Article
Neurosciences
Prachi Ojha, Subhajit Pal, Samarjit Bhattacharyya
Summary: Norbin protein plays a critical role in the internalization process of Group I mGluRs and may be associated with mGluR-mediated synaptic plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Ruihan Shi, Lei Hou, Li Wei, Jue Liu
Summary: Clathrin-mediated endocytosis serves as the initial step for effective viral infection by allowing viruses to enter cells. Adaptor proteins play a crucial role in this process, with their research shedding light on the viral life cycle and paving the way for novel therapeutics.
MICROBIAL PATHOGENESIS
(2021)
Review
Biochemistry & Molecular Biology
Ivana Strazic Geljic, Paola Kucan Brlic, Lucija Musak, Dubravka Karner, Andreja Ambriovic-Ristov, Stipan Jonjic, Peter Schu, Tihana Lenac Rovis
Summary: Viruses manipulate cellular protein trafficking pathways, particularly adaptor protein complexes (AP), to facilitate viral replication and evade host immune defenses. The interactions between viruses and AP complexes are found across major viral families, with well-documented cases in human immunodeficiency virus and human herpesviruses. High priority disease-causing agents like Ebola, Nipah, and SARS-CoV-2 underscore the importance of further understanding virus-AP interplay for designing novel antiviral therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Xue Li, Xiaorong Deng, Xin Guo, Yabo Wei, Yunfeng Zhao, Xiaobing Guo, Xinrong Zhu, Jian Zhang, Ling Hu
Summary: The present study investigates the freshness indicator protein of Coregonus peled and the effects of oxidation on the quality of fish during 4 degrees C storage. A total of 382 differential proteins were identified, and 20 proteins related to oxidation were found to have the potential as biomarkers for protein oxidative damage. Actin was identified as an indicator for fish softening during postmortem storage. The changes in protein structure and biomarkers were influenced by oxidation. Bioinformatics analysis suggested that differentially expressed proteins participated in the metabolic pathway during 4 degrees C storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Eva Gato, Ignacio Pedro Constanso, Bruno Kotska Rodino-Janeiro, Paula Guijarro-Sanchez, Tyler Alioto, Manuel Jesus Arroyo, Gema Mendez, Luis Mancera, Marta Gut, Ivo Gut, Miguel Alvarez-Tejado, German Bou, Marina Oviano
Summary: Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been used for direct detection of KPC-producing isolates by analyzing the 11,109 Da mass peak representing the P019 protein. The study found the P019 peak prevalence in bla(KPC) K. pneumoniae isolates to be 49.2%, while it was absent in other carbapenemase or noncarbapenemase producers. Variability of P019 presence was observed in different geographical locations within the EuSCAPE collection, indicating a need for reconsideration when applying this technique in a clinical setting.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Cell Biology
Yu Wu, Xinyou Lv, Haiting Wang, Kai Qian, Jinjun Ding, Jiejie Wang, Shushan Hua, Tiancheng Sun, Yiting Zhou, Lina Yu, Shuang Qiu
Summary: Neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor APPL1, which is necessary for the regulation of gene transcription and maintenance of hippocampal late-phase long-term potentiation. These results illustrate an APPL1-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Food Science & Technology
Alessandra Casagrande Ribeiro, Edimar Aparecida Filomeno Fontes, Camilo Jose Ramirez Lopez, Wassali Valadares Sousa, Isabela Souza Gomes, Edvaldo Barros, Jane Selia dos Reis Coimbra, Sylvia do Carmo Castro Franceschini, Danielle Aparecida Silva, Maria Cristina Baracat-Pereira
Summary: This study uses proteomics analysis to find differential proteoforms in human milk, which are present in colostrum, transition milk, and mature milk. These findings provide important insights into neonates' protein needs.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Environmental Sciences
Jisu Yeom, Nayeon Park, Raehyuk Jeong, Wonchoel Lee
Summary: The study examined whether spectra patterns of different species can be used for species identification using MALDI-TOF mass spectrometry, finding that they can form three clear clusters. It confirmed the viability of MALDI-TOF MS as a higher-resolution species identification methodology and proposed a new species.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Neurosciences
Marius Seidenthal, Barbara Janosi, Nils Rosenkranz, Noah Schuh, Nora Elvers, Miles Willoughby, Xinda Zhao, Alexander Gottschalk
