Article
Surgery
Anne-Line Volden Havshoi, Ulrik Deding, Sofie Sajan Jensen, Per Vadgaard Andersen, Lasse Kaalby, Issam Al-Najami
Summary: CCE had lower completion rates compared to CT colonography and AA colonoscopy, but showed higher polyp detection rates. The completion rate of CCE following incomplete colonoscopy was suboptimal in this study.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Naoki Hosoe, Kenji J. L. Limpias Kamiya, Yukie Hayashi, Tomohisa Sujino, Haruhiko Ogata, Takanori Kanai
Summary: While the incidence and mortality of colorectal cancer are decreasing in the United States, they are increasing in Japan, highlighting the importance of controlling colorectal cancer in the latter. Colon capsule endoscopy, introduced in 2006, offers a promising alternative to traditional colonoscopy in certain situations, but challenges such as reading burden and lesion oversight still exist. Progress is being made in the development of artificial intelligence for automatic diagnosis of colon capsule endoscopy.
DIGESTIVE ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Ulrik Deding, Pablo Cortegoso Valdivia, Anastasios Koulaouzidis, Gunnar Baatrup, Ervin Toth, Cristiano Spada, Ignacio Fernandez-Urien, Marco Pennazio, Thomas Bjorsum-Meyer
Summary: Patient preferences for colon capsule endoscopy and conventional colonoscopy showed no significant difference, with rare procedural adverse events reported for either investigation. The tolerability was high for both methods.
Article
Health Care Sciences & Services
Sarah Bond, Charalampos Kyfonidis, Matthew Jamieson, Roma Maguire, Lisa McCann, Angus Watson, Michelle Brogan, Marilyn Lennon
Summary: The aim of this study was to capture and report patient experiences of the CCE technology and the new clinical pathway for the CCE service in Scotland. The findings showed that patients perceived the CCE service as valuable, mentioning benefits such as reduced travel times, reduced waiting times, and the ability to complete the procedure at home. Recommendations for future implementations of CCE services include promoting CCE among clinical teams, understanding patients' reasons for choosing or not choosing CCE, providing clear information to patients, improving bowel preparation, and embedding formative evaluation within the service itself.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Ulrik Deding, Henrik Boggild, Gunnar Baatrup, Lasse Kaalby, Jacob Hjelmborg, Marianne Kirstine Thygesen, Benedicte Schelde-Olesen, Morten Kobaek-Larsen
Summary: Individual income and educational level are associated with participation rates in colorectal cancer screening. Expected discomfort from diagnostic procedures may act as a potential barrier for participation, particularly in higher socioeconomic groups. A randomized clinical trial within the Danish colorectal cancer screening program investigated the expected discomfort from colonoscopy and colon capsule endoscopy using questionnaires. The findings suggest that expected discomfort is not a significant contributor to the inequalities in screening uptake.
PREVENTIVE MEDICINE
(2023)
Review
Medicine, General & Internal
Trevor Tabone, Anastasios Koulaouzidis, Pierre Ellul
Summary: Colon capsule endoscopy is increasingly recognized as a safe diagnostic tool, especially in the context of reduced endoscopy services. It allows for standardization of reporting and reproducibility through various scores, and can be used to monitor inflammatory bowel disease activity and for colorectal cancer screening.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Gastroenterology & Hepatology
Anastasios Koulaouzidis, Gunnar Baatrup
Summary: Colon capsule endoscopy (CCE) is currently used for specific indications. The increasing demand for outpatient treatment along with advancements in technology and clinical quality may allow for broader use of CCE. Artificial intelligence-based analysis and quality assessment could enhance the quality and affordability of CCE.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
C. Macleod, A. Foxton, P. Wilson, S. Treweek, A. J. M. Watson
Summary: Among symptomatic patients, younger age was associated with obtaining a successful CCE test. Clinicians could consider patient selection based on these results to improve the rate of successful testing in clinical practice.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
C. MacLeod, R. Oliphant, J. G. Docherty, A. J. M. Watson
Summary: Colon capsule endoscopy is a non-invasive alternative to colonoscopy with high sensitivity and specificity for detecting clinically significant colonic neoplasia. However, a case of colorectal cancer missed entirely by CCE has been reported, highlighting the need for further research to determine the post-CCE interval CRC rate.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Isabella Papalia, Douglas Tjandra, Stephanie Quah, Christina Tan, Alexandra Gorelik, Suresh Sivanesan, Finlay Macrae
Summary: This study compared the performance of PCC2 and ileocolonoscopy in assessing mucosal Crohn's disease, showing that PCC2 has promising potential in evaluating ileocolonic mucosa, especially in proximal bowel segments, with greater visualization reach in the small bowel.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Mohd Syafiq Ismail, Greg Murphy, S. Semenov, D. McNamara
Summary: This study compared colon capsule endoscopy (CCE) with colonoscopy and found that CCE had higher comfort and satisfaction ratings. The majority of patients preferred CCE over colonoscopy.
