Article
Oncology
Xiaoxia Jia, Ting Guo, Zhemin Li, Meng Zhang, Yi Feng, Bin Dong, Zhongwu Li, Ying Hu, Ziyu Li, Xiaofang Xing, Shuqin Jia, Jiafu Ji
Summary: Epstein-Barr virus-associated gastric cancer patients are characterized by younger age, low-differentiated adenocarcinoma, and less vascular invasion. Increased infiltration of immune cells affects patient prognosis, particularly in EBVaGC patients with higher CD3(+) T lymphocyte density, leading to longer survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yan-li Wang, Yuehua Gong, Zhi Lv, Liang Li, Yuan Yuan
Summary: The study investigated the expression of PD1/PDL1 and their correlation with CD8+ T cell/CD68+ macrophage densities in gastric cancer at different microsatellite statuses. The results showed that PD1/PDL1 expression varied in GC at different microsatellite statuses, with potential benefits for immunotherapy in patients with high PD1/PDL1 expression or high CD8+ T cell/CD68+ macrophage densities in MSI GC.
Article
Oncology
Yixian Guo, Shouyu Ke, Feng Xie, Jieqiong Chen, Xu Liu, Zeyu Wang, Danhua Xu, Yanying Shen, Gang Zhao, Wenyi Zhao, Hong Lu
Summary: SIGLEC10 is shown to have an immunosuppressive role in gastric cancer by suppressing the proliferation and function of CD8(+) T cells through the Akt/P38/Erk signaling pathway. Blocking SIGLEC10 promotes CD8(+) T cell effector function and is correlated with a better clinical prognosis. Thus, SIGLEC10 holds promise as a target for immunotherapy and as a potential predictor of the clinical prognosis of gastric cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Oncology
Zidi Zhou, Zhilong Yang, Jingzhi Wang, Qiang Wang, Heng Zhang, Xiaoli Ju
Summary: Tumour-associated macrophages (TAMs) play a crucial role in gastric cancer, with their quantity predicting disease progression and metastasis, significantly impacting the treatment and prognosis of patients with gastric cancer.
Article
Oncology
Taohua Yue, Jichang Li, Jing Zhu, Shuai Zuo, Xin Wang, Yucun Liu, Jia Liu, Xiaoyun Liu, Pengyuan Wang, Shanwen Chen
Summary: Immunotherapy can be effective in treating cancer, but many colorectal cancer patients do not respond to it. This study shows that reducing H2S levels can help reverse the tumor-supportive functions and improve the efficacy of immunotherapy.
Article
Oncology
Alexandra Giatromanolaki, Achilleas Mitrakas, Ioannis Anestopoulos, Andreas Kontosis, Ioannis M. Koukourakis, Aglaia Pappa, Mihalis I. Panayiotidis, Michael I. Koukourakis
Summary: The study showed that high CD47 expression by cancer cells, along with high SIRPα expression by CD68+ TAMs, low TIL-score, and poor prognosis are correlated in NSCLC. CD68+ TAMs play an important role in the prognosis of operable NSCLC. Targeting the CD47/SIRPα axis may improve adjuvant immunotherapy strategies in NSCLC.
Review
Oncology
Fei Liu, Zixian Wang, Xiaofan Li, Zhen Zhang, Yue Yang, Junquan Chen, Dinghua Chen, Lingling Wu, Xiangyu Liu, Sujun Han, Fangming Wang, Wasilijiang Wahafu, Yibo Gao, Shancheng Ren, Nianzeng Xing, Guangyan Cai, Xiangmei Chen
Summary: Using a network meta-analysis approach, this study examined the comparative risk of acute kidney injury (AKI) in cancer patients receiving different immune checkpoint inhibitors (ICIs). The results revealed the relative safety of existing ICI drugs for AKI. Additionally, several potential risk factors for immune-related AKI, such as tumor type and treatment paradigm, were identified.
