Article
Microbiology
Ya Jin, Wei Zhang, Shen Cong, Qi-Guo Zhuang, Yi-Lin Gu, Yi-Nan Ma, Melanie J. Filiatrault, Jun-Zhou Li, Hai-Lei Wei
Summary: The bacterial plant pathogen Pseudomonas syringae uses a type III secretion system (T3SS) to deliver effector proteins into plant cells for infection. The T3SS protein HrpP induces host cell death, suppresses pattern-triggered immunity (PTI), and interacts with MKK2 to manipulate plant immunity. This study highlights the importance of HrpP in effector translocation and immune manipulation. Rating: 8/10.
MICROBIOLOGY SPECTRUM
(2023)
Article
Plant Sciences
Sara M. Klee, Judith P. Sinn, Jeremy Held, Chad Vosburg, Aleah C. Holmes, Brian L. Lehman, Kari A. Peter, Timothy W. McNellis
Summary: The transcription antiterminator RfaH plays a crucial role in the full virulence of Erwinia amylovora by reducing pausing in the synthesis of key virulence factors. RfaH specifically suppresses operon polarity in the synthesis of amylovoran and lipopolysaccharides, which are essential for the pathogenicity of E. amylovora.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bingsen Wang, Tianjiu He, Xueao Zheng, Botao Song, Huilan Chen
Summary: The study revealed that T3 effectors of Ralstonia solanacearum can impact the abundance of immune-related proteins in potato roots in a redundant manner. Proteins such as miraculin, HBP2, and TOM20 contribute to immunity against the pathogen, while PP1 contributes to susceptibility. Interestingly, the downregulated proteins were not downregulated at the transcriptional level, indicating significant posttranscriptional regulation.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Biotechnology & Applied Microbiology
Julie Ming Liang, Lisa Ann Burdette, Han Teng Wong, Danielle Tullman-Ercek
Summary: Protein production using bacteria is costly and inefficient. Researchers have engineered a bacterial secretion system to improve the production process by directly secreting soluble proteins into the culture media. They explored different activation methods and created strains capable of efficiently producing heterologous proteins. They also discovered a genetic relationship between T3SS regulators, hilE and hilD, further enhancing the industrial competitiveness of protein production strains.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Stephan Wimmi, Alexander Balinovic, Hannah Jeckel, Lisa Selinger, Dimitrios Lampaki, Emma Eisemann, Ina Meuskens, Dirk Linke, Knut Drescher, Ulrike Endesfelder, Andreas Diepold
Summary: Current research shows that in gastrointestinal pathogens, the external pH plays a crucial role in regulating the assembly of T3SS cytosolic components, preventing T3SS activity in the stomach and facilitating its reactivation in the intestine.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Marc-Andre Leblanc, Morgan R. Fink, Thomas T. Perkins, Marcelo C. Sousa
Summary: The study shows that effector proteins from certain bacteria can be injected into host cells through a type III secretion system. These proteins need to be partially unfolded to pass through the narrow channel. Mechanical unfolding of the proteins revealed that they exhibit low force and high mechanical compliance, facilitating efficient secretion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Julia Sanchez-Garrido, David Ruano-Gallego, Jyoti S. Choudhary, Gad Frankel
Summary: Recent studies have shown that T3SS effectors interact with each other in the host, revealing their interdependency and context-dependent essentiality, which is of great significance for understanding the pathogenesis of the pathogens.
TRENDS IN MICROBIOLOGY
(2022)
Article
Microbiology
Kevin Munoz Navarrete, Ladislav Bumba, Tatyana Prudnikova, Ivana Malcova, Tania Romero Allsop, Peter Sebo, Jana Kamanova
Summary: The study reveals that BopN is a gatekeeper of the Bordetella T3SS, responsible for regulating the secretion and translocation of the BteA effector into host cells. It is similar to gatekeepers that control access to the T3SS channel from the bacterial cytoplasm. Deletion of the bopN gene in B. bronchiseptica increased secretion of BteA, but decreased the translocation of BteA into host cell cytoplasm.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Douaa Zakaria, Shigeaki Matsuda, Tetsuya Iida, Tetsuya Hayashi, Masanori Arita
Summary: In this study, a new type III secretion system (T3SS3) category was identified in Vibrio, which shares similarities with the Ssa-Esc family of T3SSs found in Salmonella, Shewanella, and Sodalis. This suggests a possible genetic exchange among marine bacteria with similar habitats.
