Article
Gastroenterology & Hepatology
Peter Draganov, Hiroyuki Aihara, Michael S. Karasik, Saowanee Ngamruengphong, Abdul Aziz Aadam, Mohamed O. Othman, Neil Sharma, Ian S. Grimm, Alaa Rostom, B. Joseph Elmunzer, Salmaan A. Jawaid, Donevan Westerveld, Yaseen B. Perbtani, Brenda J. Hoffman, Alexander Schlachterman, Amanda Siegel, Roxana M. Coman, Andrew Y. Wang, Dennis Yang
Summary: In this large multicenter prospective North American experience, it was demonstrated that ESD can be performed safely and effectively, with a low recurrence rate. The technical resection outcomes achieved in this study align with established consensus quality parameters and support the implementation of ESD for the treatment of select gastrointestinal neoplasms.
Article
Surgery
Yuki Kamigaichi, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Akira Furudoi, Seiji Onogawa, Hideharu Okanobu, Takeshi Mizumoto, Tomohiro Miwata, Shiro Okamoto, Kenichi Yoshimura, Kazuaki Chayama
Summary: Severe submucosal fibrosis and poor scope operability are common risk factors for interruption, piecemeal resection, and perforation in standardized colorectal ESD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Nozomu Kobayashi, Yoji Takeuchi, Ken Ohata, Masahiro Igarashi, Masayoshi Yamada, Shinya Kodashima, Kinichi Hotta, Keita Harada, Hiroaki Ikematsu, Toshio Uraoka, Naoto Sakamoto, Hisashi Doyama, Takashi Abe, Atsushi Katagiri, Shinichiro Hori, Tomoki Michida, Takehito Yamaguchi, Masakatsu Fukuzawa, Shinsuke Kiriyama, Kazutoshi Fukase, Yoshitaka Murakami, Hideki Ishikawa, Yutaka Saito
Summary: This multicenter prospective trial in Japan aimed to quantify the rates of en bloc and curative resections, as well as complications, in endoscopic submucosal dissection (ESD) for colorectal lesions. The study revealed higher curability, shorter procedure time, and lower risk of complications compared to previous reports.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Ken Ohata, Nozomu Kobayashi, Eiji Sakai, Yoji Takeuchi, Akiko Chino, Hiroyuki Takamaru, Shinya Kodashima, Kinichi Hotta, Keita Harada, Hiroaki Ikematsu, Toshio Uraoka, Takashi Murakami, Shigetsugu Tsuji, Takashi Abe, Atsushi Katagiri, Shinichiro Hori, Tomoki Michida, Takuto Suzuki, Masakatsu Fukuzawa, Shinsuke Kiriyama, Kazutoshi Fukase, Yoshitaka Murakami, Hideki Ishikawa, Yutaka Saito
Summary: Colorectal endoscopic submucosal dissection (ESD) is a standard treatment for colorectal epithelial neoplasms, with a favorable long-term prognosis. Patients with curative resection had no metastasis, while patients with non-curative resection had metastatic occurrences.
