Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Article
Endocrinology & Metabolism
Katherine W. Reeves, Gabriela Vieyra, Nydjie P. Grimes, Jaymie Meliker, Rebecca D. Jackson, Jean Wactawski-Wende, Robert Wallace, R. Thomas Zoeller, Carol Bigelow, Susan E. Hankinson, JoAnn E. Manson, Jane A. Cauley, Antonia M. Calafat
Summary: The study found that certain phthalate biomarkers were associated with greater percentage decreases in total hip and femoral neck bone mineral density (BMD), suggesting that phthalate exposure may have clinically significant effects on BMD and potentially increase fracture risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Graziamaria Corbi, Vincenzo Nobile, Valeria Conti, Alessandro Cannavo, Vincenzo Sorrenti, Alessandro Medoro, Giovanni Scapagnini, Sergio Davinelli
Summary: This study aimed to evaluate the effects of equol and resveratrol on bone turnover biomarkers in postmenopausal women. The results showed that the combination of equol and resveratrol significantly improved bone turnover biomarkers and increased bone mineral density, suggesting a potential approach to prevent age-related bone loss in postmenopausal women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Yi-Ming Guo, Jian-Hao Cheng, Hao Zhang, Jin-Wei He, Hua Yue, Wei-Wei Hu, Jie-Mei Gu, Yun-Qiu Hu, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: This study investigated the association between genetic variation of the POSTN gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women. The study found that the rs9603226 variant of POSTN was significantly associated with vertebral fractures, while the rs3923854 variant was associated with serum periostin levels. These findings suggest that genetic variation of the POSTN gene may be a predicting factor for the risk of vertebral fractures, and serum periostin levels could be a potential biochemical parameter for osteoporosis in Chinese postmenopausal women.
Article
Nutrition & Dietetics
Pilar Sanchis, Rafael Maria Prieto, Jadwiga Konieczna, Felix Grases, Itziar Abete, Jordi Salas-Salvado, Vicente Martin, Miguel Ruiz-Canela, Nancy Babio, Jesus Francisco Garcia-Gavilan, Albert Goday, Antonia Costa-Bauza, Jose Alfredo Martinez, Dora Romaguera
Summary: The main objective of this study was to examine the relationship between dietary phytate intake and bone mineral density (BMD) in a Mediterranean population of postmenopausal women. The results showed that phytate intake was positively associated with BMD in Mediterranean postmenopausal women, indicating a potential protective effect on bone. However, further large-scale, long-term, and randomized prospective clinical studies are needed to assess the potential benefits of phytate consumption on BMD in postmenopausal women.
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study evaluated the association between dietary selenium consumption and bone mineral density in postmenopausal women. The results showed that postmenopausal women with higher selenium consumption were less likely to have osteoporosis.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Albert Shieh, Kristine M. Ruppert, Gail A. Greendale, Yinjuan Lian, Jane A. Cauley, Sherri-Ann Burnett-Bowie, Carrie Karvonen-Guttierez, Arun S. Karlamangla
Summary: Years since the final menstrual period (FMP) is more strongly associated with postmenopausal bone mineral density (BMD) than chronological age, and earlier menopause is associated with more fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Olga N. Fazullina, Anton Korbut, Vadim V. Klimontov
Summary: This study aimed to identify the clinical and body composition parameters that affect the trabecular bone score (TBS) in postmenopausal women with type 2 diabetes (T2D) and normal bone mineral density (BMD). The results showed that greater height and central adiposity were associated with impaired bone microarchitecture.