Review
Microbiology
Elizabeth A. Rucks
Summary: Type III secretion systems (T3SS) are utilized by Gram-negative pathogens to deliver effector proteins into target eukaryotic cells for manipulating cell functions and enhancing pathogenesis. This review will discuss the history, biochemical characterization, and function of chlamydial T3SS, as well as the use of heterologous/surrogate models for studying it. The review will also cover the history of chlamydial effectors and recent advances in the field.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Eduardo Soto, Jorge E. Galan, Marfa Lara-Tejero
Summary: In this study, an extensive in vivo cross-linking strategy aided by structure modeling was used to investigate the sorting platform complex of type III secretion systems. The assembly process of this bacterial structure was mapped using identified cross-links as signatures for pairwise intersubunit interactions and systematic genetic deletions. Insights generated by this study could be used for the rational development of antivirulence strategies against medically important bacterial pathogens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Gastroenterology & Hepatology
Ce Zhang, Min Liu, Ying Wu, Xixi Li, Chen Zhang, Douglas R. Call, Ming Liu, Zhe Zhao
Summary: In Vibrio parahaemolyticus, the expression of T3SS1 is regulated by a complex quorum sensing phosphorelay circuit involving the hybrid histidine kinase ArcB, sensor kinase LuxQ, and response regulator LuxO. The study shows that LuxQ can directly interact with ArcB under high oxygen conditions, leading to phosphorylation of LuxO and activation of T3SS1 expression. Under hypoxic conditions, ArcB autophosphorylates and phosphorylates ArcA, but ArcA does not participate in regulating T3SS1 expression.
Review
Immunology
Albane Jouault, Alessandra Mattos Saliba, Lhousseine Touqui
Summary: This mini-review discusses how the type III secretion system (T3SS) of Pseudomonas aeruginosa and the bacterial effectors secreted through this system can activate and manipulate the host immune response, promoting the survival and establishment of the pathogen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nidhi Singh, Thales Kronenberger, Andrea Eipper, Felix Weichel, Mirita Franz-Wachtel, Boris Macek, Samuel Wagner
Summary: The study found that the salt bridges in the assembly of virulence-associated T3SS are not critical, but facilitate the incorporation of the next subunit. The conserved charged residues are crucial for type III-dependent secretion and play a key role in the function of T3SS.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Manuel Halte, Marc Erhardt
Summary: The T3SS utilizes proton motive force to export substrate proteins across the inner membrane of pathogenic bacteria. It consists of an export gate and a soluble ATPase complex in the cytoplasm. Recent research on T3SS focuses on energy transduction and protein transport across the cytoplasmic membrane.
Article
Plant Sciences
Mireia Marce Escursell, Alexia Roschi, Theo H. M. Smits, Fabio Rezzonico
Summary: This study reveals that the high resistance of Erwinia amylovora to streptomycin is mainly due to the K43R mutation in the rpsL gene, which enables the bacteria to maintain environmental fitness even in the absence of antibiotic pressure. Analysis of resistant colonies also identified two previously undescribed mutations in rpsL, resulting in conditional-lethal streptomycin-dependent phenotypes.
JOURNAL OF PLANT PATHOLOGY
(2021)
Article
Microbiology
Zala Schmautz, Carlos A. Espinal, Andrea M. Bohny, Fabio Rezzonico, Ranka Junge, Emmanuel Frossard, Theo H. M. Smits
Summary: The study found that microbial communities in different compartments of the aquaponic system are influenced by oxygen levels; aerobic system compartments are highly biodiverse and function primarily as nitrifying biofilters, while biofilms in anaerobic compartments contain a less diverse community.
