Article
Nutrition & Dietetics
Kirsty M. Mckenzie, Reeja Nasir, Yang Kong, Hasthi U. Dissanayake, Rowena McMullan, Adrienne Gordon, Alice Meroni, Melinda Phang, Michael R. Skilton
Summary: Evidence from animal models suggests that maternal diet during pregnancy may affect offspring cardiometabolic health. However, in healthy pregnancies, neither the quantity nor quality of maternal carbohydrate intake appears to have a significant impact on newborn aortic intima-medial thickness, except for fiber intake in overweight or obese women. The effect of carbohydrate quality may be more pronounced in high-risk pregnancies.
Review
Genetics & Heredity
Zhen Zhou, Alana C. Cecchi, Siddharth K. Prakash, Dianna M. Milewicz
Summary: This article discusses the main risk factors associated with thoracic aortic aneurysms and dissections (TAD), including genetic variants and environmental conditions, and explores the underlying mechanisms leading to TAD.
Article
Engineering, Biomedical
Marta Kozun, Agnieszka Chwilkowska, Celina Pezowicz, Magdalena Kobielarz
Summary: This study analyzed the influence of atherosclerosis on the anisotropic and incompressible behavior of the human thoracic aortic wall under mechanical loads. It found that atherosclerosis progression leads to a gradual loss of anisotropic character in the thoracic aortic wall, while the incompressibility remains unaffected. The study is the first to present changes in mechanical properties at all stages of atherosclerotic development.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Axel Diederichsen, Jes Sanddal Lindholt, Jacob Eifer Moller, Oke Gerke, Lars Melholt Rasmussen, Jordi S. Dahl
Summary: This study describes the natural history of aortic valve calcification (AVC) progression in the general population and identifies sex differences in factors associated with this progression rate. The magnitude of the AVC score was the most important marker of AVC progression, but dyslipidemia was associated with progression only among men and hypertension was associated with progression only among women.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Rheumatology
Sabina Oreska, Hana Storkanova, Aneta Pekacova, Jaroslav Kudlicka, Vladimir Tuka, Ondrej Mikes, Zdislava Krupickova, Martin Satny, Eva Chytilova, Jan Kvasnicka, Maja Spiritovic, Barbora Hermankova, Petr Cesak, Marian Rybar, Karel Pavelka, Ladislav Senolt, Herman Mann, Jiri Vencovsky, Michal Vrablik, Michal Tomcik
Summary: This study aimed to evaluate cardiovascular (CV) risk in patients with idiopathic inflammatory myopathies (IIM) compared with healthy controls (HC) and assess its association with disease-specific features. The study found a significantly higher prevalence of traditional CV risk factors, carotid artery disease (CARD), abnormal ankle-brachial index (ABI) and pulse wave velocity (PWV) in IIM patients compared with HC. Furthermore, the study demonstrated that the Systematic COronary Risk Evaluation (SCORE) was inaccurate in predicting CV risk in IIM.
Article
Cardiac & Cardiovascular Systems
Edward Franek, Prem Pais, Jan Basile, Claudia Nicolay, Sohini Raha, Ana Hickey, Nadia. N. N. Ahmad, Manige Konig, Hong Kan, Hertzel. C. C. Gerstein
Summary: In this post hoc analysis, researchers analyzed data from 4952 patients with type 2 diabetes and found that waist-to-hip ratio, waist circumference, and waist circumference adjusted for hip circumference were independent risk factors for cardiovascular disease outcomes. However, body mass index was only a risk factor for heart failure requiring hospitalization. These findings indicate the importance of considering body fat distribution when assessing cardiovascular risk.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Peripheral Vascular Disease
Christian Zambach, Artur Fedorowski, Sofia Gerward, Madeleine Johansson, Gunnar Engstrom, Viktor Hamrefors
Summary: This study examined the relationship between orthostatic blood pressure response, resting heart rate, and cardiovascular risk factors in the general population. The findings suggest that subclinical abnormalities in cardiovascular autonomic function, such as impaired and exaggerated orthostatic blood pressure response and increased resting heart rate, are associated with markers of increased cardiovascular risk.
