期刊
GENE
卷 517, 期 1, 页码 46-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2012.12.092
关键词
Tumor necrosis factor-receptor associated factor 1; Polymorphism; Rheumatoid arthritis; Systemic lupus erythematosus; Meta-analysis
资金
- National Natural Science Foundation of China [30830089, 81102192]
- Anhui Provincial Natural Science Foundation [11040606M183]
To determine whether the tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 (TRAF1/C5) polymorphism (rs10818488) confers susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE), a meta-analysis was performed. A total of 11 studies with 17 comparisons (11 for RA, 6 for SLE) were available for this meta-analysis, which consisted of 13,456 patients, 12,259 controls for RA and 1,894 patients, 6,729 controls for SLE. A significant association of the A allele of TRAF1/C5 polymorphism (rs10818488) with RA susceptibility was detected in the North Africa population (OR = 1557, 95% Cl: 1.225-1.977). Furthermore, the association between this allelic variant and SLE risk was additionally found in population of European (OR = 1.247, 95% Cl: 1.060-1.466). Analysis also showed the A/G allelic frequency of TRAF1/C5 variant (rs10818488), in different healthy populations, had a different distribution (chi(2) = 269.41, P<0.001). Taken together, our study demonstrates that the TRAF1/C5 polymorphism (rs10818488) may confer susceptibility to RA in North Africa population, and in European population, it might be a contributory factor towards SLE. (c) 2013 Elsevier B.V. All rights reserved.
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