Article
Neurosciences
Caitlin A. Orsini, Travis E. Brown, Travis E. Hodges, Yanaira Alonso-Caraballo, Catharine A. Winstanley, Jill B. Becker
Summary: Sex differences in motivation for food rewards, gambling, and drugs of abuse are influenced by sensory stimuli, gonadal hormones, and cognitive bias. Neural systems regulating executive functions respond differently to cues, drugs of abuse, and a high-fat diet in males and females. Gonadal hormones mediate sex differences in risky decision-making, cognitive bias, and motivation for food and drugs of abuse in both sexes.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Multidisciplinary Sciences
Xinyu Qian, Michelle L. Townsend, Wan Jie Tan, Brin F. S. Grenyer
Summary: Borderline Personality Disorder (BPD) is often perceived as a disorder more prevalent in females, however, the literature on sex differences is inconclusive. This scoping review aimed to synthesize available research evidence on potential sex differences in BPD. The review found that males with BPD were more likely to exhibit externalizing symptoms and comorbid disorders, while females with BPD were more likely to exhibit internalizing symptoms and comorbid disorders. However, there is a lack of research on sex differences in treatment outcomes, developmental factors, and biological markers of BPD.
Article
Substance Abuse
Jennifer L. L. Stewart, Kaiping Burrows, Chrysantha B. B. Davis, Ricardo A. A. Wilhelm, Breanna A. A. McNaughton, Rayus Kuplicki, Martin P. P. Paulus, Sahib S. S. Khalsa, Evan J. J. White
Summary: This study aimed to investigate sex differences in the relationship between impulsivity and amphetamine use disorder (AMP). The results showed that both male and female amphetamine users exhibited impulsive behavior in the presence of positive and negative mood states and activated right hemisphere regions during inhibitory processing. However, female amphetamine users had difficulties in planning ahead, while male amphetamine users required additional left hemisphere resources during inhibitory processing.
Article
Neurosciences
Wojciech Glac, Joanna Dunacka, Beata Grembecka, Grzegorz Swiatek, Irena Majkutewicz, Danuta Wrona
Summary: The study found that chronic, random AMPH treatment and AMPH challenge after withdrawal led to prolonged peripheral immunosuppressive responses and accelerated drug-induced systemic corticosterone responses. This suggests prolonged immunosuppressive effects and an increase in the incidence of infectious diseases.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hasitha Chavva, Daniel A. Brazeau, James Denvir, Donald A. Primerano, Jun Fan, Sarah L. Seeley, Boyd R. Rorabaugh
Summary: The study found that female rats are more sensitive than males to methamphetamine-induced changes in the myocardial transcriptome, with the largest changes involving genes that impact myocardial ischemic injury. However, all changes in gene expression identified at day 11 returned to baseline by day 30 after discontinuation of methamphetamine.
Article
Endocrinology & Metabolism
Jay O'Shields, Jeremy J. Gibbs
Summary: The study explores the relationship between childhood maltreatment and adult depressive symptoms, examining the mediating role of allostatic load. Differences in predicting depressive symptoms between males and females were found, emphasizing the need to consider sex differences in predictor variables for future studies.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura E. J. Peeters, Leonardien K. Tjong, Wim J. R. Rietdijk, Teun van Gelder, Birgit C. P. Koch, Jorie Versmissen
Summary: This study aimed to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients, as well as adherence to spironolactone and other antihypertensive drugs (AHDs) between sexes. The findings showed no significant sex differences in spironolactone and canrenone concentrations after adjusting for dose and time. Non-adherence to spironolactone was not significantly different between males and females, but it was associated with non-adherence to other AHDs. Although not statistically significant, females were more likely to be non-adherent to spironolactone compared to males, and thus more likely to be non-adherent to other AHDs.
