Review
Immunology
Chunjiao Zheng, Yuling Shi, Ying Zou
Summary: The use of immune checkpoint inhibitors (ICIs) in cancer treatment may lead to progressive atopic dermatitis (AD) by affecting T cell reactivation. T cell co-signaling pathways play a critical role in the pathogenesis of AD, determining the magnitude of the T cell response to antigens. Understanding these pathways is important for investigating the mechanism and treatment of AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Gilberto Betancor, Madeleine Bangham, Jun Ki Jeon, Kanisha Shah, Steven Lynham, Jose M. Jimenez-Guardeno, Michael H. Malim
Summary: Phosphorylation of MX2 plays a crucial role in regulating its antiviral activity and determining susceptible viral substrates.
Review
Immunology
Kehong Zheng, Xiaojun Zheng, Wei Yang
Summary: T-cell exhaustion, caused by metabolic dysfunction, impairs the ability of T cells to eliminate pathogens during chronic viral infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yulia Alexandrova, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Summary: Despite successful antiretroviral therapy, people living with HIV still experience a higher rate of respiratory infections, lung cancers, and chronic lung disease. The lung mucosa, previously overlooked as an HIV reservoir site, plays a significant role in this phenomenon. Residual levels of HIV in deep tissues, combined with chronic immune activation and pulmonary inflammation, contribute to viral persistence. Factors such as smoking, gut and lung dysbiosis, and co-infections further exacerbate residual viral replication and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
T. T. Guimaraes, S. M. R. Gomes, R. A. A. C. Albuquerque, A. K. C. Lima, G. F. Braga, J. B. Souza, M. Assis, A. C. S. Brito, R. F. Santos, T. Da Silva, L. M. Siqueira, B. D. Ventura, L. S. Rodrigues, R. Terra, S. A. G. Da Silva, P. M. L. Dutra
Summary: Moderate exercise promotes resistance to infections, while high intensity exercise may increase susceptibility. The study demonstrates that high volume aerobic training can enhance BALB/C mice susceptibility to L. major infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Ya-Lang Huang, Ming-Ting Huang, Pei-Shan Sung, Teh-Ying Chou, Ruey-Bing Yang, An-Suei Yang, Chung-Ming Yu, Yu-Wen Hsu, Wei-Chiao Chang, Shie-Liang Hsieh
Summary: Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress viral replication, and increase mice survival rate after flu infection infection.
COMMUNICATIONS BIOLOGY
(2021)
Review
Immunology
John D. Sears, Kevin J. Waldron, Jian Wei, Chih-Hao Chang
Summary: CD8 T-cells play a vital role in clearing virus-infected cells, but can become metabolically dysfunctional in chronic viral infections. Research suggests that targeting the metabolic state of CD8 T-cells could be a promising option for reversing this dysfunction and developing novel therapies for treating chronic infections.
Review
Immunology
Yue Zhang, Xiaobin Zhou, Shuyi Chen, Xinchen Sun, Chenglin Zhou
Summary: Viral myocarditis is a major cause of dilated cardiomyopathy, leading to heart failure and sudden cardiac death. Current therapies for chronic myocarditis are unsatisfactory, possibly due to persistent viral or immunological insults to the heart. Cellular and mouse models using CVB3 virus infection have shed light on the pathophysiology of viral myocarditis. This review discusses the immunological mechanisms of innate and adaptive immunity in the development of CVB3-induced myocarditis.
Article
Immunology
Ida Uddback, Emily K. Cartwright, Amalie S. Scholler, Alexander N. Wein, Sarah L. Hayward, Jenna Lobby, Shiki Takamura, Allan R. Thomsen, Jacob E. Kohlmeier, Jan P. Christensen
Summary: The study demonstrates that lung tissue-resident memory T cells (T-RM) can be maintained for at least a year post vaccination with an adenovirus expressing influenza nucleoprotein. The lung T-RM cells continued to proliferate in situ 8 months after vaccination, requiring airway vaccination and antigen persistence in the lung for long-term maintenance. Additionally, the lung T-RM pool is sustained by continual replenishment from circulating memory CD8 T cells in vaccinated mice.
MUCOSAL IMMUNOLOGY
(2021)
Review
Physiology
Martina Barnova, Anna Bobcakova, Veronika Urdova, Radovan Kosturiak, Lenka Kapustova, Dusan Dobrota, Milos Jesenak
Summary: COVID-19, caused by SARS-CoV-2, primarily affects the respiratory system and can lead to serious lung infections or pneumonia in severe cases. Clinical studies have shown that severe cases of SARS-CoV-2 infection can cause acute tissue damage due to a pathological immune response.
