Article
Nutrition & Dietetics
Matthias Wittstock, Matthias Kaestner, Stephan Kolbaske, Tina Sellmann, Katrin Porath, Robert Patejdl
Summary: Delayed gastric emptying is a common and poorly understood complication in patients with acute neurological diseases. This study aimed to investigate the best method for measuring gastric emptying and its association with clinical parameters. The results showed that refractometry provided the most precise and least biased results compared to handheld glucose meter and Bradford protein assay. Additionally, calculations of nutrition transport revealed associations with blood glucose and sufentanil dosage, and could distinguish patients with feeding intolerance.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Guangxuan Lv, Tao Zhang, Luping Wang, Xin Fu, Yucong Wang, Hua Yao, Huang Fang, Xiaoxiao Xia, Jing Yang, Bo Wang, Zhongwei Zhang, Xiaodong Jin, Yan Kang, Yisong Cheng, Qin Wu
Summary: This study developed a technique to assess the feasibility of predicting the efficacy of prokinetic agents in critically ill patients. The results showed that gastric antrum echodensity can predict the effectiveness of prokinetic agents. The findings of this study can assist clinicians in deciding whether to use prokinetic agents when feeding intolerance occurs in critically ill patients.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Ting Zheng, Kia Vosoughi, Camille Lupianez-Merly, Deborah Eckert, Irene Busciglio, Duane Burton, Saam Dilmaghani
Summary: Objective symptoms of gastroparesis and functional dyspepsia overlap, and using egg protein substitute to measure gastric emptying can help reclassify patients. This study assessed the inter-individual and intra-individual coefficients of variation in gastric emptying in symptomatic patients with gastroparesis or functional dyspepsia. The results suggest that the 320 kcal (30% fat) gastric emptying scintigraphic test provides consistent diagnoses in the majority of patients.
Article
Multidisciplinary Sciences
Tomosuke Mukoyama, Shingo Kanaji, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
Summary: This study aimed to investigate the risk factors and severity of delayed gastric emptying (DGE) after gastrectomy. Female sex, diabetes, and distal gastric tumors were identified as independent risk factors for DGE. The DGE group had a longer hospital stay compared to the non-DGE group, and most DGE cases occurred after 1 week following surgery.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Lai Wei, Rajan Singh, Se Eun Ha, Alyce M. Martin, Lauren A. Jones, Byungchang Jin, Brian G. Jorgensen, Hannah Zogg, Tyler Chervo, Andres Gottfried-Blackmore, Linda Nguyen, Aida Habtezion, Nick J. Spencer, Damien J. Keating, Kenton M. Sanders, Seungil Ro
Summary: The study utilized a transgenic mouse line specific to EC cells to investigate the pathophysiologic roles of 5-HT deficiency in gastric motility. Findings indicated a new mechanism of 5-HT deficiency in idiopathic gastroparesis.
Article
Nutrition & Dietetics
Nick Goelen, Pieter Janssen, Jan Tack, John Morales, Tine Honinx, Greet van den Berghe, Michael P. Casaer, Jan Gunst
Summary: A pilot study in critically ill patients showed no significant correlation between balloon-assessed gastric motility and emptying. The feasibility and safety profile of the balloon tube appear to be similar to that of standard nasogastric tubes, with a high success rate of tube placement but also instances of balloon leakage leading to adverse events.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Maria Rosaria Marchili, Antonella Diamanti, Valeria Zanna, Giulia Spina, Cristina Mascolo, Marco Roversi, Benedetta Guarnieri, Gianluca Mirra, Giulia Testa, Umberto Raucci, Antonino Reale, Alberto Villani
Summary: Nutritional rehabilitation with naso-gastric feeding (NGF) is crucial for weight restoration in hospitalized anorexia nervosa (AN) patients. Patients treated with NGF have a lower BMI on admission and discharge, longer hospital stay, and a longer time to relapse compared to patients without NGF. Early NGF intervention is associated with a shorter length of hospitalization and facilitates faster recovery.
Article
Medicine, Research & Experimental
Guang Yang, Aijing Deng, Bojun Zheng, Jian Li, Yi Yu, Honglian Ouyang, Xin Huang, Hong Chen
Summary: This study aims to observe the effects of different feeding methods on critically ill patients, including parameters such as energy target and gastrointestinal motility, in order to improve quality of life and reduce case fatality rate.