BMC GASTROENTEROLOGY
(2022)
Review
Medicine, General & Internal
Alexandros Toskas, Faidon-Marios Laskaratos, Sergio Coda, Saswata Banerjee, Owen Epstein
Summary: According to research, the Pillcam (TM) Crohn's capsule has been found to have high sensitivity and specificity in evaluating the severity and treatment effects of Crohn's disease in both adults and children, making it a reliable imaging modality.
Article
Gastroenterology & Hepatology
Mao Matsubayashi, Taku Kobayashi, Shinji Okabayashi, Masaru Nakano, Shintaro Sagami, Ryo Ozaki, Hiroki Kiyohara, Hiromu Morikubo, Kunio Asonuma, Yusuke Miyatani, Shin Maeda, Toshifumi Hibi
Summary: CSUC score can predict relapse within one year in UC patients during clinical remission, especially when used 6 months after induction treatment.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Joao Pedro Sousa Ferreira, Miguel Jose da Quinta E Costa de Mascarenhas Saraiva, Joao Pedro Lima Afonso, Tiago Filipe Carneiro Ribeiro, Helder Manuel Casal Cardoso, Ana Patricia Ribeiro Andrade, Miguel Nuno Gameiro de Mascarenhas Saraiva, Marco Paulo Lages Parente, Renato Natal Jorge, Susana Isabel Oliveira Lopes, Guilherme Manuel Goncalves de Macedo
Summary: A deep learning model capable of automatically detecting ulcers and erosions in PillCam(TM) Crohn's Capsule images was developed for the first time. The model showed high sensitivity and specificity in detecting ulcers and erosions.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Writaja Halder, Faidon-Marios Laskaratos, Hanan El-Mileik, Sergio Coda, Stevan Fox, Saswata Banerjee, Owen Epstein
Summary: The COVID-19 pandemic has heavily impacted healthcare services for patients with chronic diseases. This review explores the use of colon capsule endoscopy as a method for assessing and treating inflammatory bowel disease. Despite its limitations, there is increasing evidence to support the use of the second-generation colon capsule.
Review
Gastroenterology & Hepatology
Antonio Facciorusso, Paraskevas Gkolfakis, Daryl Ramai, Georgios Tziatzios, Janice Lester, Stefano Francesco Crino, Leonardo Frazzoni, Ioannis S. Papanikolaou, Marianna Arvanitakis, Daniel Blero, Arnaud Lemmers, Pierre Eisendrath, Lorenzo Fuccio, Konstantinos Triantafyllou, Armando Gabbrielli, Jacques Deviere
Summary: All treatments except mechanical lithotripsy were more effective than sphincterotomy in terms of stone removal rate. Cholangioscopy ranked the highest in increasing the success rate of stone removal, followed by S+EPLBD. None of the interventions showed significant differences in adverse event rates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Paraskevas Gkolfakis, Romane Fostier, Georgios Tziatzios, Nikolaos Lazaridis, Michael Fernandez Y. Viesca, Antonio Facciorusso, Edward Despott, Konstantinos Triantafyllou, Jacques Deviere, Marianna Arvanitakis
Summary: Pharmacologic treatment significantly reduces bleeding episodes and the need for transfusion in patients with gastrointestinal angiodysplasias (GIADs), leading to higher hemoglobin levels. However, approximately one-third of patients experience adverse events related to the treatment.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Liboria Laterza, Marina La Marca, Rocco Maurizio Zagari, Franco Radaelli, Cesare Hassan, Alessandro Repici, Antonio Facciorusso, Paraskevas Gkolfakis, Cristiano Spada, Konstantinos Triantafyllou, Franco Bazzoli, Mario Dinis-Ribeiro, Lorenzo Fuccio
Summary: This study assessed the diagnostic performance of alarm features (rectal bleeding, anemia, change in bowel habit, and weight loss) for colorectal cancer (CRC) diagnosis through a systematic review and meta-analysis. The results showed variable accuracy for each alarm feature, and rectal bleeding and anemia were identified as the most practical features for selecting patients for colonoscopy.
