Article
Multidisciplinary Sciences
Diane M. Bogdan, Keith Studholme, Adriana DiBua, Chris Gordon, Martha P. Kanjiya, Mei Yu, Michelino Puopolo, Martin Kaczocha
Summary: The endocannabinoid anandamide can produce both anti-pain effects and exacerbate pain. FABP5 plays a key role in regulating the levels of endocannabinoids in nociceptors, affecting pain perception. Decreasing the expression of FABP5 can increase the levels of endocannabinoids, leading to anti-pain effects.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Summary: Oral cancer patients experience sensitivity to spicy foods and liquids, but the mechanism behind this sensitivity is not yet understood. In a mouse model of oral cancer, researchers found increased expression of TRPV1 in trigeminal ganglion neurons, indicating an anatomical basis for chemosensitivity. They also discovered that PAR(2) plays a role in mediating the sensitivity induced by TRPV1 in tongue afferents in the oral cancer mouse model.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Alexander Hamers, Christopher P. Primus, Charlotte Whitear, Nitin Ajit Kumar, Michael Masucci, Shanik A. Montalvo Moreira, Krishnaraj Rathod, Jianmin Chen, Kristen Bubb, Romain Colas, Rayomand S. Khambata, Jesmond Dalli, Amrita Ahluwalia
Summary: This study demonstrates that endogenously generated 20-HETE activates TRPV1, leading to C-fiber activation and edema formation, which may be a potential pathway for therapeutic intervention in conditions characterized by neurogenic inflammation, such as certain skin diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Wen-Wen Zhang, Hong Cao, Yang Li, Xian-Jun Fu, Yu-Qiu Zhang
Summary: This study reveals the important role of peripheral adenylyl cyclase isoform AC3 in nociceptive transmission and regulation of opioid receptor signaling. The conditional knockout of AC3 in mouse DRGs led to increased nociceptive responses, decreased Kv channel currents, and increased neuronal excitability. Furthermore, AC3 knockout abolished the analgesic effect of KOR agonist and its inhibition on Kv channel, suggesting the involvement of AC3 in KOR opioid analgesia through classical G alpha(i/o) signaling or direct interaction with KOR. Additionally, the upregulation of AC1 and cAMP levels in AC3-deficient DRGs highlights the compensatory role of AC1 in the absence of AC3.
Review
Pharmacology & Pharmacy
Kazuhide Inoue, Makoto Tsuda
Summary: Chronic pain, especially neuropathic pain, is a significant clinical issue due to the ineffectiveness of available drugs. Research on extracellular ATP and P2 receptors in pain signaling provides insight into the mechanisms underlying chronic pain and potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Neurosciences
Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, Hongzhen Hu
Summary: By ablating the sensory channels TRPV1 and Piezo2 from colon-innervating neurons, the visceromotor responses (VMR) induced by colorectal distention (CRD) are significantly reduced in mice. Selective ablation of Piezo2 channels in TRPV1 lineage neurons reduces mechanically evoked visceral afferent action potential firing and CRD-induced VMR under physiological conditions, as well as in mouse models of zymosan-induced IBS and partial colon obstruction (PCO). These findings demonstrate the important role of the mechanosensitive Piezo2 channels in TRPV1-lineage neurons in visceral mechanosensitivity and nociception under physiological conditions, as well as in visceral hypersensitivity under pathological conditions.
Article
Biochemistry & Molecular Biology
Jenny Wilzopolski, Manfred Kietzmann, Santosh K. Mishra, Holger Stark, Wolfgang Baeumer, Kristine Rossbach
Summary: The study found that both TRPV1 and TRPA1 channels play important roles in the transmission of histamine-induced itch, with TRPV1 inhibition reducing itch induced by both H1R and H4R, while TRPA1 inhibition only reduced H4R-induced itch. In vitro experiments showed that inhibition of TRPV1 and TRPA1 led to reduced Ca2+ influx into sensory neurons.
