期刊
GENE
卷 504, 期 2, 页码 166-174出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2012.05.030
关键词
Xrcc3; Rad51; Single nucleotide polymorphism; Head and neck cancer; Cancer risk
资金
- Nofer Institute of Occupational Medicine fund [IMP1.5/2009]
A case-control study was conducted to analyze the possible associations between the head and neck cancer (HNC) risk and fourteen single nucleotide polymorphisms (SNPs) and haplotypes in Xrcc3 and Rad51 genes. This study involved 81 HNC cases and 111 healthy control subjects. A significant risk-increasing effect of rs3212057 (p.Arg94His) SNP in Xrcc3 (OR = 6.6; p<0.01) was observed. On the other hand, risk-decreasing effect was found for rs5030789 (g.3997A>G) and rs1801321 (c.-60G>T) in 5' near gene and 5'UTR regions of Rad51, respectively (OR = 0.3 and OR = 0.2, p<0.05, respectively). Moreover, these effects were shown to be modulated by tobacco-smoking status and gene-gene interactions. Concluding, the genetic variability of Xrcc3 and/or Rad51 genes might be of relevance with respect to HNC risk. (c) 2012 Elsevier B.V. All rights reserved.
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