CANCER COMMUNICATIONS
(2023)
Review
Microbiology
Yuzhen Li, Xiaona Huang, Desheng Tong, Chenyu Jiang, Xiaodan Zhu, Zhipeng Wei, Tingjie Gong, Chunhui Jin
Summary: This paper reviews the relationship between microorganisms and gastric cancer, as well as the potential of combining microorganisms with immunotherapy to enhance immune response in gastric cancer patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Duncan C. Humphries, Ross Mills, Ross Dobie, Neil C. Henderson, Tariq Sethi, Alison C. Mackinnon
Summary: Selective depletion of Gal-3 in myeloid cells leads to reduced neutrophil recruitment into the interstitium, resulting in decreased pulmonary inflammation after acute lung injury. This suggests that targeting Gal-3 could be a promising new therapy for lung inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nandie Wu, Fangcen Liu, Ying Huang, Xinyu Su, Yaping Zhang, Lixia Yu, Baorui Liu
Summary: The high-risk group of gastric cancer patients showed higher clinical stage or grade and worse prognosis compared to the low-risk group. The low-risk group had higher levels of immunity and immune cell infiltration. Necroptosis was triggered by the TNF pathway in myeloid cells and the glycolysis pathway was altered. In vitro experiments demonstrated that necroptosis-related genes modulated cell function, including proliferation and migration, and the low-risk subgroup showed higher sensitivity to potential drugs. These findings contribute to a better understanding and improvement of treatment potential and prognosis in gastric cancer patients.
Review
Medicine, General & Internal
Yukiya Narita, Kei Muro
Summary: Gastric cancer treatments are rapidly evolving, with immune checkpoint inhibitors targeting PD-1 or PD-L1 showing long-term efficacy in some patients and currently being the first-line therapy. Approved immunotherapies for untreated gastric cancer patients include monotherapy and chemotherapy-immunotherapy combinations. Clinical trials have indicated the importance of PD-L1 expression in regimen selection, although other biomarkers, clinicopathologic factors, and patient preference might also be relevant. Novel biomarkers and therapeutic strategies are currently being assessed, potentially refining the current treatment paradigm. This review describes current treatment regimens for gastric cancer patients and details our approach to selecting first-line immunotherapy regimens.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Jiaqing Zhang, Can Hu, Ruolan Zhang, Jingli Xu, Yanqiang Zhang, Li Yuan, Shengjie Zhang, Siwei Pan, Mengxuan Cao, Jiangjiang Qin, Xiangdong Cheng, Zhiyuan Xu
Summary: This article reviews recent advances in the understanding of the origin, types, and polarization of macrophages in gastric cancer (GC). It provides an overview of the role of macrophages in GC carcinogenesis and development, as well as their interaction with the GC immune microenvironment and flora. Additionally, the article explores the role of macrophages in drug resistance and treatment of GC in preclinical and clinical trials to assess their potential therapeutic value in this disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Mingwei Ma, Juan Sun, Zhen Liu, Siwen Ouyang, Zimu Zhang, Ziyang Zeng, Jie Li, Weiming Kang
Summary: This article reviews the recent research progress in prognostic prediction and the immune microenvironment of gastric cancer, and discusses the possibility of new therapeutic targets for gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Xin Chen, Yuechao Zhao, Keying Liu, Zexu Li, Xingru Tan, Yulong Wang, Na Gao, Chenming Liu, Xiaoqi Fang, Yanlong Wang
Summary: The study found that lycopene has a protective effect on ethanol-induced gastric injury, but may exacerbate acute gastric mucosal injury at high doses. Additionally, lycopene has a protective effect on the stomach and liver when ethanol is not consumed.
FRONTIERS IN NUTRITION
(2021)
Review
Biotechnology & Applied Microbiology
Matthew J. Olnes, Holly A. Martinson
Summary: Gastric cancer (GC) is the third leading cause of cancer mortality worldwide, and while surgery is a cure for localized cases, most patients present with advanced non-operable disease. Recent advances in understanding the molecular and immune pathogenesis of GC have led to the development of novel therapeutics, including immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies, offering new treatment options for select patients with GC.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Cameron Schlegel, Lynne A. Lapierre, Victoria G. Weis, Janice A. Williams, Izumi Kaji, Carolina Pinzon-Guzman, Nripesh Prasad, Braden Boone, Angela Jones, Hernan Correa, Shawn E. Levy, Xianlin Han, Miao Wang, Kelly Thomsen, Sari Acra, James R. Goldenring