Review
Pharmacology & Pharmacy
Juan Tamargo, Ricardo Caballero, Eva Delpon
Summary: There are significant differences between men and women with heart failure (HF), including the distribution of HF types and response to treatment. However, current clinical guidelines do not provide specific recommendations for women with HF, particularly in terms of drug efficacy and safety.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Neurosciences
Emily J. Jaehne, Joel D. Smith, Maarten van den Buuse
Summary: The aim of this study was to compare the levels of methamphetamine (Meth) and amphetamine (Amph) in the brains of male and female mice. The results showed that Meth and Amph levels were significantly higher at 30 min compared to 120 min after administration of Meth. There were no sex differences in Meth levels, but females had significantly higher levels of Amph compared to males. The ratio of Amph to Meth levels was significantly higher in females at 120 min after Meth administration. In a separate cohort of mice, Meth treatment induced locomotor hyperactivity, which was similar between males and females. However, mild hyperactivation was observed in female mice at 60-120 min post-injection with a lower dose of Meth. These findings suggest sex differences in the conversion of Meth to Amph in mice, which may contribute to sex differences in the behavioral, addictive, and neurotoxic properties of Meth.
NEUROSCIENCE LETTERS
(2022)
Review
Pharmacology & Pharmacy
Christine M. Madla, Francesca K. H. Gavins, Hamid A. Merchant, Mine Orlu, Sudaxshina Murdan, Abdul W. Basit
Summary: There is a clear gender gap in pharmaceutical research, with women experiencing more adverse reactions and suboptimal drug therapy than men. Researchers are recommended to consider sex differences in methodologies and analyses to strengthen scientific rigor and promote personalized medicine.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Medicine, General & Internal
Andre Farkouh, Christoph Baumgaertel, Roman Gottardi, Margit Hemetsberger, Martin Czejka, Alexandra Kautzky-Willer
Summary: There is increasing evidence of sex differences in the action of anti-inflammatory drugs, with women being at significantly higher risk of adverse effects. Men tend to have stronger anti-thrombotic activity with COX-inhibitors, while women are more sensitive to corticosteroids when their estradiol levels are high. Research on sex differences in drug effectiveness and safety is growing, but findings are often anecdotal and controversial, with a lack of systematic sex-differentiated reporting in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Behavioral Sciences
Norbert Abela, Katie Haywood, Giuseppe Di Giovanni
Summary: Adolescence is a critical developmental period with significant anatomical, neurochemical and behavioral changes. Adolescents are more sensitive to the long-term negative effects of drug abuse, particularly binge-like consumption of alcohol, marijuana and smoking. However, the long-term effects of simultaneous exposure to these substances during adolescence have not yet been experimentally investigated.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Substance Abuse
Taisuke Yamamoto, Takashi Kimura, Akiko Tamakoshi, Toshihiko Matsumoto
Summary: This study examined the use of methamphetamine among patients in Japan, focusing on sex differences. The findings suggest that treatment for methamphetamine use disorder should consider the social relationships of women, and provide more accessible outpatient clinics and treatment programs for younger and working patients. Comorbid substance abuse should also be assessed and treated.
AMERICAN JOURNAL ON ADDICTIONS
(2022)
Review
Pharmacology & Pharmacy
Yuting Shan, Lee Cheung, Yuqi Zhou, Yingbo Huang, R. Stephanie Huang
Summary: This review summarizes the current knowledge on sex differences in adverse drug reactions (ADRs) of commonly used psychotropic, cardiovascular, and analgesic medications. The main findings suggest that more than half of the evaluated ADRs show a sex difference in occurrence rate, with some medications causing more adverse reactions in women and others in men.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Criminology & Penology
Nicholas D. Thomson, Kiril Bozgunov, Elena Psederska, Michel Aboutanos, Georgi Vasilev, Jasmin Vassileva
Summary: Research has found differences in the relationship between psychopathy and aggression in men and women, with the moderating effect of lifetime physical abuse (LPA). Physical aggression is associated with the affective facet of psychopathy in both genders, while verbal aggression is linked to the antisocial facet and LPA in men. Indirect aggression is related to different facets of psychopathy in men and women, with protective factors identified for women. The interaction between LPA and psychopathy plays a role in shaping the risk of aggression forms for men and women, highlighting the need for gender-specific interventions.
JOURNAL OF INTERPERSONAL VIOLENCE
(2021)