Article
Immunology
Jean-Paul Motta, Corinne Rolland, Anissa Edir, Ana-Carolina Florence, David Sagnat, Chrystelle Bonnart, Perrine Rousset, Laura Guiraud, Muriel Quaranta-Nicaise, Emmanuel Mas, Delphine Bonnet, Elena F. Verdu, Derek M. McKay, Etienne Buscail, Laurent Alric, Nathalie Vergnolle, Celine Deraison
Summary: Imbalance between proteases and their inhibitors is crucial in the development of Inflammatory Bowel Diseases (IBD). This study identifies a previously unrevealed production of elastase 2A (ELA2A) by colonic epithelial cells in IBD patients, leading to inflammation and loss of barrier function. Targeting ELA2A hyperactivity could be a potential treatment for IBD.
MUCOSAL IMMUNOLOGY
(2021)
Review
Immunology
Xiangjun Xiao, Xiangbing Mao, Daiwen Chen, Bing Yu, Jun He, Hui Yan, Jianping Wang
Summary: This review provides a detailed overview of the role of micro-ribonucleic acids (miRNAs) in the intestinal epithelial barrier of inflammatory bowel disease (IBD), including their regulation of inflammation, immunity, and microorganisms. The findings of this review contribute to the understanding of the interaction between miRNAs and the intestinal epithelial barrier in IBD and provide a theoretical reference for future prevention and treatment of IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Vanoli, Federica Grillo, Daniela Furlan, Giovanni Arpa, Oneda Grami, Camilla Guerini, Roberta Riboni, Luca Mastracci, Antonio Di Sabatino
Summary: The broader use of gastrointestinal endoscopic procedures has resulted in an increased detection of small intestinal precancerous and cancerous epithelial lesions, which are often associated with hereditary tumor syndromes and immune-related disorders. These lesions exhibit different molecular pathogenetic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lidiya V. Boldyreva, Maryana V. Morozova, Snezhanna S. Saydakova, Elena N. Kozhevnikova
Summary: Inflammatory bowel diseases (IBD) are chronic conditions characterized by inflammation in the gastrointestinal tract, with metabolic deregulation and changes in phospholipids being common features. Alterations in phospholipid composition, especially in phosphatidylcholine and lysophosphatidylcholine, are associated with the severity of inflammation in IBD patients. New strategies for treating IBD may involve controlling phospholipid and fatty acid levels through diet or pharmacological interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Liliana Lykowska-Szuber, Anna Maria Rychter, Magdalena Dudek, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Piotr Eder, Maciej Lesiak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Studies have shown an increased risk of cardiovascular disease in patients with IBD, potentially due to inflammation-induced endothelial dysfunction and development of CVD, as well as gut microbiota dysbiosis. Dietary patterns have also been identified to influence the relationship between IBD and CVD.
Review
Chemistry, Medicinal
Ines Ben Ghezala, Maeva Charkaoui, Christophe Michiels, Marc Bardou, Maxime Luu
Summary: Inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and Ulcerative Colitis (UC), are chronic disorders with an unclear pathogenesis. While tumor necrosis factor (TNF)-alpha inhibitors and other compounds have significantly improved the clinical management of IBDs, approximately one third of patients still have insufficient efficacy. Therefore, orally administered Small Molecules Drugs (SMDs) are being developed to address these issues.