JOURNAL OF HYPERTENSION
(2023)
Article
Medicine, General & Internal
Hai Deng, Ting-Xuan Tang, Liang-Sheng Tang, Deng Chen, Jia-Liu Luo, Li-Ming Dong, Si-Hai Gao, Zhao-Hui Tang
Summary: This study found that the incidence of blunt aortic injury in patients with burst fractures of the thoracic spine is 11.3% and often missed. Risk factors for aortic injury include injury severity score, mechanism of injury (such as crush), flail chest, and neurological deficit.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Onur B. B. Dolmaci, Sulayman El Mathari, Antoine H. G. Driessen, Robert J. M. Klautz, Robert E. E. Poelmann, Jan H. N. Lindeman, Nimrat Grewal
Summary: This study aimed to test whether thoracic aortic aneurysms are also associated with an increased cardiovascular risk burden. The results showed a higher prevalence of hypertension and a lower prevalence of diabetes in patients with thoracic aneurysms compared to the general population. Therefore, unlike abdominal aortic aneurysms, thoracic aneurysms do not need cardiovascular risk management in treatment guidelines, but hypertension should be treated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Jian-Jun Li, Hui-Hui Liu, Sha Li
Summary: China is facing a cardiovascular disease crisis due to rapid economic growth and changes. The prevalence of cardiometabolic risk factors has increased over the past decades, leading to a rise in deaths from cardiovascular diseases. This narrative review provides an updated overview of the epidemiology of cardiometabolic risk factors in China and discusses strategies to tackle this pandemic. Effective interventions and treatments for these risk factors are also highlighted in this review.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Rebecca Angoff, Ramya C. Mosarla, Connie W. Tsao
Summary: AoS is a maladaptive response to hemodynamic stress, associated with increased afterload for the heart, making it a marker of cardiovascular health and metabolic dysfunction. Research on biomarkers linked to increased AoS may provide insights into future pathophysiologic pathways and therapeutic targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lida Khurrami, Jacob Eifer Moller, Jordi Sanchez Dahl, Rasmus Carter-Storch, Nicolaj Lyhne Christensen, Manan Pareek, Jes Sanddal Lindholt, Axel Cosmus Pyndt Diederichsen
Summary: The study aimed to assess aortic valve calcification (AVC) in individuals aged 65-75 using non-contrast cardiac computed tomography (NCCT), finding that AVC is associated with most known cardiovascular risk factors and that AVC >= 300 AU is linked to concentric remodeling and left atrial dilatation.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Josephina Haunschild, Sarah Jane Barnard, Martin Misfeld, Diyar Saeed, Piroze Davierwala, Sergey Leontyev, Meinhard Mende, Michael A. Borger, Christian D. Etz
Summary: The study found that aortic diameter and conventional indices of aortic risk do not correlate with aortic wall thickness, suggesting the need for other indicators to identify high-risk patients for aortic complications.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Julie W. Doberne, Ashraf A. Sabe, Andrew M. Vekstein, Charles M. Wojnarski, Jatin Anand, Soraya Voight, Vignesh Raman, Samantha Halpern, Jenna L. Armstrong, Alexander Zhu, E. Hope Weissler, Oliver K. Jawitz, Adam R. Williams, G. Chad Hughes
Summary: This study investigated the incidence, risk factors, and outcomes of stent graft-induced aortic wall injury (SAWI) after thoracic endovascular aortic repair (TEVAR). The results showed that the incidence of SAWI after TEVAR was low (9%), but nearly one third of the patients required reintervention. TEVAR for acute dissection and use of devices with proximal bare springs or barbs were associated with an increased incidence of SAWI.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, Research & Experimental
