期刊
GENE
卷 445, 期 1-2, 页码 66-72出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2009.06.003
关键词
Large Maf; c-Maf; F4/80; Macrophage
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japanese Society for the Promotion of Science [18390081]
- The Naito Foundation
- Astellas Foundation for Research on Metabolic Disorders
- The Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [18390081] Funding Source: KAKEN
c-Maf. which is one of the large Maf transcription factors, can bind to Maf recognition element (MARE) and activates transcription of target genes. Although c-Maf is expressed in macrophages and directly regulates the expression of interleukin-10, detailed information regarding its function in the null mutant phenotype of tissue macrophages remain unknown. In this study, we demonstrated that c-Maf is specifically expressed in the F4/80 positive fetal liver and adult macrophages. The expression of F4/80, which is a tissue macrophage-specific seven trans-membrane receptor, was dramatically suppressed in the c-Maf-deficient macrophage, whereas the expression of Mac-1 was not affected, suggesting that c-Maf is not necessary for the lineage commitment of macrophages. Luciferase reporter and EMSA showed that c-Maf directly regulates the expression of F4/80 by interacting with the half-MARE site of the F4/80 promoter. These results suggest that c-Maf is required for the F4/80 expression in macrophages in vivo. (C) 2009 Elsevier B.V. All rights reserved.
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