Article
Gastroenterology & Hepatology
Jia-Kui Sun, Shuai Nie, Yong-Ming Chen, Jing Zhou, Xiang Wang, Su-Ming Zhou, Xin-Wei Mu
Summary: Intestinal mucosal barrier injury and gastrointestinal dysfunction are important causes of sepsis. This study found that early moderate enteral underfeeding (60% of goal requirements) could improve intestinal barrier function and nutritional status without increasing the risk of sepsis symptoms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Christopher Roberts, Maryam Hussein, Esme Poole, Vinod Kolimarala, Mich Erlewyn-Lajeunesse, R. Mark Beattie, Francis Sundrum, Nadeem Afzal
Summary: This study aimed to identify the best predicting factors for delayed gastric emptying (DGE) and assess the response to treatment in children. The analysis showed that prior surgery was a key factor in predicting highly DGE. After 2 years, symptoms and medication usage significantly reduced.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Article
Veterinary Sciences
Stephanie Rutherford, Frederic Gaschen, Roman Husnik, Jon Fletcher, Lorrie Gaschen
Summary: This study evaluated the effects of azithromycin on gastric emptying (GE) and gastric motility in healthy cats. It found that azithromycin and erythromycin both shortened GE time in a comparable manner. Further evaluation of their efficacy in cats with gastric dysmotility is warranted.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
I-Hsuan Huang, Jolien Schol, Florencia Carbone, Yaozhu J. Chen, Karen Van den Houte, Lukas Michaja Balsiger, Bert Broeders, Tim Vanuytsel, Jan Tack
Summary: This study investigated the symptom patterns in distinguishing gastroparesis from functional dyspepsia. The results showed that patients with gastroparesis-like symptoms had a higher prevalence of delayed gastric emptying and higher symptom severity compared to patients with FD symptoms.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Roland N. Dickerson, Catherine E. Corley, Whitney L. Holmes, Saskya Byerly, Dina M. Filiberto, Peter E. Fischer
Summary: This study aimed to evaluate the tolerance of gastric feeding in critically ill patients receiving sustained neuromuscular blocker (NMB) pharmacotherapy. The findings showed that most patients tolerated intragastric enteral nutrition during NMB pharmacotherapy, indicating that NMB pharmacotherapy is not an absolute contraindication for gastric feeding.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Anesthesiology
Jennifer J. Lee, Jerri C. Price, Andrew Duren, Alon Shertzer, Robert Hannum, Francis A. Akita, Shuang Wang, Judy H. Squires, Oliver Panzer, Jacquelin Herrera, Lena S. Sun, Nicholas A. Davis
Summary: Ultrasound examination in healthy neonates showed that gastric emptying times after formula feeding are significantly shorter than the current 6 h fasting recommendation, potentially reducing the risks and discomfort associated with prolonged fasting in newborns.
Article
Medicine, General & Internal
Keno Mentor, Jade Lembo, Samantha Carswell, Mike Jones, Sanjay Pandanaboyana
Summary: This study aims to investigate the mechanism of delayed gastric emptying (DGE) after pancreaticoduodenectomy (PD) by using body surface gastric mapping (BSGM) to assess gastric motility in postoperative PD patients. The study will be conducted at a large hepatobiliary unit in the UK, with 50 planned PD patients included. BSGM measurements will be performed at four timepoints and key parameters will be compared between different patient subgroups. Symptoms will be self-reported by patients during the recording using an iPad application, and quality of life and patient experience will be assessed using standardized questionnaires.
Article
Critical Care Medicine
Samuel Gluck, Alice Andrawos, Matthew J. Summers, Jarrod Lange, Marianne J. Chapman, Mark E. Finnis, Adam M. Deane
Summary: This study aimed to evaluate the feasibility of extracting location data from smartphones of survivors of ICU admission and assessing participation during their recovery. The results showed an increase in the number of activities and distance travelled between 3 and 6 months, suggesting a potential improvement in participation over time.
AUSTRALIAN CRITICAL CARE
(2022)
Article
Nutrition & Dietetics
Ra'eesa Doola, Adam M. Deane, Helen L. Barrett, Satomi Okano, Debbie M. Tolcher, Kye Gregory, Jeff S. Coombes, Casper Schalkwijk, Alwyn S. Todd, Josephine M. Forbes, David J. Sturgess
Summary: The study found that intake of nutritional formula with higher AGE load may increase the insulin required to maintain blood glucose within normal range in critically ill patients. Moreover, there was an inverse relationship between exogenous insulin and plasma inflammatory markers.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Critical Care Medicine
Lee-Anne S. Chapple, Imre W. K. Kouw, Matthew J. Summers, Luke M. Weinel, Samuel Gluck, Eamon Raith, Peter Slobodian, Stijn Soenen, Adam M. Deane, Luc J. C. van Loon, Marianne J. Chapman
Summary: The ability of critically ill patients to synthesize muscle protein from ingested protein is significantly reduced, despite relatively normal protein digestion and amino acid absorption.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Alexis P. Poole, Mark E. Finnis, James Anstey, Rinaldo Bellomo, Shailesh Bihari, Vishwanath Biradar, Sarah Doherty, Glenn Eastwood, Simon Finfer, Craig J. French, Simon Heller, Michael Horowitz, Palash Kar, Peter S. Kruger, Matthew J. Maiden, Johan Martensson, Colin J. McArthur, Shay P. McGuinness, Paul J. Secombe, Antony E. Tobin, Andrew A. Udy, Paul J. Young, Adam M. Deane
Summary: This study investigates the effect of blood glucose target range on patient outcomes in ICU patients with type 2 diabetes. The results show that a liberal approach to blood glucose targets can reduce the incidence of hypoglycemia, but does not improve patient-centered outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Endocrinology & Metabolism
Adam M. Deane, Michael P. Casaer
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2022)
Article
Nutrition & Dietetics
Neha Kaul, Judy Nation, Joshua Laing, John-Paul Nicolo, Adam M. Deane, Andrew A. Udy, Patrick Kwan, Terence J. O'Brien
Summary: This study analyzed the outcomes of adults with super-refractory status epilepticus (SRSE) who received a lower ketogenic ratio of 2:1 grams of fat to non-fat grams, including medium chain triglycerides. The results showed that the low ratio ketogenic therapy was tolerable for adults with SRSE, with a resolution rate of 83%. However, further studies are needed to determine the optimal timing, nutrition prescription, and duration of ketogenic therapy for SRSE treatment.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Critical Care Medicine
Mark P. Plummer, Louise Rait, Mark E. Finnis, Craig J. French, Samantha Bates, James Douglas, Mansi Bhurani, Tessa Broadley, Tony Trapani, Adam M. Deane, Andrew A. Udy, Aidan J. C. Burrell
Summary: This study aimed to determine the prevalence and outcomes of diabetes in Australian ICU patients with severe COVID-19. The study found that diabetes is prevalent in ICU patients with COVID-19 in Australia, and patients with diabetes have longer hospital stays and higher mortality rates.
