Is there a role for second-look capsule endoscopy in patients with obscure GI bleeding after a nondiagnostic first test?

Background: Long-term follow-up data on patients with obscure GI bleeding subjected to capsule endoscopy (CE) are missing. Objective: Our purpose was to follow up patients with a nondiagnostic test and determine whether a second-look CE would be beneficial. Patients: We enrolled 293 subjects. CE studies were classified as diagnostic (Positive findings) or nondiagnostic (findings of uncertain significance/no findings). Patients were followed up for a mean (SD) 24.8 (5.2) months. Outcome was defined as continued or complete resolution of bleeding. Interventions: Patients with a nondiagnostic test were subjected to a repeat CE if they manifested a new bleeding episode or a drop in hemoglobin >= 2 g/dL. Results: Positive findings, findings of uncertain significance, and no findings were identified in 41.6%, 16.0%, and 42.3% of our patients, respectively. Therapeutic intervention was possible in 72.1% of those with positive findings and in 30% of those with findings of uncertain significance. Complete resolution of bleeding occurred more often in patients with a diagnostic test (65.2%) compared with those with a nondiagnostic test (35.4% P < .001). Second-look CE was performed in a subgroup of our Patients (n = 76) and was diagnostic in those whose Presentation changed from occult to overt or those whose hemoglobin dropped >= 4 g/dL. Conclusions: In patients with obscure GI bleeding, a diagnostic CE leads to therapeutic interventions and a favorable outcome. Patients with a nondiagnostic test would definitely benefit from a second-look CE if the bleeding Presentation changes from occult to overt or if the hemoglobin value drops >= 4 g/dL. (Gastrointest Endosc 2009;69:850-6.)