Summary: pH-sensitive fluorescent proteins are used to study synaptic vesicle fusion and recycling. By tagging these proteins to the lumen of synaptic vesicles, their fluorescence is quenched by acidic pH and increased by neutral pH after fusion. This all-optical approach combines pH-sensitive proteins with light-gated channelrhodopsins for stimulation and visualization of vesicle recycling.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Georgiana F. Stan, Deborah K. Shoemark, Dominic Alibhai, Jonathan G. Hanley
Summary: BAR domain proteins play a critical role in regulating cellular membrane geometry, with PICK1 dimerization being regulated by Ca2+ ions leading to membrane tubulation. The transient increase in PICK1 dimerization following NMDA receptor stimulation is observed, pointing towards a novel mechanism for regulating BAR domain dimerization and function.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Jessica J. A. Hummel, Casper C. Hoogenraad
Summary: In this study, the authors systematically investigated the selectivity and regulation of KIF1A-driven transport of different types of vesicles, emphasizing the importance of phosphorylation for vesicle binding and the role of specific adaptors in achieving cargo specificity. They propose a model where motor dimerization, posttranslational modifications, and specific adaptors regulate selective KIF1A cargo trafficking.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Chemistry, Analytical
Liang Shan, Han Gao, Jing Zhang, Wentao Li, Yue Su, Yinlong Guo
Summary: This study combined MALDI-TOF MS with EM technology to directly analyze exosomal proteins in human plasma and serum. The results showed that EM had higher sensitivity in the high-mass range and characteristic exosomal proteins were identified. Furthermore, when using EM as a detector, there was a good linear relationship between peak intensity and concentration.
Article
Cell Biology
Felichi Mae Arines, Aaron Jeremy Hamlin, Xi Yang, Yun-Yu Jennifer Liu, Ming Li
Summary: This study discusses how the yeast E3 ligase adaptor Ssh4 recognizes the lysine transporter Ypq1 only under lysine starvation conditions, showing an interaction between transmembrane helices and suggesting that transport-associated conformational changes may determine selectivity. Recent structural studies have implied that major conformational changes in substrate transport may contribute to this specificity, providing critical insights into how transmembrane domains are specifically recognized in response to changing environmental conditions.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah M. Smith, Gabrielle Larocque, Katherine M. Wood, Kyle L. Morris, Alan M. Roseman, Richard B. Sessions, Stephen J. Royle, Corinne J. Smith
Summary: The interaction between Clathrin and the AP2 complex plays a crucial role in coated-pit assembly, with a beta 2 appendage able to bind in at least two positions in the clathrin cage. This multi-modal binding is shown to be a fundamental property of clathrin-AP2 interactions.
Article
Microbiology
Gisele Bacanelli, Flabio Ribeiro Araujo, Newton Valerio Verbisck
Summary: This study compared two cell preparation protocols for Mycobacterium tuberculosis identification using MALDI-TOF MS. It was found that the MycoLyser protocol with cell disruption using the MagNA Lyser instrument improved the efficacy of the method.
Article
Biochemistry & Molecular Biology
Maria S. Eriksen, Oleksii Nikolaienko, Erik I. Hallin, Sverre Grodem, Helene J. Bustad, Marte I. Flydal, Ian Merski, Tomohisa Hosokawa, Daniela Lascu, Shreeram Akerkar, Jorge Cuellar, James J. Chambers, Rory O'Connell, Gopinath Muruganandam, Remy Loris, Christine Touma, Tambudzai Kanhema, Yasunori Hayashi, Margaret M. Stratton, Jose M. Valpuesta, Petri Kursula, Aurora Martinez, Clive R. Bramham
Summary: The study identified a 28-amino-acid stretch in the mammalian Arc N-terminal domain that is crucial for self-association and a 7-residue oligomerization motif critical for virus-like capsid formation. The atomic-resolution crystal structure of the oligomerization region peptide revealed an antiparallel coiled-coil interface supporting NT-NT domain interactions in Arc oligomerization. The study also showed that Arc mRNA enhances higher-order oligomerization dependent on the oligomerization motif, leading to the formation of virus-like capsids.
Article
Biochemical Research Methods
Oleksii Nikolaienko, Per Eystein Lonning, Stian Knappskog
Summary: With recent advances in the field of epigenetics, there is a growing focus on rare transmitted constitutional epimutations. The research team developed a method called ramr to identify aberrantly methylated DNA regions and confirmed its applicability for cancer risk analysis.