Article
Microbiology
Sonja Lick, Daniel Wibberg, Annika Winkler, Jochen Blom, Christina Grimmler, Alexander Goesmann, Jorn Kalinowski, Lothar Kroeckel
Summary: This study isolated two strains of Pseudomonas bacteria associated with beef ripening, naming them Pseudomonas paracarnis sp. nov. and UBT403. Through genetic sequence analysis, fatty acid profile examination, and lipid characterization, they were classified as a novel species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Agricultural Engineering
Zala Schmautz, Carlos A. Espinal, Theo H. M. Smits, Emmanuel Frossard, Ranka Junge
Summary: This study investigated the transformation of nitrogen forms within an aquaponic system, revealing significant differences between compartments attributed to individual microenvironments and microbial processes.
AQUACULTURAL ENGINEERING
(2021)
Article
Plant Sciences
Chiaraluce Moretti, Fabio Rezzonico, Benedetta Orfei, Chiara Cortese, Alba Moreno-Perez, Harrold A. van den Burg, Andrea Onofri, Giuseppe Firrao, Cayo Ramos, Theo H. M. Smits, Roberto Buonaurio
Summary: The endophytic bacterium P. agglomerans DAPP-PG 734's T3SS injects effector proteins into plant cells and its Hrp mutants fail to induce hypersensitive response. While wildtype P. agglomerans did not cause disease in olive plants like P. savastanoi pv. savastanoi DAPP-PG 722, the hrpY mutant reduced knot size significantly. Coinoculation showed nonoverlapping localization patterns of the two bacteria in knots, suggesting that suppression of olive plant defences by P. agglomerans positively impacts the virulence of P. savastanoi pv. savastanoi.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Christopher Schoelzel, Valeria Blesius, Gernot Ernst, Alexander Goesmann, Andreas Dominik
Summary: The in silico experiments in systems biology are thought to be less prone to reproducibility issues compared to wet-lab experiments, but studies show that only half of published mathematical models of biological systems can be reproduced without extensive effort. The case study of a one-dimensional mathematical model of the atrioventricular node reveals various reasons for failed or cumbersome reproductions, such as missing information, errors in equations and parameters, lack of available data files, and incomplete experiment protocols. To address these issues, techniques from software engineering are applied to re-implement the model in a more reproducible and understandable manner.
Article
Microbiology
Seomun Kwon, Oliver Rupp, Andreas Brachmann, Christopher Frederik Blum, Anton Kraege, Alexander Goesmann, Michael Feldbruegge
Summary: Research has shown that EV-associated mRNAs secreted by the maize smut pathogen are resistant to degradation by RNases and contain mRNAs related to metabolism and virulence. Known effectors and proteins linked to virulence are also present in EVs, and some of these mRNAs are upregulated during infection.
Article
Microbiology
Nay C. Dia, Johan Van Vaerenbergh, Cinzia Van Malderghem, Jochen Blom, Theo H. M. Smits, Bart Cottyn, Joel F. Pothier
Summary: This study identified and characterized a novel species isolated from nursery-grown Hydrangea arborescens cultivars in Flanders, Belgium. The strains were confirmed to be pathogenic to their isolation host and Hydrangea quercifolia, showing a close relation to Xanthomonas hortorum. Through genomic analysis, a genomics-based loop-mediated isothermal amplification assay was developed for early detection of the new species, proposed to be named Xanthomonas hydrangeae sp. nov.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Oliver Schwengers, Lukas Jelonek, Marius Alfred Dieckmann, Sebastian Beyvers, Jochen Blom, Alexander Goesmann
Summary: This article introduces a new command-line software tool called Bakta for the rapid, taxon-independent annotation of bacterial genomes. Bakta outperforms other tools in terms of functional annotations, database cross-references, while providing comparable runtime.
MICROBIAL GENOMICS
(2021)
Review
Infectious Diseases
Theo H. M. Smits, Lavinia N. V. S. Arend, Sofia Cardew, Erika Tang-Hallback, Marcelo T. Mira, Edward R. B. Moore, Jorge L. M. Sampaio, Fabio Rezzonico, Marcelo Pillonetto
Summary: With improvements in genomics, it is now possible to accurately identify clinical isolates at the species level and analyze past occurrences of specific organisms. This approach can aid in the classification of clinically relevant taxa that have previously gone unrecognized in clinical diagnostics.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Genetics & Heredity
Bardya Djahanschiri, Gisela Di Venanzio, Jesus Distel, Jennifer F. Breisch, Marius Alfred Dieckmann, Alexander Goesmann, Beate Averhoff, Stephan Goettig, Gottfried Wilharm, Mario Feldman, Ingo Ebersberger
Summary: This study investigates the genetic basis of human-pathogen interaction in Acinetobacter calcoaceticus-baumannii (ACB) complex, a group of multi-drug resistant bacteria. By analyzing over 3,000 Acinetobacter genomes, the researchers identify evolutionarily stable gene clusters (ESGCs) that are associated with the pathogenic phenotype. These clusters reveal the metabolic pathways, transcriptional regulators, and carbon source utilization that allow the pathogens to adapt to their human host. The study also demonstrates that the ACB clade has the unique ability to utilize kynurenine, a substance produced by humans as part of the immune response. This research provides valuable insights for the development of novel therapeutic strategies.