WORLD JOURNAL OF DIABETES
(2022)
Article
Orthopedics
Weibin Du, Zhenwei Wang, Yi Dong, Jintao Hu, Xiaoping Chen
Summary: This study aimed to examine the relationship between fibrinogen and bone mineral density (BMD) in postmenopausal women. The findings of this cross-sectional analysis showed a negative association between fibrinogen levels and total BMD in most postmenopausal women, with a lack of significant correlation in Non-Hispanic Blacks.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Medicine, Research & Experimental
Qing Wu, Jongyun Jung
Summary: This study introduces a novel genome-wide polygenic score (GPS) to quantify inherited susceptibility to osteoporosis and osteoporotic fracture, providing new opportunities for clinical prevention and risk assessment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
E. Michael Lewiecki, Edward Czerwinski, Chris Recknor, Anna Strzelecka, Guillermo Valenzuela, Mary Lawrence, Stuart Silverman, Jose Cardona, Susan M. Nattrass, Neil Binkley, Miriam Annett, Leny Pearman, Bruce Mitlak
Summary: This study evaluated the safety and efficacy of the abaloparatide microstructured transdermal system (abaloparatide-sMTS) as an alternative to subcutaneous injection. The results showed that the abaloparatide-sMTS was not noninferior to the subcutaneous injection in terms of lumbar spine bone density at 12 months, but both treatments significantly increased lumbar spine and total hip bone density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hubert Wolski, Grazyna Kurzawinska, Marcin Ozarowski, Aleksandra E. Mrozikiewicz, Krzysztof Drews, Tomasz M. Karpinski, Anna Bogacz, Agnieszka Seremak-Mrozikiewicz
Summary: It was found that VDR BsmI genetic polymorphism may play a role in the etiology of recurrent miscarriages (RM), while specific maternal haplotypes were shown to prevent RM occurrence.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Christa Ellis, Herculina S. Kruger, Michelle Viljoen, Joel A. Dave, Marlena C. Kruger
Summary: The study found that changes in bone mineral density and bone resorption markers over two years were minimal in black postmenopausal women living with HIV. Despite a decrease in serum vitamin D, there were small or no changes in BMD and CTx over the 2-year period.
Article
Pathology
Eduardo Cardenas Cardenas, Alberto Tenorio-Torres, Juan Pablo Mendez, Leticia Orozco-Arguelles, Marcela Leal-Garcia, Ramon Mauricio Coral-Vazquez, Claudia Cecilia Vega-Garcia, Veronica Bautista-Pina, Patricia Canto
Summary: This study investigated the expression of leptin and its receptor in breast cancer tissue of postmenopausal women with different body mass indexes, and found higher expression in patients with obesity. Additionally, positive expression of LEPR was associated with poorer recurrence-free survival.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Pathology
Maria Elena Tejeda, Patricia Canto, Alberto Tenorio-Torres, Letica Orozco-Arguelles, Ramon Mauricio Coral-Vazquez, Alejandro Zentella-Dehesa, Marcela Leal-Garcia, Claudia Cecilia Vega-Garcia, Veronica Bautista-Pina, Juan Pablo Mendez
Summary: The study found that postmenopausal women with breast cancer and obesity had significantly increased FNDC5/irisin expression in their tumorous tissue compared to women with a normal BMI. Additionally, different breast cancer cell lines were capable of synthesizing and expressing FNDC5/irisin, with the BT-474 cell line exhibiting the highest intensity of expression.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sergio De los Santos, Ramon Mauricio Coral-Vazquez, Marta Menjivar, Maria de los Angeles Granados-Silvestre, Sebastian De la Rosa, Luis Antonio Reyes-Castro, Juan Pablo Mendez, Elena Zambrano, Patricia Canto
Summary: Both maternal obesity and high-fat diet have negative effects on the offspring, but treatment with epicatechin can reverse these effects. In male rats descended from obese mothers and fed a high-fat diet, epicatechin reduced fat mass and increased lean mass, but did not fully restore body mineral density.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Energy & Fuels
German Buendia Rodriguez, Diego Alfredo Cardoso Carmona, Mona M. Y. Elghandour, Abdelfattah Z. M. Salem, Hector Reyes Soto, Ricardo Ruiz Sanchez, Moyosore J. Adegbeye
Summary: The addition of sodium butyrate to milk replacement for Holstein calves improved their productive performance, energy metabolism, and rumen microbiota. The best results were observed with the addition of 5 grams of sodium butyrate.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Obstetrics & Gynecology
T. Canto-Cetina, D. Silva-Nicanor, R. M. Coral-Vazquez, L. J. Cano-Martinez, L. Gonzalez Herrera, S. Garcia, E. Lara Padilla, P. Canto
Summary: The study identified a significant association between rs3480 and osteopenia at the total hip and femoral neck, while rs16835198 was found to be positively associated with osteopenia at these sites.