PHYSIOLOGICAL RESEARCH
(2021)
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Leo Swadling, Mala K. Maini
Summary: Despite the infectious nature of SARS-CoV-2, some individuals resist developing detectable infections, suggesting the occurrence of abortive infections. This type of infection is a desirable outcome as it prevents disease development and allows for the study of highly effective immunity. The identification of abortive infections using sensitive immunoassays and transcriptomic signatures is challenging, but there is evidence supporting their occurrence in various viral infections. Furthermore, the role of T cells in terminating early viral replication in abortive infections needs to be considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Sachin Mulik, Engin Berber, Sharvan Sehrawat, Barry Tyrrell Rouse
Summary: In this review, various immune modulating approaches to counteract tissue-damaging viral immunoinflammatory lesions in chronic viral infections are discussed. The authors highlight the role of host response in mediating cell and tissue damage, rather than the virus itself. The article identifies aspects of the host reactions that influence immune responsiveness and describes successful approaches to modulate damaging participants and control viral-induced lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yubing Fu, Jinjia Wang, Chenfeng Liu, Kunyu Liao, Xianjun Gao, Ronghan Tang, Binbin Fan, Yazhen Hong, Nengming Xiao, Changchun Xiao, Wen-Hsien Liu
Summary: Cellular immunity mediated by CD8(+) T cells is essential for clearing bacterial and viral infections as well as cancers. However, prolonged antigen stimulation can lead to exhaustion or dysfunction of CD8(+) T cells. This study shows that the deletion of Gsk3α and Gsk3β in CD8(+) T cells results in decreased differentiation and effector function during viral infection and failed tumor control. Additionally, GSK3 regulates T-cell exhaustion by suppressing NFAT-mediated exhaustion-related gene expression.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Microbiology
Kul Raj Rai, Prasha Shrestha, Bincai Yang, Yuhai Chen, Shasha Liu, Mohamed Maarouf, Ji-Long Chen
Summary: Viral infections can cause widespread diseases in humans, requiring robust immune responses to prevent potentially fatal acute viral infections. While innate immunity plays a crucial role in viral clearance, it can also contribute to disease progression through immune-mediated host tissue injury.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Allergy
Tristan Holland, Dirk Wohlleber, Samira Marx, Thomas Kreutzberg, Salvador Vento-Asturias, Christine Schmitt-Mbamunyo, Meike Welz, Marianne Janas, Karl Komander, Sarah Eickhoff, Anna Brewitz, Mike Hasenberg, Linda Maenn, Matthias Gunzer, Christoph Wilhelm, Wolfgang Kastenmueller, Percy Knolle, Zeinab Abdullah, Christian Kurts, Natalio Garbi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Editorial Material
Gastroenterology & Hepatology
William Alazawi, Percy A. Knolle
JOURNAL OF HEPATOLOGY
(2018)
Article
Pathology
K. Steiger, S. Ballke, H. -Y. Yen, O. Seelbach, A. Alkhamas, M. Boxberg, K. Schwamborn, P. A. Knolle, W. Weichert, C. Mogler
Article
Multidisciplinary Sciences
Felix Tolksdorf, Julita Mikulec, Bernd Geers, Jessica Endig, Paulina Sprezyna, Lukas C. Heukamp, Percy A. Knolle, Waldemar Kolanus, Linda Diehl
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Julia Matthias, Julia Maul, Rebecca Noster, Hanna Meinl, Ying-Yin Chao, Heiko Gerstenberg, Florian Jeschke, Gilles Gasparoni, Anna Welle, Joern Walter, Karl Nordstroem, Klaus Eberhardt, Dennis Renisch, Sainitin Donakonda, Percy Knolle, Dominik Soll, Stephan Grabbe, Natalie Garzorz-Stark, Kilian Eyerich, Tilo Biedermann, Dirk Baumjohann, Christina E. Zielinski
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patrick Helbling, Cesar Nombela-Arrieta, Anahita Rafiei, Martina Hinterleitner, Marcel Rall, Florian Baku, Oliver Borst, Caroline L. Wilson, Jack Leslie, Tracy O'Connor, Christopher J. Weston, David H. Adams, Lozan Sheriff, Ana Teijeiro, Marco Prinz, Ruzhica Bogeska, Natasha Anstee, Malte N. Bongers, Mike Notohamiprodjo, Tobias Geisler, Dominic J. Withers, Jerry Ware, Derek A. Mann, Hellmut G. Augustin, Alexandros Vegiopoulos, Michael D. Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Roser Pinyol, Frank Tacke, Roland Rad, Matthias Matter, Nabil Djouder, Paul Kubes, Percy A. Knolle, Kristian Unger, Lars Zender, Bernhard Nieswandt, Meinrad Gawaz, Achim Weber, Mathias Heikenwalder