Article
Multidisciplinary Sciences
L. F. Araujo, A. D. D. Siena, J. R. Placa, D. B. Brotto, I. I. Barros, B. R. Muys, C. A. O. Biagi Jr, K. C. Peronni, J. F. Sousa, G. A. Molfetta, L. C. West, A. P. West, A. M. Leopoldino, E. M. Espreafico, W. A. Silva Jr
SCIENTIFIC REPORTS
(2018)
Article
Gastroenterology & Hepatology
Amy C. Engevik, Izumi Kaji, Melinda A. Engevik, Anne R. Meyer, Victoria G. Weis, Anna Goldstein, Michael W. Hess, Thomas Muller, Hermann Koepsell, Pradeep K. Dudeja, Matthew Tyska, Lukas A. Huber, Mitchell D. Shub, Nadia Ameen, James R. Goldenring
Article
Oncology
Bruna Rodrigues Muys, Josane F. Sousa, Jessica Rodrigues Placa, Luiza Ferreira de Araujo, Aishe A. Sarshad, Dimitrios G. Anastasakis, Xiantao Wang, Xiao Ling Li, Greice Andreotti de Molfetta, Anelisa Ramao, Ashish Lal, Daniel Onofre Vidal, Markus Hafner, Wilson A. Silva
Review
Oncology
Demond Williams, Barbara Fingleton
CLINICAL & EXPERIMENTAL METASTASIS
(2019)
Article
Multidisciplinary Sciences
Sylvain Darnet, Aline C. Dragalzew, Danielson B. Amaral, Josane F. Sousa, Andrew W. Thompson, Amanda N. Cass, Jamily Lorena, Eder S. Pires, Carinne M. Costa, Marcos P. Sousa, Nadia B. Froebisch, Guilherme Oliveira, Patricia N. Schneider, Marcus C. Davis, Ingo Braasch, Igor Schneider
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Adamo Davi Diogenes Siena, Jessica Rodrigues Placa, Luiza Ferreira Araujo, Isabela Ichihara de Barros, Kamila Peronni, Greice Molfetta, Carlos Alberto Oliveira de Biagi Jr, Enilza Maria Espreafico, Josane Freitas Sousa, Wilson Araujo Silva Jr
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Babak Banan, Jacob A. Beckstead, Lauren E. Dunavant, Yoojin Sohn, Jamie M. Adcock, Sachiyo Nomura, Naji Abumrad, James R. Goldenring, Barbara Fingleton
CLINICAL & EXPERIMENTAL METASTASIS
(2020)
Article
Evolutionary Biology
Nicholas D. Leigh, Sofia Sessa, Aline C. Dragalzew, Duygu Payzin-Dogru, Josane F. Sousa, Anthony N. Aggouras, Kimberly Johnson, Garrett S. Dunlap, Brian J. Haas, Michael Levin, Igor Schneider, Jessica L. Whited
EVOLUTION & DEVELOPMENT
(2020)
Article
Biology
Kellen Matos Verissimo, Louise Neiva Perez, Aline Cutrim Dragalzew, Gayani Senevirathne, Sylvain Darnet, Wainna Renata Barroso Mendes, Ciro Ariel dos Santos Neves, Erika Monteiro dos Santos, Cassia Nazare de Sousa Moraes, Ahmed Elewa, Neil Shubin, Nadia Belinda Froebisch, Josane de Freitas Sousa, Igor Schneider
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Review
Oncology
Wendy E. Bindeman, Barbara Fingleton
Summary: Metastasis plays a significant role in cancer-related deaths, with glycosylation emerging as a key player in determining cancer cells' tropism for different metastatic sites.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Cell Biology
Adamo Davi Diogenes Siena, Isabela Ichihara de Barros, Camila Baldin Storti, Carlos Alberto Oliveira de Biagi Junior, Larissa Anastacio da Costa Carvalho, Silvya Stuchi Maria-Engler, Josane de Freitas Sousa, Wilson Araujo Silva Jr
Summary: This study investigates the role of lncRNA U73166 in melanoma progression and resistance to vemurafenib. Experimental results show that lncRNA U73166 is associated with migration and invasion in melanoma cells, and its expression is higher in vemurafenib-resistant samples. These findings suggest that lncRNA U73166 could be a potential biomarker or target for overcoming clinical vemurafenib resistance.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Oncology
Ebony Hargrove-Wiley, Barbara Fingleton
Summary: Sex hormones such as estrogens and androgens play a crucial role in the pathophysiology of various cancers by regulating genomic and cellular processes. They can modulate immune signals and activities in tumor cells and leukocytes, affecting cancer progression. Understanding the impact of sex hormones on tumor immunity in the breast cancer microenvironment is important for developing effective therapies. Combining endocrine therapy with immunotherapy can enhance the antitumor immune response.
Article
Gastroenterology & Hepatology
Cameron Schlegel, Victoria G. Weis, Byron C. Knowles, Lynne A. Lapierre, Martin G. Martin, Paul Dickman, James R. Goldenring, Mitchell D. Shub
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Oncology
Barbara Fingleton, Kelly Lange, Beth Caldwell, Katherine V. Bankaitis
CLINICAL & EXPERIMENTAL METASTASIS
(2017)