Article
Gastroenterology & Hepatology
Yurii Stepanov, Iuliia Golovynska, Nataliia Dziubenko, Halyna M. Kuznietsova, Nataliia Petriv, Inessa Skrypkina, Sergii Golovynskyi, Liudmyla Stepanova, Yevhenii Stohnii, Liudmyla Garmanchuk, Liudmyla Ostapchenko, Tetyana Yevsa, Junle Qu, Tymish Y. Ohulchanskyy
Summary: We have demonstrated the expression of NMDAR during the early stages of cancer, specifically HCC, in the cell transformation process. The aim of our study was to define the disease stages from precancerous liver disease to liver cancer progression when NMDAR subunits were expressed/detected. A fibrosis/HCC rat model, immunohistochemistry combined with epifluorescence microscopy imaging, and Western blotting were employed. The dynamics of appearance of NMDAR subunits, their expression, and methylation status during the development of HCC were shown and discussed.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Oncology
Andreas Venizelos, Hege Elvebakken, Aurel Perren, Oleksii Nikolaienko, Wei Deng, Inger Marie B. Lothe, Anne Couvelard, Geir Olav Hjortland, Anna Sundlov, Johanna Svensson, Harrish Garresori, Christian Kersten, Eva Hofsli, Sonke Detlefsen, Merete Krogh, Halfdan Sorbye, Stian Knappskog
Summary: High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are a rare and understudied type of tumors, with a very poor prognosis. Molecular analysis of 181 HG GEP-NEN patients revealed unique genetic alterations and copy number changes in different subgroups of tumors, indicating potential personalized treatment options. Limited similarities were found with small-cell lung cancer (SCLC), suggesting the need for subtype-specific therapeutic approaches.
ENDOCRINE-RELATED CANCER
(2022)
Article
Anesthesiology
Volodymyr Krotov, Kirill Agashkov, Marharyta Krasniakova, Boris Safronov, Pavel Belan, Nana Voitenko
Summary: This study reveals the input sources and regulation mechanisms of spinal lamina X neurons, demonstrating that primary afferent fibers are regulated by both spinal and supraspinal control through at least 5 distinct pathways.
Article
Neurosciences
Feilin Liu, Dmytro Morderer, Melissa C. Wren, Sara A. Vettleson-Trutza, Yanzhe Wang, Benjamin E. Rabichow, Michelle R. Salemi, Brett S. Phinney, Bjorn Oskarsson, Dennis W. Dickson, Wilfried Rossoll
Summary: The most common inherited cause of ALS and FTD is the expansion of GGGGCC repeats in the C9orf72 gene. In addition to haploinsufficiency and toxic RNA foci, other disease mechanisms are involved. Through the use of the BioID approach, it was found that DPR aggregates are associated with specific proteins that play important roles in protein folding and degradation. Heat shock proteins and co-chaperones were found to be closely associated with one of the DPRs, poly-GA, and may play a significant role in reducing its aggregation.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Takahiro Tadokoro, Mariana Bravo-Hernandez, Kirill Agashkov, Yoshiomi Kobayashi, Oleksandr Platoshyn, Michael Navarro, Silvia Marsala, Atsushi Miyanohara, Tetsuya Yoshizumi, Michiko Shigyo, Volodymyr Krotov, Stefan Juhas, Jana Juhasova, Duong Nguyen, Helena Kupcova Skalnikova, Jan Motlik, Hana Studenovska, Vladimir Proks, Rajiv Reddy, Shawn P. Driscoll, Thomas D. Glenn, Taratorn Kemthong, Suchinda Malaivijitnond, Zoltan Tomori, Ivo Vanicky, Manabu Kakinohana, Samuel L. Pfaff, Joseph Ciacci, Pavel Belan, Martin Marsala
Summary: Changing the excitatory neurotransmitter phenotype of secondary spinal cord neurons to inhibitory can successfully treat neuropathic pain without causing detectable side effects.
Article
Biochemistry & Molecular Biology
Indre Valiulyte, Aiste Pranckeviciene, Adomas Bunevicius, Arimantas Tamasauskas, Hanna Svitina, Inessa Skrypkina, Paulina Vaitkiene
Summary: This study examines the potential of miR-181a as a biomarker for the diagnosis and prognosis of glioma patients. Lower expression of miR-181a is associated with higher tumor grade, IDH1 wild-type gliomas, and worse overall survival. Additionally, miR-181a levels are correlated with functional status and quality of life in glioma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Per E. Lonning, Oleksii Nikolaienko, Kathy Pan, Allison W. Kurian, Hans P. Eikesdal, Mary Pettinger, Garnet L. Anderson, Ross L. Prentice, Rowan T. Chlebowski, Stian Knappskog
Summary: This study found a significant association between constitutional normal tissue BRCA1 promoter methylation and the risk of developing triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC).
