Article
Biochemistry & Molecular Biology
Hongtao Hu, Hanqiu Zhang, Yue Xing, Yan Zhou, Jianing Chen, Cheng Li, Jingjing Xu, Yanyan Guo, Jie Wang, Qi He, Xinmei Liu, Jianzhong Sheng, Erwei Song, Yanting Wu, Hefeng Huang
Summary: Emerging evidence suggests that the long non-coding RNA THOR plays a critical role in the development of breast cancer. THOR interacts with hnRNPD to regulate downstream signaling pathways, promoting cell proliferation and metastasis in breast cancer. The THOR-hnRNPD-PDK1-MAPK/PI3K-AKT axis may serve as a potential therapeutic target for breast cancer treatment.
Article
Multidisciplinary Sciences
Ivan Vannini, Manuela Ferracin, Francesco Fabbri, Muller Fabbri
Summary: The expression of non-coding RNAs is dysregulated in human cancers, particularly the transcribed ultraconserved regions (T-UCRs). In lung cancer, uc.83-, an antisense ultraconserved element, is upregulated and plays a role in cell growth. AKT and ERK 1/2 signaling pathways are involved in the oncogenic function of uc.83-. Inhibition of uc.83- could be a potential therapeutic treatment for non-small cell lung cancer.
Review
Biochemistry & Molecular Biology
Pietro Laneve, Paolo Tollis, Elisa Caffarelli
Summary: RNA metabolism is crucial to cellular physiopathology, with ncRNAs playing a key role in maintaining neural system homeostasis and potentially contributing to neurodegenerative diseases like ALS. Research explores the link between ncRNA dysregulation and ALS, presenting the possibility of using them as diagnostic biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Anu Thomas, Frederick Rehfeld, He Zhang, Tsung-Cheng Chang, Mohammad Goodarzi, Frank Gillet, Joshua T. Mendell
Summary: In this study, the researchers developed a genome-wide screening strategy to investigate the mechanism of export of NORAD, an intronless cytoplasmic long noncoding RNA (lncRNA). They found that an RNA binding protein, RBM33, is responsible for directing the nuclear export of NORAD and multiple other transcripts. RBM33 directly binds to target transcripts and recruits components of the TREX-NXF1/NXT1 RNA export pathway. High GC content in the transcripts is found to be the feature specifying RBM33-dependent nuclear export. These findings provide a broadly applicable strategy for studying nuclear export mechanisms and reveal a long-sought pathway for the nuclear export of transcripts with GC-rich sequences.
GENES & DEVELOPMENT
(2022)
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Tommaso Villa, Odil Porrua
Summary: This review focuses on the actors and strategies used by yeasts to control noncoding RNA production, and discusses recent findings highlighting the dangers of losing control over pervasive transcription.
Review
Cell Biology
Alexandrina Machado de Amorim, Sutapa Chakrabarti
Summary: This passage discusses the significance of multicomponent protein-RNA complexes in facilitating mRNA turnover in all domains of life, as well as the role of sensor components in these complexes in selecting substrates for processing and orchestrating activities in RNA decay processes.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Article
Multidisciplinary Sciences
Xiaoqing Gao, Yunyang Qiao, Shanwen Li, Huimin Shi, Gaoting Qu, Jialing Ji, Weihua Gan, Aiqing Zhang
Summary: This study found that tRF-003634 is underexpressed in podocyte injury and overexpression of tRF-003634 can alleviate podocyte injury by reducing the stability of TLR4 mRNA.
Review
Biochemistry & Molecular Biology
Uciel Chorostecki, Nicolas G. Bologna, Federico Ariel
Summary: This review comprehensively analyzes the relationship between plant noncoding RNA transcripts and environmental cues, highlighting the importance of different types of noncoding RNAs in plant development and stress responses. It emphasizes the need for further research to uncover the molecular mechanisms and exploit the potential of noncoding transcripts for crop resilience.
Article
Medicine, Research & Experimental
Huishan Wang, Yuli Chen, Yanwen Liu, Qiuhui Li, Jing Luo, Li Wang, Yuanyuan Chen, Chen Sang, Wen Zhang, Xianxiu Ge, Zhifeng Yao, Lin Miao, Xianghua Liu
Summary: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths globally. This study reveals that ZFAS1 is overexpressed in CRC and positively correlated with tumor size and metastasis. ZFAS1 binds to PABP2 to stabilize SREBP1 mRNA accumulation, promoting lipid accumulation in CRC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Chemistry, Multidisciplinary
Guoping Li, Aidan C. Manning, Alex Bagi, Xinyu Yang, Priyanka Gokulnath, Michail Spanos, Jonathan Howard, Patricia P. Chan, Thadryan Sweeney, Robert Kitchen, Haobo Li, Brice D. Laurent, Sary F. Aranki, Maria Kontaridis, Louise C. Laurent, Kendall Van Keuren-Jensen, Jochen Muehlschlegel, Todd M. Lowe, Saumya Das
Summary: The study highlights the crucial role of transfer RNA-derived small RNAs in different stress responses and introduces a new sequencing technique for generating a comprehensive abundance landscape of cellular and extracellular tDRs. It also reveals that extracellular tDRs have distinct fragmentation signatures which are better indicators of different stress responses than miRNAs.
Article
Genetics & Heredity
Wenxiu Zhao, Xiangxu Meng, Jiahong Xu, Zijia Liu, Yangyang Hu, Bingyu Li, Jinhui Chen, Bing Cao
Summary: This study identified differentially expressed genes and microRNAs associated with xylem development in Dalbergia odorifera using RNA sequencing and small RNA sequencing. Further analysis revealed that these genes and miRNAs may play a role in the formation and development of xylem in D. odorifera.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura, Noriyuki Miyoshi
Summary: Polyphenols have anticancer effects by acting as antioxidants and modulating cell signaling pathways, with ncRNA modulation enhancing these effects.
Review
Medicine, Research & Experimental
Shukla Sakshi, Ravichandran Jayasuriya, Kumar Ganesan, Baojun Xu, Kunka Mohanram Ramkumar
Summary: Circular RNAs (circRNAs) play a crucial role in regulating mRNA expression through microRNA-mediated pathways, and dysregulation of this network is associated with the pathogenesis of various diseases, including diabetes. This complex interaction network is closely related to the pathogenesis of diabetes and its complications.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Amir Safi, Mohammadreza Saberiyan, Mohammad-Javad Sanaei, Samaneh Adelian, Fateme Davarani Asl, Mahsa Zeinaly, Mahdi Shamsi, Reza Ahmadi
Summary: Metabolic reprogramming is a well-known feature of cancer, and noncoding RNAs (ncRNAs) have been found to play a role in this process. This review focuses on the metabolism of glucose, lipids, and amino acids in cancer cells, and highlights the therapeutic potential of targeting ncRNAs in cancer treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.