl-CoA dehydrogenase activity due to GCDH gene mutations. Symptoms include neurological deterioration, seizures, and dystonia, with difficulties in diagnosis and treatment in countries like Brazil. Genetic analysis is crucial for confirming the diagnosis as the disease is mainly caused by GCDH gene mutations.
METABOLIC BRAIN DISEASE
(2021)
Article
Neurosciences
Felipe Kawa Odorcyk, R. T. Ribeiro, A. C. Roginski, L. E. Duran-Carabali, N. S. Couto-Pereira, C. Dalmaz, M. Wajner, C. A. Netto
Summary: The study demonstrates an age-dependent vulnerability of the hippocampus in neonatal rats to hypoxia-ischemia, with younger animals showing increased susceptibility to brain injury. Mitochondrial damage and apoptosis were more evident in younger rats compared to older ones under hypoxia-ischemia conditions. Differences in metabolic responses were observed in neonatal rats of different ages, indicating the need for different treatments for hypoxia-ischemia newborns with varying gestational ages.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leonardo de Moura Alvorcem, Renata Britto, Cristiane Cecatto, Ana Cristina Roginski, Francieli Rohden, Juliete Nathali Scholl, Fatima C. R. Guma, Fabricio Figueiro, Alexandre Umpierrez Amaral, Geancarlo Zanatta, Bianca Seminotti, Moacir Wajner, Guilhian Leipnitz
Summary: The study revealed that EMA inhibits mitochondrial respiration, particularly glutamate oxidation, and induces mitochondrial permeability transition, potentially contributing to the pathogenesis of cerebellar abnormalities in ethylmalonic encephalopathy (EE).
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Gilian Guerreiro, Jessica Faverzani, Alana Pimentel Moura, Vitoria Volfart, Bianca Gome dos Reis, Angela Sitta, Esteban Alberto Gonzalez, Gabriel de Lima Rosa, Adriana Simon Coitinho, Guilherme Baldo, Moacir Wajner, Carmen Regla Vargas
Summary: Glutaric acidemia type 1 (GA1) is characterized by neurological symptoms and metabolic blockage, with treatment involving protein/lysine restriction and L-carnitine supplementation. In a study with mice, L-carnitine showed significant protective effects on behavioral abnormalities and pro-inflammatory status in the striatum, suggesting its potential therapeutic benefits for GA1 patients.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biophysics
Bianca Seminotti, Ana Cristina Roginski, Angela Zanatta, Alexandre Umpierrez Amaral, Thabata Fernandes, Kaleb Pinto Spannenberger, Lucas Henrique Rodrigues da Silva, Rafael Teixeira Ribeiro, Guilhian Leipnitz, Moacir Wajner
Summary: In this study, the effects of AdoMet on mitochondrial functions and redox homeostasis in rat liver were investigated. AdoMet was found to decrease mitochondrial membrane potential and Ca2+ retention capacity, increase ROS production, provoke protein and lipid oxidation, and reduce GSH levels and the activities of aconitase and alpha-ketoglutarate dehydrogenase. These findings suggest that disturbance of mitochondrial functions associated with mPT and redox unbalance may play a role in liver damage caused by AdoMet accumulation in certain disorders.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Neurosciences
Leticia Barbieri Caus, Mayara Vendramin Pasquetti, Bianca Seminotti, Michael Woontner, Moacir Wajner, Maria Elisa Calcagnotto
Summary: This study investigated the impact of quinolinic acid on the neurological features of GA-I, finding that Gcdh(-/-)-Lys mice showed increased susceptibility to quinolinic acid-induced seizures and enduring alterations in brain oscillation patterns.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Nutrition & Dietetics
Andrey Vinicios S. Carvalho, Rafael T. Ribeiro, Luz Elena Duran-Carabali, Ana Paula R. Martini, Eduarda Hoeper, Eduardo F. Sanches, Eduardo Luis Konrath, Carla Dalmaz, Moacir Wajner, Carlos Alexandre Netto
Summary: This study demonstrates that the Plinia trunciflora fruit extract (PTE) has a neuroprotective role in neonatal rats with experimental brain hypoxia-ischemia (HI). PTE effectively prevents oxidative stress and inflammatory response induced by HI, as evidenced by reduced lipoperoxidation levels and interleukin-1 beta levels. PTE also prevents neuronal loss, astrocyte reactivity, anxiety-like behavior, spatial memory impairment, and neural tissue loss caused by HI.