Article
Gastroenterology & Hepatology
Marco Pennazio, Emanuele Rondonotti, Edward J. Despott, Xavier Dray, Martin Keuchel, Tom Moreels, David S. Sanders, Cristiano Spada, Cristina Carretero, Pablo Cortegoso Valdivia, Luca Elli, Lorenzo Fuccio, Begona Gonzalez Suarez, Anastasios Koulaouzidis, Lumir Kunovsky, Deirdre McNamara, Helmut Neumann, Enrique Perez-Cuadrado-Martinez, Enrique Perez-Cuadrado-Robles, Stefania Piccirelli, Bruno Rosa, Jean-Christophe Saurin, Reena Sidhu, Ilja Tacheci, Erasmia Vlachou, Konstantinos Triantafyllou
Summary: According to the recommendations from ESGE, small-bowel capsule endoscopy is the recommended first-line examination for suspected small-bowel bleeding due to its excellent safety profile and patient tolerability. In cases of overt suspected small-bowel bleeding, small-bowel capsule endoscopy should be conducted as soon as possible, ideally within 48 hours after the bleeding episode to maximize diagnostic and therapeutic benefits. Routine second-look endoscopy before small-bowel capsule endoscopy is not recommended for patients with suspected small-bowel bleeding or iron-deficiency anemia. Conservative management is recommended for patients with suspected small-bowel bleeding and negative small-bowel capsule endoscopy. If lesions are identified, device-assisted enteroscopy can be used for confirmation and possibly treatment. Small-bowel capsule endoscopy is recommended as the first-line examination for patients with iron-deficiency anemia when small bowel evaluation is indicated. Small-bowel capsule endoscopy is also recommended in patients with suspected Crohn's disease and negative ileocolonoscopy findings, as well as in patients with unremarkable or nondiagnostic findings from dedicated small-bowel cross-sectional imaging if it is likely to influence patient management. A patency capsule should be used before small-bowel capsule endoscopy in patients with established Crohn's disease to decrease the capsule retention rate. Device-assisted enteroscopy can be used as an alternative to surgery for retrieving foreign bodies in the small bowel in patients without acute intestinal obstruction. Additionally, DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) is recommended as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy, except for Billroth II patients.
Review
Gastroenterology & Hepatology
Apostolis Papaefthymiou, Daryl Ramai, Marcello Maida, Georgios Tziatzios, Michael Fernandez Y. Viesca, Ioannis Papanikolaou, Konstantina Paraskeva, Konstantinos Triantafyllou, Alessandro Repici, Cesare Hassan, Cecilia Binda, Torsten Beyna, Antonio Facciorusso, Marianna Arvanitakis, Paraskevas Gkolfakis
Summary: This systematic review and meta-analysis found that motorized spiral enteroscopy (mSE) has high rates of diagnostic and therapeutic success with a low prevalence of severe adverse events.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Microbiology
Georgios Tziatzios, Paraskevas Gkolfakis, Gabriela Leite, Ruchi Mathur, Georgia Damoraki, Evangelos J. J. Giamarellos-Bourboulis, Konstantinos Triantafyllou
Summary: Functional dyspepsia (FD) is a common disorder with no definitive, universal treatment. Probiotics have been suggested as a potential therapeutic option for FD due to their effects on gastrointestinal symptoms in patients with Irritable Bowel Syndrome (IBS). However, the evidence for the efficacy of probiotics in FD remains unclear. This review aims to summarize the available evidence for the use of probiotics in FD.
Article
Gastroenterology & Hepatology
Peter J. Lee, Ali Lahooti, Stacey Culp, Andrew Boutsicaris, Phillip Holovach, Kayla Wozniak, Ila Lahooti, Pedram Paragomi, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin Traian Babu, Haq Nawaz, Silvia Cristina Gutierrez, Narcis Zarnescu, Gabriele Capurso, Jeffrey Easler, Konstantinos Triantafyllou, Mario Pelaez Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Phil A. Hart, Somashekar G. Krishna, Luis Lara, Samuel Han, Georgios I. Papachristou
Summary: This study aimed to determine the adjusted effects of body mass index (BMI) and alcoholic etiology on the risk of multisystem organ failure (MSOF) in patients with acute pancreatitis (AP). The results showed that alcoholic etiology was independently associated with increased risk of MSOF compared to non-alcohol etiologies, and obese men (but not women) were more susceptible to MSOF.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Simon M. Everett, Konstantinos Triantafyllou, Cesare Hassan, Klaus Mergener, Tony C. Tham, Nuno Almeida, Giulio Antonelli, Andrew Axon, Raf Bisschops, Michael Bretthauer, Vianna Costil, Farid Foroutan, James Gauci, Istvan Hritz, Helmut Messmann, Maria Pellise, Philip Roelandt, Andrada Seicean, Georgios Tziatzios, Andrei Voiosu, Ian M. Gralnek
Summary: All endoscopic procedures carry risks, so endoscopists should involve patients in the decision-making process and respect their right to self-determination. The European Society of Gastrointestinal Endoscopy has established a series of statements as a minimum standard of practice for informed consent, but there is a lack of guidance in many countries, leading to variations in care and potential legal risks.
