Article
Food Science & Technology
Fei Gao, Lin Sui, Guangqing Mu, Fang Qian, Xuemei Zhu
Summary: This study isolated and identified two potential probiotic Lactobacillus strains from healthy infant feces, which showed inhibitory effects on Helicobacter pylori. These strains significantly reduced the viable count of H. pylori when co-cultured with live cells or cell-free supernatants.
Article
Agriculture, Dairy & Animal Science
Laipeng Xu, Xiangli Sun, Xianhua Wan, Keke Li, Fuchun Jian, Wenting Li, Ruirui Jiang, Ruili Han, Hong Li, Xiangtao Kang, Yanbin Wang
Summary: Clostridium butyricum is considered as an antibiotic substitute that can enhance antioxidant capacity, mucosal barrier function, and stabilize the cecal microbiota, resulting in improved growth performance in broilers.
Article
Multidisciplinary Sciences
Martijn G. H. Sanders, Tamar Nijsten, Joost Verlouw, Robert Kraaij, Luba M. Pardo
Summary: The study found differences in the microbiome composition between patients with seborrheic dermatitis (SD) and individuals without diseases, mainly in the genus Staphylococcus.
Article
Food Science & Technology
Devin A. A. Bowes, Erin M. M. Driver, Sonja Savic, Qiwen Cheng, Corrie M. M. Whisner, Rosa Krajmalnik-Brown, Rolf U. U. Halden
Summary: This study demonstrates that wastewater-based epidemiology can be used for near real-time population dietary assessments, providing a promising tool for actionable and cost-effective data collection to support public health nutrition at the population scale.
Review
Microbiology
Meng Zhang, Lixin Shen, Jiajia Shi, Linxia Chen, Ying Luo, Jiquan Sun, Deliang Fan, Shintaro Hara, Zhihua Bao
Summary: The novel bacterial strain MHJ-10J(T) was isolated from a grassland in Inner Mongolia, China, showing growth at a wide range of temperature, pH, and salt concentrations. Phylogenetic analysis revealed its classification within the genus Pseudomonas, leading to the proposal of a new species designation as Pseudomonas pratensis sp. nov. based on phenotypic, genotypic, chemotaxonomic, and phylogenetic analyses.
CURRENT MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
D. Vinu, K. Govindaraju, R. Vasantharaja, S. Amreen Nisa, M. Kannan, K. Vijai Anand
Summary: This study investigated the biogenic preparation of ZnO, CuO, and Se nanoparticles using the marine brown alga Sargassum swartzii. The nanoparticles were characterized and their antibacterial activity against V. parahaemolyticus was studied, showing strong inhibition at dose-dependent manner. The results suggest the potential use of these nanomaterials for managing aquatic diseases when incorporated with shrimp feed in the future.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hubiao Jiang, Luqiong Lv, Temoor Ahmed, Shaomin Jin, Muhammad Shahid, Muhammad Noman, Hosam-Eldin Hussein Osman, Yanli Wang, Guochang Sun, Xuqing Li, Bin Li
Summary: This study found that metal oxide nanoparticles can reduce the incidence of tomato bacterial wilt and alter the composition and structure of the rhizosphere bacterial community. Among them, the application of CuO nanoparticles significantly affected the abundance of beneficial Streptomyces bacteria. This research provides evidence and strategies for using metal oxide nanoparticles to prevent and control soil-borne disease tomato bacterial wilt.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yeon Bee Kim, Tae Woong Whon, Joon Yong Kim, Juseok Kim, Yujin Kim, Se Hee Lee, Seong-Eun Park, Eun-Ju Kim, Hong-Seok Son, Seong Woon Roh
Summary: Although little is known about the urogenital archaeome, several reports have indicated its association with health in other body sites. This study aimed to determine the presence and diversity of archaeomes in the human urogenital tract. Analysis of urine samples from 373 asymptomatic individuals revealed the presence of diverse archaea, including Methanobacteriota, Thermoproteota, and Halobacteriota. The urogenital archaeome showed partial taxonomic compositional similarities with archaeomes from other body sites. These findings provide new insights into the role of archaea in urinary tract health.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Massa Saab, Denis Mestivier, Masoudreza Sohrabi, Christophe Rodriguez, Mahmood Reza Khonsari, Amirhossein Faraji, Iradj Sobhani
Summary: The study found a significant difference in biliary microbiota between extrahepatic cholangiocarcinoma (CCA) patients and controls without associated diseases, indicating a specific CCA-related dysbiosis. This suggests that a microbial community may be involved in the pathogenesis of CCA.