Article
Multidisciplinary Sciences
Francesca Alfei, Kristiyan Kanev, Maike Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, Dirk Wohlleber, Katja Steiger, Doron Merkler, Mauro Delorenzi, Percy A. Knolle, Cyrille J. Cohen, Robert Thimme, Benjamin Youngblood, Dietmar Zehn
Article
Multidisciplinary Sciences
Annika Schneider, Sandra Kurz, Katrin Manske, Marianne Janas, Mathias Heikenwaelder, Thomas Misgeld, Michaela Aichler, Sebastian FelixWeissmanns, Hans Zischka, Percy Knolle, Dirk Wohlleber
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Anna D. Kosinska, Abdul Moeed, Nina Kallin, Julia Festag, Jinpeng Su, Katja Steiger, Marie-Louise Michel, Ulrike Protzer, Percy A. Knolle
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Tracy O'Connor, Xiaolan Zhou, Jan Kosla, Arlind Adili, Maria Garcia Beccaria, Elena Kotsiliti, Dominik Pfister, Anna-Lena Johlke, Ankit Sinha, Roman Sankowski, Markus Schick, Richard Lewis, Nikolaos Dokalis, Bastian Seubert, Bastian Hoechst, Donato Inverso, Danijela Heide, Wenlong Zhang, Petra Weihrich, Katrin Manske, Dirk Wohlleber, Martina Anton, Alexander Hoellein, Gitta Seleznik, Juliane Bremer, Sabine Bleul, Helmut G. Augustin, Florian Scherer, Uwe Koedel, Achim Weber, Ulrike Protzer, Reinhold Foerster, Thomas Wirth, Adriano Aguzzi, Felix Meissner, Marco Prinz, Bernd Baumann, Uta E. Hoepken, Percy A. Knolle, Louisa von Baumgarten, Ulrich Keller, Mathias Heikenwalder
Article
Immunology
Chris D. Hermann, Benjamin Schoeps, Celina Eckfeld, Enkhtsetseg Munkhbaatar, Lukas Kniep, Olga Prokopchuk, Nils Wirges, Katja Steiger, Daniel Haeussler, Percy Knolle, Emily Poulton, Rama Khokha, Barbara T. Gruenwald, Ihsan Ekin Demir, Achim Krueger
Summary: This study uncovers a sex disparity in liver metastasis independent of lifestyle, with TIMP1 playing a role in promoting liver metastasis in male pancreatic cancer patients and mice. Identifying subpopulations with increased TIMP1 levels may have implications for precision medicine.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Celina Eckfeld, Benjamin Schoeps, Daniel Haeussler, Julian Fraedrich, Felix Bayerl, Jan Philipp Boettcher, Percy Knolle, Simone Heisz, Olga Prokopchuk, Hans Hauner, Enkhtsetseg Munkhbaatar, Ihsan Ekin Demir, Chris D. Hermann, Achim Krueger
Summary: The study reveals that TIMP-1 interacts with APP family members and triggers monocyte activation, leading to proinflammatory cytokine expression. This mechanism is confirmed in clinical cancer samples and suggests that TIMP-1 can be a potential therapeutic target for inflammatory diseases.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Neda Yahoo, Michael Dudek, Percy Knolle, Mathias Heikenwaelder
Summary: The liver plays a central role in metabolism and immune functions. When overwhelmed by obesity and a sedentary lifestyle, it can lead to the development of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Genetic and environmental factors, including the gut microbiome, also contribute to the development and progression of NAFLD and liver cancer. CD8+CXCR6+PD1+ T cells are implicated in the transition from NASH to hepatocellular carcinoma (HCC), and their characteristics may affect responses to immune checkpoint inhibitors. This review focuses on the role of T cells in NASH and discusses preventive measures and therapeutic strategies for managing NASH-HCC.
JOURNAL OF HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Valter Bergant, Daniel Schnepf, Niklas de Andrade Kraetzig, Philipp Hubel, Christian Urban, Thomas Engleitner, Ronald Dijkman, Bernhard Ryffel, Katja Steiger, Percy A. A. Knolle, Georg Kochs, Roland Rad, Peter Staeheli, Andreas Pichlmair
Summary: Bergant et al. provide evidence that Influenza A viruses cause alternative polyadenylation of host mRNAs, leading to an attenuated phenotype in mice. This may constitute a common immune evasion mechanism employed by a variety of pathogenic viruses.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Jochen M. Wettengel, Katharina Strehle, Catharina von Lucke, Hedwig Roggendorf, Samuel D. Jeske, Catharina Christa, Otto Zelger, Bernhard Haller, Ulrike Protzer, Percy A. Knolle
Summary: This study demonstrates the usefulness of a second-generation rapid antigen test for early detection of infection with the SARS-CoV-2 Omicron variant of concern (VoC) and reveals a higher sensitivity to detect immune escape Omicron VoCs compared to a first-generation rapid antigen test (89.4% vs 83.7%) in the high-risk group of healthcare workers.
MICROBIOLOGY SPECTRUM
(2023)