Article
Biochemistry & Molecular Biology
Stefanie Volkart, Urs Kym, Olivier Braissant, Edgar Delgado-Eckert, Samer Al-Samir, Rebecca Angresius, Zihe Huo, Stefan Holland-Cunz, Stephanie J. J. Gros
Summary: This study analyzed the distribution and localization of AQP1 in the entire intestinal tract of mice. A specific pattern of AQP1 expression was found throughout the gastrointestinal tract. AQP1 expression correlated with the expression profiles of hypoxia-dependent proteins and was associated with changes in intestinal wall anatomy and bacterial stool microbiome composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jackson L. K. Yip, Soniya Xavier, Gayathri K. Balasuriya, Elisa L. Hill-Yardin, Sarah J. Spencer
Summary: Intestinal macrophages play a crucial role in regulating colonic motility and maintaining a healthy intestinal structure. Our study provides novel insights into the interplay between intestinal macrophages and the enteric nervous system in colonic motility, highlighting them as a potential therapeutic target for gastrointestinal motility disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Premysl Falt, Jana Zapletalova, Ondrej Urban
Summary: The study evaluated the efficacy and safety of endoscopic full-thickness resection (FTR) in the treatment of colorectal lesions <= 30 mm, comparing it to endoscopic submucosal dissection (ESD). It found that FTR had significantly higher technical success rate, R0 and curative resection rate, as well as lower complication rate compared to ESD, but had a higher incidence of local residual neoplasia. Further research, including randomized trials, is needed to compare both resection techniques.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Neurosciences
Dominic R. Parker, Lukasz Wiklendt, Adam Humenick, Bao Nan Chen, Tiong Cheng Sia, David A. Wattchow, Phil G. Dinning, Simon J. H. Brookes
Summary: This study found that sympathetic axons in the myenteric plexus preferentially target cholinergic excitatory cells over nitrergic neurons, which likely plays a role in the inhibitory modulation of human colonic motility by the sympathetic nervous system.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Claire M. Werner, Lisa B. Willing, Hannah J. Goudsward, Amanda R. McBride, Salvatore L. Stella Jr, Gregory M. Holmes
Summary: This study found that ICC-MP showed resilience in neurogenic bowel following SCI, and the extent of its neuronal remodeling was gender-dependent. In contrast, ICC-CM did not demonstrate any changes. These results highlight the importance of further understanding the neuromuscular changes driving colonic dysmotility after SCI in order to develop therapeutic targets for neurogenic bowel treatment.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Yan-Rong Li, Yan Li, Yuan Jin, Mang Xu, Hong-Wei Fan, Qian Zhang, Guo-He Tan, Jing Chen, Yun-Qing Li
Summary: This study investigates the effects of nitric oxide (NO) on colonic motility in a rat model of ulcerative colitis (UC), and the role of the enteric nervous system (ENS) in UC-related colonic motility. The results suggest that changes in the expression of nitric oxide synthase (NOS) in nitrergic neurons can influence colonic motility, and intervention in NOS activity may prevent colonic motor dysfunction in UC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Kehao Wang, Pingting Gao, Mingyan Cai, Baohui Song, Pinghong Zhou
Summary: Minimally invasive surgery, particularly endoscopic surgery, has become the dominant theme in modern surgery. The technique of endoscopic surgery has continuously evolved through extensive research, improving treatment options and broadening its indications. Endoscopic full-thickness resection (EFTR), as an active perforation endoscopic technique, is primarily used for the treatment of submucosal tumors (SMTs) in the gastrointestinal tract. This paper discusses the indications, techniques, clinical outcomes, and future perspectives for EFTR based on clinical experience and current research. A bibliometric study on EFTR literature and a brief meta-analysis provide robust data on the topic.
