期刊
GENE
卷 525, 期 2, 页码 220-228出版社
ELSEVIER
DOI: 10.1016/j.gene.2013.03.097
关键词
Therapeutic angiogenesis; Peripheral artery disease; Limb ischemia; Gene therapy; Cell therapy; Heme oxygenase-1
资金
- European Union [POIG 01.01.02-00-109/09, 01.02.00-069/09]
- L'Oreal Poland for Women in Science Scholarship
- START Scholarship of the Foundation for Polish Science (FNP)
- Wellcome Trust
Therapeutic angiogenesis for peripheral artery disease (PAD), achieved by gene and cell therapy, has recently raised a great deal of hope for patients who cannot undergo standard revascularizing treatment Although pre-clinical studies gave very promising data, still clinical trials of gene therapy have not provided satisfactory results. On the other hand, cell therapy approach, despite several limitations, demonstrated more beneficial effects but initial clinical studies must be constantly validated by larger randomized, multi-center, double-blinded, placebo-controlled trials. This review focuses on previous and recent gene and cell therapy studies for limb ischemia, including both experimental and clinical research, and summarizes some important papers published in this field. Moreover, it provides a short comment on combined gene and cell therapy approach on the example of heme oxygenase-1 overexpressing cells with therapeutic properties. (C) 2013 Elsevier B.V. All rights reserved.
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