Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Biochemistry & Molecular Biology
Lin Yan, Sneha Sundaram, Bret M. Rust, Matthew J. Picklo, Michael R. Bukowski
Summary: Metabolomic analysis revealed significant differences in amino acid and energy metabolism in Lewis lung carcinoma (LLC) metastases compared to the lungs, and alterations in lipid metabolism during LLC metastatic progression. Understanding these metabolic differences can inform targeted studies for cancer prevention and treatment.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Oncology
Jia Sun, Jin-Rui Hu, Chao-Feng Liu, Yuan Li, Wei Wang, Rong Fu, Min Guo, Hai-Long Wang, Min Pang
Summary: ANKRD49 accelerates invasion and metastasis of NSCLC cells through JNK-mediated transcription activation of c-Jun and ATF2, which regulates the expression of MMP-2/MMP-9.
Article
Pharmacology & Pharmacy
Qingxin Song, Fan Zhang, Kun Wang, Zhi Chen, Quan Li, Zude Liu, Hongxing Shen
Summary: The study found that the expression level of miR-874-3p was significantly decreased in IDD patients, and it could target and repress MMP2 and MMP3 expression, potentially providing a diagnostic marker and treatment candidate for IDD, as well as direction for future investigations on cancer and inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Yunxiao Dou, Yan Tan, Tongya Yu, Xiaoye Ma, Yuchen Zhou, Yichen Zhao, Yanxin Zhao, Xueyuan Liu
Summary: In diabetic rats, cognitive abilities were found to be altered with beta-DG protein degradation in hippocampal and cortical tissues. Long-term exposure to high glucose environment down-regulates miR-132 in neurons, leading to up-regulation of MMP-9 mRNA and protein, which in turn increases beta-DG degradation and affects synaptic structure and function related to cognition decline. These findings may contribute to understanding the molecular mechanism of diabetes-induced cognitive dysfunction.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shaojian Lin, Yue Zhu, Chengcheng Ji, Weiming Yu, Cheng Zhang, Langping Tan, Miaoyun Long, Dingyuan Luo, Xinzhi Peng
Summary: This study suggests that the overexpression of METTL3 is associated with malignant behaviors in thyroid carcinoma (TC), and it promotes tumor development and metastasis by regulating the expression levels of miR-222-3p and STK4.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Wansong Lin, Jie Lin, Jieyu Li, Ying Lin, Shuping Chen, Yijuan Wu, Lingfeng Chen, Hui Cheng, Lin Liu, Xiaoyan Chen, Yunbin Ye
Summary: This study reveals that Kindlin-2 regulates HCC cell migration and metastasis through the suppression of miR-1258 and the upregulation of TCF4 expression. It also identifies a positive feedback loop between Kindlin-2, miR-1258, and TCF4. These findings provide important evidence for the potential therapeutic targeting of Kindlin-2 in HCC.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Clinical Neurology
Taylor E. Branyan, Amutha Selvamani, Min Jung Park, Kriti E. Korula, Kelby F. Kosel, Rahul Srinivasan, Farida Sohrabji
Summary: The study identifies miR-20a-3p as a potential therapeutic for stroke and reveals different expression levels of this microRNA in astrocytes of different genders and age groups. Results show that miR-20a-3p has more neuroprotective effects when expressed in neurons, and intravenous injections of miR-20a-3p mimic significantly improve stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Zahra Saadatian, Yaser Mansoori, Lida Nariman-Saleh-Fam, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Ziba Nariman-Saleh-Fam
Summary: This study evaluated the alteration of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with coronary artery stenosis and insignificant coronary artery stenosis compared to healthy individuals. The results showed that three of these miRNAs have the potential to differentiate between coronary artery stenosis patients and healthy individuals, suggesting they could be novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Bin Sun, Weidan Ji, Chunying Liu, Xuejing Lin, Lei Chen, Haihua Qian, Changqing Su
Summary: miR-2392 is significantly down-regulated in HCC and functions as a tumor suppressor by targeting JAG2 to inhibit proliferation, clonogenicity, mobility, spheroid formation, and maintenance of CSC-like characteristics in HCC cells. CTCs from HCC patients with lower serum miR-2392 levels exhibit stronger spheroid formation ability, and a negative correlation between miR-2392 levels in serum and the number of CTC spheroids has been observed. JAG2 is highly expressed in HCC and is associated with poor prognosis and patient survival.