DIGESTIVE ENDOSCOPY
(2023)
Article
Surgery
Y. Ichkhanian, K. Vosoughi, D. L. Diehl, I. S. Grimm, T. W. James, A. W. Templeton, K. Hajifathalian, J. L. Tokar, J. B. Samarasena, N. El Hage Chehade, J. Lee, K. Chang, M. Mizrahi, M. Barawi, S. Irani, S. Friedland, P. Korc, A. A. Aadam, M. A. Al-Haddad, T. E. Kowalski, A. Novikov, G. Smallfield, G. G. Ginsberg, V. M. Oza, D. Panuu, N. Fukami, H. Pohl, M. Lajin, N. A. Kumta, S. J. Tang, Y. M. Naga, S. K. Amateau, G. O. I. Brewer, V. Kumbhari, R. Sharaiha, M. A. Khashab
Summary: The study evaluated the outcomes of FTRD among early users in the USA and found that EFTR is a technically feasible, safe, and effective technique for resecting difficult colonic lesions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Lei Gu, Yu Wu, Jun Yi, Miao Ouyang, Xiaowei Liu
Summary: The study compared the therapeutic outcomes of EFTR-L and EFTR in the treatment of small gastric subepithelial tumors (SET-MPs), and found that EFTR-L had shorter operation time and lower cost compared to EFTR. Both methods had similar complete resection rates, but the incidence of abdominal pain was lower in the EFTR-L group.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Mengjuan Lin, Guiying Hu, Baoping Yu
Summary: This study reveals the significance of CBS/H2S signaling in stress-induced colonic dysmotility, and demonstrates that treatment with SAM can alleviate this excessive motility.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Hugo Bilder, Mariano Villarroel, Juan Lasa, Ignacio Zubiaurre
Summary: Endoscopic full-thickness resection is a technique used for block resection of colonic lesions in patients in whom conventional endoscopic methods have failed. This procedure can be successful in cases where patients have a history of difficult-to-resect colon adenomas, avoiding the risks associated with unnecessary surgery.
MEDICINA-BUENOS AIRES
(2021)
Article
Gastroenterology & Hepatology
Yervant Ichkhanian, Mohammed Barawi, Talal Seoud, Shyam Thakkar, Truptesh H. Kothari, Maan El Halabi, Asad Ullah, Wedi Edris, Patrick Aepli, Thomas Kowalski, Brianna Shinn, Reem Z. Shariaha, Srihari Mahadev, Jeffrey D. Mosko, Gianluca Andrisani, Francesco Maria Di Matteo, Heinz Albrecht, Andrew Q. Giap, Shou-jiang Tang, Yehia M. Naga, Erwin van Geenen, Shai Friedland, Benjamin Tharian, Shayan Irani, Andrew S. Ross, Laith H. Jamil, Daniel Lew, Andrew S. Nett, Jad Farha, Thomas M. Runge, Manol Jovani, Mouen A. Khashab
Summary: The FTRD is a promising non-surgical alternative for resecting appendiceal lesions, but appendicitis occurs in 1/6 cases.
Article
Gastroenterology & Hepatology
C. F. Rushfeldt, M. Nordbo, S. E. Steigen, T. Dehli, P. Gjessing, S. Norderval
Summary: This study evaluated the safety and efficacy of rectal endoscopic full-thickness dissection (EFTD) for dysplastic or malignant rectal lesions. The preliminary results showed that EFTD in the rectum can be conducted with satisfactory perioperative results and low risk of serious complications.
TECHNIQUES IN COLOPROCTOLOGY
(2022)
Review
Gastroenterology & Hepatology
Elijah J. Mun, Mihir S. Wagh
Summary: Endoscopic full-thickness resection (EFTR) is an effective technique for managing gastrointestinal lesions that cannot be treated with conventional approaches. The full-thickness resection device (FTRD) system has been developed for EFTR, initially for the colorectum and now for the upper gastrointestinal tract as well. This review provides an overview of the FTRD system, discussing recent advances and current challenges.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Phillip S. Ge, Hiroyuki Aihara
Summary: Endoscopic resection is the preferred treatment for superficial neoplasms in the gastrointestinal tract, and it is increasingly being used for small deep lesions as well. Traditional methods have limitations, but recent advancements in technology provide more options for en bloc and margin-negative resection of larger lesions.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Surgery
Charlotte Desprez, Henri Damon, Guillaume Meurette, Diane Mege, Jean-Luc Faucheron, Charlene Brochard, Elsa Lambrescak, Guillaume Gourcerol, Francois Mion, Vincent Wyart, Igor Sielezneff, Laurent Siproudhis, Isabelle Etienney, Nadine Ajamie, Paul-Antoine Lehur, Thomas Duflot, Valerie Bridoux, Anne-Marie Leroi
Summary: The effectiveness of sacral nerve modulation (SNM) was assessed in a large cohort of patients implanted for at least 10 years. The study found that approximately half of the patients with fecal incontinence maintained long-term efficacy after SNM treatment.
