Article
Endocrinology & Metabolism
Jie Yang, Jia Zhang, Rui Wang, Ya Liu, Yonghua Chen
Summary: In patients with pancreatic benign and low-grade malignant tumors (PBLMT), 70% had dysglycemia before surgery, with old age and reduction in RPV being independent risk factors for developing dysglycemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Xu, Jia Guo, Hai-qiang Yang, Qing-lian Ji, Rui-jie Song, Feng Hou, Hao-yu Liang, Shun-li Liu, Lan-tian Tian, He-xiang Wang
Summary: This study evaluated the ability of a preoperative contrast-enhanced CT (CECT)-based radiomics nomogram to differentiate between benign and malignant primary retroperitoneal tumors (PRT). Using machine learning algorithms and clinical data, a predictive model was developed that incorporated facial features, clinical data, and radiomics features to determine the nature of the tumor. The results of the study showed that the radiomics predictive model had high accuracy and clinical value in differentiating between benign and malignant PRT.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kwadwo Antwi, Patricia Wiesner, Elmar M. Merkle, Christoph J. Zech, Daniel T. Boll, Damian Wild, Emanuel Christ, Tobias Heye
Summary: This study analyzed 49 patients with symptoms of endogenous hyperinsulinemic hypoglycemia using MRI and PET/CT imaging, revealing that most PICTs present with atypical signal characteristics and are difficult to detect. A multiparametric approach, including factors like lesion size and different sequence characteristics, is necessary for accurate PICT detection.
Article
Biochemistry & Molecular Biology
Dongmei Zhu, Junyu Li, Yan Li, Ji Wu, Lin Zhu, Jian Li, Zimo Wang, Jinfeng Xu, Fajin Dong, Jun Cheng
Summary: The study aims to establish a multimodal ultrasound fusion network (MUF-Net) model for automatically classifying benign and malignant solid renal tumors, and compare its performance with radiologists' assessments. Results showed that the MUF-Net model achieved better performance than senior radiologists.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yi-Wen Chen, Jian Xu, Xiang Li, Wei Chen, Shun-Liang Gao, Yan Shen, Min Zhang, Jian Wu, Ri-Sheng Que, Jun Yu, Ting-Bo Liang, Xue-Li Bai
Summary: This study retrospectively enrolled 296 patients who underwent CP or DP for benign and low-malignant neoplasms. The perioperative outcomes and long-term morbidity of endocrine/exocrine function were evaluated.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Zihao Yang, Yicui Niu, Hui Ma, Wenqing Gong, Lu Yu, Liwen Liu, Minjuan Zheng
Summary: This study aimed to explore the diagnostic value of contrast-enhanced echocardiography (CEE) in benign and malignant cardiac tumors and detect the correlation of CEE parameters and immunohistochemistry (IHC) markers. The results showed that there were differences in TTE and CEE parameters between benign and malignant cardiac tumors. CEE was helpful in differentiating the properties of cardiac tumors, and there was a correlation between CEE parameters and IHC markers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Susumu Hijioka, Yoshikuni Nagashio, Akihiro Ohba, Yuta Maruki, Takuji Okusaka
Summary: Endoscopic ultrasonography (EUS) has increased spatial resolution compared to other imaging modalities and is essential for evaluating gallbladder lesions and suspected gallbladder cancer. EUS-FNA can provide precise diagnoses and differentiate between benign and malignant conditions. Advancements in NGS technology allow for potential predictive genomic biomarkers to be identified for treatment response in gallbladder cancer.
Article
Acoustics
Liuhong Shi, Dingting Wu, Xu Yang, Caoxin Yan, Pintong Huang
Summary: The combination of contrast-enhanced ultrasound (CEUS) and strain elastography (SE) is valuable for distinguishing between benign parotid tumors (BPT) and malignant parotid tumors (MPT).