Review
Medicine, General & Internal
Michael Stuerzl, Meik Kunz, Susanne M. Krug, Elisabeth Naschberger
Summary: Inflammatory bowel disease is a chronic inflammatory disorder with a rising incidence. Disease development involves the breakdown of the epithelial cell barrier, where blood vessels play a significant role in disease progression. The communication between the gut-vascular barrier and the epithelial barrier may contribute to the pathogenesis of IBD.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Sengul Beyaz, Erdem Akbal
Summary: This study investigated circulating levels of nesfatin-1 in patients with inflammatory bowel diseases (IBD), showing significantly elevated levels during active disease periods with good diagnostic value for IBD. Nesfatin-1 could serve as an additional inflammatory marker for the diagnosis of IBD.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Immunology
Zhou Zhou, Leonie G. G. Plug, Thiago A. A. Patente, Eveline S. M. de Jonge-Muller, Amir Abou Elmagd, Andrea E. van der Meulen-de Jong, Bart Everts, Marieke C. C. Barnhoorn, Lukas J. A. C. Hawinkels
Summary: Inflammatory bowel disease (IBD) is a chronic relapsing inflammation of the intestinal tract with unclear pathogenesis. This study found that glycolysis was increased in IBD intestinal samples and that PFKFB3 expression was elevated in IBD-derived stromal cells. Inhibition of PFKFB3 reduced the severity of colitis and suppressed inflammatory characteristics of fibroblasts.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Daniel C. Baumgart, Catherine Le Berre
Summary: This review discusses newer biologic and small-molecule therapies for inflammatory bowel disease, emphasizing the importance of achieving clinical and endoscopic remission as well as more precise molecular targeting of inflammatory cascades.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Francesca Penagini, Luisa Lonoce, Luisa Abbattista, Valentina Silvera, Giulia Rendo, Lucia Cococcioni, Dario Dilillo, Valeria Calcaterra, Gian Vincenzo Zuccotti
Summary: This review summarizes the most up-to-date literature on pediatric inflammatory bowel diseases (IBDs), including current treatment options and new strategies such as small molecule drugs and combination therapy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Sarah M. M. Ajabnoor, Atheer Attar, Noof BinJahlan, Nawal Almutairi, Shimaa Bashmail, Almoutaz Hashim, Alastair Forbes, Hani Jawa
Summary: This study investigated the practices and perceptions of gastroenterologists in Saudi Arabia regarding the use of enteral nutrition (EN) in patients with inflammatory bowel disease (IBD). The results showed that EN was mostly used for the prevention and correction of undernutrition, preoperative optimization, and induction of remission in patients with active and long-standing Crohn's disease (CD). The study also identified barriers to using EN, such as low patient acceptance and poor adherence.
Article
Oncology
J. Yu, E. Refsum, V Perrin, L. M. Helsingen, P. Wieszczy, M. Loberg, M. Bretthauer, H. O. Adami, W. Ye, J. Blom, M. Kalager
Summary: This population-based cohort study found that patients with inflammatory bowel disease (IBD) have a higher risk of small bowel adenocarcinoma and neuroendocrine tumors. Specifically, patients with Crohn's disease (CD) had an eightfold increased risk of small bowel adenocarcinoma, patients with both UC and CD had about a twofold increased risk of neuroendocrine tumors, and patients with UC had a twofold increased risk of small bowel adenocarcinoma. However, due to the small absolute excess cancer risk, active surveillance to diagnose small intestinal cancer early may not be cost-effective.
ANNALS OF ONCOLOGY
(2022)
Article
Immunology
Guanghui Cui, Shaojie Li, Hui Ye, Yao Yang, Qiuyue Huang, Yingming Chu, Zongming Shi, Xuezhi Zhang
Summary: The study revealed a significant causal association between genetically predicted Parkinson's disease and ulcerative colitis, while there was no causal link between genetically predicted Alzheimer's disease and inflammatory bowel disease. Further animal experiments or population-based observational studies are needed to elucidate the underlying mechanisms between Parkinson's disease and inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sumona Bhattacharya, Uni Wong, Mian Khalid, Hanna Blaney, Matthew G. Menkart, Jenna L. Oringher, Sonia L. Taneja, Christa S. Zerbe, Suk See De Ravin, Harry L. Malech, Steven M. Holland, Christopher Koh, Theo Heller