LIVER INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Mediha Becirovic-Agic, Upendra Chalise, Michael J. Daseke, Shelby Konfrst, Jeffrey D. Salomon, Paras K. Mishra, Merry L. Lindsey
Summary: MMP-9 plays a dual role in myocardial infarction wound healing by exacerbating inflammatory response and aiding in transition to reparative cells, as well as influencing neovascularization and scar formation. Targeting MMP-9 only for its detrimental actions is important for effective treatment strategies.
Article
Biochemistry & Molecular Biology
Hector Vazquez-Lorente, Dusko M. Dundjerovic, Svetislav B. Tatic, Sara Rodriguez-Menendez, Hector Gonzalez-Iglesias, Claudio M. Gomes, Ivan R. Paunovic, Vesna V. Dragutinovic
Summary: The content of trace elements in medullary thyroid carcinoma (MTC) is related to its related biomarkers, especially zinc (Zn), which is correlated with the proportion and intensity of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs).
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Meng-Lu Chen, Chun-Gu Hong, Tao Yue, Hong-Ming Li, Ran Duan, Wen-Bao Hu, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Si-Yuan Tang, Hui Xie, Zheng-Zhao Liu
Summary: The study found biphasic changes of miR-331-3p and miR-9-5p in AD progression, inhibiting these two microRNAs can promote autophagic clearance of A beta and prevent AD development. This was demonstrated in experiments and offers a potential new therapeutic strategy for AD patients.
Article
Genetics & Heredity
Lin Yang, Hong-Gang Sui, Meng-Meng Wang, Jia-Yin Li, Xiao-Feng He, Jing-Yuan Li, Xiao-Zeng Wang
Summary: Plasma levels of miR-30c-1-3p and MMP-9 may serve as candidate biomarkers for AAA progression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Medicine, Research & Experimental
Lorena Cayetano-Salazar, Dania A. Nava-Tapia, Kevin D. Astudillo-Justo, Adan Arizmendi-Izazaga, Cesar Sotelo-Leyva, Mayra Herrera-Martinez, Socrates Villegas-Comonfort, Napoleon Navarro-Tito
Summary: Cancer is a leading cause of death globally, with invasion and metastasis being directly responsible. Current therapeutic approaches for cancer suffer from toxicity and chemoresistance, highlighting the need for alternative treatment options. Natural products, particularly flavonoids, have shown promise as they possess antitumor properties in various study models. This review discusses the regulation of tissue inhibitors of metalloproteinases (TIMPs) expression and the role of flavonoids as therapeutic molecules that target TIMPs. Flavonoids exhibit chemopreventive and cytotoxic effects against different types of cancer through various mechanisms and also regulate crucial signaling pathways involved in cancer cell migration, invasion, and metastasis.
Article
Obstetrics & Gynecology
Douglas V. N. P. Oliveira, Julie Hentze, Colm J. O'Rourke, Jesper B. Andersen, Claus Hogdall, Estrid V. Hogdall
Summary: Ovarian cancer is a severe form of malignancy with low survival rates, and epigenetic studies, particularly DNA methylation profiling, show promise in cancer diagnostics. Abnormal cell morphology and molecular factors crucial to carcinogenesis can be detected through methylation analysis, indicating potential use in ovarian cancer diagnostics. The concordance of methylation profiles between formalin-fixed paraffin-embedded tissue and fresh frozen tissue might provide insights into the clinical use of FFPE tissues in methylation studies.
REPRODUCTIVE SCIENCES
(2021)
Review
Oncology
Lau K. Vestergaard, Douglas N. P. Oliveira, Claus K. Hogdall, Estrid V. Hogdall
Summary: This article highlights the importance of precise identification and annotation of mutations in clinical oncology, as well as the impact of sequencing technologies development and bioinformatic tools on the results. Genomic alterations are crucial in personalized medicine for treatment efficacy. Therefore, evaluating and validating bioinformatic pipelines, as well as vigilance towards different tools, are essential.