Jing Yang, Jiayi Lu, Junyan Miao, Jiacong Li, Meng Zhu, Juncheng Dai, Hongxia Ma, Guangfu Jin, Dong Hang
Summary: This study evaluated the predictive ability of blood biomarkers for mortality risk and identified 13 biomarkers for men and 17 biomarkers for women that independently predict mortality risk. Blood biomarker scores can predict overall mortality and specific diseases, and can help identify high-risk individuals and improve targeted prevention of premature death.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Luis R. Lopes, Maria-Angela Losi, Nabeel Sheikh, Cecile Laroche, Philippe Charron, Juan Gimeno, Juan P. Kaski, Aldo P. Maggioni, Luigi Tavazzi, Eloisa Arbustini, Dulce Brito, Jelena Celutkiene, Albert Hagege, Ales Linhart, Jens Mogensen, Jose Manuel Garcia-Pinilla, Tomas Ripoll-Vera, Hubert Seggewiss, Eduardo Villacorta, Alida Caforio, Perry M. Elliott
Summary: Common cardiovascular risk factors are associated with a more severe form of hypertrophic cardiomyopathy, suggesting the need for proactive management. There is an interaction between genotype and cardiovascular risk factors in certain traits.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Endocrinology & Metabolism
Anitha Pitchika, Marcello Ricardo Paulista Markus, Sabine Schipf, Alexander Teumer, Sandra Van der Auwera, Matthias Nauck, Marcus Doerr, Stephan Felix, Hans Joergen Grabe, Henry Voelzke, Till Ittermann
Summary: The study aims to examine the association of different APOE alleles with T2DM and MetS, as well as the influence of hs-CRP on these associations. The results show that E4 carriers have a lower odds of developing T2DM, while both E2 and E4 carriers have higher odds of developing MetS. The association between E4 alleles and T2DM is moderately attenuated after adjusting for hs-CRP levels.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Eliana Portilla-Fernandez, Derek Klarin, Shih-Jen Hwang, Mary L. Biggs, Joshua C. Bis, Stefan Weiss, Susanne Rospleszcz, Pradeep Natarajan, Udo Hoffmann, Ian S. Rogers, Quynh A. Truong, Uwe Voelker, Marcus Doerr, Robin Buelow, Michael H. Criqui, Matthew Allison, Santhi K. Ganesh, Jie Yao, Melanie Waldenberger, Fabian Bamberg, Kenneth M. Rice, Jeroen Essers, Daniek M. C. Kapteijn, Sander W. van der Laan, Rob J. de Knegt, Mohsen Ghanbari, Janine F. Felix, M. Arfan Ikram, Maryam Kavousi, Andre G. Uitterlinden, Anton J. M. Roks, A. H. Jan Danser, Philip S. Tsao, Scott M. Damrauer, Xiuqing Guo, Jerome Rotter, Bruce M. Psaty, Sekar Kathiresan, Henry Voelzke, Annette Peters, Craig Johnson, Konstantin Strauch, Thomas Meitinger, Christopher J. O'Donnell, Abbas Dehghan
Summary: In this study, genetic and clinical determinants of abdominal aortic diameter (AAD) were investigated, revealing associations of the LDLRAD4 and SLC22A20 genes with AAD, as well as establishing a causal relationship between pulse pressure, triglycerides, height, and AAD. These findings offer insights into new biology and highlight gene regions in mechanisms previously implicated in the genetics of other vascular diseases.
HUMAN MOLECULAR GENETICS
(2022)
Article
Immunology
Rico Feldtmann, Andreas Kuemmel, Bishwas Chamling, Anne Strohbach, Kristin Lehnert, Stefan Gross, Lisa Loerzer, Alexander Riad, Diana Lindner, Dirk Westermann, Jens Fielitz, Marcus Doerr, Stephan B. Felix
Summary: Plasma levels of myeloid differentiation factor-2 (MD-2), a co-receptor of toll-like-receptor 4 (TLR4), predict mortality independently in patients with dilated cardiomyopathy (DCM). This study shows that MD-2 contributes to immune activation and inflammatory status in DCM patients by promoting monocyte activation and endothelial cell-mediated monocyte recruitment.