AUSTRALIAN CRITICAL CARE
(2023)
Article
Medicine, General & Internal
Emma J. Ridley, Michael Bailey, Marianne Chapman, Lee-anne S. Chapple, Adam M. Deane, Carol Hodgson, Victoria L. King, Andrea Marshall, Eliza G. Miller, Sp McGuinness, Rachael Parke, Andrew A. Udy
Summary: This study aims to determine the feasibility of a whole hospital nutrition intervention in critically ill patients and whether it can deliver more total energy compared to usual care. Through a randomized controlled trial, the study will observe the impact of nutrition therapy on daily energy delivery and other related clinical outcomes.
Review
Endocrinology & Metabolism
Mark P. Plummer, Jeroen Hermanides, Adam M. Deane
Summary: The use of personalised glucose targets in critically ill patients, especially those with preexisting diabetes, remains controversial. There is inadequate data to support the adoption of personalised glucose targets in critical care practice, although there is potential for future trials in patients with chronic hyperglycaemia.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2022)
Review
Critical Care Medicine
Adam M. Deane, Mark P. Plummer, Yasmine Ali Abdelhamid
Summary: This review provides a comprehensive summary of the recent evidence on the relationship between critical illness and disordered glucose metabolism. It highlights the importance of personalized glucose targets based on preexisting glycemia and the need for optimized glucose monitoring in the ICU. The review also emphasizes the risk of nocturnal hypoglycemia for patients with preexisting diabetes and the association between stress hyperglycemia and the development of diabetes, particularly in critically ill patients with COVID-19.
CURRENT OPINION IN CRITICAL CARE
(2022)
Review
Nutrition & Dietetics
John K. Noyahr, Oana A. Tatucu-Babet, Lee-Anne S. Chapple, Christopher Jake Barlow, Marianne J. Chapman, Adam M. Deane, Kate Fetterplace, Carol L. Hodgson, Jacinta Winderlich, Andrew A. Udy, Andrea P. Marshall, Emma J. Ridley
Summary: This study assessed the methodological quality of clinical practice guidelines for nutrition care in critically ill adults and the recommendations for determining energy expenditure. The findings showed that the guidelines were developed using systematic methods but lacked stakeholder engagement and specific guidance. The quality of the energy expenditure determination recommendations was low.
Article
Medical Laboratory Technology
Lucy Sharrock, Melissa J. Ankravs, Adam M. Deane, Thomas Rechnitzer, Steven C. Wallis, Jason A. Roberts, Rinaldo Bellomo
Summary: This study measured the clearance of piperacillin-tazobactam and vancomycin in patients receiving CVVHDF with regional citrate anticoagulation, and found that both drugs have high clearance, providing key information for optimal dosing.
THERAPEUTIC DRUG MONITORING
(2023)
Article
Medicine, General & Internal
Yasmine Ali Abdelhamid, Adam Deane, Rinaldo Bellomo
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Nutrition & Dietetics
Kym Wittholz, Kate Fetterplace, Amalia Karahalios, Yasmine Ali Abdelhamid, Lisa Beach, David Read, Rene Koopman, Jeffrey J. Presneill, Adam M. Deane
Summary: This study aimed to determine the feasibility of administering a blinded nutrition supplement in the ICU and continuing it after ICU discharge. The results showed that daily enteral supplementation of 3g HMB for up to 28 days is feasible, but the effect of HMB on attenuating muscle wasting after traumatic injury remains uncertain.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Endocrinology & Metabolism
Ryan Joseph Jalleh, Mahesh Michael Umapathysivam, Mark Philip Plummer, Adam Deane, Karen Louise Jones, Michael Horowitz
Summary: Following bariatric surgery, individuals with post-bariatric surgery hypoglycemia show higher responses in GLP-1, GIP, insulin, and C-peptide, and lower levels of HbA(1c).
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)