Article
Anthropology
Ingrid Yali Ibarra-Tapia, Ariadna Juarez-Sandoval, Itzel Torres Perez, Luis Javier Cano-Martinez, Sergio Sanchez-Garcia, Juana Marlen Ruiz-Batalla, Irma Angelica Aroche-Reyes, Silvia Garcia, Patricia Canto, David-Rojano Mejia, Ramon Mauricio Coral-Vazquez
Summary: This study found a significant association between the rs1131620 polymorphism of the LTBP4 gene and sarcopenia in patients with type 2 diabetes. This suggests that LTBP4 polymorphisms may play a role in the development of sarcopenia in these patients.
ANNALS OF HUMAN BIOLOGY
(2022)
Article
Nutrition & Dietetics
Guadalupe L. L. Rodriguez-Gonzalez, Sergio De Los Santos, Dayana Mendez-Sanchez, Luis A. A. Reyes-Castro, Carlos A. A. Ibanez, Patricia Canto, Elena Zambrano
Summary: Offspring of obese mothers develop obesity and metabolic alterations in adulthood. In addition, poor postnatal dietary patterns exacerbate these health issues. Our study found that a high-fat diet consumed by the offspring of obese mothers worsens body fat accumulation, metabolic abnormalities, and adipocyte size distribution.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Genetics & Heredity
Carlos Palma-Flores, Paola B. Zarate-Segura, J. Manuel Hernandez-Hernandez, Sergio de los Santos, Andrea S. Tejeda-Gomez, Luis Javier Cano-Martinez, Patricia Canto, Jorge Omar Garcia-Rebollar, Ramon M. Coral-Vazquez
Summary: This study demonstrates that (-)-epicatechin upregulates miRNAs involved in muscle adaptation, induces muscle hypertrophy, and increases the level of myogenic proteins.
Article
Genetics & Heredity
Luis Javier Cano-Martinez, Sergio De los Santos, Ramon Mauricio Coral-Vazquez, Juan Pablo Mendez, Silvia Trejo, Bladimir Roque-Ramirez, Juan Carlos Perez-Razo, Patricia Canto
Summary: The aim of this study was to investigate the expression of apelin (APLN) and its receptor (APLNR) in visceral adipose tissue (VAT), and its effect on the downstream expression of endothelial nitric oxide synthase (eNOS) in individuals with class 3 obesity, with or without hypertension. The results showed that individuals with class 3 obesity and hypertension had altered expression of APLN and APLNR in visceral adipose tissue, which led to a decrease in the phosphorylation level of eNOS.
Article
Cell Biology
Carlos Palma-Flores, Luis Javier Cano-Martinez, Francisca Fernandez-Valverde, Itzel Torres-Perez, Sergio de los Santos, J. Manuel Hernandez-Hernandez, Adriana Fabiola Hernandez-Herrera, Silvia Garcia, Patricia Canto, Alejandro Zentella-Dehesa, Ramon Mauricio Coral-Vazquez
Summary: The study aimed to explore the expression of proteins involved in the repair process in different muscles at an early stage of muscular dystrophy. The results showed that muscles with different metabolic characteristics showed distinct expression patterns of proteins, which could be relevant in designing therapies for genetic and acquired myopathy.
JOURNAL OF MOLECULAR HISTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sergio De los Santos, Luis Antonio Reyes-Castro, Ramon Mauricio Coral-Vazquez, Juan Pablo Mendez, Elena Zambrano, Patricia Canto
Summary: This study evaluated the effects of (-)-epicatechin on the apelinergic system and proteins involved in adipose tissue metabolism. The results showed that (-)-epicatechin increased the expression of apelin and its receptor, and promoted AMPK activation while reducing lipogenesis-related protein Fas. These findings suggest that (-)-epicatechin may have beneficial effects on obesity and fat metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Thelma Canto-Cetina, Diana Silva-Nicanor, Ramon Mauricio Coral-Vazquez, Luis Javier Cano-Martinez, Patricia Canto
Summary: The rs3480 and rs16835198 of FNDC5/Irisin and their haplotypes were found to be associated with the presence of type 2 diabetes mellitus in Maya-Mestizo women.
METABOLIC SYNDROME AND RELATED DISORDERS
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.