Article
Public, Environmental & Occupational Health
Henry Volzke, Janka Schoessow, Carsten Oliver Schmidt, Clemens Juergens, Adrian Richter, Andre Werner, Nicole Werner, Dorte Radke, Alexander Teumer, Till Ittermann, Birgit Schauer, Vivien Henck, Nele Friedrich, Anke Hannemann, Theresa Winter, Matthias Nauck, Marcus Doerr, Martin Bahls, Stephan B. Felix, Beate Stubbe, Ralf Ewert, Fabian Frost, Markus M. Lerch, Hans J. Grabe, Robin Buelow, Markus Otto, Norbert Hosten, Wolfgang Rathmann, Ulf Schminke, Rico Grossjohann, Frank Tost, Georg Homuth, Uwe Voelker, Stefan Weiss, Silva Holtfreter, Barbara M. Broeker, Kathrin Zimmermann, Lars Kaderali, Marc Winnefeld, Boris Kristof, Klaus Berger, Stefanie Samietz, Christian Schwahn, Birte Holtfreter, Reiner Biffar, Stefan Kindler, Katharina Wittfeld, Wolfgang Hoffmann, Thomas Kocher
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Hematology
Gerard Temprano-Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin-Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater-Lleal
Summary: This study discovered four novel genetic loci by combining summary data of different hemostatic traits and disease events, contributing to the understanding of the relationship between hemostasis and cardiovascular events and elucidating common genetic factors between these traits.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Catherine M. Francis, Matthias E. Futschik, Jian Huang, Wenjia Bai, Muralidharan Sargurupremraj, Alexander Teumer, Monique M. B. Breteler, Enrico Petretto, Amanda S. R. Ho, Philippe Amouyel, Stefan T. Engelter, Robin Buelow, Uwe Voelker, Henry Voelzke, Marcus Doerr, Mohammed-Aslam Imtiaz, N. Ahmad Aziz, Valerie Lohner, James S. Ware, Stephanie Debette, Paul Elliott, Abbas Dehghan, Paul M. Matthews
Summary: The study identifies genetic variants associated with aortic distensibility, highlighting the causal relationships between aortic distensibility and aortic aneurysms as well as brain small vessel disease. The findings provide new insights into the mechanisms related to cardiovascular development, extracellular matrix production, and smooth muscle cell contraction.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Andreas Kuemmel, Stefan Gross, Rico Feldtmann, Bishwas Chamling, Anne Strohbach, Kristin Lehnert, Martin Bahls, Lisa Loerzer, Katharina Moormann, Jeannine Witte, Alexander Riad, Marcus Doerr, Jens Fielitz, Stephan B. Felix
Summary: This study found that the levels of HMGB1 were associated with increased mortality in patients with dilated cardiomyopathy. Multivariable Cox regression analysis confirmed HMGB1 as a risk factor for mortality in DCM patients, independent of NT-proBNP, age, and gender.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Genetics & Heredity
Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Tim Moore, Daiane Hemerich, Marilyn C. Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S. Ahluwalia, Traci M. Bartz, Amy R. Bentley, Lawrence F. Bielak, Mike Chong, Audrey Y. Chu, Diane Berry, Rajkumar Dorajoo, Nicole D. Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F. Feitosa, Christian Gieger, Mariaelisa Graff, Leanne M. Hall, Toomas Haller, Fernando P. Hartwig, David A. Hillis, Ville Huikari, Nancy Heard-Costa, Christina Holzapfel, Anne U. Jackson, Asa Johansson, Anja Moltke Jorgensen, Marika A. Kaakinen, Robert Karlsson, Kathleen F. Kerr, Boram Kim, Chantal M. Koolhaas, Zoltan Kutalik, Vasiliki Lagou, Penelope A. Lind, Mattias Lorentzon, Leo-Pekka Lyytikainen, Massimo Mangino, Christoph Metzendorf, Kristine R. Monroe, Alexander Pacolet, Louis Perusse, Rene Pool, Rebecca C. Richmond, Natalia Rivera, Sebastien Robiou-Du-Pont, Katharina E. Schraut, Christina-Alexandra Schulz, Heather M. Stringham, Toshiko Tanaka, Alexander Teumer, Constance Turman, Peter J. Van der Most, Mathias Vanmunster, Frank J. A. Van Rooij, Jana V. Van Vliet-Ostaptchouk, Xiaoshuai Zhang, Jing-Hua Zhao, Wei Zhao, Zhanna Balkhiyarova, Marie N. Balslev-Harder, Sebastian E. Baumeister, John Beilby, John Blangero, Dorret Boomsma, Soren Brage, Peter S. Braund, Jennifer A. Brody, Marcel Bruinenberg, Ulf Ekelund, Ching-Ti Liu, John W. Cole, Francis S. Collins, L. Adrienne Cupples, Tonu Esko, Stefan Enroth, Jessica D. Faul, Lindsay Fernandez-Rhodes, Alison E. Fohner, Oscar H. Franco, Tessel E. Galesloot, Scott D. Gordon, Niels Grarup, Catharina A. Hartman, Gerardo Heiss, Jennie Hui, Thomas Illig, Russell Jago, Alan James, Peter K. Joshi, Taeyeong Jung, Mika Kahonen, Tuomas O. Kilpelainen, Woon-Puay Koh, Ivana Kolcic, Peter P. Kraft, Johanna Kuusisto, Lenore J. Launer, Aihua Li, Allan Linneberg, Jian'An Luan, Pedro Marques Vidal, Sarah E. Medland, Yuri Milaneschi, Arden Moscati, Bill Musk, Christopher P. Nelson, Ilja M. Nolte, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Christine Power, Olli T. Raitakari, Magi Reedik, Alex P. Reiner, Paul M. Ridker, Igor Rudan, Kathy Ryan, Mark A. Sarzynski, Laura J. Scott, Robert A. Scott, Stephen Sidney, Kristin Siggeirsdottir, Albert Smith, Jennifer A. Smith, Emily Sonestedt, Marin Strom, E. Shyong Tai, Koon K. Teo, Barbara Thorand, Anke Toenjes, Angelo Tremblay, Andre G. Uitterlinden, Jagadish Vangipurapu, Natasja Van Schoor, Uwe Volker, Gonneke Willemsen, Kayleen Williams, Quenna Wong, Huichun Xu, Kristin L. Young, Jian Min Yuan, M. Carola Zillikens, Alan B. Zonderman, Adam Ameur, Stefania Bandinelli, Joshua C. Bis, Michael Boehnke, Claude Bouchard, Daniel Chasman, George Davey Smith, Eco J. C. De Geus, Louise Deldicque, Marcus Dorr, Michele K. Evans, Luigi Ferrucci, Myriam Fornage, Caroline Fox, Theodore Garland, Vilmundur Gudnason, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo L. Horta, Elina Hypponen, Marjo-Riitta Jarvelin, W. Craig Johnson, Sharon L. R. Kardia, Lambertus A. Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimaki, Loic Le Marchand, Patrik K. E. Magnusson, Nicholas G. Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E. North, Claes Ohlsson, Albertine J. Oldehinkel, Marju Orho-Melander, Guillaume Pare, Taesung Park, Oluf Pedersen, Brenda W. J. H. Penninx, Tune H. Pers, Ozren Polasek, Inga Prokopenko, Charles N. Rotimi, Nilesh J. Samani, Xueling Sim, Harold Snieder, Thorkild I. A. Sorensen, Tim D. Spector, Nicholas J. Timpson, Rob M. Van Dam, Nathalie Van der Velde, Cornelia M. Van Duijn, Peter Vollenweider, Henry Volzke, Trudy Voortman, Gerard Waeber, Nicholas J. Wareham, David R. Weir, Heinz-Erich Wichmann, James F. Wilson, Andrea L. Hevener, Anna Krook, Juleen R. Zierath, Martine A. Thomis, Ruth J. F. Loos, Marcel Den Hoed
Summary: Physical activity and sedentary behavior have genetic components, and this study identified 99 genetic loci associated with self-reported physical activity, leisure screen time, and sedentary behavior. Some genetic variants were found to affect muscle function and possibly protect against exercise-induced muscle damage. Mendelian randomization analyses also revealed that the beneficial effects of reducing sedentary behavior and increasing physical activity on health outcomes may be mediated or confounded by body mass index.
