Article
Clinical Neurology
Javad Nadaf, Leanne de Kock, Anne-Sophie Chong, Marta Korbonits, Paul Thorner, Naciba Benlimame, Lili Fu, Andrew Peet, Justin Warner, Oswald Ploner, Shanop Shuangshoti, Steffen Albrecht, Nancy Hamel, John R. Priest, Barbara Rivera, Jiannis Ragoussis, William D. Foulkes
Summary: Pituitary blastomas are rare and potentially lethal pediatric intracranial tumors with DICER1 pathogenic variants inducing improper processing of miRNA precursors, leading to dysregulation of miRNAs and mRNA targets. The tumors show dysregulation of key signaling pathways like RAR, WNT, and NOTCH, and activation of PI3K pathway. Comparative methylation profiling reveals distinct features of PitBs compared to other CNS tumors.
ACTA NEUROPATHOLOGICA
(2021)
Article
Multidisciplinary Sciences
Juan A. Sanchez, Maria C. Ingaramo, Maria P. Gerve, Maria G. Thomas, Graciela L. Boccaccio, Andres Dekanty
Summary: The adipose tissue plays a crucial role in metabolism, stress resistance, and longevity. The depletion of Dicer1 in the fat body leads to changes in lipid metabolism, enhanced resistance to stress, and increased lifespan. The JNK-FOXO axis controls nutrient responses in the fat body by suppressing Dicer1 expression, providing a novel understanding of physiological responses at the organismal level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang
Summary: This study investigated the effects of resveratrol (RSV) on the apoptosis of porcine ovarian granulosa cells (POGCs) through miRNA regulation. The results showed that RSV promoted POGCs apoptosis by regulating the expression of miRNAs, and also provided insights into the role of miRNAs combined with RSV in ovarian granulosa cell development in pigs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keng Po Lai, Cherry Chi Tim Leung, Delbert Almerick T. Boncan, Nathan Tam, Xiao Lin, Simon Yuan Wang, Ting Fung Chan, Rudolf Shiu Sun Wu, Richard Yuen Chong Kong
Summary: Hypoxia can cause dysregulation of miRNA in the ovaries, leading to reproductive impairments in fish. Integrated miRNA-mRNA analysis reveals several dysregulated miRNA that are involved in biological processes related to reproduction. Furthermore, the study identifies specific miRNA-mRNA pairs that play a potential epigenetic role in hypoxia-induced reproductive impairments.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Zubing Cao, Xu Tong, Huiqun Yin, Naru Zhou, Xiangdong Zhang, Mengya Zhang, Xin Wang, Qiuchen Liu, Yelian Yan, Yangyang Ma, Tong Yu, Yunsheng Li, Yunhai Zhang
Summary: The study revealed that CARM1 specifically catalyzes H3R26me2 in porcine embryos to promote blastocyst formation and participates in blastocyst development. Functional studies using chemical inhibition and RNA interference demonstrated that inhibition or knockdown of CARM1 severely compromised blastocyst development and altered the transcriptome characterized by downregulation of key genes associated with Hippo and PI3K-AKT signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Jiang, Zhirong Zhang, Min Hou, Xiaohe Yang, Linlin Cui
Summary: This study investigates the effect of plasma exosomes and exosomal miRNAs from polycystic ovary syndrome (PCOS) patients on the estrus cycle, hormone secretion, and proliferation of granulosa cells in mice. The results show that PCOS plasma-derived exosomal miRNAs, particularly miR-126-3p, affect the estrus cycle, hormone synthesis, and granulosa cell proliferation through the inhibition of PDGFR beta and PI3K-AKT pathway.