Article
Gastroenterology & Hepatology
M. K. Collard, S. Benoist, L. Maggiori, P. Zerbib, J. H. Lefevre, Q. Denost, A. Germain, E. Cotte, L. Beyer-Berjot, H. Corte, V Desfourneaux, A. Rahili, J. P. Duffas, K. Pautrat, C. Denet, V Bridoux, G. Meurette, J. L. Faucheron, J. Loriau, R. Souche, E. Vicaut, Y. Panis, A. Brouquet
Summary: Surgery following successful non-operative management of intra-abdominal abscess complicating CD provides good early and long-term outcomes. The use of systemic steroids preoperatively and lack of preoperative enteral support were identified as significant risk factors for residual fluid collection.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Surgery
Michel Prudhomme, Eric Rullier, Zaher Lakkis, Eddy Cotte, Yves Panis, Bernard Meunier, Philippe Rouanet, Jean-Jacques Tuech, Mehrdad Jafari, Guillaume Portier, Anne Dubois, Igor Sielezneff, Yann Parc, Jean-Luc Faucheron, Guillaume Meurette, Bernard Lelong, Guillaume Piessen, Mehdi Karoui, Pascale Fabbro-Peray, Christophe Demattei, Martin M. Bertrand
Summary: The study did not find evidence that systematic mesh implantation during primary colostomy creation was effective in preventing parastomal hernia. The positioning of the mesh in a retro-muscular position with a central incision for colon passage was not recommended as a method to prevent parastomal hernia. Optimization of mesh location and reinforcement material is recommended for future research.
Article
Gastroenterology & Hepatology
Guillaume Meurette, Laurent Siproudhis, Anne-Marie Leroi, Henri Damon, David Urs Josef Keller, Jean-Luc Faucheron
Summary: This study confirms the clinical effectiveness, safety, and positive effect of sacral neuromodulation with the InterStim(TM) system for the treatment of faecal incontinence, showing significant improvements in quality of life and symptoms with high patient satisfaction. Main device-related adverse events include the need for reprogramming, infection, and surgical revision.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Felicity Creamer, Alessandra Orlando, Maximillian Brunner, Steen Buntzen, Alexander Dennis, Laura Gomez-Fernandez, Claudia Handtrack, Ann Hanly, Klaus E. Matzel, Arantxa Munoz Duyos, Guillaume Meurette, P. Ronan O'Connell, Cristina Perez Alonso, Yolanda Ribas, Mona Rydningen, Vincent Wyart, Carolynne J. Vaizey, Yasuko Maeda
Summary: The study compared different clinical scoring systems for assessing the severity of defecation incontinence symptoms, revealing that younger patients are more likely to experience symptoms of depression and anxiety, and have a greater impact on their quality of life.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Review
Surgery
P. Viannay, F. de la Codre, C. Brochard, T. Thubert, G. Meurette, G. Legendre, A. Venara
Summary: Obstetrical anal sphincter injuries (OASI) are common complications of childbirth, with a high percentage of patients developing anal incontinence 15 to 25 years postpartum. Early repair and preventive measures are crucial in avoiding complications.
JOURNAL OF VISCERAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Laurent Abramowitz, Charlene Brochard, Francois Pigot, Pauline Roumeguere, Helene Pillant, Beatrice Vinson Bonnet, Jean Luc Faucheron, Agnes Senejoux, Guillaume Bonnaud, Guillaume Meurette, Jean Marie Fayette, Cecile Train, Ghislain Staumont, Laurent Siproudhis, Dominique Bouchard
Summary: The study results suggest that in patients with fistulizing perianal Crohn's disease controlled by initial drainage combined with adalimumab, seton removal alone may not be more effective than a secondary surgical step (especially glue injection). The findings should be interpreted cautiously.
COLORECTAL DISEASE
(2022)
Letter
Gastroenterology & Hepatology
Frederic de la Codre, Carine Korkmaz, Emilie Duchalais, Nicolas Regenet, Guillaume Meurette
COLORECTAL DISEASE
(2022)
Review
Surgery
N. de'Angelis, R. Micelli Lupinacci, S. Abdalla, P. Genova, A. Beliard, E. Cotte, Q. Denost, N. Goasguen, Z. Lakkis, B. Lelong, G. Manceau, G. Meurette, C. Perrenot, D. Pezet, P. Rouanet, A. Valverde, P. Pessaux, S. Azagra, D. Mege, S. Di Saverior, C. de Chaisemartinx, E. Espin-Basanys, S. Gaujouxt, M. Gomez-Ruiz, C. Gronnierv, M. Karouiy, G. Spinogliow, G. Spinogliow
Summary: Robotic-assisted right colectomy (RRC) does not provide significant benefits compared to laparoscopy for patients undergoing right colectomy for a benign pathology or cancer, but it offers a benefit in terms of post-operative morbidity compared to laparotomy. RRC has longer operating times and higher costs.