Article
Surgery
Yuki Okamoto, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Seiji Onogawa, Takeshi Mizumoto, Hideharu Okanobu, Morihisa Akagi, Kazuaki Chayama
Summary: This study investigated the clinical outcomes of hybrid ESD for colorectal tumors that met the 30 mm lesion size criterion. The salvage group had a higher perforation rate overall, but a lower rate during snaring. During the second period compared to the first, there were significantly higher complete en bloc resection rates and experienced operator rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Hiroaki Tanabe, Takuma Higurashi, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Shungo Goto, Jun Arimoto, Keiichi Ashikari, Leo Taniguchi, Hideyuki Chiba, Atsushi Nakajima
Summary: This study was a prospective multicenter observational trial aiming to investigate the impact of colorectal ESD on postoperative abdominal symptoms. The overall GSRS scores slightly improved after ESD, with statistically significant differences in indigestion syndrome and constipation syndrome, indicating that colorectal ESD is a minimally invasive treatment with no clinically significant differences in postoperative abdominal symptoms.Unicode is a registered trademark of Unicode, Inc. in the United States and other countries.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Masami Ijiri, Takahiro Sasaki, Mikihiro Fujiya, Takuya Iwama, Yuki Murakami, Keitaro Takahashi, Kazuyuki Tanaka, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe, Yusuke Saito, Toshikatsu Okumura
Summary: The study found that local lidocaine injection is an effective option for shortening procedural time, relieving bowel peristalsis, particularly in the proximal colon, leading to reduced antispasmodic drug use during colorectal endoscopic submucosal dissection (ESD).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Satoki Shichijo, Noriya Uedo, Atsushi Sawada, Kingo Hirasawa, Hirohisa Takeuchi, Nobutsugu Abe, Masaki Miyaoka, Kenshi Yao, Akira Dobashi, Kazuki Sumiyama, Tsukasa Ishida, Yoshinori Morita, Hiroyuki Ono
Summary: Endoscopic full-thickness resection for gastric submucosal tumors (SMT) of 11-30 mm in diameter is effective, with a 100% complete resection rate achieved in all 46 patients. Further validation in larger cohort studies is needed to determine long-term outcomes for patients with gastric gastrointestinal stromal tumors (GIST).
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
William King, Peter V. Draganov, V. Subhash Gorrepati, Maham Hayat, Hiroyuki Aihara, Michael Karasik, Saowanee Ngamruengphong, Abdul Aziz Aadam, Mohamed O. Othman, Neil Sharma, Ian S. Grimm, Alaa Rostom, B. Joseph Elmunzer, Dennis Yang
Summary: Recent Western studies support the safety and efficacy of endoscopic submucosal dissection (ESD) for lesions throughout the GI tract. This study aimed to evaluate the safety and feasibility of same-day discharge (SDD) after ESD and factors associated with post-ESD admission.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Jun Arimoto, Ken Ohata, Hideyuki Chiba, Jun Tachikawa, Naoya Okada, Hiroki Kuwabara, Michiko Nakaoka, Keiichi Ashikari, Rindo Ishii, Yohei Minato, Maiko Takita, Eiji Sakai, Takashi Muramoto, Nobuyuki Matsuhashi, Tohru Goto, Atsushi Nakajima
Summary: The study aimed to evaluate the safety and efficacy of a novel multifunctional snare, SOUTEN snare, for colorectal endoscopic submucosal dissection (ESD). The results demonstrated that SOUTEN-ESD had good surgical outcomes, with low perforation rate and high enbloc resection rate.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Surgery
Yoshiki Tsujii, Yoshito Hayashi, Ryu Ishihara, Shinjiro Yamaguchi, Masashi Yamamoto, Takuya Inoue, Kengo Nagai, Hideharu Ogiyama, Takuya Yamada, Masanori Nakahara, Takashi Kizu, Takashi Kanesaka, Noriko Matsuura, Takashi Ohta, Dai Nakamatsu, Shunsuke Yoshii, Shinichiro Shinzaki, Tsutomu Nishida, Hideki Iijima, Tetsuo Takehara
Summary: The study evaluates the validity of a diagnostic strategy combining conventional endoscopy (CE) and endoscopic ultrasonography (EUS) and determines the additional value of EUS for EGC suspected of submucosal (SM) invasion. The results show that the combination of CE and EUS has a higher diagnostic accuracy compared to CE alone, particularly in differentiating lesion types and low-confidence CE-SM2 lesions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Hidenori Tanaka, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Takeshi Mizumoto, Hideharu Okanobu, Kazuaki Chayama
Summary: Colorectal ESD is an effective treatment for local residual/recurrent and ER interrupted tumors, achieving en bloc resection and reducing the rate of re-recurrence. The intraoperative perforation rate is relatively low, making it a safe treatment option.