Review
Cell Biology
Yong-ho Choe, Jacob Sorensen, Daniel J. Garry, Mary G. Garry
Summary: Organ transplantation is the only curative therapy for many endstage diseases, but the limited supply of donor organs calls for new strategies. Recent advancements in gene editing and stem cell technologies have enabled the pursuit of interspecies chimeric organs with promising early results. However, there are still hurdles to be addressed in order to successfully transplant these organs to patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Genetics & Heredity
Ronit Machtinger, Andrea A. Baccarelli, Haotian Wu
Summary: Extracellular vesicles play a crucial role in intercellular communication and contain a variety of molecules that can influence recipient cells. In female reproduction, these vesicles may have significant impacts on folliculogenesis, fertilization, embryo quality, and implantation. Further research is needed to address potential pitfalls and gaps in the current literature regarding the role of EVs in female reproduction.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Laura Marsh, Mark R. Hutchinson, Clive McLaughlan, Stefan T. Musolino, Michelle L. Hebart, Robyn Terry, Paul J. Verma, Stefan Hiendleder, Alexandra L. Whittaker
Summary: The study found that circulating miRNA in pigs is not an effective biomarker for emotional state. The challenge remains that current physiological and behavioral indices are either unable to distinguish between positive and negative emotional states, or they are simply not suitable for a production environment.
Article
Genetics & Heredity
David Connor Hawke, Danyal Baber Ahmed, Andrew John Watson, Dean Harvey Betts
Summary: The study demonstrates that extracellular miRNA sequences released by embryos can be used as biomarkers for assessing embryonic health, panel analysis can differentiate conditioned media from embryos at different stages, and embryonic cell death can be detected as an influential factor using this method.
FRONTIERS IN GENETICS
(2021)
Article
Medical Laboratory Technology
Klaas E. A. Max, Victoria R. Wang, Michael S. Chang, Jonathan Liau, Zachary R. Weiss, Stephanie Morgan, Jenny Li, Kimberly A. Bogardus, Pavel Morozov, Hemant Suryawanshi, Kemal M. Akat, Iddo Z. Ben-Dov, Arlene M. Hurley, Kathleen Dowd, Zev Williams, Thomas Tuschl
Summary: This study characterized the exRNA composition of plasma from 236 healthy individuals, revealing the variability of miRNA abundance. The study found correlation between more variable miRNAs in normal plasma and cell-lineage-specific miRNAs of liver, neuroendocrine organs, epithelial cells, and muscle. Additionally, significant abundance changes of miRNAs observed in pregnancy and subject P12 exceeded the variability of healthy individuals.
CLINICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Maria Oczkowicz, Klaudia Pawlina-Tyszko, Malgorzata Swiatkiewicz, Tomasz Szmatola
Summary: This study aimed to determine the effects of different sources of fat and different amounts of cDDGS on the miRNA profile in pig fat. The results showed that animals fed with a diet containing coconut oil had the highest number of differentially expressed miRNAs compared to other treatments, while cDDGS had little effect on miRNA expression. Additionally, the study identified several miRNAs regulated by dietary fats that are considered biomarkers in human and animal diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Zhiyuan Li, Yuwen Guo, Charles Brighton Ndandala, Huadong Chen, Chunren Huang, Guangwen Zhao, Hai Huang, Guangli Li, Huapu Chen
Summary: This study evaluated the molecular mechanisms of IGF3 in ovarian maturation and highlighted the role of circRNAs and miRNAs in reproduction in spotted scat. The findings provide new insights into the regulatory effects of circRNAs and miRNAs in IGF3-induced ovarian maturation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Toxicology
Andressa Gonsioroski, Ariana M. Aquino, Luiz G. Alonso-Costa, Luis F. Barbisan, Wellerson R. Scarano, Jodi A. Flaws
Summary: This study investigated the effects of maternal exposure to a phthalate mixture on folliculogenesis, steroidogenesis, and ovarian microRNA in the F1 and F2 generations of female rats. The results showed that the phthalate mixture impaired folliculogenesis and steroidogenesis in both generations of female rats, and altered ovarian miRNA expression in the F1 generation.
TOXICOLOGICAL SCIENCES
(2022)
Review
Genetics & Heredity
Sarah M. Greising, Joshua I. Weiner, Daniel J. Garry, David H. Sachs, Mary G. Garry
Summary: Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights the potential and impact of using gene edited pigs as a novel treatment platform.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.