Article
Microbiology
Celine M. Riyanti, Celine M. Zumkeller, Marius Spohn, Sanja Mihajlovic, Oliver Schwengers, Alexander Goesmann, Riviani Riviani, Maria D. N. F. Meinita, Till F. Schaeberle, Harwoko Harwoko
Summary: Sinomicrobium sp. strain PAP.21 (EXT111902) was isolated from the coast of Cenderawasih Bay National Park in West Papua, Indonesia. Its genome was assembled into 151 contigs with a total size of 5.439 Mbp, enabling the prediction of its specialized metabolite production capacity.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Celine M. Riyanti, Celine Zumkeller, Marius Spohn, Sanja Mihajlovic, Oliver Schwengers, Alexander A. Goesmann, Nur F. Choironi, Till Schaberle, Harwoko Harwoko
Summary: In this study, we report the draft genome sequences of two strains, Algoriphagus sp. strain PAP.12 (EXT111900) and Roseivirga sp. strain PAP.19 (EXT111901), isolated from marine samples. We also evaluated their specialized metabolite production capacity. Genome-based analysis suggests that Algoriphagus sp. strain PAP.12 represents a candidate new species.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Agronomy
Nay C. Dia, Bart Cottyn, Jochen Blom, Theo H. M. Smits, Joel F. Pothier
Summary: This study developed loop-mediated isothermal amplification (LAMP) diagnostic assays for rapid and accurate detection of the X. hortorum - X. hydrangeae species complex. Genomic analysis was used to identify genomic targets for the assays. The assays showed 100% sensitivity, specificity, and efficiency on a set of reference strains and a validation set.
FRONTIERS IN AGRONOMY
(2022)
Correction
Microbiology
Alison E. Murray, John Freudenstein, Simonetta Gribaldo, Roland Hatzenpichler, Philip Hugenholtz, Peter Kampfer, Konstantinos T. Konstantinidis, Christopher E. Lane, R. Thane Papke, Donovan H. Parks, Ramon Rossello-Mora, Matthew B. Stott, Iain C. Sutcliffe, J. Cameron Thrash, Stephanus N. Venter, William B. Whitman, Silvia G. Acinas, Rudolf I. Amann, Karthik Anantharaman, Jean Armengaud, Brett J. Baker, Roman A. Barco, Helge B. Bode, Eric S. Boyd, Carrie L. Brady, Paul Carini, Patrick S. G. Chain, Daniel R. Colman, Kristen M. DeAngelis, Maria Asuncion de los Rios, Paulina de los Santos, Christopher A. Dunlap, Jonathan A. Eisen, David Emerson, Thijs J. G. Ettema, Damien Eveillard, Peter R. Girguis, Ute Hentschel, James T. Hollibaugh, Laura A. Hug, William P. Inskeep, Elena P. Ivanova, Hans-Peter Klenk, Wen-Jun Li, Karen G. Lloyd, Frank E. Loffler, Thulani P. Makhalanyane, Duane P. Moser, Takuro Nunoura, Marike Palmer, Victor Parro, Carlos Pedros-Alio, Alexander J. Probst, Theo H. M. Smits, Andrew D. Steen, Emma T. Steenkamp, Anja Spang, Frank J. Stewart, James M. Tiedje, Peter Vandamme, Michael Wagner, Feng-Ping Wang, Pablo Yarza, Brian P. Hedlund, Anna-Louise Reysenbach
Summary: An amended version of this paper has been published and is accessible via a link at the top of the page.
NATURE MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