Summary: Patients with chronic granulomatous disease (CGD) may develop inflammatory bowel disease (IBD), but there is limited information about small bowel disease in this population. This study aimed to determine the prevalence and characteristics of small bowel disease, as well as evaluate the usefulness of video capsule endoscopy (VCE) for diagnosis. The results showed a high prevalence of small bowel IBD in patients with CGD, and radiology and duodenal/ileal disease did not correlate with VCE findings. Therefore, VCE-driven investigation should be considered for small bowel disease in CGD-associated IBD patients, especially those with colonic disease.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ammar Hassanzadeh Keshteli, Robert Tso, Levinus A. Dieleman, Heekuk Park, Karen I. Kroeker, Juan Jovel, Patrick M. Gillevet, Masoumeh Sikaroodi, Rupasri Mandal, Richard N. Fedorak, Karen L. Madsen
INFLAMMATORY BOWEL DISEASES
(2018)
Article
Gastroenterology & Hepatology
Garett Dunsmore, Petya Koleva, Nafiseh Ghobakhloo, Reed Sutton, Lindsy Ambrosio, Xuanyi Meng, Naomi Hotte, Vivian Nguyen, Karen L. Madsen, Levinus A. Dieleman, Vivian Huang, Shokrollah Elahi
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Gastroenterology & Hepatology
Xuanyi Meng, Garett Dunsmore, Petya Koleva, Yesmine Elloumi, Richard You Wu, Reed Taylor Sutton, Lindsy Ambrosio, Naomi Hotte, Vivian Nguyen, Karen L. Madsen, Levinus A. Dieleman, Hongbing Chen, Vivian Huang, Shokrollah Elahi
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Microbiology
Heather Armstrong, Misagh Alipour, Rosica Valcheva, Michael Bording-Jorgensen, Juan Jovel, Deenaz Zaidi, Prachi Shah, Yuefei Lou, Cory Ebeling, Andrew L. Mason, Dawson Lafleur, Jeremy Jerasi, Gane K. -S. Wong, Karen Madsen, Matthew W. Carroll, Hien Q. Huynh, Levinus A. Dieleman, Eytan Wine
Article
Gastroenterology & Hepatology
Ammar Hassanzadeh Keshteli, Karen L. Madsen, Rupasri Mandal, Guy E. Boeckxstaens, Premysl Bercik, Giada De Palma, David E. Reed, David Wishart, Stephen Vanner, Levinus A. Dieleman
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Editorial Material
Gastroenterology & Hepatology
Ammar Hassanzadeh Keshteli, Karen L. Madsen, Rupasri Mandal, Guy E. Boeckxstaens, Premysl Bercik, Giada De Palma, David E. Reed, David Wishart, Stephen Vanner, Levinus A. Dieleman
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Medicine, General & Internal
Samaneh Khanpour Ardestani, Joan L. Robinson, Levinus A. Dieleman, Hien Q. Huynh, Hsing Jou, Sunita Vohra
Review
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Karen L. Madsen, Levinus A. Dieleman
Review
Nutrition & Dietetics
Richa Chibbar, Levinus A. Dieleman
Article
Gastroenterology & Hepatology
Parul Tandon, Eugenia Y. Lee, Cynthia Maxwell, Lara Hitz, Lindsy Ambrosio, Levinus Dieleman, Brendan Halloran, Karen Kroeker, Vivian M. Huang
Summary: Elevated fecal calprotectin levels during pregnancy in patients with inflammatory bowel disease may be associated with adverse pregnancy outcomes, serving as a potential marker for prediction.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Genetics & Heredity
Williams Turpin, Larbi Bedrani, Osvaldo Espin-Garcia, Wei Xu, Mark S. Silverberg, Michelle I. Smith, Juan Antonio Raygoza Garay, Sun-Ho Lee, David S. Guttman, Anne Griffiths, Paul Moayyedi, Remo Panaccione, Hien Huynh, Hillary A. Steinhart, Guy Aumais, Levinus A. Dieleman, Dan Turner, Andrew D. Paterson, Kenneth Croitoru
BMC MEDICAL GENETICS
(2020)
Article
Medicine, General & Internal
Paul Moayyedi, Glenda MacQueen, Charles N. Bernstein, Stephen Vanner, Premysl Bercik, Karen L. Madsen, Michael Surette, John D. Rioux, Levinus A. Dieleman, Elena Verdu, Russell J. de Souza, Anthony Otley, Laura Targownik, John Lavis, Jennifer Cunningham, Deborah A. Marshall, Sandra Zelinsky, Aida Fernandes
Review
Medicine, General & Internal
Richa Chibbar, Jordan Nostedt, Dana Mihalicz, Jean Deschenes, Ross McLean, Levinus A. Dieleman
FRONTIERS IN MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Bhairavi Balram, Harshad Joshi, Karen Wong, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Daniel C. Baumgart, Farhad Peerani
Summary: This study found that continuing 5-ASA therapy in ulcerative colitis patients escalated to infliximab did not provide additional benefit in controlling inflammation, and was not associated with increased likelihood of achieving clinical and endoscopic remission.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Rosica Valcheva, Petya Koleva, Ines Martinez, Jens Walter, Michael G. Ganzle, Levinus A. Dieleman