Article
Multidisciplinary Sciences
William J. Young, Najim Lahrouchi, Aaron Isaacs, Thuy Vy Duong, Luisa Foco, Farah Ahmed, Jennifer A. Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey Haessler, Leo-Pekka Lyytikainen, Linda Repetto, Maria Pina Concas, Marten E. van den Berg, Stefan Weiss, Antoine R. Baldassari, Traci M. Bartz, James P. Cook, Daniel S. Evans, Rebecca Freudling, Oliver Hines, Jonas L. Isaksen, Honghuang Lin, Hao Mei, Arden Moscati, Martina Mueller-Nurasyid, Casia Nursyifa, Yong Qian, Anne Richmond, Carolina Roselli, Kathleen A. Ryan, Eduardo Tarazona-Santos, Sebastien Theriault, Stefan van Duijvenboden, Helen R. Warren, Jie Yao, Dania Raza, Stefanie Aeschbacher, Gustav Ahlberg, Alvaro Alonso, Laura Andreasen, Joshua C. Bis, Eric Boerwinkle, Archie Campbell, Eulalia Catamo, Massimiliano Cocca, Michael J. Cutler, Dawood Darbar, Alessandro De Grandi, Antonio De Luca, Jun Ding, Christina Ellervik, Patrick T. Ellinor, Stephan B. Felix, Philippe Froguel, Christian Fuchsberger, Martin Gogele, Claus Graff, Mariaelisa Graff, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Paul L. Huang, Heikki Huikuri, Nina Hutri-Kahonen, M. Arfan Ikram, Rebecca D. Jackson, Juhani Junttila, Maryam Kavousi, Jan A. Kors, Thiago P. Leal, Rozenn N. Lemaitre, Henry J. Lin, Lars Lind, Allan Linneberg, Simin Liu, Peter W. MacFarlane, Massimo Mangino, Thomas Meitinger, Massimo Mezzavilla, Pashupati P. Mishra, Rebecca N. Mitchell, Nina Mononen, May E. Montasser, Alanna C. Morrison, Matthias Nauck, Victor Nauffal, Pau Navarro, Kjell Nikus, Guillaume Pare, Kristen K. Patton, Giulia Pelliccione, Alan Pittman, David J. Porteous, Peter P. Pramstaller, Michael H. Preuss, Olli T. Raitakari, Alexander P. Reiner, Antonio Luiz P. Ribeiro, Kenneth M. Rice, Lorenz Risch, David Schlessinger, Ulrich Schotten, Claudia Schurmann, Xia Shen, M. Benjamin Shoemaker, Gianfranco Sinagra, Moritz F. Sinner, Elsayed Z. Soliman, Monika Stoll, Konstantin Strauch, Kirill Tarasov, Kent D. Taylor, Andrew Tinker, Stella Trompet, Andre Uitterlinden, Uwe Voelker, Henry Voelzke, Melanie Waldenberger, Lu-Chen Weng, Eric A. Whitsel, James G. Wilson, Christy L. Avery, David Conen, Adolfo Correa, Francesco Cucca, Marcus Dorr, Sina A. Gharib, Giorgia Girotto, Niels Grarup, Caroline Hayward, Yalda Jamshidi, Marjo-Riitta Jarvelin, J. Wouter Jukema, Stefan Kaab, Mika Kahonen, Jorgen K. Kanters, Charles Kooperberg, Terho Lehtimaki, Maria Fernanda Lima-Costa, Yongmei Liu, Ruth J. F. Loos, Steven A. Lubitz, Dennis O. Mook-Kanamori, Andrew P. Morris, Jeffrey R. O'Connell, Morten Salling Olesen, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Bruce M. Psaty, Jerome Rotter, Bruno Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James F. Wilson, Dan E. Arking, Julia Ramirez, Pier D. Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B. Munroe
Summary: This study identified genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease associated with the heritable electrocardiographic measure, the QT interval. The findings advance our understanding of ventricular depolarization and repolarization and highlight potential therapeutic targets for arrhythmia.