JOURNAL OF VISCERAL SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Aglae Herbreteau, Philippe Aubert, Mikael Croyal, Philippe Naveilhan, Stephanie Billon-Crossouard, Michel Neunlist, Yves Delneste, Dominique Couez, Laetitia Aymeric
Summary: The brain-gut axis is a bidirectional functional connection between the brain and gut, which is associated with gastrointestinal diseases and tumor progression. Using a glioma model, antibiotic treatment was shown to delay mouse death and alter the proportion of cells in brain tumors.
Article
Gastroenterology & Hepatology
Charles de Ponthaud, Morgan Roupret, Dewi Vernerey, Francois Audenet, Antoine Brouquet, Eddy Cotte, Xavier Cuvillier, Frederic Kanso, Guillaume Meurette, Patrick Ledaguenel, Leon Maggiori, Yann Neuzillet, Mehdi Ouaissi, Mathieu Roumiguie, Veronique Phe, Nam-Son Vuong, Yann Parc, Jeremie H. Lefevre
Summary: In France, the market for stoma therapy has evolved rapidly in the past decade, with increased activities of home health providers. Studies have shown the impact of ST follow-up on improving ostomy patient's QoL. This study aims to evaluate the added value of enhanced follow-up by STs on health-related QoL for ostomy patients receiving care at home.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Farouk Drissi, Arnaud Bourreille, Michel Neunlist, Guillaume Meurette
Summary: The purpose of this study is to evaluate the clinical, biological, and endoscopic response, as well as safety, of sacral neuromodulation in patients with refractory ulcerative colitis (UC). The results showed that the effects of sacral neuromodulation on disease activity were mainly observed after 16 weeks. This study suggests that sacral neuromodulation could be a way to reinforce medical therapy and reduce the use of immunosuppressive drugs.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Surgery
Guillaume Meurette, Jean-Luc Faucheron, Eddy Cotte, Quentin Denost, Guillaume Portier, Jerome Loriau, Andreas Wolff Hansen, Eric Vicaut, Zaher Lakkis
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Alexandra M. Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura D'Allens, Caterina Allmer, Andrea Alvarez, Rocio Anula, Mihailo Andric, Sam Atallah, Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Andrew Beggs, Felipe Bellolio, Melissa-Rose Bennett, Vicki Bevan, Sebastiano Biondo, Gabriele Bislenghi, Marc Bludau, Nelleke Brouwer, Carl Brown, Christiane Bruns, Daniel D. Buchanan, Pamela Buchwald, Jacobus W. A. Burger, Nikita Burlov, Michela Campanelli, Maylis Capdepont, Michele Carvello, Hwee-Hoon Chew, Dimitri Christoforidis, David Clark, Marta Climent, Rowan Collinson, Kyle G. Cologne, Tomas Contreras, Roland Croner, Ian R. Daniels, Giovanni Dapri, Justin Davies, Paolo Delrio, Quentin Denost, Michael Deutsch, Andre Dias, Andre D'Hoore, Evgeniy Drozdov, Daniel Duek, Malcolm Dunlop, Adam Dziki, Aleksandra Edmundson, Sergey Efetov, Alaa El-Hussuna, Brodie Elliot, Sameh Emile, Eloy Espin, Martyn Evans, Seraina Faes, Omar Faiz, Nuno Figueiredo, Fergal Fleming, Caterina Foppa, George Fowler, Matteo Frasson, Tim Forgan, Frank Frizelle, Shamil Gadaev, Jose Gellona, Tamara Glyn, Barisic Goran, Emma Greenwood, Marianne G. Guren, Stephanie Guillon, Ida Gutlic, Dieter Hahnloser, Heather Hampel, Ann