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Medicine, General & Internal
Tae Hui Yun, Yoon Young Jeong, Sun Jae Lee, Youn Seok Choi, Jung Min Ryu
Summary: The purpose of this study was to investigate whether the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can be used as supplementary tools to differentiate between benign, borderline, and malignant ovarian tumors. The results showed that NLR and PLR were significantly higher in malignant ovarian tumors than in benign or borderline tumors, with no significant difference between benign and borderline tumors. High preoperative NLR and PLR may indicate a higher likelihood of epithelial ovarian cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yuyun Xu, Zhenyu Shu, Ge Song, Yijun Liu, Peipei Pang, Xuehua Wen, Xiangyang Gong
Summary: This study aimed to develop and validate a prediction model for differentiating between benign and malignant parotid gland tumors based on clinicoradiological data and CT-radiomics. The combination model incorporating rad-score and CT radiological features showed good performance in evaluating tumor malignancy, with location, lymph node status, and rad-score as independent predictors. The model demonstrated high accuracy, specificity, and sensitivity in both training and test sets.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Mindy L. Yang, Chandni Bhimani, Robyn Roth, Pauline Germaine
Summary: Contrast-enhanced mammography (CEM) has become a widely used modality in breast imaging, showing high diagnostic performance in cancer detection. It is comparable to MRI in sensitivity with lower false positive rates. Familiarity with CEM and its implementation is of great clinical significance, as it can be used for screening dense breasts as well as staging known breast malignancies.
Review
Oncology
Charlotte L. Vietor, Sara G. Creemers, Folkert J. van Kemenade, Tessa M. van Ginhoven, Leo J. Hofland, Richard A. Feelders
Summary: This review summarizes current diagnostic strategies and challenges in distinguishing benign from malignant adrenal lesions. It focuses on radiological and biochemical assessments for preoperative diagnosis, and histopathological and molecular assessments postoperatively. New non-invasive strategies such as liquid biopsies are also discussed for their potential in diagnosing Adrenocortical carcinoma.
Article
Oncology
Jianing Zhu, Nan Li, Ping Zhao, Yanjie Wang, Qing Song, Luda Song, Qiuyang Li, Yukun Luo
Summary: The CEUS features of solid renal tumors vary according to tumor size. Consideration of tumor size is necessary when diagnosing benign and malignant tumors using CEUS.
Article
Engineering, Environmental
Yanhua Liu, Yang Li, Shanshan Dong, Lu Han, Ruixin Guo, Yourong Fu, Shenghu Zhang, Jianqiu Chen
Summary: Environmental pollution poses a threat to public health, with research suggesting that organophosphate esters (OPEs) may be associated with the risk of female-specific cancers. Variations in correlations of OPEs between different patient groups imply differences in metabolism.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Medicine, Research & Experimental
Kang Fang, Gen Sun, Ming Zha, Shuju Tu, Yuanpeng Xiong, Siqing Yi, Yonghao Ouyang, Yong Li, Weidong Xiao
Summary: This study retrospectively analyzed the clinical data of 101 patients who underwent organ-sparing pancreatectomy and found that this surgical technique is associated with acceptable perioperative risk and postoperative complications, as well as better long-term outcomes in benign or low-grade malignant pancreatic tumors.
MEDICAL SCIENCE MONITOR
(2022)
Article
Gastroenterology & Hepatology
Takuya Ishikawa, Eizaburo Ohno, Yasuyuki Mizutani, Tadashi Iida, Toshinari Koya, Yutaka Sasaki, Hiroshi Ogawa, Fumie Kinoshita, Yoshiki Hirooka, Hiroki Kawashima
Summary: EOB-MRI had a higher sensitivity in diagnosing liver metastasis, while CE-US following CH-EUS demonstrated a higher specificity and PPV, especially in the differentiation between liver metastasis and abscess.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Review
Medicine, General & Internal
Kazunori Nakaoka, Senju Hashimoto, Ryoji Miyahara, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takamichi Kuwahara, Hiroyuki Tanaka, Yoshiki Hirooka
Summary: Chronic pancreatitis is characterized by the loss of exocrine pancreatic parenchyma and irregular fibrosis. Diagnosing CP objectively can be challenging due to insufficient standard criteria, but techniques like ultrasonography elastography can help assess tissue hardness. SE and shear wave elastography are specific diagnostic techniques used to measure tissue hardness, with different methods for interpreting SE images.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Food Science & Technology
Hiroshi Matsuoka, Takumi Tochio, Ayako Watanabe, Kohei Funasaka, Yoshiki Hirooka, Tenagy Hartanto, Yuka Togashi, Misa Saito, Yuichiro Nishimoto, Yoshinori Mizuguchi, Masanobu Kumon, Chieko Sakuragi, Kouichi Suda, Yuichi Hirose, Isao Morita
Summary: Enteral nutrition causes dysbiosis of the intestinal microbiota and an imbalance in some intestinal metabolites in patients in a persistent vegetative state, and intervention with probiotics does not improve dysbiosis.