Article
Biochemistry & Molecular Biology
Olga Kopach, Yulia Dobropolska, Pavel Belan, Nana Voitenko
Summary: The dorsal horn (DH) neurons of the spinal cord play a critical role in processing nociceptive input in the central nervous system. The hyperexcitability of DH neurons has been linked to Ca2+-permeable AMPA receptors (AMPARs) and contributes to nociceptive hypersensitivity. Inflammatory pain conditions result in changes in action potential (AP) parameters in DH neurons, and selective inhibition of Ca2+-permeable AMPARs can alleviate nociceptive hypersensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bilal Khalil, Deepak Chhangani, Melissa C. Wren, Courtney L. Smith, Jannifer H. Lee, Xingli Li, Christian Puttinger, Chih-Wei Tsai, Gael Fortin, Dmytro Morderer, Junli Gao, Feilin Liu, Chun Kim Lim, Jingjiao Chen, Ching-Chieh Chou, Cara L. Croft, Amanda M. Gleixner, Christopher J. Donnelly, Todd E. Golde, Leonard Petrucelli, Bjorn Oskarsson, Dennis W. Dickson, Ke Zhang, James Shorter, Shige H. Yoshimura, Sami J. Barmada, Diego E. Rincon-Limas, Wilfried Rossoll
Summary: The study found that members of the nuclear import receptor protein family can reduce the formation of pathological TDP-43 aggregates. Using KPNB1 as a model, it was discovered that its activity depends on the prion-like C-terminal region of TDP-43, mediating co-aggregation with nucleoporins such as Nup62. KPNB1 acts as a molecular chaperone in these co-aggregates, reversing the aberrant phase transition of Nup62 and TDP-43.
MOLECULAR NEURODEGENERATION
(2022)
Article
Neurosciences
Volodymyr Krotov, Kirill Agashkov, Sergii Romanenko, Oleh Halaidych, Yaroslav Andrianov, Boris V. V. Safronov, Pavel Belan, Nana Voitenko
Summary: Although our understanding of how afferent-driven presynaptic inhibition shapes peripheral input to nociceptive neurons is limited, this study examined this effect on primary afferent input to spinal neurons in two nociceptive-processing regions. The results showed that attenuation of presynaptic inhibition resulted in the appearance of new mono- and polysynaptic excitatory postsynaptic current components. These mechanisms are important for shaping primary afferent input to neurons in the spinal nociceptive-processing network.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tetiana Bukreieva, Hanna Svitina, Viktoriia Nikulina, Alyona Vega, Oleksii Chybisov, Iuliia Shablii, Alina Ustymenko, Petro Nemtinov, Galyna Lobyntseva, Inessa Skrypkina, Volodymyr Shablii
Summary: This study investigated the effects of mesenchymal stem cell (MSC) transplantation on severe COVID-19 patients. The results showed that triple MSC transplantation was safe and did not cause severe adverse reactions. CT imaging revealed that MSC transplantation resulted in significantly lower fibrotic changes in the lung compared to conventional anti-viral treatment. Additionally, MSC therapy improved lymphocyte recovery and reduced inflammation markers in the peripheral blood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Insinska-Rak, Anna Golczak, Mateusz Gierszewski, Zubair Anwar, Volodymyr Cherkas, Dorota Kwiatek, Ewa Sikorska, Igor Khmelinskii, Gotard Burdzinski, Radek Cibulka, Lucyna Mrowczynska, Jacek Lukasz Kolanowski, Marek Sikorski
Summary: This article reports the photophysical properties of 5-deazaalloxazine (1a) in different solvents. It is found that the triplet excited states of 1a in water and acetonitrile have microsecond lifetimes, and 1a can efficiently generate singlet oxygen under oxygen conditions. In addition, experiments using human red blood cell models show that 1a has antioxidant and cytotoxic activities.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Genetics & Heredity
Oleksii Nikolaienko, Hans P. Eikesdal, Elisabet Ognedal, Bjornar Gilje, Steinar Lundgren, Egil S. Blix, Helge Espelid, Jurgen Geisler, Stephanie Geisler, Emiel A. M. Janssen, Synnove Yndestad, Laura Minsaas, Beryl Leirvaag, Reidun Lillestol, Stian Knappskog, Per E. Lonning
Summary: This study found that approximately 20% of TNBC and low-ER expression breast cancers may be caused by prenatal BRCA1 epimutations. The constitutional mosaic BRCA1 methylation likely arises through gender-related mechanisms in utero, independent of Mendelian inheritance.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