Hanly, Hirotoshi Hasegawa, Lene Hjerrild Iversen, Andrew Hill, James Hill, Jiri Hoch, Roel Hompes, Luis Hurtado, Fabiano Iaquinandi, Ugne Imbrasaite, Rumana Islam, Mehrenah D. Jafari, Andrea Jimenez Salido, Marta Jimenez Toscano, Yukihide Kanemitsu, Aleksei Karachun, Ahmer A. Karimuddin, Deborah S. Keller, Justin Kelly, Rory Kennelly, Gleb Khrykov, Peter Kocian, Cherry Koh, Neils Kok, Katrina A. Knight, Joep Knol, Christos Kontovounisios, Hartwig Korner, Zoran Krivokapic, Irmgard Kronberger, Hidde Maarten Kroon, Marius Kryzauskas, Said Kural, Miranda Kusters, Zaher Lakkis, Timur Lankov, David Larson, Gyorgy Lazar, Kai-Yin Lee, Suk Hwan Lee, Jeremie H. Lefevre, Anna Lepisto, Christopher Lieu, Lynette Loi, Craig Lynch, Helene Maillou-Martinaud, Annalisa Maroli, Sean Martin, Anna Martling, Klaus E. Matzel, Julio Mayol, Frank McDermott, Guillaume Meurette, Monica Millan, Martin Mitteregger, Andrei Moiseenko, John R. T. Monson, Stefan Morarasu, Konosuke Moritani, Gabriela Moslein, Martino Munini, Caio Nahas, Sergio Nahas, Ionut Negoi, Anastasia Novikova, Misael Ocares, Koji Okabayashi, Alexandra Olkina, Luis Onate-Ocana, Jaime Otero, Cihan Ozen, Ugo Pace, Guilherme Pagin Sao Juliao, Lidiia Panaiotti, Yves Panis, Demetris Papamichael, Swati Patel, Juan Carlos Patron Uriburu, Sze-Lin Peng, Miguel Pera, Rodrigo O. Perez, Alexei Petrov, Frank Pfeffer, Terry P. Phang, Tomas Poskus, Heather Pringle, David Proud, Ivana Raguz, Nuno Rama, Shahnawaz Rasheed, Manoj J. Raval, Daniela Rega, Christoph Reissfelder, Juan Carlos Reyes Meneses, Frederic Ris, Stefan Riss, Homero Rodriguez-Zentner, Campbell S. Roxburgh, Avanish Saklani, Tarik Sammour, Deborah Saraste, Martin Schneider, Ryo Seishima, Aleksander Sekulic, Toni Seppala, Kieran Sheahan, Alexandra Shlomina, Guiseppe Sigismondo, Tongplaew Singnomklao, Leandro Siragusa, Neil Smart, Alejandro Solis-Pena, Antonino Spinelli, Roxane D. Staiger, Michael J. Stamos, Scott Steele, Ker-Kan Tan, Pieter J. Tanis, Paris Tekkis, Biniam Teklay, Sabrina Tengku, Petr Tsarkov, Matthias Turina, Alexis Ulrich, Bruna B. Vailati, Meike van Harten, Cornelis Verhoef, Satish Warrier, Steven Wexner, Hans de Wilt, Benjamin A. Weinberg, Cameron Wells, Albert Wolthuis, Evangelos Xynos, Nancy You, Justino Zeballos, Jonathan Zhou, Des C. Winter
Summary: The molecular profile of early-onset colonic cancer is not well-defined. This study analyzed the clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. The results showed that early-onset colonic cancer patients had a higher prevalence of microsatellite instability (MSI) and were associated with family history, proximal colon lesions, and BRAF/KRAS mutations. Compared with older patients with MSI cancers, early-onset patients with MSI tumors had more adverse pathological features.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Surgery