Review
Microbiology
Maroulla D. Nikolaki, Arezina N. Kasti, Konstantinos Katsas, Konstantinos Petsis, Sophia Lambrinou, Vasiliki Patsalidou, Sophia Stamatopoulou, Katerina Karlatira, John Kapolos, Konstantinos Papadimitriou, Konstantinos Triantafyllou
Summary: This review explores the role of branched short-chain fatty acids (BCFAs) on gut inflammation in patients with irritable bowel syndrome (IBS) and the impact of low-FODMAP diet (LFD) on BCFAs production. The included studies have contradictory findings about the effects of BCFAs on intestinal health in IBS patients.
Review
Medicine, General & Internal
Thomas Vasilakis, Dimitrios Ziogas, Georgios Tziatzios, Paraskevas Gkolfakis, Eleni Koukoulioti, Christina Kapizioni, Konstantinos Triantafyllou, Antonio Facciorusso, Ioannis S. Papanikolaou
Summary: Gastric subepithelial lesions (SELs) are intramural lesions beneath the gastric mucosa. Accurate diagnosis is crucial as SELs can be benign, malignant, or have malignant potential. Endosonography is the gold standard for diagnosis, but histological examination may be necessary for certain lesions, particularly smaller ones. New methods such as contrast enhanced endosonography, EUS elastography, and artificial intelligence systems have been developed to assist decision making. This review provides a comprehensive overview and summarizes the latest diagnostic advances in endosonography for gastric SELs in the past decade.
Review
Gastroenterology & Hepatology
Magdalini Manti, Georgios Tziatzios, Antonio Facciorusso, Apostolis Papaefthymiou, Daryl Ramai, Ioannis Papanikolaou, Cesare Hassan, Konstantinos Triantafyllou, Konstantina Paraskeva, Paraskevas Gkolfakis
Summary: Add-on devices with projections placed on the distal tip of the colonoscope improve the detection of precancerous lesions during colonoscopy for screening purposes. Meta-analysis results indicate that the use of these devices results in a higher adenoma detection rate compared to standard colonoscopy.
ANNALS OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Eleni Manthopoulo, Daryl Ramai, Alexandros Ioannou, Paraskevas Gkolfakis, Ioannis S. Papanikolaou, Benedetto Mangiavillano, Konstantinos Triantafyllou, Stefano Francesco Crino, Antonio Facciorusso
Summary: Endoscopic ultrasound (EUS) is a technique that allows for the collection of tissue samples via a fine needle while visualizing the area. This study focuses on EUS tissue acquisition in organs other than the pancreas, including the liver, biliary tree, lymph nodes, and gastrointestinal tracts. The review discusses the evolving techniques used for tissue sampling under EUS guidance, as well as the importance of needle type and size in sample quality.
ANNALS OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Paraskevas Gkolfakis, Christina Kapizioni, Georgios Tziatzios, Antonio Facciorusso, Leonardo Frazzoni, Konstantinos Thomopoulos, Spyros Potamianos, Dimitrios Christodoulou, Vasilios Papadopoulos, Lorenzo Fuccio, Cesare Hassan, Konstantinos Triantafyllou
Summary: This study evaluated the comparative efficacy of predictive scores in predicting inadequate bowel cleansing among hospitalized patients undergoing colonoscopy. The results showed that Model B outperformed its comparators in predicting inadequate bowel preparation, particularly in mobilized inpatients.
ANNALS OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Paraskevas Gkolfakis, Maria Chiara Petrone, Mario Tadic, Georgios Tziatzios, Ioannis Karoumpalis, Stefano Francesco Crino, Antonio Facciorusso, Istvan Hritz, Dimitrios Kypraios, Athanasios D. Sioulas, Ilias Scotiniotis, Antonios Vezakis, Bank Keczer, Eleni Koukoulioti, Nicola Muscatiello, Konstantinos Triantafyllou, Andreas Polydorou, Ivica Grgurevic, Paolo Giorgio Arcidiacono, Ioannis S. Papanikolaou
Summary: EUS-guided drainage of peripancreatic fluid collections achieves high rates of technical and clinical success. Drainage using lumen-apposing metal stents (LAMS) has a shorter duration, but the complication rate is similar between LAMS and double pigtail plastic stents (DPPS).
ANNALS OF GASTROENTEROLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Ali Lahooti, Andrew Boutsicaris, Phillip Holovach, Kayla Wozniak, Tejas Subramanian, Ila Lahooti, Pedram Paragomi, Kwonho Jeong, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin T. Babu, Haq Nawaz, Silvia C. Gutierrez, Narcis Zarnescu, Livia Archibugi, Jeffrey J. Easler, Konstantinos Triantafyllou, Mario Pelaez Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Phil A. Hart, Somashekar G. Krishna, Samuel Han, Georgios Papachristou, Peter Lee