Article
Neurosciences
Adrien Tassou, Maxime Thouaye, Damien Gilabert, Antoine Jouvenel, Jean-Philippe Leyris, Corinne Sonrier, Lucie Diouloufet, Ilana Mechaly, Sylvie Mallie, Juliette Bertin, Myriam Chentouf, Madeline Neiveyans, Martine Pugniere, Pierre Martineau, Bruno Robert, Xavier Capdevila, Jean Valmier, Cyril Rivat
Summary: Acute pain can lead to chronic pain, and the FLT3-tyrosine kinase receptor plays a crucial role in pain chronification after peripheral nerve injury. This study aimed to investigate whether injury-induced pain sensitization can also contribute to long-term mood disorders. The results showed that mice with double paw incisions exhibited an anxiodepressive-like phenotype and increased pain sensitivity compared to those with single incisions. These behavioral changes were associated with peripheral and spinal changes, including increased microglia activation. Blocking FLT3 and microglia activation alleviated the exaggerated pain sensitivity and anxiodepressive behaviors induced by double incisions. Humanized antibodies against FLT3 also reduced behavioral and microglia changes. Overall, this study suggests that peripheral lesions can not only cause exaggerated pain behaviors but also induce anxiodepressive disorders, and targeting peripheral FLT3 may provide a potential therapeutic approach.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Li Cheng, Cenglin Xu, Lu Wang, Dadao An, Lei Jiang, Yanrong Zheng, Yixin Xu, Yi Wang, Yujing Wang, Kuo Zhang, Xiaodong Wang, Xiangnan Zhang, Aimin Bao, Yudong Zhou, Jingyu Yang, Shumin Duan, Dick F. Swaab, Weiwei Hu, Zhong Chen
Summary: This study indicates that the deficiency of histamine H-1 receptor in cholinergic neurons in the basal forebrain is critical for sensorimotor gating deficit, social impairments, and anhedonia-like behavior in patients with schizophrenia. Deletion of the H1R gene in cholinergic neurons in mice resulted in functional deficiency of cholinergic projections and led to behavioral deficits, which could be rescued by re-expressing H1R or by chemogenetic activation of cholinergic neurons in the BF.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Caroline J. Tuck, Amal Abu Omar, Giada De Palma, Samira Osman, Nestor N. Jimenez-Vargas, Yang Yu, Sean M. P. Bennet, Cintya Lopez-Lopez, Josue O. Jaramillo-Polanco, Corey C. Baker, Aidan S. W. Bennett, Mabel Guzman-Rodriguez, Quentin Tsang, Taylor Alward, Sebastien Rolland, Celine Morissette, Elena F. Verdu, Premysl Bercik, Stephen J. Vanner, Alan E. Lomax, David E. Reed
Summary: Objective dietary therapies for IBS have shown that reducing the consumption of fermentable carbohydrates can relieve abdominal pain. This study suggests that changes in luminal neuroactive metabolites may contribute to the reduction in pain symptoms.
Article
Neurosciences
Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli
Summary: The loss of hypothalamic neurons producing wake-promoting orexin is responsible for narcolepsy type 1. While histamine neurons are increased in NT1 patients, orexin-deficient mice show inconsistent results. However, histamine deficiency does not significantly affect orexin neuron development in mammals.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Luisa Zupin, Egidio Barbi, Raffaella Sagredini, Giulia Ottaviani, Sergio Crovella, Fulvio Celsi
Summary: This study found that PBMT at 800 and 970 nm wavelengths has a positive effect on nociceptive sensory neuronal cell line by reducing capsaicin-induced calcium flow, increasing ATP, and MMP hyperpolarization. Additionally, the 800 nm wavelength also increased ROS and O-2(-) levels.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Engineering, Biomedical
Kevin Xu, Yaoheng Yang, Zhongtao Hu, Yimei Yue, Yan Gong, Jianmin Cui, Joseph P. Culver, Michael R. Bruchas, Hong Chen
Summary: The feasibility and safety of TRPV1-mediated sonogenetics in targeting the motor cortex to modulate the locomotor behavior of mice was evaluated. Stimulation at 0.7 MPa successfully evoked rotational behavior and activated cortical neurons without inducing inflammation or apoptosis. However, higher acoustic pressure at 1.1 MPa may cause meningeal damage.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Anesthesiology
Dominic Anthony Friston, Joshua Cuddihy, Jessica Souza Luiz, An Hoai Truong, Laptin Ho, Meirvaan Basra, Peter Santha, Orsolya Oszlacs, Joao de Sousa Valente, Tim Marczylo, Sini Junttila, Helen Laycock, Declan Collins, Marcela Vizcaychipi, Attila Gyenesei, Zoltan Takats, Gabor Jancso, Elizabeth Want, Istvan Nagy
Summary: Tissue injuries, including burns, release intracellular molecules and induce inflammatory reactions, leading to persistent pain. This study reveals that 18:0 LPC, a lysophosphatidylcholine, plays a significant role in burn injury-induced pain. It activates pain-sensing neurons and causes hypersensitivities through the transient receptor potential ion channel. These findings have implications for improving patient care.
Article
Gastroenterology & Hepatology
Zhongcheng Shi, Yuko Mori-Akiyama, Wa Du, Robert Fultz, Yanling Zhao, Wenly Ruan, Susan Venable, Melinda A. Engevik, James Versalovic
Summary: This study found that blocking H2R signaling enhances the proinflammatory responses of mature neutrophils and suppresses neutrophil maturation, leading to accelerated progression of inflammation-associated colonic tumorigenesis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)