Article
Multidisciplinary Sciences
Alexander T. Neu, Eric E. Allen, Kaustuv Roy
Summary: The term core microbiome refers to a set of microbial taxa or attributes associated with those taxa that are characteristic of a host or environment, with little consensus on how it should be quantified in practice. Various metrics have been used, but many are susceptible to biases, highlighting the need for standardized metrics for studying core microbiomes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Hao-En Jan, Chin-Shiang Tsai, Nan-Yao Lee, Pei-Fang Tsai, Li-Rong Wang, Po-Lin Chen, Wen-Chien Ko
Summary: This case report describes a rare infection of Francisella novicida in Taiwan, in a patient with end-stage renal disease and a history of other medical conditions. The patient recovered after antimicrobial therapy.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Miranda K. Stotz, Darren D. Henry, Whitney L. Crossland
Summary: Bovine liver abscesses have been characterized by both cultural and DNA methods, with non-abscessed livers showing presence of potentially pathogenic bacteria in apparently healthy tissue.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Medicine, General & Internal
Lauro Vieira Perdigao Neto, Micheli Medeiros, Suzete Cleusa Ferreira, Anna Shoko Nishiya, Denise Brandao de Assis, Icaro Boszczowski, Silvia Figueiredo Costa, Anna S. Levin
Summary: This study aimed to develop and test a molecular method for diagnosing bacterial meningitis after neurosurgery. The results showed that the molecular method could successfully identify microorganisms in culture-negative samples, providing important guidance for the diagnosis and treatment of meningitis.
Article
Multidisciplinary Sciences
Ahmed Saeedi, Nicola J. Cummings, Denise McLean, Ian F. Connerton, Phillippa L. Connerton
Summary: ASxL5(T) is a novel Gram-stain negative bacterium with unique growth characteristics and morphology, closely related to members of the Oceanospirillaceae.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Vassilis E. Papadopoulos, Kostas Patas, Argyro Tountopoulou, Georgios Velonakis, Fotini Boufidou, Stylianos Chatzipanagiotou, Sofia Vassilopoulou
Summary: Neurobrucellosis can present in various clinical forms and diagnosis can be challenging, requiring multiple testing methods such as analysis of cerebrospinal fluid and serological testing. This case highlights the importance of establishing diagnostic criteria for neurobrucellosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemical Research Methods
Duleepa Jayasundara, Damayanthi Herath, Damith Senanayake, Isaam Saeed, Cheng-Yu Yang, Yuan Sun, Bill C. Chang, Sen-Lin Tang, Saman K. Halgamuge
BMC BIOINFORMATICS
(2019)
Article
Chemistry, Medicinal
Thuy G. Le, Abhijit Kundu, Atanu Ghoshal, Nghi H. Nguyen, Sarah Preston, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Jennifer Keiser, Andreas Hofmann, Bill C. H. Chang, Jose Garcia-Bustos, Timothy N. C. Wells, Michael J. Palmer, Abdul Jabbar, Robin B. Gasser, Jonathan B. Baell
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Review
Infectious Diseases
Ali Rostami, Guangxu Ma, Tao Wang, Anson Koehler, Andreas Hofmann, Bill C. H. Chang, Calum N. Macpherson, Robin B. Gasser
INFECTION GENETICS AND EVOLUTION
(2019)
Article
Chemistry, Medicinal
H. M. P. Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Aya C. Taki, Russell S. Addison, Sasha Hayes, Karren D. Beattie, Sean L. McGee, Sheree D. Martin, Merrick G. Ekin, John N. A. Hooper, Bill C. H. Chang, Andreas Hofmann, Rohan A. Davis, Robin B. Gasser
Article
Biochemical Research Methods
Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K. Korhonen, Andreas J. Stroehlein, Neil D. Young, Andreas Hofmann, Bill C. H. Chang, Nicholas A. Williamson, Robin B. Gasser
JOURNAL OF PROTEOMICS
(2020)
Article
Parasitology
Marziyeh Anari, Andreas J. Stroehlein, Ross S. Hall, Bill C. H. Chang, Robin B. Gasser, Neil D. Young
PARASITES & VECTORS
(2020)
Article
Biochemistry & Molecular Biology
H. M. P. Dilrukshi Herath, Aya C. Taki, Nghi Nguyen, Jose Garcia-Bustos, Andreas Hofmann, Tao Wang, Guangxu Ma, Bill C. H. Chang, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Article
Microbiology
Aya C. Taki, Robert Brkljaca, Tao Wang, Anson Koehler, Guangxu Ma, Jill Danne, Sarah Ellis, Andreas Hofmann, Bill C. H. Chang, Abdul Jabbar, Sylvia Urban, Robin B. Gasser
Article
Chemistry, Medicinal
Sarah Preston, Jose Garcia-Bustos, Liam G. Hall, Sheree D. Martin, Thuy G. Le, Abhijit Kundu, Atanu Ghoshal, Nghi H. Nguyen, Yaqing Jiao, Banfeng Ruan, Lian Xue, Fei Huang, Bill C. H. Chang, Sean L. McGee, Timothy N. C. Wells, Michael J. Palmer, Abdul Jabbar, Robin B. Gasser, Jonathan B. Baell
Summary: A series of novel compounds were synthesized as potent inhibitors of Haemonchus contortus, the parasitic nematode of sheep, showing high selectivity in mammalian cell lines but causing acute toxicity in rodents, possibly due to respiratory inhibition. Additionally, potent cytotoxicity was observed in rat hepatocytes, unrelated to toxicity in respiring cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Neil D. Young, Andreas J. Stroehlein, Liina Kinkar, Tao Wang, Woon-Mok Sohn, Bill C. H. Chang, Parwinder Kaur, David Weisz, Olga Dudchenko, Erez Lieberman Aiden, Pasi K. Korhonen, Robin B. Gasser
Summary: The Chinese liver fluke causes the disease clonorchiasis, affecting millions of people in various regions. Chronic clonorchiasis can lead to cholangitis and even cholangiocarcinoma. Control of the disease in endemic regions is difficult due to the risk of drug resistance, underscoring the need for new interventions. By using advanced DNA sequencing and informatics, a high-quality reference genome for C. sinensis was constructed, which can expedite molecular investigations and aid in the discovery of new interventions for this neglected disease complex.