Article
Gastroenterology & Hepatology
Yosuke Inukai, Kenta Yamamoto, Takashi Honda, Takanori Ito, Norihiro Imai, Yoji Ishizu, Masanao Nakamura, Hiroki Kawashima, Masatoshi Ishigami
Summary: This study investigates the relationship between the intestinal microbiome and diarrhea caused by lenvatinib treatment. Differences in the composition of the microbiome and enrichment of functional pathways were found between patients with and without diarrhea, suggesting that the intestinal microbiome may influence the incidence of diarrhea during lenvatinib treatment.
DIGESTIVE DISEASES
(2023)
Review
Gastroenterology & Hepatology
Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Yasuyuki Mizutani, Tadashi Iida, Takeshi Yamamura, Naomi Kakushima, Kazuhiro Furukawa, Masanao Nakamura
Summary: Endoscopic management for perihilar cholangiocarcinoma is evolving to improve diagnosis and drainage. Different imaging methods are used to determine resectability and optimal surgical planning, while new diagnostic imaging methods such as video peroral cholangioscopy and probe-based confocal laser endomicroscopy are being clinically applied. The approach to preoperative drainage has shifted to endoscopic nasobiliary drainage to reduce the risk of metastasis seeding. Various endoscopic techniques, including the use of self-expandable metallic stents and endoscopic ultrasonography-guided approach, are employed depending on the resectability and prognosis.
DIGESTIVE ENDOSCOPY
(2022)
Article
Chemistry, Applied
Motohiro Yasui, Naoko Tahara, Hiroshi Matsubara, Norihiko Takeda, Masafumi Ueda
Summary: This study developed a sequential gold-catalyzed reaction for synthesizing 4-aryl-3-(2H)-isoxazolones with a hydroxy group. The method allows the introduction of an aryl and hydroxy group in a single procedure, exhibiting good chemoselectivity and tolerance towards reactive functional groups.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Gastroenterology & Hepatology
Masatoshi Ishigami, Takashi Honda, Yoji Ishizu, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Hiroki Kawashima
Summary: This study aimed to investigate the factors associated with improvement of liver functional reserve after sustained virological response using interferon-free, direct-acting antiviral combination treatment in patients with compensated, severe fibrosis. The study found that baseline serum alpha-fetoprotein might be a predictive factor for improvement of liver function after sustained virological response in patients with severe fibrosis.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Medicine, General & Internal
Kazunori Nakaoka, Eizaburo Ohno, Naoto Kawabe, Teiji Kuzuya, Kohei Funasaka, Yoshihito Nakagawa, Mitsuo Nagasaka, Takuya Ishikawa, Ayako Watanabe, Takumi Tochio, Ryoji Miyahara, Tomoyuki Shibata, Hiroki Kawashima, Senju Hashimoto, Yoshiki Hirooka
Summary: Pancreatic ductal adenocarcinoma (PDAC) can be treated with surgery, chemotherapy, and radiotherapy. However, surgery is currently the only curative treatment, and early detection of smaller tumors is critical for better prognosis. Imaging features and genetic tests play important roles in the accurate diagnosis of early-stage PDAC.