Article
Oncology
Douglas V. N. P. Oliveira, Tine H. Schnack, Tim S. Poulsen, Anne P. Christiansen, Claus K. Hogdall, Estrid V. Hogdall
Summary: Ovarian clear cell carcinoma (OCCC) presents unique molecular traits and can be stratified into four molecular subgroups based on cancer-associated gene mutations. The subgroups share common characteristics like ageing and defective MMR, while also exhibiting unique signatures. These findings suggest the potential for more individualized therapy regimens based on specific molecular backgrounds.
Article
Oncology
Christoph Wohlmuth, Vladimir Djedovic, Susanne K. Kjaer, Allan Jensen, Rosalind Glasspool, Patricia Roxburgh, Anna DeFazio, Sharon E. Johnatty, Penelope M. Webb, Francesmary Modugno, Diether Lambrechts, Joellen M. Schildkraut, Andrew Berchuck, Liv Cecilie Vestrheim Thomsen, Line Bjorge, Estrid Hogdall, Claus K. Hogdall, Ellen L. Goode, Stacey J. Winham, Keitaro Matsuo, Beth Y. Karlan, Jenny Lester, Marc T. Goodman, Pamela J. Thompson, Tanja Pejovic, Marjorie J. Riggan, Katherine Lajkosz, Alicia Tone, Taymaa May
Summary: This study analyzed data from 176 women with low-grade serous ovarian cancer through a multi-center collaborative effort, revealing that elevated post-treatment CA-125 levels are significantly associated with poor survival, while FIGO staging and residual disease also impact patient outcomes.
Article
Cell Biology
Sara Bonlokke, Magnus Stougaard, Boe Sandahl Sorensen, Berit Bargum Booth, Estrid Hogdall, Gitte-Bettina Nyvang, Jacob Christian Lindegaard, Jan Blaakaer, Jesper Bertelsen, Katrine Fuglsang, Mikael Lenz Strube, Suzan Lenz, Torben Steiniche
Summary: Circulating cell-free HPV DNA (ccfHPV DNA) can serve as a marker for cervical cancer. This study used digital droplet PCR (ddPCR) to detect and quantify ccfHPV DNA in plasma from patients with HPV16- or HPV18-associated cervical cancer. The results showed that ccfHPV DNA may not be useful for early detection of cervical cancer, but it can be a promising tool for establishing tumor burden and monitoring the disease in advanced stage cervical cancer patients.
Article
Chemistry, Medicinal
Yagmur Sisman, Lau Kraesing Vestergaard, Douglas Nogueira Perez de Oliveira, Tim Svenstrup Poulsen, Tine Henrichsen Schnack, Claus Hogdall, Estrid Hogdall
Summary: This study analyzed the mutational profile of 128 Danish patients with high-grade serous ovarian cancer and found PARP inhibitors to be the most frequent potential targeted therapy, while indicating the relevance of investigating other targeted therapies based on mutational findings.
Article
Chemistry, Analytical
Edyta Biskup, Lone Schejbel, Douglas Nogueira Perez de Oliveira, Estrid Hogdall
Summary: This article presents a successful attempt to enhance the quantity of RNA isolated from clinical specimens. By comparing different purification methods, it was found that the addition of proteinase K can significantly increase RNA and DNA yield. The AllPrep DNA/RNA/miRNA Universal Kit can be used to extract comparable amounts of RNA as the phenol-chloroform extraction method, and it is also capable of simultaneous extraction of DNA and total RNA, regardless of the tissue of origin.
Article
Oncology
Charlotte Margareta Brinch, Estrid Hogdall, Niels Junker, Holger Jon Moeller, Birgitte Sandfeld-Paulsen, Pieter de Heer, Luit Penninga, Philip Blach Rossen, Anders Krarup-Hansen, Ninna Aggerholm-Pedersen
Summary: This study investigates the prognostic value of plasma Programmed Death Protein-1 (PD-1) and Programmed Death-Ligand 1 (PD-L1) concentrations in patients with Gastrointestinal Stromal Tumor (GIST). The results show that the plasma concentrations of PD-1 and PD-L1 are associated with the activity of GIST, and high concentration of PD-L1 is related to poor prognosis.