DIGESTIVE ENDOSCOPY
(2021)
Article
Surgery
Ivo Boskoski, Jun Hamanaka, Federico Barbaro, Vincenzo Arena, Pietro Mascagni, Maria Emiliana Caristo, Martina De Siena, Camilla Gallo, Guido Costamagna
Summary: This study aimed to evaluate the feasibility and safety of nebulizing Glubran 2 over ESD surfaces, showing that this technique was both technically easy and time-effective with no adverse events reported in the animal trial. Further research and human trials are needed to determine the efficacy of Glubran 2 in preventing and treating delayed micro-perforations and bleedings in ESD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Clara Yzet, Yann Le Baleur, Jeremie Albouys, Jeremie Jacques, Paul Doumbe-Mandengue, Maximilien Barret, Einas Abou Ali, Marion Schaefer, Jean-Baptiste Chevaux, Sarah Leblanc, Vincent Lepillez, Jocelyn Privat, Thibault Degand, Timothee Wallenhorst, Jerome Rivory, Ulriikka Chaput, Arthur Berger, Karim Aziz, Gabriel Rahmi, Emmanuel Coron, Eric Kull, Ludovic Caillo, Geoffroy Vanbiervliet, Stephane Koch, Fabien Subtil, Mathieu Pioche
Summary: This study compared the efficacy and safety of using the full thickness resection device (FTRD) system and endoscopic submucosal dissection (ESD) for the treatment of residual colorectal neoplasia (RCN). The results showed that ESD was effective in achieving R0 resection regardless of the size and location of the lesions. When residual lesions were smaller than 20 mm, FTRD was an effective alternative.
Article
Gastroenterology & Hepatology
Takaya Shimura, Hiroyasu Iwasaki, Takanori Ozeki, Takahito Katano, Yusuke Okuda, Yusuke Mizuno, Shigeki Fukusada, Naomi Sugimura, Mika Kitagawa, Hirotada Nishie, Hiromi Kataoka
Summary: In this study, we found that the use of the maXium electrosurgical unit did not reduce the incidence of post-endoscopic submucosal dissection coagulation syndrome (PECS) after colorectal endoscopic submucosal dissection (ESD). However, the maXium unit had equivalent performance to a conventional electrosurgical unit used for colorectal ESD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Toshio Uraoka, Noriya Uedo, Tsuneo Oyama, Yutaka Saito, Naohisa Yahagi, Ai Fujimoto, Yoshiro Kawahara, Katsuhiro Mabe, Takuto Hikichi, Yorimasa Yamamoto, Hisao Tajiri
Summary: This study compared the effectiveness of the novel hemostatic peptide TDM-621 with conventional hemostatic methods for treating intraoperative blood oozing during endoscopic submucosal dissection (ESD). The results showed that the TDM-621 group had significantly reduced coagulations with hemostatic forceps, a higher rate of hemostasis achievement with only TDM-621, and no serious safety concerns.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Kohei Shigeta, Kenichiro Imai, Kinichi Hotta
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Daiki Nemoto, Zhe Guo, Shinichi Katsuki, Takahito Takezawa, Ryo Maemoto, Keisuke Kawasaki, Ken Inoue, Takashi Akutagawa, Hirohito Tanaka, Koichiro Sato, Teppei Omori, Kunihiro Takanashi, Yoshikazu Hayashi, Yuki Nakajima, Yasuyuki Miyakura, Takayuki Matsumoto, Naohisa Yoshida, Motohiro Esaki, Toshio Uraoka, Hiroyuki Kato, Yuji Inoue, Boyuan Peng, Ruiyao Zhang, Takashi Hisabe, Tomoki Matsuda, Hironori Yamamoto, Noriko Tanaka, Alan Kawarai Lefor, Xin Zhu, Kazutomo Togashi