Article
Chemistry, Organic
Toshiki Kawabata, Hiroshi Matsubara
Summary: Although diazomethane is highly explosive, the phase-vanishing method using highly fluorinated solvents was employed to safely generate it for organic synthesis. A two-chamber reactor was used to gradually evolve and consume diazomethane under PV conditions, such as the methylation of carboxylic acids. This PV system provides a facile and safe method for the generation of hazardous diazomethane.
TETRAHEDRON LETTERS
(2023)
Article
Oncology
Teiji Kuzuya, Naoto Kawabe, Mizuki Ariga, Eizaburo Ohno, Kohei Funasaka, Mitsuo Nagasaka, Yoshihito Nakagawa, Ryoji Miyahara, Tomoyuki Shibata, Takeshi Takahara, Yutaro Kato, Yoshiki Hirooka
Summary: Cabozantinib has shown potential therapeutic efficacy and safety in patients previously treated with atezolizumab plus bevacizumab for advanced hepatocellular carcinoma, particularly in patients with good liver function and overall condition. (4)
Article
Chemistry, Physical
Kenichi Iwamoto, Genki Inoue, Hiroshi Matsubara
Summary: The C5H7+ fragment ion derived from 3-methyl1,4-pentadiene (MPD) was investigated using an ion mobility/mass spectrometer. The reduced mobilities (K0) of the C5H7+ fragment ions generated by MPD and cyclohexene correlated with effective temperature in He buffer gas, indicating that these fragments were identical cyclopentenium cations. Density functional theory calculations revealed the feasibility of the dissociation of MPD to cyclopentenium cations.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Gastroenterology & Hepatology
Hirotoshi Ishiwatari, Takanori Kawabata, Hiroki Kawashima, Yousuke Nakai, Shin Miura, Hironari Kato, Hideyuki Shiomi, Nao Fujimori, Takeshi Ogura, Osamu Inatomi, Kensuke Kubota, Toshio Fujisawa, Mamoru Takenaka, Hiroshi Mori, Kensaku Noguchi, Yuki Fujii, Teiichi Sugiura, Noboru Ideno, Tomoki Nakafusa, Atsushi Masamune, Hiroyuki Isayama, Naoki Sasahira
Summary: For preoperative biliary drainage (PBD) of malignant hilar biliary obstruction (MHBO), the proportion of adverse events (AEs), including cholangitis, after endoscopic biliary drainage (EBD) until surgery was similar when either endoscopic nasobiliary drainage (ENBD) or endoscopic biliary stenting (EBS) was used.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Yoshihisa Takada, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Noriaki Gibo, Eizaburo Ohno, Hiroki Kawashima
Summary: The study aimed to identify factors associated with endoscopically controlled ampullary carcinoma (AC). The results showed that if AC was confined to the mucosa and the resection margins were negative or uncertain, the tumor could be well-controlled endoscopically.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Medicine, General & Internal
Eiko Sakurai, Kazunori Nakaoka, Seiji Yamada, Naoe Goto, Akihiro Tomita, Yoshiki Hirooka, Tetsuya Tsukamoto
Summary: This is a rare case of extramedullary plasmacytoma originating from the biliary tract, which is the fifth reported case. The patient presented with jaundice and a tumor was found in the gallbladder and bile ducts. Pathological examination confirmed the tumor to be a plasmacytoma. Despite endoscopic biliary drainage and chemotherapy, the tumor continued to grow and caused complications. Eventually, pancreaticoduodenectomy and cholecystectomy were performed, but the patient died seven months after the diagnosis due to the treatment-resistant tumor.
Article
Surgery
Masahiro Fujita, Masaya Nakauchi, Kazumitsu Suzuki, Akiko Serizawa, Shingo Akimoto, Tsuyoshi Tanaka, Susumu Shibasaki, Kazuki Inaba, Takumi Tochio, Yoshiki Hirooka, Ichiro Uyama, Koichi Suda
Summary: This study retrospectively analyzed 1476 patients undergoing minimally invasive surgery for gastric cancer and found a 6.0% incidence of postoperative diarrhea. Older age and TG were identified as significant risk factors for diarrhea.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