Article
Immunology
Estrid V. S. Hogdall, Ib Jarle Christensen, Claus Hogdall
Summary: Bio-and GenomeBank, Denmark (RBGB) is a national infrastructure that includes the Danish CancerBiobank (DCB). This study aimed to assess the collected biological material in DCB for patients with primary ovarian cancer registered in The Danish Gynecologic Cancer Database (DGCD) and investigate the concordance between predicted organ of disease and final diagnosis. Data from DGCD and DCB were extracted. 62% of the patients with primary ovarian cancer (1347 out of 2172) had biological materials stored in DCB. The median age of patients with biological material in DCB was 67 years, while it was 69 years for patients without biological material (p = 0.0001).
Article
Hematology
Marie Fredslund Breinholt, Lone Schejbel, Anne Ortved Gang, Torsten Holm Nielsen, Lars Moller Pedersen, Estrid Hogdall, Peter Norgaard
Summary: In this study, next generation sequencing (NGS) analysis was implemented in routine diagnostic work-up for B-cell non-Hodgkin's lymphoma (B-NHL). Mutations were detected in 94% of samples, and 50% of unclassified cases could be assigned a likely diagnostic subtype based on mutational findings. This gene sequencing approach provides potential diagnostic, prognostic, and predictive value for classification and risk-stratification of B-NHL.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Simon Ezban Grutzmeier, Bojan Kovacevic, Peter Vilmann, Charlotte Vestrup Rift, Linea Cecilie Melchior, Morten Orebo Holmstrom, Lene Brink, Hazem Hassan, John Gasdal Karstensen, Hanne Grossjohann, Deepthi Chiranth, Anders Toxvaerd, Carsten Palnaes Hansen, Estrid Hogdall, Jane Preuss Hasselby, Pia Klausen
Summary: Pancreatic cancer is a devastating disease with a low survival rate. Patient-derived 3D cultures have shown promise for personalized treatment, but most models do not include supportive tissue cells. In this study, a co-culture model was created using cells from endoscopic biopsies, showing interaction between tumor and stromal cells. The study also highlights the need to include cancer-associated fibroblasts (CAFs) in models, as CAFs impact treatment response.
Article
Immunology
Estrid V. S. Hogdall, Ib Jarle Christensen, Claus Hogdall
Summary: Bio-and GenomeBank, Denmark (RBGB) is a nationwide infra-structure. Danish Cancer Biobank (DCB) is a biobank in RBGB. The aim of this study is to evaluate the degree of biological material collected in DCB for primary ovarian cancer patients and investigate the concordance between presumed diagnosis and final diagnosis. Data extraction from relevant databases showed that biological materials were present for 62% of primary ovarian cancer patients. The optimal possibility for translational research and the potential need for additional biomarkers to aid in patient treatment were also highlighted.
Article
Medicine, General & Internal
Lau K. Vestergaard, Nicolai S. Mikkelsen, Douglas V. N. P. Oliveira, Tim S. Poulsen, Estrid V. Hoegdall
Summary: The implementation of next-generation sequencing (NGS) in clinical oncology allows for the analysis of multiple cancer-associated genes. Detection of pathogenic mutations is crucial for disease management. Obtaining the mutational profile is challenging in samples with low DNA yields, such as FFPE tissue and needle biopsies. This study demonstrates that vacuum centrifugation can concentrate low-yield DNA samples without compromising the mutational profile.
Article
Biochemistry & Molecular Biology
Patrick H. D. Petersen, Joanna Lopacinska-Jorgensen, Claus K. Hogdall, Estrid V. Hogdall
Summary: This study aimed to identify microRNAs that are stably expressed in the plasma of HGSOC and benign ovarian tumor patients. RNA was isolated from plasma samples of 60 HGSOC and 48 benign patients, and RT-qPCR was performed to analyze the stability of 40 microRNAs and 8 controls. It was found that hsa-miR-126-3p and hsa-miR-23a-3p were the most stable miRNAs in HGSOC samples, while hsa-miR-191-5p and hsa-miR-27a-3p were the most stable in benign samples.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Obstetrics & Gynecology
Douglas V. N. P. Oliveira, Kira P. Prahm, Ib J. Christensen, Anker Hansen, Claus K. Hogdall, Estrid Hogdall
Summary: This study assessed the expression levels of a panel of noncoding RNA in different subtypes of ovarian cancer and identified SNORA68 and SNORD74 as potential biomarkers associated with patient survival and disease aggressiveness. Overexpression of these targets correlated with poorer outcomes, indicating their potential clinical relevance for more individualized patient follow-up.
REPRODUCTIVE SCIENCES
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