NATURE COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Juliane Bauer, Madlen Steinbrueckner, Marcus Doerr, Martin Bahls, Thorsten Schmidt, Sabina Ulbricht
Summary: This study investigated sedentary behavior and physical activity levels in pregnant women. The results showed that pregnant women spent most of their day in sedentary activities, and only half of them met the recommendations for physical activity in the second and third trimester. The study suggests that sedentary behavior and physical activity should be given more attention in clinical practice and research to motivate pregnant women to adopt an active lifestyle.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2023)
Article
Cardiac & Cardiovascular Systems
Magdalena E. Haid, Stephanie Zylla, Marcello Ricardo Paulista Markus, Nele Friedrich, Ralf Ewert, Sven Glaeser, Stephan B. Felix, Marcus Doerr, Martin Bahls
Summary: The study found that cardiorespiratory fitness (CRF) was only associated with Gal-3 levels in men, while CRF adjusted for body weight was related to Gal-3 levels in women and men. Results suggest that the adverse consequences of low CRF may be mediated by Gal-3. Further research is needed to understand the sex-specific association between CRF and Gal-3 and their clinical relevance.
Article
Obstetrics & Gynecology
Guillermo Pierdant, Till Ittermann, Jennis Freyer-Adam, Ulrike Siewert-Markus, Hans Joergen Grabe, Marcus Doerr, Matthias Heckmann, Marek Zygmunt, Anja Erika Lange, Marcello Ricardo Paulista Markus
Summary: This study investigated the associations between the mother's socioeconomic and lifestyle factors, life satisfaction, and the delivery of a small for gestational age (SGA) infant. The study found that lower education and smoking during pregnancy were risk factors for delivering an SGA infant. Additionally, mothers of SGA infants were more frequently dissatisfied with their employment and financial status.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
Summary: This article introduces a method that combines radiotelemetry system and running wheels to determine spontaneous cage activity and voluntary exercise levels of individual animals in group-housed rodents. A software tool is developed for fast and reliable data analysis. This method can be used to study the benefits of physical activity and the impact of therapeutic interventions on animal behavior.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Norbert Hosten, Robin Buelow, Henry Voelzke, Martin Domin, Carsten Oliver Schmidt, Alexander Teumer, Till Ittermann, Matthias Nauck, Stephan Felix, Marcus Doerr, Marcello Ricardo Paulista Markus, Uwe Voelker, Amro Daboul, Christian Schwahn, Birte Holtfreter, Torsten Mundt, Karl-Friedrich Krey, Stefan Kindler, Maria Mksoud, Stefanie Samietz, Reiner Biffar, Wolfgang Hoffmann, Thomas Kocher, Jean-Francois Chenot, Andreas Stahl, Frank Tost, Nele Friedrich, Stephanie Zylla, Anke Hannemann, Martin Lotze, Jens-Peter Kuehn, Katrin Hegenscheid, Christian Rosenberg, Georgi Wassilew, Stefan Frenzel, Katharina Wittfeld, Hans J. Grabe, Marie-Luise Kromrey
Summary: The Study of Health in Pomerania conducted a population-based study using whole-body MR imaging in a rural area. Through analyzing the imaging sequences used and their citation frequency, fruitful sequences and focused body parts were identified. The study suggests that more precise goals should be defined when allocating imaging time and proposes recording the number and impact of published work for quality control.