Article
Pharmacology & Pharmacy
Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Nicolas Manzke Glanzel, Leonardo de Moura Alvorcem, Morgana Brondani, Renata Britto, Mateus Grings, Vanessa Duarte Ortiz, Patrick Turck, Alex Sander da Rosa Araujo, Moacir Wajner, Guilhian Leipnitz
Summary: Barth syndrome and dilated cardiomyopathy with ataxia syndrome are characterized by high levels of 3-methylglutaric acid in urine and plasma. This study found that 3-methylglutaric acid induced lipid peroxidation, altered antioxidant defenses and reduced mitochondrial function in rat heart. It also affected signaling pathways and mitochondrial biogenesis. Vascular reactivity in the aorta was further disturbed by 3-methylglutaric acid. Pretreatment with bezafibrate mitigated most of these effects but did not prevent vascular reactivity disturbances.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Bianca Seminotti, Morgana Brondani, Rafael Teixeira Ribeiro, Guilhian Leipnitz, Moacir Wajner
Summary: This study investigated the changes in redox homeostasis, inflammatory response, mitochondrial biogenesis and dynamics, ER-mitochondria crosstalk, and ER stress in the brains of a GA1 mouse model. The results showed alterations in these processes, which were normalized by treatment with the pan-PPAR agonist bezafibrate. These novel findings may contribute to understanding the pathogenesis of GA1 and suggest bezafibrate as a potential adjuvant therapy for GA1.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandre Umpierrez Amaral, Moacir Wajner
Summary: Maple syrup urine disease (MSUD) is a rare neurometabolic disorder characterized by acute episodes of encephalopathy and progressive neurological deterioration. The pathogenesis of MSUD is not fully understood, but evidence suggests that the branched-chain amino acids (BCAA) and branched-chain alpha-keto acids (BCKA) may play a role in the brain injury associated with this disease.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Carlos Eduardo Diaz Jacques, Franciele Fatima Lopes, Edina Poletto, Luisa Natalia Pimentel Vera, Priscila Vianna, Luiza Steffens Reinhardt, Guilherme Baldo, Carmen Regla Vargas
Summary: This study investigated the pathophysiology of MPS II cells and found evidence of oxidative stress and DNA damage. Additionally, it demonstrated the protective effects of genistein and coenzyme Q10 against oxidative damage in vitro.
METABOLIC BRAIN DISEASE
(2023)
Article
Endocrinology & Metabolism
Tatiane Grazieli Hammerschmidt, Bruna Donida, Marco Raabe, Jessica Lamberty Faverzani, Franciele de Fatima Lopes, Andryele Z. Machado, Rejane G. Kessler, Luiza S. Reinhardt, Fernanda Poletto, Dinara J. Moura, Carmen R. Vargas
Summary: Niemann-Pick C disease (NPC) is a severe genetic disorder with no cure. Recent studies have found that beta-cyclodextrin (beta-CD) can reduce cholesterol accumulation in cells of NPC1 patients, and the combination with antioxidants can further improve the treatment effect.
METABOLIC BRAIN DISEASE
(2023)
Article
Chemistry, Medicinal
Caroline Guerra Marangon, Camila Schafer Rojas, Marina Zaneti Michelsen, Satchie Sakamoto, Carlos Eduardo Diaz Jacques, Gilsane Lino von Poser, Carmen Regla Vargas, Stela Maris Kuze Rates
Summary: This study aimed to investigate the effect of uliginosin B on hippocampal stress oxidative and inflammation markers, and the results showed that uliginosin B has an antidepressant-like effect and enhances the levels of glutathione reduced, MCP-1, and IL-10.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.