Summary: This study aimed to develop a computer-aided diagnosis (CADx) system using nonmagnified endoscopic white-light images to diagnose early-stage colorectal cancers (CRCs). The CADx system showed high specificity and accuracy for diagnosing T1b lesions, surpassing trainees and comparable to experts. The CADx system has promising potential for clinical application.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Yoshiki Kajiwara, Shiro Oka, Shinji Tanaka, Takahiro Nakamura, Shoichi Saito, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Kinichi Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yutaka Saito, Masayoshi Yamada, Yukihide Kanemitsu, Shigeki Sekine, Shinji Nagata, Kazutaka Yamada, Nozomu Kobayashi, Soichiro Ishihara, Yusuke Saitoh, Kenji Matsuda, Kazutomo Togashi, Koji Komori, Megumi Ishiguro, Toshio Kuwai, Takashi Okuyama, Akihiro Ohuchi, Shinobu Ohnuma, Kazuhiro Sakamoto, Tamotsu Sugai, Kenji Katsumata, Hiro-o Matsushita, Hiro-o Yamano, Hirotsugu Eda, Toshio Uraoka, Naohiko Akimoto, Hirotoshi Kobayashi, Yoichi Ajioka, Kenichi Sugihara, Hideki Ueno
Summary: A novel nomogram was developed and validated based on a large-scale, real-world dataset to accurately evaluate the risk of lymph node metastasis in T1 colorectal cancer. Six independent risk factors, including submucosal invasion depth and tumor budding, were identified and incorporated into the nomogram. The nomogram demonstrated good predictive performance in both the development and validation cohorts. This nomogram, developed using real-world data, can aid in decision-making for an appropriate treatment strategy for T1 colorectal cancer.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Oncology
Takeshi Hatanaka, Atsushi Naganuma, Ai Furusawa, Yuki Tamura, Naoto Saito, Yuhei Suzuki, Takashi Hoshino, Yutaka Yata, Toshio Uraoka, Satoru Kakizaki
Summary: This retrospective study aimed to compare the chronological change in spleen volume between patients treated with Atez/Bev and LEN. The results showed that spleen volume gradually increased during Atez/Bev treatment, while it remained mostly consistent during LEN treatment. Caution is required when managing patients treated with Atez/Bev, especially those with a high NLR.
Article
Surgery
Yu Hashimoto, Shiko Kuribayashi, Keigo Sato, Yuki Itoi, Ko Nakata, Kengo Kasuga, Hirohito Tanaka, Hiroko Hosaka, Hayato Ikota, Marietta Iacucci, Toshio Uraoka
Summary: This study aims to validate the correlation between red dichromatic imaging (RDI) scores and the activity index of ulcerative colitis (UC). The results showed positive correlations between RDI scores and UCEIS, MES, and Nancy index. RDI scores had a higher correlation to histology compared to white-light imaging (WLI) scores.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Gastroenterology & Hepatology
Taishi Okumura, Kenichiro Imai, Kinichi Hotta
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Daiki Kawaguchi, Kazunori Takada, Kinichi Hotta
DIGESTIVE ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Kengo Kasuga, Keigo Sato, Ko Nakata, Hirohito Tanaka, Hiroko Hosaka, Shiko Kuribayashi, Toshio Uraoka
Article
Gastroenterology & Hepatology
Hiroko Hosaka, Shiko Kuribayashi, Osamu Kawamura, Yuki Itoi, Keigo Sato, Yu Hashimoto, Kengo Kasuga, Hirohito Tanaka, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to explore the relationship between symptom profiles and subtypes of achalasia defined by the Chicago classification. Symptoms of dysphagia and chest pain were evaluated using structured self-reported questionnaires, while esophageal motility was assessed using high-resolution manometry and esophagograms. The results showed that symptom profiles and the location and timing of lesions varied among different subtypes of achalasia, possibly due to the status of the esophageal body.