Article
Biotechnology & Applied Microbiology
Guo-Hua Liu, Pasi K. Korhonen, Neil D. Young, Jiang Lu, Tao Wang, Yi-Tian Fu, Anson V. Koehler, Andreas Hofmann, Bill C. H. Chang, Shuai Wang, Nan Li, Chu-Yu Lin, Hui Zhang, Lingzi Xiangli, Lin Lin, Wei-Min Liu, Nan Li, Hua-Wei Li, Robin B. Gasser, Xing-Quan Zhu
Summary: This study presents a draft genome of the tapeworm Dipylidium caninum and compares it with other cestode genomes. The genome of D. caninum is predicted to encode around 10,000 protein-coding genes, with various key protein groups identified and potential intervention targets predicted for further evaluation. The study also investigates the genetic relationships of cestodes using shared single-copy orthologous sequences, providing new insights into the molecular biology of D. caninum and serving as a resource for comparative genomic and genetic explorations.
Article
Biochemistry & Molecular Biology
Liina Kinkar, Robin B. Gasser, Bonnie L. Webster, David Rollinson, D. Timothy J. Littlewood, Bill C. H. Chang, Andreas J. Stroehlein, Pasi K. Korhonen, Neil D. Young
Summary: This study demonstrates how third-generation long-read sequencing and informatic methods can accurately characterize long non-coding, tandem-repetitive regions in mitochondrial genomes, overcoming challenges faced by conventional sequencing methods. The discovery of a large tandem-repetitive non-coding region in a metazoan organism raises questions about the evolution and function of potential control regions in mt genomes, prompting further exploration using Nanopore-informatic workflows.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aya C. Taki, Abdul Jabbar, Thomas Kurz, Beate Lungerich, Guangxu Ma, Joseph J. Byrne, Marc Pflieger, Yodita Asfaha, Fabian Fischer, Bill C. H. Chang, Brad E. Sleebs, Robin B. Gasser
Summary: Due to widespread multi-drug resistance in parasitic nematodes of livestock animals, there is an urgent need to discover new anthelmintics with distinct mechanisms of action. Screening of 245 chemically-diverse small molecules revealed three compounds (MPK18, MPK334, and YAK308) that showed nematocidal activity against Haemonchus contortus, inhibiting larval motility and development without toxicity to human liver cells. Further evaluation and optimization of these compounds may lead to novel anthelmintic candidates.
Article
Chemistry, Medicinal
Aya C. Taki, Joseph J. Byrne, Tao Wang, Brad E. Sleebs, Nghi Nguyen, Ross S. Hall, Pasi K. Korhonen, Bill C. H. Chang, Paul Jackson, Abdul Jabbar, Robin B. Gasser
Summary: Parasitic worms cause significant diseases in animals and humans globally, highlighting the importance of controlling them for health and productivity. A high throughput screening assay was established to identify potential inhibitors against specific larvae, potentially leading to the discovery of more effective anthelmintic drugs. This advancement in screening methods could play a key role in developing better treatments for parasitic nematodes to combat drug resistance.
Article
Biochemistry & Molecular Biology
Aya C. Taki, Joseph J. Byrne, Abdul Jabbar, Kah Yean Lum, Sasha Hayes, Russell S. Addison, Kelsey S. Ramage, Andreas Hofmann, Merrick G. Ekins, Tao Wang, Bill C. H. Chang, Rohan A. Davis, Robin B. Gasser
Summary: Screening of extracts derived from marine invertebrates from Australian waters identified several active compounds with potential anthelmintic properties, primarily sourced from sponges. Further chemical investigations on these prioritized extracts may lead to the discovery of novel anthelmintic compounds.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.