Article
Chemistry, Multidisciplinary
Jinlong Zhang, Shuai Mu, Weilin Wang, Huipeng Sun, Shuangqin Li, Xuezhao Shi, Yunbo Liu, Xiaoyan Liu, Haixia Zhang
Summary: In this study, a novel fluorescent probe was developed for the detection of H2S. The probe showed comparable imaging performance to the traditional probe but exhibited lower toxicity to cells and animals.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Harsha Gautam, Mehar Fatma, Zebus Sehar, Iqbal R. Mir, Nafees A. Khan
Summary: This study investigates the effects of gaseous signaling molecules, ethylene, nitric oxide, and hydrogen sulfide, on high temperature stress tolerance in rice. The findings suggest that these molecules can enhance thermo-tolerance and protect photosynthesis in rice, with ethylene showing the most significant effect.
Article
Environmental Sciences
Yu-Juan Lin, Xing-Hui Feng, Yu-Xi Feng
Summary: This study evaluated the importance of hydrogen sulfide (NaHS) and nitric oxide (SNP) in the antioxidant systems of rice seedlings under Cr(III) stress. The results showed that NaHS and SNP effectively alleviated the toxic effects of Cr(III) by activating different antioxidants. NaHS had a stronger regulatory effect on non-enzymatic and enzymatic antioxidants compared to SNP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Dongliang Hu, Lijuan Wei, Weibiao Liao
Summary: This review discusses the interaction between brassinosteroids (BRs) and small-molecule compounds (SMCs) in plant growth, development, and stress responses, highlighting how they promote plant development and alleviate stress damage by modulating the antioxidant system, photosynthetic capacity, and carbohydrate metabolism.
Article
Pharmacology & Pharmacy
Hussa Alshahwan, Bedoor Qabazard, Alyaa Mousa, Bindu Chandrasekhar, Krishna Santhosh, Mariam H. M. Yousif
Summary: The study indicates that GYY4137 may be a novel therapeutic tool to prevent diabetes-associated vascular dysfunction. This treatment significantly improves vascular constriction and dilation responses in diabetic rats, and affects the levels of nitric oxide and hydrogen sulfide.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kuljeet Kaur, Patrick Enders, Yumeng Zhu, Abigail F. Bratton, Chadwick R. Powell, Khosrow Kashfi, John B. Matson
Summary: A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics was reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.
CHEMICAL COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Oluwafunke R. Kolawole, Khosrow Kashfi
Summary: Acute inflammation is an adaptive host defense mechanism, but unresolved or chronic inflammation can lead to various maladies, including cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been shown to reduce the risk and mortality of many cancers. Besides targeting cyclooxygenase-2 (COX-2), NSAIDs also affect other important targets, and specialized pro-resolving mediators (SPMs) promote the resolution of inflammation and tissue healing, showing potential in inhibiting cancer growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hannah Petraitis Kuschman, Marianne B. Palczewski, Douglas D. Thomas
Summary: Nitric oxide (NO) and hydrogen sulfide (H2S) are now recognized as potent gaseous messenger molecules that rapidly transduce cellular signals and regulate various physiological functions. They often work synergistically and competitively to modulate each other's activity through chemical reactions and modifications to protein targets. In addition to their canonical modes of action, increasing evidence has shown that they also share the signaling mechanism of epigenetic regulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Subir Kumar Juin, Rosemary Ouseph, Dibson Dibe Gondim, Venkatakrishna Rao Jala, Utpal Sen
Summary: Diabetic nephropathy (DN) is still the main cause of morbidity and mortality in diabetes patients. Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), play a vital role in the development and progression of DN. Aberrant levels of gasotransmitters have been observed in patients with diabetes, and gasotransmitter donors show potential in ameliorating diabetic renal dysfunction. This review provides an overview of the physiological relevance of gasotransmitters and their interaction with other factors in the severity modulation of DN, highlighting the possible therapeutic interventions.
Article
Agronomy
Dandan Huang, Yuanyi Wang, Dingchuan Zhang, Yingfei Dong, Qingxi Meng, Shuhua Zhu, Lili Zhang
Summary: The study found that exogenous strigolactone can alleviate oxidative damage of strawberries by improving the defense capability of the antioxidant system and promoting related metabolic activities, maintaining fruit quality.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2021)
Article
Chemistry, Organic
Dipanjan Banik, Anirban Karak, Satyajit Halder, Shilpita Banerjee, Moumi Mandal, Anwesha Maiti, Kuladip Jana, Ajit Kumar Mahapatra
Summary: A novel fluorescent probe was designed and synthesized for tracking H2S in environmental and biological samples. It exhibited high selectivity, sensitivity, and successful detection of H2S in various applications.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Maxwell B. Zeigler, Emily E. Fay, Sue L. Moreni, Jennie Mao, Rheem A. Totah, Mary F. Hebert
Summary: This study aimed to investigate the changes in plasma levels of hydrogen sulfide (H2S), nitric oxide (NO), and related metabolites during pregnancy progression. The results showed significant decreases in plasma levels of NO and thiocyanate (SCN-) at 25-28 weeks and 28-32 weeks gestation, while plasma H2S levels significantly decreased at 28-32 weeks gestation. Methanethiol (CH3SH) levels did not show significant differences. These findings are important for understanding the role of these gasotransmitters in normal and pathological progression of pregnancy.
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Plant Sciences
Faisal Zulfiqar, Muhammad Nafees, Jianjun Chen, Anastasios Darras, Antonio Ferrante, John T. Hancock, Muhammad Ashraf, Abbu Zaid, Nadeem Latif, Francisco J. Corpas, Muhammad Ahsan Altaf, Kadambot H. M. Siddique
Summary: Salt stress severely limits crop productivity globally, and its effects are worsened by climate change. Plant priming, using specific chemical agents, has shown promise in enhancing plant tolerance to salt stress. This review summarizes the current knowledge on various molecules/compounds that can potentially enhance the salinity tolerance of crop plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Alexander Kastner, Theresa Mendrina, Florian Bachmann, Walter Berger, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: In this study, oxaliplatin(iv)-based complexes were developed as platinum(iv) prodrugs to release aspirin, which has shown antitumor activity against colon cancer. The newly synthesized complex demonstrated increased reduction stability compared to a cisplatin analog and exhibited desired prodrug properties in cell culture. A derivative with albumin-binding properties showed improved pharmacokinetics and tumor accumulation, leading to enhanced antitumor activity and overall survival in tumor-bearing mice.
INORGANIC CHEMISTRY FRONTIERS
(2023)