Review
Medicine, General & Internal
Shiko Kuribayashi, Hiroko Hosaka, Toshio Uraoka
Summary: Esophagogastroduodenoscopy (EGD) is used to diagnose esophageal motility disorders (EMDs) and rule out organic diseases. Abnormal endoscopic findings during EGD indicate the presence of EMDs. Several endoscopic findings related to EMDs have been reported at the esophagogastric junction and esophageal body. Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE), often associated with abnormal esophageal motility, can be detected during EGD, and image-enhanced endoscopy (IEE) can improve their detection.
Article
Biochemistry & Molecular Biology
Ken Sato, Atsushi Naganuma, Tamon Nagashima, Yosuke Arai, Yuka Mikami, Yuka Nakajima, Yuki Kanayama, Tatsuma Murakami, Sanae Uehara, Daisuke Uehara, Yuichi Yamazaki, Takayo Murase, Takashi Nakamura, Toshio Uraoka
Summary: This study measured the plasma XOR activities in patients with comprehensive liver diseases using a novel assay and evaluated their association with liver function parameters, purine metabolism-associated markers, oxidative stress markers, and inflammation markers. The results showed that plasma XOR activities were generally increased in liver diseases, especially in the active phase, and were closely correlated with liver function parameters, especially serum ALT levels.
Article
Gastroenterology & Hepatology
Kenji Watanabe, Masanori Nojima, Hiroshi Nakase, Toshiyuki Sato, Minoru Matsuura, Nobuo Aoyama, Taku Kobayashi, Hirotake Sakuraba, Masakazu Nishishita, Kaoru Yokoyama, Motohiro Esaki, Fumihito Hirai, Masakazu Nagahori, Sohachi Nanjo, Teppei Omori, Satoshi Tanida, Yoshihiro Yokoyama, Kei Moriya, Atsuo Maemoto, Osamu Handa, Naoki Ohmiya, Kiichiro Tsuchiya, Shinichiro Shinzaki, Shingo Kato, Toshio Uraoka, Hiroki Tanaka, Noritaka Takatsu, Atsushi Nishida, Junji Umeno, Masanao Nakamura, Yoshiyuki Mishima, Mikihiro Fujiya, Kenji Tsuchida, Sakiko Hiraoka, Makoto Okabe, Takahiko Toyonaga, Katsuyoshi Matsuoka, Akira Andoh, Yoshio Hirota, Tadakazu Hisamatsu, J COMBAT Study Grp
Summary: The degree of immune response to COVID-19 vaccination in IBD patients varies. Most IBD patients showed a sufficient immune response, while some had persistently low response. Factors such as age and medication were associated with the immune response.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biology
Takuya Adachi, Yukari Yoshida, Kei Shibuya, Ken Sato, Yuichi Yamazaki, Satoru Kakizaki, Toshio Uraoka, Akihisa Takahashi
Summary: Irradiation of the liver induces compensatory hypertrophy in the nonirradiated part, which is mainly caused by hepatocyte proliferation. This study aimed to evaluate the weight of compensatory hypertrophy and clarify the mechanism of hypertrophy after partial liver irradiation. The results showed that partial liver irradiation leads to significant hypertrophy in nonirradiated liver lobes, and this hypertrophy is mainly due to increased hepatocyte mitosis.
JOURNAL OF RADIATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mitsuru Esaki, Eikichi Ihara, Noriaki Manabe, Noriyuki Kawami, Katsuhiko Iwakiri, Junichi Akiyama, Shiko Kuribayashi, Toshio Uraoka, Haruei Ogino, Takatoshi Chinen, Akiko Misumi, Hiroko Watanabe, Maya Suzuki, Junji Kishimoto, Yoshihiro Ogawa
Summary: This study is the first prospective and randomized controlled trial to investigate the superiority of acotiamide over a placebo in the treatment of patients with EGJOO. The trial provides evidence that acotiamide can be used as a treatment for patients with EGJOO. Long-term outcomes cannot be assessed because this trial focuses on the short-term outcomes of acotiamide for the treatment of patients with EGJOO.