Alexandra M. Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura D'Allens, Caterina Allmer, Rocio Anula, Mihailo Andric, Sam Atallah, Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Andrew Beggs, Felipe Bellolio, Melissa-Rose Bennett, Anton Berdinskikh, Vicki Bevan, Sebastiano Biondo, Gabriele Bislenghi, Marc Bludau, Nelleke Brouwer, Carl Brown, Christiane Bruns, Daniel D. Buchanan, Pamela Buchwald, Jacobus W. A. Burger, Nikita Burlov, Michela Campanelli, Maylis Capdepont, Michele Carvello, Hwee-Hoon Chew, Dimitri Christoforidis, David Clark, Marta Climent, Rowan Collinson, Kyle G. Cologne, Tomas Contreras, Roland Croner, IanR Daniels, Giovanni Dapri, Justin Davies, Paolo Delrio, Quentin Denost, Michael Deutsch, Andre Dias, Evgeniy Drozdov, Daniel Duek, Malcolm Dunlop, Adam Dziki, Aleksandra Edmundson, Sergey Efetov, Alaa El-Hussuna, Brodie Elliott, Sameh Emile, Eloy Espin-Basany, Martyn Evans, Seraina Faes, Omar Faiz, Nuno Figueiredo, Fergal Fleming, Caterina Foppa, George Fowler, Matteo Frasson, Tim Forgan, Frank Frizelle, Shamil Gadaev, Jose Gellona, Tamara Glyn, Barisic Goran, Emma Greenwood, Marianne G. Guren, Stephanie Guillon, Ida Gutlic, Dieter Hahnloser, Heather Hampel, Ann Hanly, Hirotoshi Hasegawa, Lene Hjerrild Iversen, Andrew Hill, James Hill, Jiri Hoch, Roel Hompes, Luis Hurtado, Fabiano Iaquinandi, Ugne Imbrasaite, Rumana Islam, Mehrenah D. Jafari, Yukihide Kanemitsu, Aleksei Karachun, Ahmer A. Karimuddin, Deborah S. Keller, Justin Kelly, Rory Kennelly, Gleb Khrykov, Petr Kocian, Cherry Koh, Neils Kok, Katrina A. Knight, Joep Knol, Christos Kontovounisios, Hartwig Korner, Zoran Krivokapic, Irmgard Kronberger, Hidde MaartenKroon, Marius Kryzauskas, Said Kural, Miranda Kusters, Zaher Lakkis, Timur Lankov, David Larson, Kai-Yin Lee, Suk Hwan Lee, Anna Lepisto, Christopher Lieu, Lynette Loi, Craig Lynch, Helene Maillou-Martinaud, Annalisa Maroli, Sean T. Martin, Anna Martling, Klaus E. Matzel, Julio Mayol, Frank McDermott, Guillaume Meurette, Monica Millan, Martin Mitteregger, Andrei Moiseenko, John R. T. Monson, Stefan Morarasu, Konosuke Moritani, Martino Munini, Caio Nahas, Sergio Nahas, Ionut Negoi, Anastasia Novikova, Misael Ocares, Koji Okabayashi, Alexandra Olkina, Luis Onate-Ocana, Jaime Otero, Cihan Ozen, Ugo Pace, Guilherme Pagin Sao Juliao, Lidiia Panaiotti, Yves Panis, Demetris Papamichael, Swati Patel, Sze-Lin Peng, Miguel Pera, Rodrigo O. Perez, Alexei Petrov, Frank Pfeffer, Terry P. Phang, Tomas Poskus, Heather Pringle, David Proud, Ivana Raguz, Nuno Rama, Shahnawaz Rasheed, Manoj J. Raval, Daniela Rega, Christoph Reissfelder, Juan Carlos Reyes Meneses, Frederic Ris, Stefan Riss, Homero Rodriguez-Zentner, Campbell S. Roxburgh, Avanish Saklani, Tarik Sammour, Deborah Saraste, Martin Schneider, Ryo Seishima, Aleksandar Sekulic, Toni Seppala, Kieran Sheahan, Alexandra Shlomina, Guiseppe Sica, Tongplaew Singnomklao, Leandro Siragusa, Neil Smart, Alejandro Solis-Pena, Antonino Spinelli, Roxane D. Staiger, Michael J. Stamos, Scott Steele, Ker-Kan Tan, Pieter J. Tanis, Paris Tekkis, Biniam Teklay, Sabrina Tengku, Petr Tsarkov, Matthias Turina, Alexis Ulrich, Bruna B. Vailati, Meike van Harten, Cornelis Verhoef, Satish Warrier, Steven Wexner, Hans de Wilt, Benjamin A. Weinberg, Cameron Wells, Albert Wolthuis, Evangelos Xynos, Nancy You, Alexander Zakharenko, Justino Zeballos, Youzhi Zhou, Des C. Winter
Summary: This study of 400 patients with early-onset rectal cancer found that 12.5% of patients demonstrated microsatellite instability (MSI), which was associated with reduced likelihood of nodal positivity, increased rate of pathological complete response, and improved disease-specific survival.
BRITISH JOURNAL OF SURGERY
(2022)